{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T14:28:11Z","timestamp":1779114491354,"version":"3.51.4"},"reference-count":0,"publisher":"Knowledge E DMCC","content-domain":{"domain":["knepublishing.com"],"crossmark-restriction":true},"short-container-title":["JRI"],"abstract":"<jats:p>Background: Echocardiographic indicators may be useful as an alternative method to determine the appropriate time for intervention, especially when Doppler assessment of the middle cerebral artery peak systolic velocity (MCA-PSV) is inconclusive. In this study, arterial duct blood flow and cardiac output of fetuses with Rh alloimmunization-related anemia were compared before and after intrauterine transfusion (IUT).\r\nMethods: Fifty intrauterine blood transfusions were performed on anemic fetuses in this study. All cases were attributed to Rh alloimmunization, detected with MCA-PSV Doppler ultrasound imaging assessments. They all underwent intrauterine blood transfusion and echocardiographic assessments a day before and 24 hr after the procedure. The measured cardiac indices included the velocity time integral (VTI) of the aortic and pulmonary valves, the ductus arteriosus acceleration-to-ejection time (AT\/ET) ratio, and the MCA-PSV. Analyses were performed in SPSS v24 (p&lt;0.05) using paired t-tests for mean differences and Pearson\u2019s correlation for associations between continuous variables.\r\nResults: Aortic and pulmonary valve VTI, MCA-PSV, and ductus arteriosus AT\/ET ratio significantly decreased after intrauterine blood transfusion (p&lt;0.001). The aortic valve VTI and ductus arteriosus accurately detected anemia, with areas under the receiver operating characteristic (ROC) curve of 99.9% and 98.9%, respectively.\r\nConclusion: All the measured parameters showed significant changes after intrauterine blood transfusion. Aortic valve VTI and ductus arteriosus AT\/ET ratio seem to have the highest accuracy in detecting anemia. Echocardiographic assessment can be beneficial in defining the appropriate time for intrauterine blood transfusion in cases where MCA-PSV is inefficient.<\/jats:p>","DOI":"10.18502\/jri.v26i4.21091","type":"journal-article","created":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T11:22:29Z","timestamp":1771672949000},"update-policy":"https:\/\/doi.org\/10.18502\/knecrossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["The Effect of Fetal Intrauterine Blood Transfusion on Ductal Arterial Blood Flow Velocity and Cardiac Output Changes in Fetuses with Rhesus  Alloimmunization-Related Anemia"],"prefix":"10.18502","author":[{"given":"Behrokh","family":"Sahebdel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad Nasir","family":"Hematian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zohreh","family":"Heidary","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatemeh","family":"Rahimi-Sharbaf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatemeh","family":"Golshahi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahboobeh","family":"Shirazi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nafiseh","family":"Saedi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Faezeh Mahdavi","family":"Omran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zahra","family":"Moradi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sodabeh","family":"Rezaei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7770","published-online":{"date-parts":[[2026,2,21]]},"container-title":["Journal of Reproduction &amp; Infertility"],"original-title":[],"link":[{"URL":"https:\/\/publish.kne-publishing.com\/index.php\/JRI\/article\/download\/21091\/19840","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/publish.kne-publishing.com\/index.php\/JRI\/article\/download\/21091\/19840","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T13:26:11Z","timestamp":1779110771000},"score":1,"resource":{"primary":{"URL":"https:\/\/publish.kne-publishing.com\/index.php\/JRI\/article\/view\/21091"},"secondary":[{"URL":"https:\/\/www.jri.ir\/article\/140284","label":"UNIVERSITY"}]},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,21]]},"references-count":0,"URL":"https:\/\/doi.org\/10.18502\/jri.v26i4.21091","relation":{},"ISSN":["2251-676X","2228-5482"],"issn-type":[{"value":"2251-676X","type":"electronic"},{"value":"2228-5482","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2,21]]}}}