{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,25]],"date-time":"2024-07-25T20:32:46Z","timestamp":1721939566820},"reference-count":28,"publisher":"Federacion Colombiana de Obstetricia y Ginecologia","issue":"1","license":[{"start":{"date-parts":[[2019,3,29]],"date-time":"2019-03-29T00:00:00Z","timestamp":1553817600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Colomb. Obstet. Ginecol."],"abstract":"<jats:p>Objetivo: presentar un caso de Enfermedad de Paget (EP) mamaria sin carcinoma ductal asociado y realizar una revisi\u00f3n de literatura respecto a su diagn\u00f3stico y tratamiento.Materiales y m\u00e9todos: mujer de 59 a\u00f1os, con lesi\u00f3n pruriginosa, eritematosa y ulcerada cr\u00f3nica, en pez\u00f3n izquierdo, de 2 a\u00f1os de evoluci\u00f3n, quien recibi\u00f3 inicialmente manejo dermatol\u00f3gico con corticoides t\u00f3picos sin mejor\u00eda cl\u00ednica y acude finalmente a una instituci\u00f3n de atenci\u00f3n primaria en Tunja, Colombia para su diagn\u00f3stico, el cual se realiz\u00f3 por biopsia mediante inmunohistoqumica y posterior manejo mediante cuadrantectom\u00eda central con patolog\u00eda posquir\u00fargica negativa para malignidad, sin recurrencia al a\u00f1o de seguimiento.\u00a0\u00a0 Se realiz\u00f3 una b\u00fasqueda en las bases de datos PubMed, SciELO, ProQuest, ScienceDirect y Google Acad\u00e9mico con los t\u00e9rminos \u201cPaget\u00b4s Disease\u201d, \u201cBreast Neoplasms\u201d, \u201cMammography\u201d \u201cUltrasonography, Mammary\u201d, \u201cBiopsy\u201d y \u201cMastectomy\u201d, rastreando art\u00edculos de revisi\u00f3n bibliogr\u00e1fica, editoriales, reportes y series de casos cl\u00ednicos en ingl\u00e9s y espa\u00f1ol, sin l\u00edmite de tiempo.Resultados: se incluyeron 11 publicaciones correspondientes a 5 reportes de caso, 3 series de casos, 1 revisi\u00f3n de la literatura a partir de un caso cl\u00ednico y 2 cartas al editor que describieron casos relacionados con enfermedad de Paget del pez\u00f3n sin carcinoma asociado. El diagn\u00f3stico se fundament\u00f3 en la sospecha cl\u00ednica de la enfermedad con la posterior realizaci\u00f3n de biopsia de la lesi\u00f3n, la inmunohistoqu\u00edmica fue \u00fatil en el diagn\u00f3stico diferencial: El tratamiento vari\u00f3 desde mastectom\u00eda hasta resecci\u00f3n de complejo areola pez\u00f3n. La radioterapia tambi\u00e9n ha sido utilizada.Conclusiones: el diagn\u00f3stico de la enfermedad de Paget sin carcinoma ductal asociado se fundamenta en una sospecha cl\u00ednica temprana y el estudio histopatol\u00f3gico del complejo areola pez\u00f3n. No hay consenso sobre el manejo de quir\u00fargico de esta lesi\u00f3n. Se requieren estudios de seguimiento de este subgrupo de pacientes tratado con radioterapia o cirug\u00eda conservadora.<\/jats:p>","DOI":"10.18597\/rcog.3193","type":"journal-article","created":{"date-parts":[[2019,4,4]],"date-time":"2019-04-04T16:30:53Z","timestamp":1554395453000},"page":"58","source":"Crossref","is-referenced-by-count":2,"title":["Enfermedad de Paget de la mama sin carcinoma ductal asociado: reporte de caso y revisi\u00f3n de la literatura"],"prefix":"10.18597","volume":"70","author":[{"given":"Liseth Johana","family":"Matamoros-Parra","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel Andr\u00e9s","family":"Vertel-Vel\u00e1squez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gloria Eugenia","family":"Camargo-Villalba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7913","published-online":{"date-parts":[[2019,3,29]]},"reference":[{"key":"ref0","unstructured":"Valladares M, Conde T, D\u00edaz N. Enfermedad de Paget. Variedad especial de c\u00e1ncer mamario. Presentaci\u00f3n de un caso. Medisur [revista en Internet]. 2012 [citado 2018 Abr 12]; 10(6):522-25. Disponible en: http:\/\/www.medisur.sld.cu\/index.php\/medisur\/article\/view\/2301"},{"key":"ref1","doi-asserted-by":"publisher","unstructured":"Crignis GS, Abreu LD, Bu\u00e7ard AM, Barcaui CB. Polarized dermoscopy of mammary Paget disease. An Bras Dermatol. 2013;88(2):290-2. https:\/\/doi.org\/10.1590\/S0365-05962013000200023","DOI":"10.1590\/S0365-05962013000200023"},{"key":"ref2","doi-asserted-by":"publisher","unstructured":"Gaurav A, Gupta V, Koul R, Dabas S, Sareen R, Geeta K, et al. Practical consensus recommendations for Paget's disease in breast cancer. South Asian J Cancer. 2018; 7(2): 83\u201386. https:\/\/doi.org\/10.4103\/sajc.sajc_107_18","DOI":"10.4103\/sajc.sajc_107_18"},{"key":"ref3","unstructured":"Paget J. On disease of the mammary areola preceding cancer of the mammary gland. St. Barts Hospital Rep 1874;10:87. [visitado 2019 mar 10]. Disponible en https:\/\/onlinelibrary.wiley.com\/doi\/epdf\/10.3322\/canjclin.21.5.303."},{"key":"ref4","doi-asserted-by":"publisher","unstructured":"Betal D, Puri N, Roberts K, Kalra L, Rapisarda F, Bonomi R. Hyperpigmented Paget's disease of the nipple: a diagnostic dilemma. JRSM Short Rep. 2012;3 (5): 1. https:\/\/doi.org\/10.1258\/shorts.2012.011165","DOI":"10.1258\/shorts.2012.011165"},{"key":"ref5","doi-asserted-by":"publisher","unstructured":"Dominici LS, Lester S, Liao GS, Guo L, Specht M, Smith BL, et al. Current surgical approach to Paget's disease. Am J Surg. 2012;204(1):18\u201322. https:\/\/doi.org\/10.1016\/j.amjsurg.2011.07.010","DOI":"10.1016\/j.amjsurg.2011.07.010"},{"issue":"3","key":"ref6","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1007\/s10549-007-9880-5","article-title":"Paget's disease of the breast: the experience of the European Institute of Oncology and review of the literature.","volume":"112","author":"Caliskan","year":"2008","unstructured":"Caliskan M, Gatti G, Sosnovskikh I, Rotmensz N, Botteri E, Musmeci S, et al Paget's disease of the breast: the experience of the European Institute of Oncology and review of the literature. Breast Cancer Res Treat. 2008;112(3):513-21. https:\/\/doi.org\/10.1007\/s10549-007-9880-","journal-title":"Breast Cancer Res Treat","ISSN":"http:\/\/id.crossref.org\/issn\/0167-6806","issn-type":"print"},{"key":"ref7","doi-asserted-by":"publisher","unstructured":"Adams SJ, Kanthan R.Paget's disease of the male breast in the 21st century: A systematic review. Breast. 2016;29:14-23. https:\/\/doi.org\/10.1016\/j.breast.2016.06.015","DOI":"10.1016\/j.breast.2016.06.015"},{"key":"ref8","unstructured":"Albarr\u00e1n J, Tavares A, Saldivia F, Prince J, Ramos S, Gutierrez Nestor, et al. Enfermedad de Paget de la mama. Reporte de 13 casos. Rev Venez Oncol [revista en Internet]. 2010 [citado 2018 Abr 20]; 22 (3): 194-200. Disponible en: http:\/\/www.scielo.org.ve\/scielo.php?script=sci_arttext&pid=S0798-05822010000300008&lng=es."},{"key":"ref9","doi-asserted-by":"publisher","unstructured":"Lopes LL, Lopes IM, Lopes LR, Enokihara MM, Michalany AO, Matsunaga N. Mammary and extramammary Paget's disease. An Bras Dermatol. 2015; 90(2):225-31. https:\/\/doi.org\/10.1590\/abd1806-4841.20153189","DOI":"10.1590\/abd1806-4841.20153189"},{"key":"ref10","volume-title":"World Health Organization Classification of Tumours Pathology and Genetics of Tumours of the Breast and Female Genital Organs","author":"Tavassoli","year":"2003","unstructured":"Tavassoli FA, Devilee P (Eds.). World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Breast and Female Genital Organs. IARC Press, Lyon; 2003"},{"key":"ref11","unstructured":"Muttarak M, Siriya B, Kongmebhol P, Chaiwun B, Sukhamwang N. Paget's disease of the breast: clinical, imaging and pathologic findings: a review of 16 patients. Biomed Imaging Interv J. 2011;7(2):e16. https:\/\/doi.org\/10.2349\/biij.7.2.e16."},{"key":"ref12","unstructured":"Bas A, Rodr\u00edguez T, Arias LC. Enfermedad de Paget de la mama. Revista Electr\u00f3nica Dr. Zoilo E. Marinello Vidaurreta [revista en Internet]. 2014 [citado 2018 Abr 26]; 39 (7). Disponible en: http:\/\/revzoilomarinello.sld.cu\/index.php\/zmv\/article\/view\/172\/310"},{"issue":"1","key":"ref13","first-page":"3","article-title":"Enfermedad de Paget mamaria.","volume":"36","author":"Casimiro","year":"2008","unstructured":"Casimiro L, Vilata JJ, Zaragoza V. Enfermedad de Paget mamaria. Med Cutan Iber Lat Am. 2008; 36 (1): 3-12.","journal-title":"Med Cutan Ibero Lat Am","ISSN":"http:\/\/id.crossref.org\/issn\/0210-5187","issn-type":"print"},{"key":"ref14","first-page":"137","article-title":"Patolog\u00eda dermatol\u00f3gica de la mama. A prop\u00f3sito de 3 casos.","volume":"61","author":"Vilchez","year":"2011","unstructured":"Vilchez M, Villarreal M, Garay I, Kurpis M, Ruiz A. Patolog\u00eda dermatol\u00f3gica de la mama. A prop\u00f3sito de 3 casos. Arch Argent Dermatol. 2011; 61: 137-41.","journal-title":"Arch Argent Dermatol","ISSN":"http:\/\/id.crossref.org\/issn\/0066-6750","issn-type":"print"},{"key":"ref15","doi-asserted-by":"publisher","unstructured":"Duan X, Sneige N, Gullett AE, Prieto VG, Resetkova E, Andino LM, et al. Invasive Paget Disease of the Breast Clinicopathologic Study of an Underrecognized Entity in the Breast. Am J Surg Pathol. 2012;36(9):1353-8. https:\/\/doi.org\/10.1097\/PAS.0b013e318259ef7f.","DOI":"10.1097\/PAS.0b013e318259ef7f"},{"key":"ref16","doi-asserted-by":"publisher","unstructured":"Siponen E, Hukkinen K, Heikkla P, Joensuu H, Leidenius M. Surgical treatment in Paget\u00b4s disease of the breast. Am J Surg. 2010;200(2):241-6. https:\/\/doi.org\/10.1016\/j.amjsurg.2009.07.044","DOI":"10.1016\/j.amjsurg.2009.07.044"},{"key":"ref17","doi-asserted-by":"publisher","unstructured":"Jones RE. Mammary Paget\u00b4s disease without underlying carcinoma. Am J Dermatopathol. 1985;7(4):361-5. https:\/\/doi.org\/10.1097\/00000372-198508000-00009","DOI":"10.1097\/00000372-198508000-00009"},{"key":"ref18","doi-asserted-by":"publisher","unstructured":"O\u00b4Sullivan ST, McGreal GT, Lyons A, Bruke L, Geoghegan JG, Brady MP. Paget's disease of the breast in a man without underlying breast carcinoma. J Clin Pathol. 1994;47(9):851-2. https:\/\/doi.org\/10.1136\/jcp.47.9.851","DOI":"10.1136\/jcp.47.9.851"},{"key":"ref19","doi-asserted-by":"publisher","unstructured":"Mori O, Hachisuka H, Nakano S, Maeyama Y, Sasai Y. A Case of Mammary Paget's Disease without an Underlying Carcinoma: Microscopic Analysis of the DNA Content in Paget Cells. J Clin Pathol. 1994;21(3):160-5. https:\/\/doi.org\/10.1111\/j.1346-8138.1994.tb01714.x","DOI":"10.1111\/j.1346-8138.1994.tb01714.x"},{"key":"ref20","doi-asserted-by":"publisher","unstructured":"Takeuchi T, Komatsuzaki M, Minesaki Y, Yokoi K, Kamide R, Niimura M, et al. Paget\u00b4s disease arising near a male areola without an underlying carcinoma. J Clin Pathol. 1999; 26(4): 248-252. https:\/\/doi.org\/10.1111\/j.1346-8138.1999.tb03466.x","DOI":"10.1111\/j.1346-8138.1999.tb03466.x"},{"key":"ref21","doi-asserted-by":"publisher","unstructured":"Bansal S, Sahoo B, Agarwal P, Garg V, Rao S. A rare presentation of mammary Paget's disease involving the entire breast in the absence of any underlying ductal malignancy. Indian J Dermatol Venereol Leprol. 2013; 79(4):518-21. https:\/\/doi.org\/10.4103\/0378-6323.113085","DOI":"10.4103\/0378-6323.113085"},{"issue":"3","key":"ref22","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1002\/1097-0142(19840801)54:3<545::AID-CNCR2820540327>3.0.CO;2-M","article-title":"Paget's Disease of the Nipple Alternative Management in Cases Without or With Minimal Extent of Underlying Breasf Carcinoma.","volume":"54","author":"Lagios","year":"1984","unstructured":"Lagios MD, Westdahl PR, Rose MR, Concannon S. Paget's Disease of the Nipple Alternative Management in Cases Without or With Minimal Extent of Underlying Breasf Carcinoma. Cancer. 1984;54(3):545-51. https:\/\/doi.org\/10.1002\/1097-0142(19840801)54:3<545::AID-NCR2820540327>3.0.CO;2-M","journal-title":"Cancer","ISSN":"http:\/\/id.crossref.org\/issn\/0008-543X","issn-type":"print"},{"key":"ref23","doi-asserted-by":"publisher","unstructured":"Fourquet A, Campana F, Vielh P, Schlienger P, Jullien D, Vilcog JR. Paget's disease of the nipple without detectable breast tumor: conservative management with radiation therapy. Int. J. Radiation Oncology Biol. Phys. 1987;13(10):1463-5. https:\/\/doi.org\/10.1016\/0360-3016(87)90311-7","DOI":"10.1016\/0360-3016(87)90311-7"},{"key":"ref24","unstructured":"Torres L, Puerto JA, Guerra E, Caballero N. Caracterizaci\u00f3n cl\u00ednico-epidemiol\u00f3gica de la enfermedad de Paget de la mama. Estudio de 37 a-os. MediSur [revista en Internet]. 2017 [citado 2018 Abr 26]; 15(2): 277-281. Disponible en: https:\/\/www.redalyc.org\/articulo.oa?id=180046859011"},{"key":"ref25","doi-asserted-by":"publisher","unstructured":"Broecker JS, Sewell CW, Shehata BM, Memis B, Adsay NV, Styblo TM. An atypical presentation of Paget's Disease of the breast without nipple involvement: Case report and review of the literature. Pathol Res Pract. 2017; 213(11): 1454\u20131456. https:\/\/doi.org\/10.1016\/j.prp.2017.06.002","DOI":"10.1016\/j.prp.2017.06.002"},{"key":"ref26","doi-asserted-by":"publisher","unstructured":"Hanna M, Jaffer S, Bleiweiss IJ, Nayak A. Minimally invasive mammary Paget's disease without an underlying breast carcinoma. Virchows Arch. 2013; 463(3): 471-473. https:\/\/doi.org\/10.1007\/s00428-013-1446-9","DOI":"10.1007\/s00428-013-1446-9"},{"key":"ref27","doi-asserted-by":"publisher","unstructured":"Shiomi T, Ogata D, Iwata M, Arai E, Tsuchida T. Pigmented mammary Paget's disease without underlying carcinoma. The journal of dermatology. 2018; 45(11): e321-e322. https:\/\/doi.org\/10.1111\/1346-8138.14461","DOI":"10.1111\/1346-8138.14461"}],"container-title":["Revista Colombiana de Obstetricia y Ginecolog\u00eda"],"original-title":[],"link":[{"URL":"https:\/\/revista.fecolsog.org\/index.php\/rcog\/article\/viewFile\/3193\/3360","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/revista.fecolsog.org\/index.php\/rcog\/article\/viewFile\/3193\/3360","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,8]],"date-time":"2019-04-08T12:58:02Z","timestamp":1554728282000},"score":1,"resource":{"primary":{"URL":"https:\/\/revista.fecolsog.org\/index.php\/rcog\/article\/view\/3193"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,29]]},"references-count":28,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2019,3,29]]}},"URL":"https:\/\/doi.org\/10.18597\/rcog.3193","relation":{},"ISSN":["2463-0225","0034-7434"],"issn-type":[{"value":"2463-0225","type":"electronic"},{"value":"0034-7434","type":"print"}],"subject":[],"published":{"date-parts":[[2019,3,29]]}}}