{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T02:18:52Z","timestamp":1792030732161,"version":"4.4.0"},"reference-count":0,"publisher":"Knowledge E DMCC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JTHC"],"abstract":"<jats:p>Background: Long-term outcomes in patients with idiopathic pulmonary arterial hypertension (IPAH) treated with calcium channel blockers (CCBs) are not well documented. Therefore, this study aimed to determine the long-term response to treatment with CCBs in patients with IPAH.\r\nMethods: This retrospective cohort study was performed on 81 patients with IPAH admitted to our center. Vasoreactivity testing with adenosine was performed. Twenty-five patients showed a positive response and were included in the analysis. \r\nResults: Of 24 patients, 20 (83.3%) were female, and the mean age of the patients was 45.90\u00b110.42 years. Fifteen patients improved after 1 year on CCB therapy (the long-term CCB responders group), and 9 showed no improvement (the CCB failure group). The CCB responders group had a greater proportion of patients in the New York Heart Association (NYHA) functional class I or II (93.3%), a longer distance walked, and less severe hemodynamic parameters. At the 1-year evaluation, the long-term CCB responders showed more improvements in the mean 6-minute walk test result (437.43\u00b1125.32 vs 268.17\u00b1130.06; P=0.040), the mixed venous oxygen saturation level (71.84\u00b19.87 vs 59.03\u00b19.95; P=0.041), and the cardiac index (4.76\u00b11.12 vs 3.15\u00b10.90; P=0.012). Additionally, mPAP was lower in the long-term CCB responders group (47.35\u00b112.70 vs 67.23\u00b114.08; P=0.034).\u00a0 Finally, all the CCB responders were in the NYHA functional class I or II (P=0.001).\r\nConclusion: Our study illustrated that long-term treatment with oral CCBs was effective in 60% of acute responders and 18.5% of the entire study population.<\/jats:p>","DOI":"10.18502\/jthc.v18i1.12583","type":"journal-article","created":{"date-parts":[[2023,4,30]],"date-time":"2023-04-30T07:41:59Z","timestamp":1682840519000},"source":"Crossref","is-referenced-by-count":2,"title":["The Long-term Response to Treatment with Calcium Channel Blockers in Patients with Idiopathic Pulmonary Arterial Hypertension"],"prefix":"10.18502","author":[{"given":"Azam","family":"Kiani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Razieh","family":"Omidvar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nasim","family":"Naderi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sepideh","family":"Taghavi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marzieh","family":"Mirtajaddini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7770","published-online":{"date-parts":[[2023,4,29]]},"container-title":["The Journal of Tehran University Heart Center"],"original-title":[],"link":[{"URL":"https:\/\/publish.kne-publishing.com\/index.php\/JTHC\/article\/download\/12583\/11781","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/publish.kne-publishing.com\/index.php\/JTHC\/article\/download\/12583\/11781","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T14:46:40Z","timestamp":1734446800000},"score":1,"resource":{"primary":{"URL":"https:\/\/publish.kne-publishing.com\/index.php\/JTHC\/article\/view\/12583"},"secondary":[{"URL":"https:\/\/jthc.tums.ac.ir\/index.php\/jthc\/article\/view\/1756","label":"UNIVERSITY"},{"URL":"https:\/\/publish.kne-publishing.com\/index.php\/JTHC\/article\/view\/12583","label":"PUBLISHER"}]},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,29]]},"references-count":0,"URL":"https:\/\/doi.org\/10.18502\/jthc.v18i1.12583","relation":{},"ISSN":["2008-2371","1735-8620"],"issn-type":[{"value":"2008-2371","type":"electronic"},{"value":"1735-8620","type":"print"}],"subject":[],"published":{"date-parts":[[2023,4,29]]}}}