{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,9]],"date-time":"2026-08-09T09:42:14Z","timestamp":1786268534853,"version":"build-2736575974"},"reference-count":0,"publisher":"Knowledge E DMCC","content-domain":{"domain":["knepublishing.com"],"crossmark-restriction":true},"short-container-title":["JRI"],"abstract":"<jats:p>Background: Although the balanced carriers of Robertsonian translocations (ROBs) typically exhibit normal phenotypes, they may experience recurrent abortions or have offspring with chromosomal disorders. A proposed mechanism is the inter-chromosomal effect (ICE), where disrupted meiotic segregation may increase aneuploid gamete production. This study presents a male case carrier of t(13;14) who had a deceased child with Down syndrome (DS) and investigates t(13;14) as a potential factor contributing to the birth of a child with DS.\u00a0\r\nCase Presentation: A couple with a history of recurrent abortions and a deceased child with DS was referred to a medical genetics laboratory. Karyotype analysis revealed that the male partner was a carrier of t(13;14) (45,XY,t(13;14)), while the female partner had a normal karyotype. The couple\u2019s subsequent pregnancy resulted in a healthy female fetus inheriting t(13;14). The deceased child had a karyotype of 47, XY, +21, consistent with DS. In this study, the role of t(13;14) and ICE as potential contributors to the birth of a child with DS was explored.\u00a0\r\nConclusion: Prenatal screening for carriers of ROBs is strongly recommended to assess the risk of unbalanced chromosomal disorders in offspring<\/jats:p>","DOI":"10.18502\/jri.v27i1.22124","type":"journal-article","created":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T07:41:51Z","timestamp":1785224511000},"update-policy":"https:\/\/doi.org\/10.18502\/knecrossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Inter-chromosomal Effect in a Robertsonian Translocation (13;14) Carrier with a Child Affected by Down Syndrome: A Case Report"],"prefix":"10.18502","author":[{"given":"Sahra","family":"Sahraeean","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asiyeh","family":"Jebelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saeed Ghadimi","family":"Haddadan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kobra","family":"Tayyari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leila","family":"Emrahi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7770","published-online":{"date-parts":[[2026,7,28]]},"container-title":["Journal of Reproduction &amp; Infertility"],"original-title":[],"link":[{"URL":"https:\/\/publish.kne-publishing.com\/index.php\/JRI\/article\/download\/22124\/20534","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/publish.kne-publishing.com\/index.php\/JRI\/article\/download\/22124\/20534","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,9]],"date-time":"2026-08-09T09:30:22Z","timestamp":1786267822000},"score":1,"resource":{"primary":{"URL":"https:\/\/publish.kne-publishing.com\/index.php\/JRI\/article\/view\/22124"},"secondary":[{"URL":"https:\/\/www.jri.ir\/article\/140293","label":"SECONDARY_JRI"}]},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,28]]},"references-count":0,"URL":"https:\/\/doi.org\/10.18502\/jri.v27i1.22124","relation":{},"ISSN":["2251-676X","2228-5482"],"issn-type":[{"value":"2251-676X","type":"electronic"},{"value":"2228-5482","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7,28]]}}}