{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T12:47:00Z","timestamp":1763642820611,"version":"3.40.5"},"reference-count":25,"publisher":"Federacion Colombiana de Obstetricia y Ginecologia","issue":"4","license":[{"start":{"date-parts":[[2019,12,30]],"date-time":"2019-12-30T00:00:00Z","timestamp":1577664000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Colomb. Obstet. Ginecol."],"abstract":"<jats:p>Objetivo: presentar el caso de una paciente con s\u00edndrome de Mayer-Rokitansky-K\u00fcster-Hauser, con diagn\u00f3stico de carcinoma escamoso en neovagina, y realizar una revisi\u00f3n de la literatura del tratamiento y pron\u00f3stico de las neoplasias o la infecci\u00f3n por VPH de tejidos neovaginales en mujeres transg\u00e9nero o con s\u00edndrome MRKH. Materiales y m\u00e9todos: mujer de 56 a\u00f1os de edad que consulta en un hospital universitario regional de la ciudad de Sevilla (Espa\u00f1a). Tras la exploraci\u00f3n cl\u00ednica se aprecia una tumoraci\u00f3n exof\u00edtica en fondo de vagina, con resultado de biopsia de carcinoma escamoso y cultivo positivo para virus del papiloma humano (VPH) tipo 16. Se realiz\u00f3 una b\u00fasqueda bibliogr\u00e1fica en la base de datos Medline v\u00eda PubMed, con los t\u00e9rminos: \u201ccongenital abnormalities\u201d; \u201cmullerian aplasia\u201d; \u201cneovagina\u201d; \u201cvaginal neoplasms\u201d; \u201csquamous carcinoma\u201d; \u201cHPV infection\u201d, de reportes y series de caso, y estudios observacionales publicados desde el a\u00f1o 2000 hasta octubre de 2019 en ingl\u00e9s y espa\u00f1ol. Resultados: se incluyeron 14 estudios; de estos, siete correspondieron a carcinoma escamocelular, tres a adenocarcinoma y cuatro informan infecci\u00f3n solo por VPH. Todos los carcinomas escamocelulares presentaban estadios avanzados por compromiso local o linf\u00e1tico y recibieron radioterapia con quimioterapia concomitante o cirug\u00eda radical. El pron\u00f3stico fue malo en tres de los casos. Las pacientes con adenocarcinoma tambi\u00e9n presentaron lesiones avanzadas con compromiso local, el tratamiento fue quir\u00fargico, con quimioterapia concomitante en dos de los casos. Solo una paciente tuvo seguimiento mayor a cinco a\u00f1os. La infecci\u00f3n por VPH es frecuente en mujeres sometidas a construcci\u00f3n de neovagina. Conclusiones: las pacientes con neovagina son susceptibles de desarrollar carcinomas escamosos si se utilizaron injertos cut\u00e1neos, o adenocarcinomas en aquellas en las que se reconstruy\u00f3 la vagina a partir de injertos tisulares intestinales. Dado que al momento del diagn\u00f3stico presentan compromiso local, a menudo requieren tratamientos radicales o combinados. Se debe investigar cu\u00e1les son las mejores estrategias de tamizaje de VPH, c\u00e1ncer escamoso y adenocarcinoma en este tipo de pacientes.<\/jats:p>","DOI":"10.18597\/rcog.3328","type":"journal-article","created":{"date-parts":[[2020,2,3]],"date-time":"2020-02-03T10:11:24Z","timestamp":1580724684000},"page":"266-276","source":"Crossref","is-referenced-by-count":5,"title":["Carcinoma epidermoide de neovagina en paciente con s\u00edndrome de Mayer-Rokitansky-K\u00fcster-Hauser. Reporte de un caso y revisi\u00f3n de la literatura"],"prefix":"10.18597","volume":"70","author":[{"given":"Marta","family":"Fern\u00e1ndez-Ruiz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8711-4083","authenticated-orcid":false,"given":"Manuel","family":"Pantoja-Garrido","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8402-3661","authenticated-orcid":false,"given":"Zoraida","family":"Fr\u00edas-S\u00e1nchez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inmaculada","family":"Rodr\u00edguez-Jim\u00e9nez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1150-4218","authenticated-orcid":false,"given":"Mar\u00eda del Valle","family":"Aguilar- Mart\u00edn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7913","published-online":{"date-parts":[[2019,12,30]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"Committee on Adolescent Health Care. 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