none 10.18502/ijph.v53i2.14926 Knowledge E DMCC Knowledge E DMCC 7770 158075779 340577 1772107303 10.18502 2026-02-26T12:01:44Z 2024-02-19T05:48:15Z 1 Iranian Journal of Public Health ijph 2251-6093 2251-6085 02 19 2024 Maja Milosevic Markovic Milan Petrovic Milan Latas Igor Djordjevic Srdjan Milovanovic Svetlana Jovanovic Background: Oral squamous cell carcinoma (OSCC) has numerous physical, psychosocial and financial implications, which significantly affect patients' quality of life. We aimed to determine the health-related quality of life (HRQoL) and identify quality of life (QoL) predictors in patients with OSCC. Methods: We included 64 consecutive patients aged 40 to 80 yr treated for OSCC from Jan to Dec 2021. Health-related QoL was evaluated using the 30-item Cancer Quality of Life Questionnaire (QLQ-C30) and the 35-item Head and Neck Cancer-Quality of Life Questionnaire (QLQ-H&N35). The demographic questionnaire and clinical parameters were also presented. Results: The functioning scale in the QLQ-C30 questionnaire with the lowest average score was Global health status. The mean QLQ-C30 summary score (80.92 ± 10.4) was higher than the Global health status score (50.5 ± 22.2). In the QLQ-H&N35 questionnaire, the symptoms with highest scores were weight loss, dry mouth, and social eating. Linear regression analysis demonstrated that Global health status score was associated with education level [β-coefficient = 19.33 (95% CI: 10.7-24.9, P=0.004], alcohol consumption [β-coefficient=10.04 (95% CI: 4.5-14.8), P=0.023] and invasive surgical procedure [β-coefficient=22.75 (95% CI: 15.0-30.5), P=0.002]. The QLQ-C30 summary score was associated with living alone [β-coefficient= -20.05 (95% CI: −29.91-(−10.21), P=0.018], smoking status [β-coefficient=4.35 (95% CI: 1.8-6.91), P=0.043] and alcohol consumption [β-coefficient =4.59 (95% CI: 1.99-7.19), P=0.037]. Conclusion: We found several significant predictors of worse perception of HRQoL among patients with OSCC, which may be useful for specific prevention and treatment in order to achieve better QoL.   02 18 2024 10.18502/ijph.v53i2.14926 https://publish.kne-publishing.com/index.php/ijph/article/view/14926 https://publish.kne-publishing.com/index.php/ijph/article/download/14926/14044 https://publish.kne-publishing.com/index.php/ijph/article/download/14926/14044 https://ijph.tums.ac.ir/index.php/ijph/article/view/29466