{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T17:25:32Z","timestamp":1772213132797,"version":"3.50.1"},"reference-count":0,"publisher":"Knowledge E DMCC","content-domain":{"domain":["kne-publishing.com","knepublishing.com","jri.ir"],"crossmark-restriction":true},"short-container-title":["JRI"],"abstract":"<jats:p>Background: The purpose of the current study was evaluation of the utility of seminal plasma (SP) resistin and leptin in predicting successful surgical sperm retrieval (SSR) in men with non-obstructive azoospermia (NOA).\r\nMethods: This prospective comparative study was conducted in the andrology clinic of a specialized fertility center. In total, 53 NOA men as candidates for either first time micro\u2010testicular sperm extraction (micro-TESE) or repeat micro-TESE and 28 normozoospermic controls were included. ELISA was used for measurement of SP resistin and leptin levels in all participants. Significance level was defined as p&lt; 0.05.\u00a0\r\nResults: The current study demonstrated a significant positive correlation between estradiol (E2) level in serum and SP resistin (r=0.342, p=0.025). Also, there was a highly significant positive correlation between SP leptin and SP resistin (r=0.568, p= 0.001). Interestingly, SP leptin was the only variable that demonstrated a significant correlation with eventful micro-TESE outcome in men who underwent micro-TESE for the first time. Finally, ROC curve showed that SP leptin level of 4.05 ng\/ml predicted successful SSR in men who underwent micro-TESE for the first time with a sensitivity of 73.3% and a specificity of 75% as 11 out of 27 (41%) cases showed eventful micro-TESE at or above this cut-off level [AUC of 0.747, 95% CI, lower bound of 0.555, and upper bound of 0.939, p=0.030].\r\nConclusion: SP leptin can be used as a non-invasive biomarker to predict successful SSR in NOA cases undergoing first time micro-TESE, while SP resistin failed to play the same role.<\/jats:p>","DOI":"10.18502\/jri.v24i2.12496","type":"journal-article","created":{"date-parts":[[2023,4,18]],"date-time":"2023-04-18T03:12:50Z","timestamp":1681787570000},"update-policy":"https:\/\/doi.org\/10.18502\/knecrossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Evaluation of the Utility of Seminal Plasma Resistin and Leptin in  Predicting Successful Surgical Sperm Retrieval in Men with Non-Obstructive Azoospermia"],"prefix":"10.18502","author":[{"given":"Medhat","family":"Kamel Amer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wael","family":"Zohdy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sameh Fayek","family":"GamalEl Din","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanan","family":"Hosni Moawad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dina Atef","family":"Hasan El Saedy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eman Ahmed","family":"Zaki Gamal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed","family":"Ragab","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7770","published-online":{"date-parts":[[2023,4,18]]},"container-title":["Journal of Reproduction &amp; Infertility"],"original-title":[],"link":[{"URL":"https:\/\/publish.kne-publishing.com\/index.php\/JRI\/article\/download\/12496\/11690","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/publish.kne-publishing.com\/index.php\/JRI\/article\/download\/12496\/11690","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T16:40:32Z","timestamp":1772210432000},"score":1,"resource":{"primary":{"URL":"https:\/\/publish.kne-publishing.com\/index.php\/JRI\/article\/view\/12496"},"secondary":[{"URL":"https:\/\/www.jri.ir\/article\/140185","label":"UNIVERSITY"},{"URL":"https:\/\/publish.kne-publishing.com\/index.php\/JRI\/article\/view\/12496","label":"PUBLISHER"}]},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,18]]},"references-count":0,"URL":"https:\/\/doi.org\/10.18502\/jri.v24i2.12496","relation":{},"ISSN":["2251-676X","2228-5482"],"issn-type":[{"value":"2251-676X","type":"electronic"},{"value":"2228-5482","type":"print"}],"subject":[],"published":{"date-parts":[[2023,4,18]]}}}