{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T17:14:12Z","timestamp":1767374052346,"version":"3.30.2"},"reference-count":0,"publisher":"Knowledge E DMCC","content-domain":{"domain":["kne-publishing.com","knepublishing.com","jri.ir"],"crossmark-restriction":true},"short-container-title":["JRI"],"abstract":"<jats:p>Background: Saffron petals have traditionally been used to treat a variety of diseases, such as gynecological diseases, primary dysmenorrhea, and premenstrual syndrome. Polycystic ovary syndrome (PCOS) is a kind of gynecological disease that causes infertility, menopausal and urogenital disorders and saffron petals seem to be an efficient treatment for such disorders.\r\nMethods: NMRI mice (total=60, each group n=12) were divided into control, PCOS, and the treatment groups. PCOS and treatment groups were injected with testosterone enanthate (TE=1 mg\/kg). After 4 weeks, the treatment group was treated with Saffron Petal Extract (SPE) for 14 days. Ovary and blood samples were collected for histological and serological analyses, and expression of NF-\u03baB, NF-\u03baB p65, and I\u03baB genes was analyzed. Finally, data were analyzed using one-way ANOVA (p&lt;0.05).\r\nResults: In this study, the number of corpus luteum decreased in PCOS mice (p&lt; 0.001) but increased with SPE treatment (p&lt;0.05, p&lt;0.01, p&lt;0.001). The number of cystic follicles increased in PCOS mice (p&lt;0.001), but decreased with SPE treatment (p&lt;0.05, p&lt;0.001). TNF\u03b1, IL1\u00df, IL6, IL18, and CRP levels increased in PCOS mice (p&lt;0.001), but decreased following SPE treatment (p&lt;0.05, p&lt;0.001). Glutathione (GSH) and glutathione S-transferase (GST) serum levels decreased in PCOS mice (p&lt;0.001), but increased with SPE treatment (p&lt;0.05, p&lt;0.001). The transcriptional level (s) of NF-\u03baB, NF-\u03baB p65, I\u03baB genes changed in PCOS condition (p&lt;0.001), and were regulated by SPE treatment (p&lt;0.05, p&lt;0.01 and p&lt;0.001).\r\nConclusion: The present study shows that SPE improved the PCOS symptoms in mice via increasing antioxidant factors and reducing inflammatory markers in serum.<\/jats:p>","DOI":"10.18502\/jri.v23i1.8447","type":"journal-article","created":{"date-parts":[[2022,1,23]],"date-time":"2022-01-23T06:53:22Z","timestamp":1642920802000},"update-policy":"https:\/\/doi.org\/10.18502\/knecrossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Investigating the Effect of Crocus sativus (Saffron) Petal Hydro-alcoholic  Extract on Ovarian Follicle, Inflammatory Markers, and Antioxidant Enzymes in Mice Model of Polycystic Ovary Syndrome"],"prefix":"10.18502","author":[{"given":"Fazeleh","family":"Moshfegh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saeedeh","family":"Zafar Balanejad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khadige","family":"Shahrokhabady","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Armin","family":"Attaranzadeh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7770","published-online":{"date-parts":[[2022,1,23]]},"container-title":["Journal of Reproduction &amp; Infertility"],"original-title":[],"deposited":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T16:48:27Z","timestamp":1734454107000},"score":1,"resource":{"primary":{"URL":"https:\/\/publish.kne-publishing.com\/index.php\/JRI\/article\/view\/8447"},"secondary":[{"URL":"https:\/\/www.jri.ir\/article\/120136","label":"UNIVERSITY"},{"URL":"https:\/\/publish.kne-publishing.com\/index.php\/JRI\/article\/view\/8447","label":"PUBLISHER"}]},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,23]]},"references-count":0,"URL":"https:\/\/doi.org\/10.18502\/jri.v23i1.8447","relation":{},"ISSN":["2251-676X","2228-5482"],"issn-type":[{"type":"electronic","value":"2251-676X"},{"type":"print","value":"2228-5482"}],"subject":[],"published":{"date-parts":[[2022,1,23]]}}}