{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T05:33:43Z","timestamp":1791178423551,"version":"4.1.0"},"reference-count":68,"publisher":"Impact Journals, LLC","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aging"],"published-print":{"date-parts":[[2014,7,19]]},"DOI":"10.18632\/aging.100680","type":"journal-article","created":{"date-parts":[[2016,3,6]],"date-time":"2016-03-06T04:42:12Z","timestamp":1457239332000},"page":"755-769","source":"Crossref","is-referenced-by-count":27,"title":["Rapamycin treatment of Mandibuloacral Dysplasia cells rescues localization of chromatin-associated proteins and cell cycle dynamics"],"prefix":"10.18632","volume":"6","author":[{"given":"Vittoria","family":"Cenni","sequence":"first","affiliation":[{"name":"National Research Council of Italy, Institute of Molecular Genetics, IGM-CNR-IOR, Bologna, Italy"},{"name":"Rizzoli Orthopedic Institute, Laboratory of Musculoskeletal Cell Biology, Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Capanni","sequence":"additional","affiliation":[{"name":"National Research Council of Italy, Institute of Molecular Genetics, IGM-CNR-IOR, Bologna, Italy"},{"name":"Rizzoli Orthopedic Institute, Laboratory of Musculoskeletal Cell Biology, Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabetta","family":"Mattioli","sequence":"additional","affiliation":[{"name":"National Research Council of Italy, Institute of Molecular Genetics, IGM-CNR-IOR, Bologna, Italy"},{"name":"Rizzoli Orthopedic Institute, Laboratory of Musculoskeletal Cell Biology, Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Columbaro","sequence":"additional","affiliation":[{"name":"Rizzoli Orthopedic Institute, Laboratory of Musculoskeletal Cell Biology, Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manfred","family":"Wehnert","sequence":"additional","affiliation":[{"name":"Institute of Human Genetics, University of Greifswald, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michela","family":"Ortolani","sequence":"additional","affiliation":[{"name":"National Research Council of Italy, Institute of Molecular Genetics, IGM-CNR-IOR, Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milena","family":"Fini","sequence":"additional","affiliation":[{"name":"Rizzoli Orthopedic Institute, Laboratory of Preclinical and Surgical Studies and BITTA, RIT, Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Novelli","sequence":"additional","affiliation":[{"name":"Department of Biomedicine and Prevention, Tor Vergata University, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessika","family":"Bertacchini","sequence":"additional","affiliation":[{"name":"Department of Laboratory, CEIA, University of Modena and Reggio Emilia, Modena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadir M.","family":"Maraldi","sequence":"additional","affiliation":[{"name":"National Research Council of Italy, Institute of Molecular Genetics, IGM-CNR-IOR, Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Marmiroli","sequence":"additional","affiliation":[{"name":"Department of Laboratory, CEIA, University of Modena and Reggio Emilia, Modena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Rosaria","family":"D'Apice","sequence":"additional","affiliation":[{"name":"Department of Biomedicine and Prevention, Tor Vergata University, Rome, Italy"},{"name":"Fondazione Policlinico Tor Vergata, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabino","family":"Prencipe","sequence":"additional","affiliation":[{"name":"National Research Council of Italy, Institute of Molecular Genetics, IGM-CNR-IOR, Bologna, Italy"},{"name":"Rizzoli Orthopedic Institute, Laboratory of Musculoskeletal Cell Biology, Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Squarzoni","sequence":"additional","affiliation":[{"name":"National Research Council of Italy, Institute of Molecular Genetics, IGM-CNR-IOR, Bologna, Italy"},{"name":"Rizzoli Orthopedic Institute, Laboratory of Musculoskeletal Cell Biology, Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanna","family":"Lattanzi","sequence":"additional","affiliation":[{"name":"National Research Council of Italy, Institute of Molecular Genetics, IGM-CNR-IOR, Bologna, Italy"},{"name":"Rizzoli Orthopedic Institute, Laboratory of Musculoskeletal Cell Biology, Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7892","published-online":{"date-parts":[[2014,7,19]]},"reference":[{"key":"1","doi-asserted-by":"crossref","first-page":"4","DOI":"10.4161\/nucl.13723","article-title":"Investigating the purpose of prelamin A processing","volume":"2","author":"Fong","year":"2011","journal-title":"Nucleus"},{"key":"2","first-page":"3628","article-title":"Prelamin A is involved in early steps of muscle differentiation","volume":"31","author":"Lattanzi","year":"2008","journal-title":"Experimental cell research"},{"key":"3","first-page":"1305","article-title":"Prelamin A-mediated recruitment of SUN1 to the nuclear envelope directs nuclear positioning in human muscle","volume":"1","author":"Lattanzi","year":"2011","journal-title":"Cell death and differentiation"},{"key":"4","first-page":"147","article-title":"Lamins are rapamycin targets that impact human longevity: a study in centenarians","volume":"12","author":"Capanni","year":"2014","journal-title":"Journal of cell science"},{"key":"5","first-page":"2200","article-title":"Prelamin A Acts to Accelerate Smooth Muscle Cell Senescence and Is a Novel Biomarker of Human Vascular Aging","volume":"12","author":"Shanahan","year":"2010","journal-title":"Circulation"},{"key":"6","first-page":"317","article-title":"Involvement of prelamin A in laminopathies","volume":"1","author":"Lattanzi","year":"2007","journal-title":"Crit Rev Eukaryot Gene Expr"},{"key":"7","first-page":"a000760","article-title":"Diseases of the nuclear envelope","volume":"2","author":"Wang","year":"2010","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"8","first-page":"2669","article-title":"Rescue of heterochromatin organization in Hutchinson-Gilford progeria by drug treatment","volume":"6","author":"Lattanzi","year":"2005","journal-title":"Cellular and molecular life sciences : CMLS"},{"key":"9","doi-asserted-by":"crossref","first-page":"4766","DOI":"10.4161\/cc.9.23.14210","article-title":"Prelamin A processing and functional effects in restrictive dermopathy","volume":"9","author":"Lattanzi","year":"2010","journal-title":"Cell cycle"},{"key":"10","first-page":"1503","article-title":"Loss of ZMPSTE24 (FACE-1) causes autosomal recessive restrictive dermopathy and accumulation of Lamin A precursors","volume":"1","author":"Cau","year":"2005","journal-title":"Human molecular genetics"},{"issue":"4","key":"11","first-page":"643","article-title":"Altered chromatin organization and SUN2 localization in mandibuloacral dysplasia are rescued by drug treatment","volume":"13","author":"Lattanzi","year":"2012","journal-title":"Histochemistry and cell biology"},{"key":"12","first-page":"1489","article-title":"Altered pre-lamin A processing is a common mechanism leading to lipodystrophy","volume":"1","author":"Lattanzi","year":"2005","journal-title":"Human molecular genetics"},{"key":"13","first-page":"653","article-title":"Fast regulation of AP-1 activity through interaction of lamin A\/C, ERK1\/2, and c-Fos at the nuclear envelope","volume":"18","author":"Andres","year":"2008","journal-title":"The Journal of cell biology"},{"key":"14","doi-asserted-by":"crossref","first-page":"309","DOI":"10.5966\/sctm.2011-0010","article-title":"Sp1 transcription factor interaction with accumulated prelamin a impairs adipose lineage differentiation in human mesenchymal stem cells: essential role of sp1 in the integrity of lipid vesicles","volume":"1","author":"Rodriguez","year":"2012","journal-title":"Stem cells translational medicine"},{"key":"15","first-page":"411","article-title":"Oct-1 recruitment to the nuclear envelope in adult-onset autosomal dominant leukodystrophy","volume":"183","author":"Lattanzi","year":"2013","journal-title":"Biochimica et biophysica acta"},{"key":"16","first-page":"e36","article-title":"Autophagic degradation of farnesylated prelamin A as a therapeutic approach to lamin-linked progeria","volume":"5","author":"Lattanzi","year":"2011","journal-title":"European journal of histochemistry : EJH"},{"key":"17","first-page":"56","article-title":"Hydrogen peroxide stimulates nuclear import of the POU homeodomain protein Oct-1 and its repressive effect on the expression of Cdx-2","volume":"1","author":"Jin","year":"2010","journal-title":"BMC cell biology"},{"key":"18","first-page":"61","article-title":"The processing pathway of prelamin A","volume":"10","author":"Dalton","year":"1994","journal-title":"J Cell Sci"},{"key":"19","first-page":"150","article-title":"Alterations of nuclear envelope and chromatin organization in mandibuloacral dysplasia, a rare form of laminopathy","volume":"2","author":"Novelli","year":"2005","journal-title":"Physiological genomics"},{"key":"20","first-page":"2196","article-title":"Premature aging in mice activates a systemic metabolic response involving autophagy induction","volume":"1","author":"Lopez-Otin","year":"2008","journal-title":"Human molecular genetics"},{"key":"21","doi-asserted-by":"crossref","first-page":"795","DOI":"10.4161\/auto.8901","article-title":"Autophagic degradation of nuclear components in mammalian cells","volume":"5","author":"Nishino","year":"2009","journal-title":"Autophagy"},{"key":"22","first-page":"1313","article-title":"Autophagy is defective in collagen VI muscular dystrophies, and its reactivation rescues myofiber degeneration","volume":"1","author":"Sandri","year":"2011","journal-title":"Nat Med"},{"key":"23","doi-asserted-by":"crossref","first-page":"188","DOI":"10.4161\/auto.7.2.14181","article-title":"Dissecting the dynamic turnover of GFP-LC3 in the autolysosome","volume":"7","author":"Ding","year":"2011","journal-title":"Autophagy"},{"key":"24","first-page":"1149","article-title":"Pre-Lamin A processing is linked to heterochromatin organization","volume":"10","author":"Capanni","year":"2007","journal-title":"Journal of cellular biochemistry"},{"key":"25","first-page":"553","article-title":"A-type lamins and signaling: the PI 3-kinase\/Akt pathway moves forward","volume":"22","author":"Lattanzi","year":"2009","journal-title":"Journal of cellular physiology"},{"key":"26","doi-asserted-by":"crossref","first-page":"4727","DOI":"10.1021\/pr800262g","article-title":"Lamin A Ser404 is a nuclear target of Akt phosphorylation in C2C12 cells","volume":"7","author":"de Pol","year":"2008","journal-title":"Journal of proteome research"},{"key":"27","first-page":"2145","article-title":"The protein kinase Akt\/PKB regulates both prelamin A degradation and Lmna gene expression","volume":"2","author":"Marmiroli","year":"2013","journal-title":"FASEB journal : official publication of the Federation of American Societies for Experimental Biology"},{"key":"28","doi-asserted-by":"crossref","first-page":"426","DOI":"10.4161\/auto.7.4.14392","article-title":"Autophagy induction rescues muscular dystrophy","volume":"7","author":"Bonaldo","year":"2011","journal-title":"Autophagy"},{"key":"29","first-page":"842","article-title":"Can autophagy promote longevity?","volume":"1","author":"Kroemer","year":"2011","journal-title":"Nat Cell Biol"},{"key":"30","first-page":"24553","article-title":"mTORC2 protein-mediated protein kinase B (Akt) serine 473 phosphorylation is not required for Akt1 activity in human platelets","volume":"28","author":"Hers","year":"2011","journal-title":"J Biol Chem"},{"key":"31","first-page":"89ra58","article-title":"Rapamycin reverses cellular phenotypes and enhances mutant protein clearance in Hutchinson-Gilford progeria syndrome cells","volume":"3","author":"Collins","year":"2011","journal-title":"Science translational medicine"},{"key":"32","first-page":"1109","article-title":"Targeting autophagy potentiates tyrosine kinase inhibitor-induced cell death in Philadelphia chromosome-positive cells, including primary CML stem cells","volume":"11","author":"Hunter","year":"2009","journal-title":"J Clin Invest"},{"key":"33","first-page":"426","article-title":"Mandibuloacral dysplasia is caused by a mutation in LMNA-encoding lamin A\/C","volume":"7","author":"Scarano","year":"2002","journal-title":"American journal of human genetics"},{"key":"34","doi-asserted-by":"crossref","first-page":"142","DOI":"10.4161\/nucl.24089","article-title":"Disruption of lamin B1 and lamin B2 processing and localization by farnesyltransferase inhibitors","volume":"4","author":"Goldman","year":"2013","journal-title":"Nucleus"},{"key":"35","doi-asserted-by":"crossref","first-page":"264","DOI":"10.18632\/aging.100651","article-title":"Prelamin A accumulation and stress conditions induce impaired Oct-1 activity and autophagy in prematurely aged human mesenchymal stem cell","volume":"6","author":"Rodriguez","year":"2014","journal-title":"Aging"},{"key":"36","first-page":"4467","article-title":"Compound heterozygosity for mutations in LMNA in a patient with a myopathic and lipodystrophic mandibuloacral dysplasia type A phenotype","volume":"9","author":"Masala","year":"2007","journal-title":"The Journal of clinical endocrinology and metabolism"},{"key":"37","first-page":"210","article-title":"Stabilization of Suv39H1 by SirT1 is part of oxidative stress response and ensures genome protection","volume":"4","author":"Vaquero","year":"2011","journal-title":"Molecular cell"},{"key":"38","first-page":"440","article-title":"SIRT1 regulates the histone methyl-transferase SUV39H1 during heterochromatin formation","volume":"45","author":"Reinberg","year":"2007","journal-title":"Nature"},{"key":"39","first-page":"2067","article-title":"Developmental control of late replication and S phase length","volume":"2","author":"O'Farrell","year":"2010","journal-title":"Current biology : CB"},{"key":"40","doi-asserted-by":"crossref","first-page":"2030","DOI":"10.4161\/cc.7.13.6149","article-title":"The R527H mutation in LMNA gene causes an increased sensitivity to ionizing radiation","volume":"7","author":"Novelli","year":"2008","journal-title":"Cell cycle"},{"key":"41","doi-asserted-by":"crossref","first-page":"e69169","DOI":"10.1371\/journal.pone.0069169","article-title":"Regulation of nucleotide excision repair by nuclear lamin b1","volume":"8","author":"Goldman","year":"2013","journal-title":"PloS one"},{"key":"42","first-page":"3997","article-title":"The accumulation of un-repairable DNA damage in laminopathy progeria fibroblasts is caused by ROS generation and is prevented by treatment with N-acetyl cysteine","volume":"2","author":"Hutchison","year":"2011","journal-title":"Human molecular genetics"},{"key":"43","doi-asserted-by":"crossref","first-page":"4112","DOI":"10.4161\/cc.8.24.10215","article-title":"Pseudo-DNA damage response in senescent cells","volume":"8","author":"Blagosklonny","year":"2009","journal-title":"Cell cycle"},{"issue":"24","key":"44","first-page":"4642","article-title":"Hyper-mitogenic drive coexists with mitotic incompetence in senescent cells","volume":"1","author":"Blagosklonny","year":"2012","journal-title":"Cell cycle"},{"key":"45","doi-asserted-by":"crossref","first-page":"159","DOI":"10.18632\/aging.100443","article-title":"Cell cycle arrest is not yet senescence, which is not just cell cycle arrest: terminology for TOR-driven aging","volume":"4","author":"Blagosklonny","year":"2012","journal-title":"Aging"},{"key":"46","doi-asserted-by":"crossref","first-page":"2231","DOI":"10.4161\/cc.21065","article-title":"Dissecting the role of mTOR complexes in cellular senescence","volume":"1","author":"Serrano","year":"2012","journal-title":"Cell cycle"},{"key":"47","first-page":"2391","article-title":"Attenuation of TORC1 signaling delays replicative and oncogenic RAS-induced senescence","volume":"1","author":"Sun","year":"2012","journal-title":"Cell cycle"},{"key":"48","doi-asserted-by":"crossref","first-page":"48","DOI":"10.18632\/aging.100633","article-title":"BMAL1-dependent regulation of the mTOR signaling pathway delays aging","volume":"6","author":"Kondratov","year":"2014","journal-title":"Aging"},{"key":"49","article-title":"Loss of lamin B1 results in prolongation of S phase and decondensation of chromosome territories","author":"Ried","year":"2014","journal-title":"FASEB journal : official publication of the Federation of American Societies for Experimental Biology"},{"key":"50","first-page":"440","article-title":"Reversal of the cellular phenotype in the premature aging disease Hutchinson-Gilford progeria syndrome","volume":"1","author":"Misteli","year":"2005","journal-title":"Nat Med"},{"key":"51","doi-asserted-by":"crossref","first-page":"213","DOI":"10.4161\/nucl.11738","article-title":"The intricacy of nuclear membrane dynamics during nucleophagy","volume":"1","author":"Devenish","year":"2010","journal-title":"Nucleus"},{"key":"52","doi-asserted-by":"crossref","first-page":"144ra103","DOI":"10.1126\/scitranslmed.3003802","article-title":"Rapamycin reverses elevated mTORC1 signaling in lamin A\/C-deficient mice, rescues cardiac and skeletal muscle function, and extends survival","volume":"4","author":"Kennedy","year":"2012","journal-title":"Science translational medicine"},{"key":"53","doi-asserted-by":"crossref","first-page":"94","DOI":"10.18632\/aging.100281","article-title":"Cell cycle arrest is not senescence","volume":"3","author":"Blagosklonny","year":"2011","journal-title":"Aging"},{"key":"54","article-title":"Increased Mammalian Lifespan and a Segmental and Tissue-Specific Slowing of Aging after Genetic Reduction of mTOR Expression","author":"Dubois","year":"2013","journal-title":"Cell reports"},{"key":"55","doi-asserted-by":"crossref","first-page":"474","DOI":"10.18632\/aging.100573","article-title":"Rapamycin suppresses brain aging in senescence-accelerated OXYS rats","volume":"5","author":"Blagosklonny","year":"2013","journal-title":"Aging"},{"key":"56","doi-asserted-by":"crossref","first-page":"709","DOI":"10.18632\/aging.100498","article-title":"Rapamycin extends lifespan and delays tumorigenesis in heterozygous p53+\/\u2212 mice","volume":"4","author":"Gudkov","year":"2012","journal-title":"Aging"},{"key":"57","first-page":"e36","article-title":"Autophagic degradation of farnesylated prelamin A as a therapeutic approach to lamin-linked progeria","volume":"5","author":"Lattanzi","year":"2011","journal-title":"Eur J Histochem"},{"key":"58","first-page":"767","article-title":"Combined treatment with statins and aminobisphosphonates extends longevity in a mouse model of human premature aging","volume":"1","author":"Freije","year":"2008","journal-title":"Nature medicine"},{"key":"59","first-page":"16666","article-title":"Clinical trial of a farnesyltransferase inhibitor in children with Hutchinson-Gilford progeria syndrome","volume":"10","author":"Statkevich","year":"2012","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"60","first-page":"3997","article-title":"The accumulation of un-repairable DNA damage in laminopathy progeria fibroblasts is caused by ROS generation and is prevented by treatment with N-acetyl cysteine","volume":"2","author":"Hutchison","year":"2011","journal-title":"Hum Mol Genet"},{"key":"61","first-page":"711","article-title":"Osteoblasts from a mandibuloacral dysplasia patient induce human blood precursors to differentiate into active osteoclasts","volume":"181","author":"Columbaro","year":"2011","journal-title":"Biochimica et biophysica acta"},{"key":"62","first-page":"R74","article-title":"Farnesyltransferase inhibitor treatment restores chromosome territory positions and active chromosome dynamics in Hutchinson-Gilford Progeria syndrome cells","volume":"1","author":"Bridger","year":"2011","journal-title":"Genome Biol"},{"key":"63","first-page":"783","article-title":"Lamin A\/C speckles mediate spatial organization of splicing factor compartments and RNA polymerase II transcription","volume":"15","author":"Parnaik","year":"2002","journal-title":"The Journal of cell biology"},{"key":"64","doi-asserted-by":"crossref","first-page":"2600","DOI":"10.4161\/cc.9.13.12080","article-title":"Lamin A precursor induces barrier-to-autointegration factor nuclear localization","volume":"9","author":"Lattanzi","year":"2010","journal-title":"Cell Cycle"},{"key":"65","first-page":"43","article-title":"Different prelamin A forms accumulate in human fibroblasts: a study in experimental models and progeria","volume":"5","author":"Maraldi","year":"2009","journal-title":"European journal of histochemistry : EJH"},{"key":"66","first-page":"453","article-title":"Drugs affecting prelamin A processing: effects on heterochromatin organization","volume":"31","author":"Lattanzi","year":"2008","journal-title":"Experimental cell research"},{"key":"67","first-page":"2946","article-title":"Ankrd2\/ARPP is a novel Akt2 specific substrate and regulates myogenic differentiation upon cellular exposure to H(2)O(2)","volume":"2","author":"Marmiroli","year":"2011","journal-title":"Molecular biology of the cell"},{"key":"68","first-page":"301","article-title":"Analysis of cell cycle by flow cytometry","volume":"28","author":"Darzynkiewicz","year":"2004","journal-title":"Methods in molecular biology"}],"container-title":["Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.100680","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,2]],"date-time":"2020-09-02T15:36:53Z","timestamp":1599061013000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.100680"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7,19]]},"references-count":68,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2014,9,1]]}},"alternative-id":["100680","25324471"],"URL":"https:\/\/doi.org\/10.18632\/aging.100680","relation":{},"ISSN":["1945-4589"],"issn-type":[{"value":"1945-4589","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7,19]]}}}