{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T16:05:03Z","timestamp":1776096303389,"version":"3.50.1"},"reference-count":51,"publisher":"Federacion Colombiana de Obstetricia y Ginecologia","issue":"3","license":[{"start":{"date-parts":[[2024,9,25]],"date-time":"2024-09-25T00:00:00Z","timestamp":1727222400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,9,25]],"date-time":"2024-09-25T00:00:00Z","timestamp":1727222400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["revista.fecolsog.org"],"crossmark-restriction":false},"short-container-title":["Rev. colomb. obstet. ginecol."],"abstract":"<jats:p>Objetivos: la preeclampsia (PE) es un trastorno hipertensivo del embarazo que puede causar complicaciones graves y resultados adversos maternos y fetales. El objetivo del estudio fue estimar el impacto econ\u00f3mico de la incorporaci\u00f3n del cociente sFlt-1\/PlGF (factor tirosinkinasa -1 soluble tipo fms \/ Placenta Growth Factor \u2013 Factor de Crecimiento Placentario) al sistema de salud uruguayo.\nMateriales y m\u00e9todos: se utiliz\u00f3 un \u00e1rbol de decisi\u00f3n para estimar, en una cohorte hipot\u00e9tica de mujeres con sospecha de PE, el impacto econ\u00f3mico anual incluidos los costos relevantes asociados con el diagn\u00f3stico, el seguimiento y el tratamiento de la presentaci\u00f3n inicial de la PE cl\u00ednicamente sospechada hasta el parto. Se analizaron los costos anuales para un escenario est\u00e1ndar de atenci\u00f3n y un escenario que incluye el cociente sFlt-1\/PlGF para PE. Se realizaron diversos an\u00e1lisis de sensibilidad determin\u00edsticos y probabil\u00edsticos.\nResultados: el modelo econ\u00f3mico estim\u00f3 que el uso del cociente sFlt-1\/PlGF permitir\u00eda al sistema de salud uruguayo ahorrar 95.432.678 pesos uruguayos (2.320.269 d\u00f3lares) anualmente: una reducci\u00f3n del 5 % en comparaci\u00f3n con el est\u00e1ndar de atenci\u00f3n, principalmente como resultado de la reducci\u00f3n de las hospitalizaciones de mujeres con sospecha de PE. El c\u00e1lculo del impacto econ\u00f3mico estim\u00f3 un ahorro neto anual de aproximadamente 10.602 pesos uruguayos (258 d\u00f3lares) por paciente.\nConclusiones: la introducci\u00f3n del cociente sFlt-1\/PlGF en el sistema de salud uruguayo probablemente genere ahorros debido a la optimizaci\u00f3n del manejo de las hospitalizaciones de mujeres con sospecha de PE, aunque la posibilidad de obtener ahorros depender\u00e1 principalmente de la tasa actual de hospitalizaci\u00f3n de estas (la eficiencia del manejo de los embarazos de alto riesgo de PE), y de los d\u00edas de internaci\u00f3n de las mujeres hospitalizadas.<\/jats:p>","DOI":"10.18597\/rcog.4148","type":"journal-article","created":{"date-parts":[[2024,10,7]],"date-time":"2024-10-07T18:48:56Z","timestamp":1728326936000},"update-policy":"https:\/\/doi.org\/10.18597\/crossmark","source":"Crossref","is-referenced-by-count":1,"title":["An\u00e1lisis econ\u00f3mico del cociente de preeclampsia sFlt- 1\/PlGF comparado con el est\u00e1ndar de atenci\u00f3n en Uruguay","Economic analysis of the use of the Flt-1\/PlGF preeclampsia ratio compared to the standard of care in Uruguay"],"prefix":"10.18597","volume":"75","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5579-5902","authenticated-orcid":false,"given":"Gonzalo","family":"Gui\u00f1az\u00fa","sequence":"first","affiliation":[{"name":"Roche Diagnostics Argentina, Buenos Aires (Argentina)."},{"name":"Roche Diagnostics Argentina, Buenos Aires (Argentina)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4424-1581","authenticated-orcid":false,"given":"Giselle","family":"Tomasso","sequence":"additional","affiliation":[{"name":"Unidad Cl\u00ednica y Epidemiol\u00f3gica Montevideo (Unicem), Montevideo (Uruguay)."},{"name":"Unidad Cl\u00ednica y Epidemiol\u00f3gica Montevideo (Unicem), Montevideo (Uruguay)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0725-4954","authenticated-orcid":false,"given":"Gerardo","family":"Vitureira","sequence":"additional","affiliation":[{"name":"Centro Hospitalario Pereira Rossell, Montevideo (Uruguay)."},{"name":"Centro Hospitalario Pereira Rossell, Montevideo (Uruguay)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5970-6302","authenticated-orcid":false,"given":"Grazzia","family":"Rey","sequence":"additional","affiliation":[{"name":"Hospital de Cl\u00ednicas Dr. Manuel Quintela, Universidad de la Rep\u00fablica, Montevideo (Uruguay)."},{"name":"Hospital de Cl\u00ednicas Dr. Manuel Quintela, Universidad de la Rep\u00fablica, Montevideo (Uruguay)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4808-9302","authenticated-orcid":false,"given":"Ver\u00f3nica","family":"Fiol","sequence":"additional","affiliation":[{"name":"Cl\u00ednica Ginecotocol\u00f3gica, Facultad de Medicina UdelaR, Montevideo (Uruguay)."},{"name":"Cl\u00ednica Ginecotocol\u00f3gica, Facultad de Medicina UdelaR, Montevideo (Uruguay)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1489-6894","authenticated-orcid":false,"given":"Leonardo","family":"Sosa","sequence":"additional","affiliation":[{"name":"Hospital de Cl\u00ednicas Dr. Manuel Quintela, Universidad de la Rep\u00fablica, Montevideo (Uruguay)."},{"name":"Hospital de Cl\u00ednicas Dr. Manuel Quintela, Universidad de la Rep\u00fablica, Montevideo (Uruguay)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4836-4247","authenticated-orcid":false,"given":"Osvaldo Ulises","family":"Garay","sequence":"additional","affiliation":[{"name":"Roche Diagnostics International Ltd., Rotkreuz (Switzerland)."},{"name":"Roche Diagnostics International Ltd., Rotkreuz (Suiza)."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7913","published-online":{"date-parts":[[2024,9,25]]},"reference":[{"key":"100162","doi-asserted-by":"crossref","unstructured":"Poon L, Shennan A, Hyett J, Kapur A, Hadar E, Divakar H, et al. 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