{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T22:23:51Z","timestamp":1740176631210,"version":"3.37.3"},"reference-count":45,"publisher":"Federacion Colombiana de Obstetricia y Ginecologia","issue":"1","license":[{"start":{"date-parts":[[2020,3,26]],"date-time":"2020-03-26T00:00:00Z","timestamp":1585180800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/100007637","name":"Departamento Administrativo de Ciencia, Tecnolog\u00eda e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["111-5777-57051"],"award-info":[{"award-number":["111-5777-57051"]}],"id":[{"id":"10.13039\/100007637","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Colomb. Obstet. Ginecol."],"abstract":"<jats:p>Objetivo: determinar la eficacia y seguridad de la monoterapia con cloroquina en gestantes colombianas con ataque agudo no complicado de malaria vivax (MGV). Materiales y m\u00e9todos: estudio de cohorte prospectiva en pacientes gestantes que consultaron de manera espont\u00e1nea entre 1 febrero de 2015 y 31 diciembre de 2017 a los puestos de malaria o de control prenatal en dos poblaciones de Colombia, en quienes se confirm\u00f3 el diagn\u00f3stico de Plasmodium vivax mediante gota gruesa y qPCR (quantitative polymerase chain reaction). Se midieron variables sociodemogr\u00e1ficas, falla terap\u00e9utica (FT) y eventos adversos serios a los 28 d\u00edas y la frecuencia de recurrencia-reca\u00edda (RR) con seguimiento de 120 d\u00edas. Se aplic\u00f3 el protocolo de la OMS para evaluar la eficacia de monoterapia con cloroquina (m-CQ). Resultados: se captaron 47 gestantes; en el seguimiento de 28 d\u00edas no hubo p\u00e9rdidas y hubo 4,2 % (2\/47) de FT. En el seguimiento de 45 mujeres entre los d\u00edas 29 y 120 hubo 11 p\u00e9rdidas (24,4 % = 11\/45) y 13 RR con frecuencia que vari\u00f3 entre 29 y 53 % seg\u00fan el tipo de an\u00e1lisis. Conclusiones: la cloroquina conserva muy alta eficacia para curar el ataque agudo de malaria vivax en malaria gestacional (MG) en Colombia, y contin\u00faa siendo una buena opci\u00f3n para el tratamiento de la fase aguda. La frecuencia de RR es alta. Se requieren estudios que eval\u00faen alternativas terap\u00e9uticas en la MG. Hay urgente necesidad de disponer de medicamentos o procedimientos que reduzcan ese alt\u00edsimo riesgo.<\/jats:p>","DOI":"10.18597\/rcog.3370","type":"journal-article","created":{"date-parts":[[2020,3,27]],"date-time":"2020-03-27T14:02:34Z","timestamp":1585317754000},"source":"Crossref","is-referenced-by-count":3,"title":["Evaluaci\u00f3n de la eficacia y seguridad de la monoterapia con cloroquina para tratar malaria gestacional aguda no complicada debida P. vivax, C\u00f3rdoba, Colombia, 2015-2017"],"prefix":"10.18597","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3928-881X","authenticated-orcid":false,"given":"Carlos J.","family":"Castro-Cavad\u00eda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0428-9887","authenticated-orcid":false,"given":"Jaime","family":"Carmona-Fonseca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7913","published-online":{"date-parts":[[2020,3,26]]},"reference":[{"issue":"1","key":"ref0","doi-asserted-by":"publisher","first-page":"27","DOI":"10.18597\/rcog.127","article-title":"Eficacia terap\u00e9utica y eventos adversos de tratamientos para malaria vivax y malaria falciparum en gestantes en las regiones de Urab\u00e1 y Alto San Jorge, Colombia, 2008-2011","volume":"64","author":"Carmona-Fonseca","year":"2013","unstructured":"Carmona-Fonseca J, Agudelo-Garc\u00eda OM, Arango-Fl\u00f3rez E. 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