{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T15:52:59Z","timestamp":1776095579821,"version":"3.50.1"},"reference-count":28,"publisher":"Federacion Colombiana de Obstetricia y Ginecologia","issue":"1","license":[{"start":{"date-parts":[[2025,2,7]],"date-time":"2025-02-07T00:00:00Z","timestamp":1738886400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,2,7]],"date-time":"2025-02-07T00:00:00Z","timestamp":1738886400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["revista.fecolsog.org"],"crossmark-restriction":false},"short-container-title":["Rev. colomb. obstet. ginecol."],"abstract":"<jats:p>Objetivos: presentar un caso de reinfecci\u00f3n por s\u00edfilis gestacional (SG) y realizar una revisi\u00f3n sistem\u00e1tica de la literatura sobre la frecuencia, el diagn\u00f3stico, el tratamiento y el seguimiento de la reinfecci\u00f3n.\nMateriales y m\u00e9todos: mujer de 21 a\u00f1os, inmigrante, quien es hospitalizada por preeclamsia y vaginosis bacteriana. Refiere que fue diagnosticada y tratada por SG en el primer trimestre, con posterior disminuci\u00f3n de los t\u00edtulos de Venereal Disease Research Laboratory (VDRL), y nueva elevaci\u00f3n de los mismos detectada a la semana 39. Se hace el diagn\u00f3stico de reinfecci\u00f3n por s\u00edfilis y recibe nuevamente tratamiento con penicilina benzat\u00ednica. El reci\u00e9n nacido presenta VDRL positivo, diluci\u00f3n (1:2), sin signos cl\u00ednicos ni secuelas de infecci\u00f3n por Treponema Pallidum; se hace diagn\u00f3stico de S\u00edfilis Cong\u00e9nita (SC) y recibi\u00f3 tratamiento con penicilina G cristalina intravenosa, con evoluci\u00f3n satisfactoria. Se realiz\u00f3 una revisi\u00f3n sistem\u00e1tica de la literatura desde el inicio de registro de cada base de datos hasta noviembre de 2023, en Medline (PubMed), Embase, Scopus, Web of Science y Lilacs. Se seleccionaron reportes de caso, series de casos y cohortes de mujeres gestantes con reinfecci\u00f3n por s\u00edfilis. Dos autores seleccionaron los estudios y extrajeron los datos de manera independiente. Se describen las caracter\u00edsticas del estudio, la poblaci\u00f3n, las caracter\u00edsticas del diagn\u00f3stico, el tratamiento de la SG y la frecuencia de casos de reinfecci\u00f3n. An\u00e1lisis descriptivo.\nResultados: se identificaron 208 t\u00edtulos potencialmente relevantes, de los cuales 12 fueron evaluados en texto completo. Finalmente, se incluyeron seis art\u00edculos. En total, 85 mujeres presentaron una reinfecci\u00f3n por s\u00edfilis durante la gestaci\u00f3n (3,8 %). La incidencia de reinfecci\u00f3n por s\u00edfilis durante el embarazo var\u00eda entre el 1,5 y 7,3 %. El diagn\u00f3stico se realiz\u00f3 en mayor medida con pruebas no trepon\u00e9micas (83,3 %). La informaci\u00f3n disponible respecto al tratamiento de la gestante con reinfecci\u00f3n, el seguimiento, el tratamiento del compa\u00f1ero y los resultados perinatales es limitada.\nConclusiones: la vigilancia activa e individual de los casos de SG tratada es importante porque permite no solo identificar la reinfecci\u00f3n, sino tambi\u00e9n garantizar el tratamiento de los compa\u00f1eros sexuales para prevenirla. Se requieren estudios prospectivos para evaluar la magnitud de este problema, sus consecuencias perinatales y la posible resistencia a la penicilina.<\/jats:p>","DOI":"10.18597\/rcog.4328","type":"journal-article","created":{"date-parts":[[2025,2,10]],"date-time":"2025-02-10T07:53:31Z","timestamp":1739174011000},"update-policy":"https:\/\/doi.org\/10.18597\/crossmark","source":"Crossref","is-referenced-by-count":0,"title":["Reinfecci\u00f3n por s\u00edfilis gestacional: reporte de caso y revisi\u00f3n sistem\u00e1tica de la literatura","Reinfection caused by gestational syphilis: A case report and systematic review of the literature"],"prefix":"10.18597","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-3513-1329","authenticated-orcid":false,"given":"Harold","family":"Villamizar","sequence":"first","affiliation":[{"name":"Health Technology and Policy Assessment Research Group (GETS), School of Medicine, Universidad Nacional de Colombia. Bogot\u00e1 (Colombia)."},{"name":"Grupo de Investigaci\u00f3n Evaluaci\u00f3n de Tecnolog\u00edas y Pol\u00edticas en Salud (GETS), Facultad de Medicina, Universidad Nacional de Colombia. Bogot\u00e1 (Colombia)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-1463-1813","authenticated-orcid":false,"given":"Natalia","family":"Vergara","sequence":"additional","affiliation":[{"name":"Health Technology and Policy Assessment Research Group (GETS), School of Medicine, Universidad Nacional de Colombia. Bogot\u00e1 (Colombia)."},{"name":"Grupo de Investigaci\u00f3n Evaluaci\u00f3n de Tecnolog\u00edas y Pol\u00edticas en Salud (GETS), Facultad de Medicina, Universidad Nacional de Colombia. Bogot\u00e1 (Colombia)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-5218-5485","authenticated-orcid":false,"given":"Daniela","family":"Mart\u00ednez-Barreto","sequence":"additional","affiliation":[{"name":"Health Technology and Policy Assessment Research Group (GETS), School of Medicine, Universidad Nacional de Colombia. Bogot\u00e1 (Colombia)."},{"name":"Grupo de Investigaci\u00f3n Evaluaci\u00f3n de Tecnolog\u00edas y Pol\u00edticas en Salud (GETS), Facultad de Medicina, Universidad Nacional de Colombia. Bogot\u00e1 (Colombia)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5655-3654","authenticated-orcid":false,"given":"Jaime","family":"Moreno-Chaparro","sequence":"additional","affiliation":[{"name":"Health Technology and Policy Assessment Research Group (GETS), School of Medicine, Universidad Nacional de Colombia. Bogot\u00e1 (Colombia)."},{"name":"Grupo de Investigaci\u00f3n Evaluaci\u00f3n de Tecnolog\u00edas y Pol\u00edticas en Salud (GETS), Facultad de Medicina, Universidad Nacional de Colombia. Bogot\u00e1 (Colombia)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2939-3648","authenticated-orcid":false,"given":"Hernando","family":"Gait\u00e1n-Duarte","sequence":"additional","affiliation":[{"name":"Health Technology and Policy Assessment Research Group (GETS), School of Medicine, Universidad Nacional de Colombia. Bogot\u00e1 (Colombia); Department of Gynecology and Obstetrics, Faculty of Medicine, School of Medicine, Universidad Nacional de Colombia. Bogot\u00e1 (Colombia)."},{"name":"Grupo de Investigaci\u00f3n Evaluaci\u00f3n de Tecnolog\u00edas y Pol\u00edticas en Salud (GETS), Facultad de Medicina, Universidad Nacional de Colombia. Bogot\u00e1 (Colombia); Departamento de Ginecolog\u00eda y Obstetricia, Facultad de Medicina, Universidad Nacional de Colombia. Bogot\u00e1 (Colombia)."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7913","published-online":{"date-parts":[[2025,2,7]]},"reference":[{"key":"102545","doi-asserted-by":"crossref","unstructured":"Ghanem K, Ram S, Rice P. The modern epidemic of syphilis. N Eng J Med. 2020;382:845-54. https:\/\/doi.org\/10.1056\/nejmra1901593.","DOI":"10.1056\/NEJMra1901593"},{"key":"102546","doi-asserted-by":"crossref","unstructured":"Peeling R, Mabey D, Kamb M, Chen X, Radolf J, Benzaken A. Syphilis. Nat Rev Dis Primers. 2017;3:17073. https:\/\/doi.org\/10.1038\/nrdp.2017.73.","DOI":"10.1038\/nrdp.2017.73"},{"key":"102547","unstructured":"World Health Organization. Global sexually transmitted infections programme: Strategic information. Strategic information [Internet]. 2023. 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Committee on Infectious Diseases [Internet]. 2006. Disponible en: https:\/\/www.cabdirect.org\/cabdirect\/abstract\/20183376718?utm_medium=email&utm_source=transaction."},{"key":"102558","doi-asserted-by":"crossref","unstructured":"Alexander J, Sheffield J, Sanchez P, Mayfield J, Wendel G. Efficacy of treatment for syphilis in pregnancy. Obstet Gynecol. 1999;93:5-8. https:\/\/doi.org\/10.1016\/S0029-7844(98)00338-X","DOI":"10.1097\/00006250-199901000-00002"},{"key":"102559","doi-asserted-by":"crossref","unstructured":"Newman L, Kamb M, Hawkes S, Gomez G, Say L, Seuc A, Broutet N. Global estimates of syphilis in pregnancy and associated adverse outcomes: Analysis of multinational antenatal surveillance data. PLoS Med. 2013. https:\/\/doi.org\/10.1371\/journal.pmed.1001396","DOI":"10.1371\/journal.pmed.1001396"},{"key":"102560","unstructured":"Colombia. Ministerio de Salud. 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