{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T15:43:43Z","timestamp":1776095023567,"version":"3.50.1"},"reference-count":15,"publisher":"Federacion Colombiana de Obstetricia y Ginecologia","issue":"4","license":[{"start":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T00:00:00Z","timestamp":1764892800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T00:00:00Z","timestamp":1764892800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["revista.fecolsog.org"],"crossmark-restriction":false},"short-container-title":["Rev. colomb. obstet. ginecol."],"abstract":"<jats:p>Objetivo: presentar un caso de histoplasmosis diseminada con compromiso endometrial que simula un carcinoma de endometrio avanzado, en una paciente con infecci\u00f3n por VIH. Se describen los hallazgos en el endometrio.\nPresentaci\u00f3n del caso: se presenta el caso de una mujer de Guinea-Bis\u00e1u, que consult\u00f3 por dolor costal a un hospital general de Bilbao (Espa\u00f1a), que atiende pacientes inmigrantes y con aseguramiento p\u00fablico. Se identificaron fracturas patol\u00f3gicas vertebrales en m\u00faltiples niveles en tomograf\u00eda computarizada. Durante los estudios realizados para aclarar la causa de las fracturas se realiz\u00f3 diagn\u00f3stico de novo de infecci\u00f3n por VIH con recuento CD4 de 395 c\u00e9lulas\/\u03bcL. Se identificaron im\u00e1genes sugestivas de abscesos vertebrales e imagen sugestiva de c\u00e1ncer de endometrio. El estudio del material \u00f3seo mostr\u00f3 presencia de esporas de hongos y la biopsia de endometrio revel\u00f3 granulomas no necrotizantes y ac\u00famulos histiocitarios, sin lesi\u00f3n neopl\u00e1sica. Las pruebas serol\u00f3gicas fueron positivas para Histoplasma capsulatum. La paciente fue tratada con anfotericina B liposomal y terapia antirretroviral con evoluci\u00f3n cl\u00ednica favorable en el seguimiento.\nConclusiones: es importante considerar infecciones oportunistas en el diagn\u00f3stico diferencial de masas p\u00e9lvicas en pacientes inmunodeprimidas. Se requieren estudios adicionales para determinar la frecuencia del compromiso endometrial en la histoplasmosis diseminada y establecer protocolos diagn\u00f3sticos espec\u00edficos.<\/jats:p>","DOI":"10.18597\/rcog.4460","type":"journal-article","created":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T15:27:48Z","timestamp":1765380468000},"update-policy":"https:\/\/doi.org\/10.18597\/crossmark","source":"Crossref","is-referenced-by-count":0,"title":["Histoplasmosis diseminada con compromiso endometrial en una paciente con VIH: reporte de caso","Disseminated histoplasmosis in an HIV-positive patient mimicking advanced endometrial carcinoma. Case report."],"prefix":"10.18597","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-4734-7776","authenticated-orcid":false,"given":"Mar\u00eda Isabel","family":"Limia P\u00e9rez","sequence":"first","affiliation":[{"name":"Gynecology and Obstetrics Service, Hospital Universitario Basurto. Bilbao (Spain)."},{"name":"Servicio de Ginecolog\u00eda y Obstetricia, Hospital Universitario Basurto. Bilbao (Espa\u00f1a)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 C.","family":"Qu\u00edlez Conde","sequence":"additional","affiliation":[{"name":"Gynecology and Obstetrics Service, Hospital Universitario Basurto. Bilbao (Spain)."},{"name":"Servicio de Ginecolog\u00eda y Obstetricia, Hospital Universitario Basurto. Bilbao (Espa\u00f1a)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Beiro Felipe","sequence":"additional","affiliation":[{"name":"Department of Gynecologic Oncology, Service of Gynecology and Obstetrics, Hospital Universitario Basurto. Bilbao (Spain)."},{"name":"Departamento de Oncolog\u00eda Ginecol\u00f3gica, Servicio de Ginecolog\u00eda y Obstetricia, Hospital Universitario Basurto. Bilbao (Espa\u00f1a)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamara","family":"Dehesa Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Department of Gynecologic Oncology, Service of Gynecology and Obstetrics, Hospital Universitario Basurto. Bilbao (Spain)."},{"name":"Departamento de Oncolog\u00eda Ginecol\u00f3gica, Servicio de Ginecolog\u00eda y Obstetricia, Hospital Universitario Basurto. Bilbao (Espa\u00f1a)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federico","family":"Mor\u00e1n Cuesta","sequence":"additional","affiliation":[{"name":"Internal Medicine Service, Hospital Universitario Basurto. Bilbao (Spain)."},{"name":"Servicio de Medicina Interna, Hospital Universitario Basurto. Bilbao (Espa\u00f1a)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda","family":"L\u00f3pez Matarranz","sequence":"additional","affiliation":[{"name":"Gynecology and Obstetrics Service, Hospital Universitario Basurto. Bilbao (Spain)."},{"name":"Servicio de Ginecolog\u00eda y Obstetricia, Hospital Universitario Basurto. Bilbao (Espa\u00f1a)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jes\u00fas Hilario","family":"De La Rosa Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Department of Gynecologic Oncology, Service of Gynecology and Obstetrics, Hospital Universitario Basurto. Bilbao (Spain)."},{"name":"Departamento de Oncolog\u00eda Ginecol\u00f3gica, Servicio de Ginecolog\u00eda y Obstetricia, Hospital Universitario Basurto. Bilbao (Espa\u00f1a)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos David","family":"P\u00e9rez Verdugo","sequence":"additional","affiliation":[{"name":"Department of Gynecologic Oncology, Service of Gynecology and Obstetrics, Hospital Universitario Basurto. Bilbao (Spain)."},{"name":"Departamento de Oncolog\u00eda Ginecol\u00f3gica, Servicio de Ginecolog\u00eda y Obstetricia, Hospital Universitario Basurto. Bilbao (Espa\u00f1a)."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7913","published-online":{"date-parts":[[2025,12,5]]},"reference":[{"key":"105178","doi-asserted-by":"crossref","unstructured":"Ara\u00faz A, Papineni P. Histoplasmosis. 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