{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T18:03:21Z","timestamp":1788890601557,"version":"build-2803163510"},"reference-count":0,"publisher":"Knowledge E DMCC","content-domain":{"domain":["kne-publishing.com","knepublishing.com","jri.ir"],"crossmark-restriction":true},"short-container-title":["JRI"],"abstract":"<jats:p>Background: Testicular torsion is a critical urological emergency that can lead to testicular ischemia and significant tissue damage. Citrulline, a supplement known for enhancing cellular metabolism and mitigating oxidative stress and inflammation, has been explored for its protective effects against testicular injury resulting from torsion and detorsion in rat models.\r\nMethods: This study involved 42 Wistar rats, divided into six groups: Sham, torsion\/detorsion (T\/D), and four groups receiving varying doses of Citrulline (300, 600, 900 mg\/kg) and vitamin E (20 mg\/kg). A surgical procedure was performed to induce torsion by rotating the left testicle for 4 hr, followed by reperfusion. Daily oral administration of the supplements continued for one week post-surgery. Assessments included oxidative stress markers, apoptosis, inflammation, pathology, and sperm parameters. Statistical analysis was conducted using GraphPad Prism.\r\nResults: Citrulline administration at doses of 600 and 900 mg\/kg significantly reduced malondialdehyde (MDA) and reactive oxygen species (ROS) levels. Additionally, it increased glutathione (GSH) levels and decreased protein carbonyl levels at the 900 mg\/kg dose. The expression of interleukin-6 (IL-6) decreased at 900 mg\/ kg, tumor necrosis factor-alpha (TNF-\u03b1) levels dropped at 600 and 900 mg\/kg, and the pro-apoptotic factor Bax was reduced at all doses. Sperm analysis showed improved sperm count and motility at the 900 mg\/kg dose. Histological examination revealed significant positive effects of Citrulline on testicular tissue.\r\nConclusion: Citrulline effectively lowers oxidative stress, inflammation, while enhancing sperm quality and pathological outcomes. These results indicate that Citrulline has potential as a therapeutic agent for testicular torsion.<\/jats:p>","DOI":"10.18502\/jri.v25i3.17014","type":"journal-article","created":{"date-parts":[[2024,11,17]],"date-time":"2024-11-17T02:05:45Z","timestamp":1731809145000},"update-policy":"https:\/\/doi.org\/10.18502\/knecrossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["The Protective Effects of Citrulline on Testicular Injury Induced by Torsion and Detorsion in Adult Male Rats: An Experimental Study"],"prefix":"10.18502","author":[{"given":"Vida","family":"Motamed Nia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nastaran","family":"Rezaei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Shokati Sayyad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Seyedabadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fereshteh Talebpour","family":"Amiri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatemeh","family":"Shaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7770","published-online":{"date-parts":[[2024,11,17]]},"container-title":["Journal of Reproduction &amp; Infertility"],"original-title":[],"link":[{"URL":"https:\/\/publish.kne-publishing.com\/index.php\/JRI\/article\/download\/17014\/15858","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/publish.kne-publishing.com\/index.php\/JRI\/article\/download\/17014\/15858","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T14:44:29Z","timestamp":1771944269000},"score":1,"resource":{"primary":{"URL":"https:\/\/publish.kne-publishing.com\/index.php\/JRI\/article\/view\/17014"},"secondary":[{"URL":"https:\/\/www.jri.ir\/article\/140241","label":"UNIVERSITY"}]},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,17]]},"references-count":0,"URL":"https:\/\/doi.org\/10.18502\/jri.v25i3.17014","relation":{},"ISSN":["2251-676X","2228-5482"],"issn-type":[{"value":"2251-676X","type":"electronic"},{"value":"2228-5482","type":"print"}],"subject":[],"published":{"date-parts":[[2024,11,17]]}}}