{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T07:54:41Z","timestamp":1787730881365,"version":"build-2784847793"},"reference-count":64,"publisher":"Federacion Colombiana de Obstetricia y Ginecologia","issue":"3","license":[{"start":{"date-parts":[[2024,10,25]],"date-time":"2024-10-25T00:00:00Z","timestamp":1729814400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,10,25]],"date-time":"2024-10-25T00:00:00Z","timestamp":1729814400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["revista.fecolsog.org"],"crossmark-restriction":false},"short-container-title":["Rev. colomb. obstet. ginecol."],"abstract":"<jats:p>El Sulfato de Magnesio completa 100 a\u00f1os en el manejo m\u00e9dico de la eclampsia. Lazard, a partir de mayo de 1924, en el Hospital General de los \u00c1ngeles, recogi\u00f3 las evidencias cl\u00ednicas de sus beneficios sobre la mortalidad de la enfermedad convulsiva del embarazo. Se analizaron dosis, esquemas, diluciones, se encontr\u00f3 seguridad terap\u00e9utica para la madre y el feto, y finalizando el siglo XX, se realizaron experimentos cl\u00ednicos aleatorizados que demostraron la utilidad cl\u00ednica del magnesio para las siguientes indicaciones: tratamiento de la eclampsia, prevenci\u00f3n de la eclampsia, protecci\u00f3n neurol\u00f3gica del cerebro del prematuro menor de 32 semanas, entre otras. Todo este camino ha sido controvertido por muchas autoridades; sin embargo, la Universidad Nacional de Colombia y su Departamento de Obstetricia y Ginecolog\u00eda han defendido desde 1982 el esquema Zuspan como el ideal en el manejo de estas pacientes. Con esta revisi\u00f3n queremos mostrar todas las evidencias que han convertido al magnesio en un f\u00e1rmaco indispensable para disminuir la mortalidad materna en todo el mundo, especialmente en los pa\u00edses subdesarrollados.<\/jats:p>","DOI":"10.18597\/rcog.4303","type":"journal-article","created":{"date-parts":[[2024,10,25]],"date-time":"2024-10-25T15:42:12Z","timestamp":1729870932000},"update-policy":"https:\/\/doi.org\/10.18597\/crossmark","source":"Crossref","is-referenced-by-count":2,"title":["SULFATO DE MAGNESIO: 100 a\u00f1os salvando vidas maternas. Un patrimonio cient\u00edfico de la humanidad","MAGNESIUM SULFATE: 100 years saving maternal lives. A scientific heritage of humanity"],"prefix":"10.18597","volume":"75","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2473-1858","authenticated-orcid":false,"given":"Alejandro Antonio","family":"Bautista-Charry","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, School of Medicine, Universidad Nacional de Colombia. Bogot\u00e1 (Colombia)"},{"name":"Departamento de Obstetricia y Ginecolog\u00eda, Facultad de Medicina, Universidad Nacional de Colombia. Bogot\u00e1 (Colombia)"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7913","published-online":{"date-parts":[[2024,10,25]]},"reference":[{"key":"100978","unstructured":"Silva-Mojica CR. Aproximaci\u00f3n hist\u00f3rica sobre el desarrollo de la Ginecoobstetricia. En: Controversias en Ginecolog\u00eda, Obstetricia Y Perinatolog\u00eda: Experiencia Institucional UN-IMI. Santaf\u00e9 de Bogot\u00e1, Universidad Nacional de Colombia. Facultad de Medicina. Instituto Materno Infantil;1994."},{"key":"100979","unstructured":"Bautista-Charry AA, Ru\u00edz-Parra AI, Garz\u00f3n-Olivares CD. Aportes del Departamento de Obstetricia y Ginecolog\u00eda de la Universidad Nacional de Colombia y el Instituto Materno Infantil a la obstetricia nacional. En: ASBOG 75 a\u00f1os. Una historia que contar\u2026;2018."},{"key":"100980","doi-asserted-by":"crossref","unstructured":"Velasco-Chiriboga A, Barriga-Garz\u00f3n H. Mortalidad materna y perinatal en los estados hipertensivos del embarazo. Rev Colomb Obstet Ginecol. 1984;35:13-35. https:\/\/doi.org\/10.18597\/rcog.1565","DOI":"10.18597\/rcog.1565"},{"key":"100981","doi-asserted-by":"crossref","unstructured":"G\u00f3mez-Palacino JA. Sulfato de magnesia intrarraqu\u00eddeo en el tratamiento de la eclampsia, observaci\u00f3n de 16 casos. 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