{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T15:52:40Z","timestamp":1776095560237,"version":"3.50.1"},"reference-count":42,"publisher":"Federacion Colombiana de Obstetricia y Ginecologia","issue":"2","license":[{"start":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T00:00:00Z","timestamp":1750377600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T00:00:00Z","timestamp":1750377600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["revista.fecolsog.org"],"crossmark-restriction":false},"short-container-title":["Rev. colomb. obstet. ginecol."],"abstract":"<jats:p>Objetivo: generar recomendaciones para la vacunaci\u00f3n de la mujer, en las diferentes etapas de su vida, a fin de disminuir la posible variabilidad de su uso actual en Colombia.\nMateriales y m\u00e9todos: el grupo desarrollador estuvo conformado por profesionales pertenecientes al \u00e1rea de la salud. Todos los participantes declararon por escrito sus conflictos de inter\u00e9s. Se formularon preguntas cl\u00ednicas contestables, se hizo la graduaci\u00f3n de los desenlaces y la pesquisa de la informaci\u00f3n se realiz\u00f3 en Medline\/PubMed, Embase y Lilacs. La b\u00fasqueda tambi\u00e9n abarc\u00f3 fuentes de literatura gris y se actualiz\u00f3 el 14 de mayo de 2024 sin restricciones por fecha o idioma. Se implement\u00f3 la metodolog\u00eda GRADE (Grading of Recommendations Assessment, Development and Evaluation) para establecer la calidad de la evidencia y la fuerza de la recomendaci\u00f3n. En virtud de las limitaciones de los estudios recuperados, y especialmente cuando se trat\u00f3 de limitaciones en la aplicabilidad de la evidencia, se acudi\u00f3 a la opini\u00f3n de expertos. Se realiz\u00f3 consenso formal acorde con la metodolog\u00eda RAND\/UCLA (RAND Corporation\/Universidad de California en Los \u00c1ngeles). Previo a la publicaci\u00f3n, el documento fue objeto de revisi\u00f3n por pares.\nResultados: se desarrollaron las siguientes recomendaciones:\n\nEl grupo desarrollador sugiere que las mujeres no inmunes a las paperas, sarampi\u00f3n o rubeola (p. ej., IgG negativo) sean vacunadas durante el periodo preconcepcional. Calidad de la evidencia: baja \u2a01\u2a01\u25ef\u25ef\nEl grupo desarrollador sugiere que todas las mujeres en periodo preconcepcional se vacunen contra la varicela si no tienen inmunidad natural confirmada (p. ej., anticuerpos IgG negativo para el virus varicela z\u00f3ster). Calidad de la evidencia: muy baja \u2a01\u25ef\u25ef\u25ef\nEl grupo desarrollador sugiere que las mujeres que viven en regiones end\u00e9micas para fiebre amarilla se vacunen durante el periodo preconcepcional si no han sido previamente inmunizadas. Calidad de la evidencia: muy baja \u2a01\u25ef\u25ef\u25ef\nEl grupo desarrollador sugiere vacunar adolescentes y adultas j\u00f3venes con la vacuna para el virus del papiloma humano (VPH), de 3 dosis (0,2 y 6 meses) con el fin de reducir la incidencia y mortalidad por c\u00e1ncer cervical. Calidad de evidencia: moderada \u2a01\u2a01\u2a01\u25ef\nEl grupo desarrollador sugiere que las mujeres gestantes sean inmunizadas contra el t\u00e9tano, la difteria y la tos ferina durante la gestaci\u00f3n, con el objetivo de reducir el riesgo de infecci\u00f3n en la madre y el neonato. Calidad de la evidencia: baja \u2a01\u2a01\u25ef\u25ef\nEl grupo desarrollador sugiere la vacunaci\u00f3n contra la influenza a cualquier edad gestacional, con el objetivo de reducir el riesgo de infecci\u00f3n en la madre y el neonato hasta los seis meses de edad. Calidad de la evidencia: muy baja \u2a01\u25ef\u25ef\u25ef\nEl grupo desarrollador sugiere la vacunaci\u00f3n materna frente al COVID-19 a cualquier edad gestacional, con el objetivo de reducir el riesgo de hospitalizaci\u00f3n y muerte de la madre y el neonato durante los primeros cuatro meses de vida. Calidad de la evidencia: muy baja \u2a01\u25ef\u25ef\u25ef\nEl grupo desarrollador sugiere la vacunaci\u00f3n contra el virus sincitial respiratorio (VSR) en mujeres gestantes, con el objetivo de reducir el riesgo de hospitalizaci\u00f3n en el neonato. Calidad de la evidencia: muy baja \u2a01\u25ef\u25ef\u25ef\nEl grupo desarrollador sugiere que la mujer adulta mayor se vacune contra el herpes z\u00f3ster, con el fin de reducir la morbilidad asociada a esta condici\u00f3n. Calidad de la evidencia: moderada \u2a01\u2a01\u2a01\u25ef\nEl grupo desarrollador sugiere que la mujer adulta mayor se vacune contra la influenza a fin de reducir la incidencia de infecci\u00f3n respiratoria aguda (IRA). Calidad de la evidencia: moderada \u2a01\u2a01\u2a01\u25ef\nEl grupo desarrollador sugiere que la mujer adulta mayor se vacune contra el neumococo a fin de reducir la incidencia de neumon\u00eda y enfermedad neumoc\u00f3cica invasora. Calidad de la evidencia: baja \u2a01\u2a01\u25ef\u25ef\nEl grupo desarrollador sugiere que la mujer adulta mayor se vacune contra el VSR a fin de reducir la incidencia de infecci\u00f3n respiratoria aguda e infecci\u00f3n respiratoria del tracto inferior. Calidad de la evidencia: baja \u2a01\u2a01\u25ef\u25ef\nEl grupo desarrollador sugiere que la mujer adulta mayor que vive en regiones end\u00e9micas para fiebre amarilla se vacune si no ha sido previamente inmunizada. Calidad de la evidencia: muy baja \u2a01\u25ef\u25ef\u25ef\n\nConclusiones: se recomienda la vacunaci\u00f3n como estrategia de prevenci\u00f3n primaria a lo largo de las diferentes etapas de la vida en la mujer. Dada la calidad de la evidencia y las serias limitaciones en la aplicabilidad de algunos estudios, especialmente en mujeres gestantes, se requieren m\u00e1s investigaciones que eval\u00faen la seguridad y la efectividad de esta intervenci\u00f3n en esta etapa de la vida.<\/jats:p>","DOI":"10.18597\/rcog.4310","type":"journal-article","created":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T09:09:21Z","timestamp":1751360961000},"update-policy":"https:\/\/doi.org\/10.18597\/crossmark","source":"Crossref","is-referenced-by-count":0,"title":["Consenso de expertos en torno a la vacunaci\u00f3n como estrategia de prevenci\u00f3n primaria para la mujer que se encuentra en edad reproductiva, gestando o en la edad adulta","Expert consensus on vaccination as a primary prevention strategy for women of reproductive age, pregnant, or adulthood"],"prefix":"10.18597","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0372-8374","authenticated-orcid":false,"given":"Jezid","family":"Miranda Quintero","sequence":"first","affiliation":[{"name":"Departament of Ginecology and Obstetrics, Universidad de Cartagena. (Cartagena, Colombia)"},{"name":"Departamento de Ginecolog\u00eda y Obstetricia, Universidad de Cartagena. (Cartagena, Colombia)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6835-1649","authenticated-orcid":false,"given":"Marcela","family":"Celis-Am\u00f3rtegui","sequence":"additional","affiliation":[{"name":"Departament of Ginecology and Obstetrics, Fundaci\u00f3n Santa Fe de Bogot\u00e1. Bogot\u00e1 (Colombia)"},{"name":"Departamento de Ginecolog\u00eda y Obstetricia, Fundaci\u00f3n Santa Fe de Bogot\u00e1. Bogot\u00e1 (Colombia)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-1564-8286","authenticated-orcid":false,"given":"Mar\u00eda Cecilia","family":"Arturo Rojas","sequence":"additional","affiliation":[{"name":"Universidad Libre. (Cali, Colombia)"},{"name":"Universidad Libre. (Cali, Colombia)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Mendoza Rosado","sequence":"additional","affiliation":[{"name":"Universidad de Santander. (Bucaramanga, Colombia)"},{"name":"Universidad de Santander. (Bucaramanga, Colombia)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5355-729X","authenticated-orcid":false,"given":"Carlos Fernando","family":"Grillo-Ardila","sequence":"additional","affiliation":[{"name":"Departament of Ginecology and Obstetrics, Universidad Nacional de Colombia. Bogot\u00e1 (Colombia)."},{"name":"Departamento de Ginecolog\u00eda y Obstetricia, Universidad Nacional de Colombia. Bogot\u00e1 (Colombia)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9504-5153","authenticated-orcid":false,"given":"Elvia Karina","family":"Grillo-Ardila","sequence":"additional","affiliation":[{"name":"Population Cancer Registry of Cali, Department of Pathology, Universidad del Valle. (Cali, Colombia)."},{"name":"Registro Poblacional de C\u00e1ncer de Cali, Departamento de Patolog\u00eda, Universidad del Valle. (Cali, Colombia)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-0074-1659","authenticated-orcid":false,"given":"Juan Jos\u00e9","family":"Ram\u00edrez-Mosquera","sequence":"additional","affiliation":[{"name":"Training in Clinical Epidemiology, Pontificia Universidad Javeriana. Bogot\u00e1 (Colombia)."},{"name":"Entrenamiento en Epidemiolog\u00eda Cl\u00ednica, Pontificia Universidad Javeriana. 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