{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:26:22Z","timestamp":1787023582015,"version":"build-2736575974"},"reference-count":0,"publisher":"Knowledge E DMCC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JTHC"],"abstract":"<jats:p>Background: Patients with mitral valve prolapse (MVP) may reveal symptoms of autonomic dysfunction and heart rate variability (HRV). We sought to explore the autonomic nervous system in children with MVP.\r\nMethods: This cross-sectional study enrolled 60 children aged between 5 and 15 years with MVP and 60 age- and sex-matched healthy children as controls. Two cardiologists performed electrocardiography and standard echocardiography. HRV parameters were explored via 24-hour rhythm 3-channel Holter monitoring. The depolarization of ventricular and atrial parameters, comprising QT max and min, QTc intervals, QT dispersion, P maximum and minimum, and P-wave dispersion, was measured and compared.\r\nResults: The mean age was 13.12\u00b11.50 years in the MVP group (F\/M: 34\/26) and 13.20\u00b11.81 years in the control group (F\/M: 35\/25). The maximum duration and P-wave dispersion in the MVP group were signi\ufb01cantly different from the healthy children (P&lt;0.001). The longest and shortest QT dispersion values and QTc values were signi\ufb01cantly different between the 2 groups (P=0.004, P=0.043, P&lt;0.001, and P&lt;0.001, respectively). The HRV parameters were signi\ufb01cantly different between the 2 groups, too. \r\nConclusion: Decreased HRV and inhomogeneous depolarization showed that our children with MVP were prone to atrial and ventricular arrhythmias. Furthermore, P-wave dispersion and QTc could be used as prognostic markers of cardiac autonomic dysfunction before it is diagnosed by 24-hour Holter monitoring.<\/jats:p>","DOI":"10.18502\/jthc.v17i3.10847","type":"journal-article","created":{"date-parts":[[2022,10,11]],"date-time":"2022-10-11T08:32:58Z","timestamp":1665477178000},"source":"Crossref","is-referenced-by-count":1,"title":["Effects of Mitral Valve Prolapse on Heart Rate Variability and the Autonomic Nervous System in Children"],"prefix":"10.18502","author":[{"given":"Mohaddese","family":"Ahmadi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bita","family":"Ghahremani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danial","family":"Habibi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saiid","family":"Sadrnia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yazdan","family":"Ghandi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7770","published-online":{"date-parts":[[2022,10,11]]},"container-title":["The Journal of Tehran University Heart Center"],"original-title":[],"link":[{"URL":"https:\/\/publish.kne-publishing.com\/index.php\/JTHC\/article\/download\/10847\/10250","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/publish.kne-publishing.com\/index.php\/JTHC\/article\/download\/10847\/10250","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T12:13:14Z","timestamp":1734437594000},"score":1,"resource":{"primary":{"URL":"https:\/\/publish.kne-publishing.com\/index.php\/JTHC\/article\/view\/10847"},"secondary":[{"URL":"https:\/\/jthc.tums.ac.ir\/index.php\/jthc\/article\/view\/1438","label":"UNIVERSITY"},{"URL":"https:\/\/publish.kne-publishing.com\/index.php\/JTHC\/article\/view\/10847","label":"PUBLISHER"}]},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,11]]},"references-count":0,"URL":"https:\/\/doi.org\/10.18502\/jthc.v17i3.10847","relation":{},"ISSN":["2008-2371","1735-8620"],"issn-type":[{"value":"2008-2371","type":"electronic"},{"value":"1735-8620","type":"print"}],"subject":[],"published":{"date-parts":[[2022,10,11]]}}}