{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T10:36:30Z","timestamp":1784198190611,"version":"3.55.0"},"reference-count":35,"publisher":"Federacion Colombiana de Obstetricia y Ginecologia","issue":"2","license":[{"start":{"date-parts":[[2021,6,30]],"date-time":"2021-06-30T00:00:00Z","timestamp":1625011200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Colomb. Obstet. Ginecol."],"abstract":"<jats:p>Objetivo: realizar un reporte de 4 casos de h\u00eddrops fetal secundario a s\u00edfilis cong\u00e9nita y hacer una revisi\u00f3n de la literatura para responder la siguiente pregunta: \u00bfcu\u00e1l es el esquema antibi\u00f3tico utilizado en los casos de s\u00edfilis gestacional complicada con h\u00eddrops fetal? Materiales y m\u00e9todos: se presentan 4 casos de s\u00edfilis cong\u00e9nita con h\u00eddrops fetal. La edad materna vari\u00f3 entre 17 y 28 a\u00f1os, la edad gestacional al momento del diagn\u00f3stico estuvo entre 25 y 30 semanas, dos de ellas no hab\u00edan iniciado control prenatal en ese momento. En tres casos se dio tratamiento para s\u00edfilis gestacional inmediatamente con penicilina cristalina entre 6 y 12 semanas antes del parto y se formul\u00f3 tratamiento a la pareja con penicilina benzat\u00ednica. Respecto a los reci\u00e9n nacidos, dos de ellos no ten\u00edan infecci\u00f3n activa o secuelas, se consider\u00f3 que uno de ellos ten\u00eda s\u00edfilis cong\u00e9nita por t\u00edtulos de prueba no trepon\u00e9mica. En uno de los casos, la paciente no alcanza a recibir tratamiento para la s\u00edfilis gestacional antes del parto, este reci\u00e9n nacido ten\u00eda signos de infecci\u00f3n activa. Se hizo una revisi\u00f3n de la literatura en las bases de datos Medline, LILACS y google scholar; los t\u00e9rminos de b\u00fasqueda fueron los siguientes: \u201ch\u00eddrops fetal\u201d, \u201clues\u201d, \u201csyphilis \u2013 prenatal diagnosis- ultrasound - penicilina \u2013 treatment\u201d. Se buscaron reportes y series de casos o cohortes de reci\u00e9n nacidos con s\u00edfilis gestacional con h\u00eddrops fetalis. Se extrajo informaci\u00f3n sobre la madre y el reci\u00e9n nacido respecto al tratamiento. Resultados: se identificaron 119 art\u00edculos, de estos 13 cumplieron con los criterios de inclusi\u00f3n, tres fueron descartados por no tener acceso al texto completo. Se incluyeron diez estudios de un total de 16 casos reportados con diagn\u00f3stico prenatal de h\u00eddrops fetal secundarios a infecci\u00f3n cong\u00e9nita. De ellos, tres presentaron anemia fetal severa y requirieron transfusi\u00f3n intrauterina; 5 casos recibieron tratamiento intrauterino con penicilina. En cuatro casos la madre recibi\u00f3 penicilina benzat\u00ednica intramuscular por 3 semanas, uno recibi\u00f3 adem\u00e1s penicilina cristalina endovenosa por 13 d\u00edas, otro recibi\u00f3 penicilina cristalina endovenosa por 14 d\u00edas. Un total de 11 casos no recibieron tratamiento durante la gestaci\u00f3n; 6 de los 16 casos (37,5%) presentaron muerte perinatal. Conclusi\u00f3n: el retraso en acudir al control prenatal y la tardanza del diagn\u00f3stico y tratamiento de la s\u00edfilis gestacional son causas importantes de la persistencia de la s\u00edfilis cong\u00e9nita. Se requieren estudios aleatorizados para determinar el mejor tratamiento del feto con s\u00edfilis cong\u00e9nita en los 30 d\u00edas previos al parto y del feto con compromiso sist\u00e9mico durante la segunda mitad de la gestaci\u00f3n.<\/jats:p>","DOI":"10.18597\/rcog.3591","type":"journal-article","created":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T15:52:27Z","timestamp":1625154747000},"page":"149-161","source":"Crossref","is-referenced-by-count":6,"title":["S\u00edfilis cong\u00e9nita con h\u00eddrops fetal: reporte de cuatro casos en un hospital general de referencia en Bogot\u00e1, Colombia entre 2016- 2020"],"prefix":"10.18597","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2606-4577","authenticated-orcid":false,"given":"Andr\u00e9s Mauricio","family":"Camacho-Monta\u00f1o","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5780-6855","authenticated-orcid":false,"given":"Reinaldo","family":"Ni\u00f1o-Alba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9529-5272","authenticated-orcid":false,"given":"Edgar","family":"P\u00e1ez-Castellanos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7913","published-online":{"date-parts":[[2021,6,30]]},"reference":[{"key":"87045","unstructured":"WHO Guideline on Syphilis Screening and Treatment for Pregnant Women. 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