{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T21:04:02Z","timestamp":1791234242225,"version":"4.1.0"},"reference-count":45,"publisher":"Impact Journals, LLC","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aging"],"published-print":{"date-parts":[[2014,7,12]]},"DOI":"10.18632\/aging.100677","type":"journal-article","created":{"date-parts":[[2016,3,5]],"date-time":"2016-03-05T23:42:01Z","timestamp":1457221321000},"page":"524-544","source":"Crossref","is-referenced-by-count":103,"title":["Genome-wide profiling of the microRNA-mRNA regulatory network in skeletal muscle with aging"],"prefix":"10.18632","volume":"6","author":[{"given":"Ji Young","family":"Kim","sequence":"first","affiliation":[{"name":"Aging Research Institute, Korea Research Institute of Bioscience & BioTechnology, 125 Gwahak-ro, Yuseong-gu, Daejeon, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young-Kyu","family":"Park","sequence":"additional","affiliation":[{"name":"Medical Genomics Research Center, Korea Research Institute of Bioscience & BioTechnology, 125 Gwahak-ro, Yuseong-gu, Daejeon, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwang-Pyo","family":"Lee","sequence":"additional","affiliation":[{"name":"Aging Research Institute, Korea Research Institute of Bioscience & BioTechnology, 125 Gwahak-ro, Yuseong-gu, Daejeon, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung-Min","family":"Lee","sequence":"additional","affiliation":[{"name":"Aging Research Institute, Korea Research Institute of Bioscience & BioTechnology, 125 Gwahak-ro, Yuseong-gu, Daejeon, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae-Wook","family":"Kang","sequence":"additional","affiliation":[{"name":"Medical Genomics Research Center, Korea Research Institute of Bioscience & BioTechnology, 125 Gwahak-ro, Yuseong-gu, Daejeon, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hee-Jin","family":"Kim","sequence":"additional","affiliation":[{"name":"Medical Genomics Research Center, Korea Research Institute of Bioscience & BioTechnology, 125 Gwahak-ro, Yuseong-gu, Daejeon, Korea"},{"name":"Department of Functional Genomics, University of Science and Technology, Daejeon, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"So Hee","family":"Dho","sequence":"additional","affiliation":[{"name":"Aging Research Institute, Korea Research Institute of Bioscience & BioTechnology, 125 Gwahak-ro, Yuseong-gu, Daejeon, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seon-Young","family":"Kim","sequence":"additional","affiliation":[{"name":"Medical Genomics Research Center, Korea Research Institute of Bioscience & BioTechnology, 125 Gwahak-ro, Yuseong-gu, Daejeon, Korea"},{"name":"Department of Functional Genomics, University of Science and Technology, Daejeon, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ki-Sun","family":"Kwon","sequence":"additional","affiliation":[{"name":"Aging Research Institute, Korea Research Institute of Bioscience & BioTechnology, 125 Gwahak-ro, Yuseong-gu, Daejeon, Korea"},{"name":"Department of Functional Genomics, University of Science and Technology, Daejeon, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7892","published-online":{"date-parts":[[2014,7,12]]},"reference":[{"key":"1","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1152\/japplphysiol.00347.2003","article-title":"Invited review: Aging and sarcopenia","volume":"9","author":"Doherty","year":"2003","journal-title":"Journal of applied physiology"},{"key":"2","first-page":"121","article-title":"Quantitative proteome analysis of age-related changes in mouse gastrocnemius muscle using mTRAQ","volume":"1","author":"Kwon","year":"2014","journal-title":"Proteomics"},{"key":"3","first-page":"827","article-title":"MicroRNAs in development and disease","volume":"9","author":"Abdellatif","year":"2011","journal-title":"Physiological reviews"},{"key":"4","first-page":"720","article-title":"miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs","volume":"1","author":"Dreyfuss","year":"2002","journal-title":"Genes & development"},{"key":"5","first-page":"7","article-title":"MicroRNAs and their roles in aging","volume":"12","author":"Slack","year":"2012","journal-title":"Journal of cell science"},{"key":"6","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.exger.2010.01.007","article-title":"Novel modulators of senescence, aging, and longevity: Small non-coding RNAs enter the stage","volume":"4","author":"Grillari-Voglauer","year":"2010","journal-title":"Experimental gerontology"},{"key":"7","first-page":"75","article-title":"Increased expression of miR-34a and miR-93 in rat liver during aging, and their impact on the expression of Mgst1 and Sirt1","volume":"13","author":"Wang","year":"2011","journal-title":"Mechanisms of ageing and development"},{"key":"8","first-page":"944","article-title":"Up-regulation of key microRNAs, and inverse down-regulation of their predicted oxidative phosphorylation target genes, during aging in mouse brain","volume":"3","author":"Wang","year":"2011","journal-title":"Neurobiology of aging"},{"key":"9","first-page":"595","article-title":"Aging and microRNA expression in human skeletal muscle: a microarray and bioinformatics analysis","volume":"4","author":"Rasmussen","year":"2011","journal-title":"Physiological genomics"},{"key":"10","first-page":"379","article-title":"The adipokine leptin increases skeletal muscle mass and significantly alters skeletal muscle miRNA expression profile in aged mice","volume":"40","author":"Mi","year":"2010","journal-title":"Biochemical and biophysical research communications"},{"key":"11","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1002\/emmm.200900045","article-title":"Molecular aging and rejuvenation of human muscle stem cells","volume":"1","author":"Conboy","year":"2009","journal-title":"EMBO molecular medicine"},{"key":"12","first-page":"E1333","article-title":"Aging differentially affects human skeletal muscle microRNA expression at rest and after an anabolic stimulus of resistance exercise and essential amino acids","volume":"29","author":"Rasmussen","year":"2008","journal-title":"American journal of physiology Endocrinology and metabolism"},{"key":"13","doi-asserted-by":"crossref","first-page":"692","DOI":"10.18632\/aging.100598","article-title":"Age-associated miRNA alterations in skeletal muscle from rhesus monkeys reversed by caloric restriction","volume":"5","author":"Abdelmohsen","year":"2013","journal-title":"Aging"},{"key":"14","first-page":"17016","article-title":"Distinctive patterns of microRNA expression in primary muscular disorders","volume":"10","author":"Whitney","year":"2007","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"15","first-page":"369","article-title":"NF-kappaB-YY1-miR-29 regulatory circuitry in skeletal myogenesis and rhabdomyosarcoma","volume":"1","author":"Guttridge","year":"2008","journal-title":"Cancer cell"},{"key":"16","first-page":"29596","article-title":"MicroRNA-1\/206 targets c-Met and inhibits rhabdomyosarcoma development","volume":"28","author":"Tu","year":"2009","journal-title":"The Journal of biological chemistry"},{"key":"17","first-page":"255","article-title":"Applications of next-generation sequencing technologies in functional genomics","volume":"9","author":"Marra","year":"2008","journal-title":"Genomics"},{"key":"18","doi-asserted-by":"crossref","first-page":"e1001246","DOI":"10.1371\/journal.pgen.1001246","article-title":"Distinct functions for the Drosophila piRNA pathway in genome maintenance and telomere protection","volume":"6","author":"Theurkauf","year":"2010","journal-title":"PLoS genetics"},{"key":"19","first-page":"107","article-title":"MicroRNAs involved in skeletal muscle differentiation","volume":"4","author":"Zhang","year":"2013","journal-title":"Journal of genetics and genomics = Yi chuan xue bao"},{"key":"20","first-page":"705","article-title":"miR-145 and miR-143 regulate smooth muscle cell fate and plasticity","volume":"46","author":"Srivastava","year":"2009","journal-title":"Nature"},{"key":"21","first-page":"1234","article-title":"MicroRNA-22 regulates cardiac hypertrophy and remodeling in response to stress","volume":"11","author":"Wang","year":"2013","journal-title":"Circulation research"},{"key":"22","first-page":"457","article-title":"Snail regulates MyoD binding-site occupancy to direct enhancer switching and differentiation-specific transcription in myogenesis","volume":"4","author":"Rudnicki","year":"2012","journal-title":"Molecular cell"},{"key":"23","first-page":"19431","article-title":"MicroRNA-378 targets the myogenic repressor MyoR during myoblast differentiation","volume":"28","author":"Dutta","year":"2011","journal-title":"The Journal of biological chemistry"},{"key":"24","first-page":"107","article-title":"MicroRNA-34a regulates cardiac ageing and function","volume":"49","author":"Girmatsion","year":"2013","journal-title":"Nature"},{"key":"25","first-page":"269","article-title":"MicroRNA group disorganization in aging","volume":"4","author":"Wang","year":"2010","journal-title":"Experimental gerontology"},{"key":"26","first-page":"607","article-title":"Genome-wide miRNA signatures of human longevity","volume":"1","author":"Franke","year":"2012","journal-title":"Aging cell"},{"key":"27","doi-asserted-by":"crossref","first-page":"e34688","DOI":"10.1371\/journal.pone.0034688","article-title":"The expression of microRNA and microRNA clusters in the aging heart","volume":"7","author":"Wei","year":"2012","journal-title":"PloS one"},{"key":"28","first-page":"37","article-title":"miRDeep2 accurately identifies known and hundreds of novel microRNA genes in seven animal clades","volume":"4","author":"Rajewsky","year":"2012","journal-title":"Nucleic acids research"},{"key":"29","first-page":"14132","article-title":"Age-dependent microRNA control of synaptic plasticity in 22q11 deletion syndrome and schizophrenia","volume":"3","author":"Zakharenko","year":"2012","journal-title":"The Journal of neuroscience : the official journal of the Society for Neuroscience"},{"key":"30","first-page":"3233","article-title":"Early growth response 1 protein, an upstream gatekeeper of the p53 tumor suppressor, controls replicative senescence","volume":"10","author":"Mercola","year":"2003","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"31","first-page":"330","article-title":"Apolipoprotein D in the aging brain and in Alzheimer's dementia","volume":"2","author":"Lacko","year":"2000","journal-title":"Neurological research"},{"key":"32","first-page":"25255","article-title":"A novel target of microRNA-29, Ring1 and YY1-binding protein (Rybp), negatively regulates skeletal myogenesis","volume":"28","author":"Wang","year":"2012","journal-title":"The Journal of biological chemistry"},{"key":"33","doi-asserted-by":"crossref","first-page":"e3420","DOI":"10.1371\/journal.pone.0003420","article-title":"An analysis of human microRNA and disease associations","volume":"3","author":"Cui","year":"2008","journal-title":"PloS one"},{"key":"34","doi-asserted-by":"crossref","first-page":"e52442","DOI":"10.1371\/journal.pone.0052442","article-title":"Heart structure-specific transcriptomic atlas reveals conserved microRNA-mRNA interactions","volume":"8","author":"Frei","year":"2013","journal-title":"PloS one"},{"key":"35","first-page":"35339","article-title":"miR-155 inhibits expression of the MEF2A protein to repress skeletal muscle differentiation","volume":"28","author":"Wang","year":"2011","journal-title":"The Journal of biological chemistry"},{"key":"36","first-page":"475","article-title":"Diversifying microRNA sequence and function","volume":"1","author":"Zamore","year":"2013","journal-title":"Nature reviews Molecular cell biology"},{"key":"37","first-page":"3350","article-title":"Comprehensive analysis of mammalian miRNA* species and their role in myeloid cells","volume":"11","author":"Karsan","year":"2011","journal-title":"Blood"},{"key":"38","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0092-8674(04)00045-5","article-title":"MicroRNAs: genomics, biogenesis, mechanism, and function","volume":"11","author":"Bartel","year":"2004","journal-title":"Cell"},{"key":"39","first-page":"1997","article-title":"The Dlk1 and Gtl2 genes are linked and reciprocally imprinted","volume":"1","author":"Tilghman","year":"2000","journal-title":"Genes & development"},{"key":"40","first-page":"939","article-title":"Origin, evolution, and biological role of miRNA cluster in DLK-DIO3 genomic region in placental mammals","volume":"2","author":"Dalrymple","year":"2008","journal-title":"Molecular biology and evolution"},{"key":"41","first-page":"795","article-title":"The microRNAs within the DLK1-DIO3 genomic region: involvement in disease pathogenesis","volume":"7","author":"Briasoulis","year":"2013","journal-title":"Cellular and molecular life sciences : CMLS"},{"key":"42","doi-asserted-by":"crossref","first-page":"e7399","DOI":"10.1371\/journal.pone.0007399","article-title":"Effect of DLK1 and RTL1 but not MEG3 or MEG8 on muscle gene expression in Callipyge lambs","volume":"4","author":"Bidwell","year":"2009","journal-title":"PloS one"},{"key":"43","first-page":"31","article-title":"MEF2A regulates the Gtl2-Dio3 microRNA mega-cluster to modulate WNT signaling in skeletal muscle regeneration","volume":"14","author":"Naya","year":"2013","journal-title":"Development"},{"key":"44","first-page":"1754","article-title":"Fast and accurate short read alignment with Burrows-Wheeler transform","volume":"2","author":"Durbin","year":"2009","journal-title":"Bioinformatics"},{"issue":"Database issue","key":"45","first-page":"D145","article-title":"fRNAdb: a platform for mining\/annotating functional RNA candidates from non-coding RNA sequences","volume":"3","author":"Asai","year":"2007","journal-title":"Nucleic acids research"}],"container-title":["Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.100677","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,2]],"date-time":"2020-09-02T11:32:56Z","timestamp":1599046376000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.100677"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7,12]]},"references-count":45,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2014,7,1]]}},"alternative-id":["100677","25063768"],"URL":"https:\/\/doi.org\/10.18632\/aging.100677","relation":{},"ISSN":["1945-4589"],"issn-type":[{"value":"1945-4589","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7,12]]}}}