{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T12:11:00Z","timestamp":1779192660616,"version":"3.51.4"},"reference-count":0,"publisher":"Knowledge E DMCC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JTHC"],"abstract":"<jats:p>Background: Ischemic heart disease is the leading cause of death worldwide. Oxidative stress plays a key role in myocardial infarction (MI). Ferroptosis, a type of iron-dependent regulated cell death caused by lipid peroxide accumulation, has been identified as a key mechanism in ischemic injury. This study aimed to investigate the association between oxidative stress and ferroptosis in patients with non\u2013ST-segment-elevation myocardial infarction (NSTEMI).\r\nMethods: In this case-control study, 25 patients with NSTEMI and 25 controls were included. In serum samples, cardiac markers (troponin I and CK-MB), oxidative stress biomarkers including lipid peroxidation (LPO), total antioxidant capacity (TAC), total thiol groups (TTG), superoxide dismutase (SOD) activity, glutathione peroxidase (GPx) activity, and iron and ferritin levels were measured.\r\nResults: In patients with NSTEMI, serum levels of cardiac markers (troponin I and CK-MB), LPO, iron, and ferritin were significantly higher than in controls. In contrast, TAC, TTG, and SOD and GPx activities were significantly lower in patients with NSTEMI.\r\nConclusion: This study demonstrated a possible role of oxidative stress in the pathophysiology of NSTEMI. Elevated iron and LPO levels and reduced GPx activity may contribute to cardiac cell death through ferroptosis.<\/jats:p>","DOI":"10.18502\/jthc.v21i1.21281","type":"journal-article","created":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T13:15:30Z","timestamp":1776690930000},"source":"Crossref","is-referenced-by-count":0,"title":["Is Ferroptosis and Oxidative Stress Involved in NSTEMI Patient\u2019s?"],"prefix":"10.18502","author":[{"given":"Ali","family":"Mirzaee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maryam","family":"Mehrpooya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akram","family":"Ranjbar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sajad","family":"Naghdi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Afsaneh","family":"Familmotaghi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seyed Saman","family":"Talebi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seyed Kianoosh","family":"Hosseini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7770","published-online":{"date-parts":[[2026,4,20]]},"container-title":["The Journal of Tehran University Heart Center"],"original-title":[],"link":[{"URL":"https:\/\/publish.kne-publishing.com\/index.php\/JTHC\/article\/download\/21281\/19865","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/publish.kne-publishing.com\/index.php\/JTHC\/article\/download\/21281\/19865","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T11:51:09Z","timestamp":1779191469000},"score":1,"resource":{"primary":{"URL":"https:\/\/publish.kne-publishing.com\/index.php\/JTHC\/article\/view\/21281"},"secondary":[{"URL":"https:\/\/jthc.tums.ac.ir\/index.php\/jthc\/article\/view\/2319","label":"UNIVERSITY"}]},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,20]]},"references-count":0,"URL":"https:\/\/doi.org\/10.18502\/jthc.v21i1.21281","relation":{},"ISSN":["2008-2371","1735-8620"],"issn-type":[{"value":"2008-2371","type":"electronic"},{"value":"1735-8620","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4,20]]}}}