{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T12:26:19Z","timestamp":1790339179435,"version":"4.1.0"},"reference-count":124,"publisher":"Impact Journals, LLC","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aging"],"published-print":{"date-parts":[[2016,3,14]]},"DOI":"10.18632\/aging.100927","type":"journal-article","created":{"date-parts":[[2016,5,25]],"date-time":"2016-05-25T15:06:09Z","timestamp":1464188769000},"page":"730-750","source":"Crossref","is-referenced-by-count":63,"title":["N-acetyl-cysteine prevents age-related hearing loss and the progressive loss of inner hair cells in \u03b3-glutamyl transferase 1 deficient mice"],"prefix":"10.18632","volume":"8","author":[{"given":"Dalian","family":"Ding","sequence":"first","affiliation":[{"name":"Center for Hearing and Deafness, University at Buffalo, Buffalo, NY 14214, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyan","family":"Jiang","sequence":"additional","affiliation":[{"name":"Center for Hearing and Deafness, University at Buffalo, Buffalo, NY 14214, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guang-Di","family":"Chen","sequence":"additional","affiliation":[{"name":"Center for Hearing and Deafness, University at Buffalo, Buffalo, NY 14214, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chantal","family":"Longo-Guess","sequence":"additional","affiliation":[{"name":"The Jackson Laboratory, Bar Harbor, ME 04609, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijaya Prakash Krishnan","family":"Muthaiah","sequence":"additional","affiliation":[{"name":"Center for Hearing and Deafness, University at Buffalo, Buffalo, NY 14214, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cong","family":"Tian","sequence":"additional","affiliation":[{"name":"The Jackson Laboratory, Bar Harbor, ME 04609, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Sheppard","sequence":"additional","affiliation":[{"name":"Center for Hearing and Deafness, University at Buffalo, Buffalo, NY 14214, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Salvi","sequence":"additional","affiliation":[{"name":"Center for Hearing and Deafness, University at Buffalo, Buffalo, NY 14214, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth R.","family":"Johnson","sequence":"additional","affiliation":[{"name":"The Jackson Laboratory, Bar Harbor, ME 04609, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7892","published-online":{"date-parts":[[2016,3,14]]},"reference":[{"key":"1","doi-asserted-by":"crossref","first-page":"45","DOI":"10.7874\/kja.2013.17.2.45","article-title":"Pathophysiology of age-related hearing loss (peripheral and central)","volume":"1","author":"Lee","year":"2013","journal-title":"Korean J Audiol"},{"key":"2","first-page":"537","article-title":"Comprehensive management of presbycusis: central and peripheral","volume":"14","author":"Gates","year":"2013","journal-title":"Otolaryngol Head Neck Surg"},{"key":"3","first-page":"401","article-title":"Genome-wide SNP-based linkage scan identifies a locus on 8q24 for an age-related hearing impairment trait","volume":"8","author":"Hannula","year":"2008","journal-title":"American journal of human genetics"},{"key":"4","first-page":"896","article-title":"Dietary antioxidant intake is associated with the prevalence but not incidence of age-related hearing loss","volume":"1","author":"Mitchell","year":"2011","journal-title":"J Nutr Health Aging"},{"key":"5","first-page":"37","article-title":"A 5-year prospective study of diabetes and hearing loss in a veteran population","volume":"2","author":"Fausti","year":"2006","journal-title":"Otol Neurotol"},{"key":"6","first-page":"345","article-title":"The complexity of age-related hearing impairment: contributing environmental and genetic factors","volume":"1","author":"Van Laer","year":"2007","journal-title":"Audiol Neurootol"},{"key":"7","first-page":"99","article-title":"The oxidative stress theory of aging: embattled or invincible? Insights from non-traditional model organisms","volume":"3","author":"Mele","year":"2008","journal-title":"Age (Dordr)"},{"key":"8","first-page":"1005","article-title":"Is the oxidative stress theory of aging dead?","volume":"179","author":"Richardson","year":"2009","journal-title":"Biochim Biophys Acta"},{"key":"9","first-page":"447","article-title":"Genetic and environmental influences on hearing in older women","volume":"6","author":"Rantanen","year":"2007","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"10","first-page":"654","article-title":"Genetic associations in age-related hearing thresholds","volume":"12","author":"Myers","year":"1999","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"11","first-page":"263","article-title":"Antioxidant enzymes, presbycusis, and ethnic variability","volume":"14","author":"Liu","year":"2010","journal-title":"Otolaryngol Head Neck Surg"},{"key":"12","first-page":"2238","article-title":"N-acetyltransferase 2 gene polymorphism and presbycusis","volume":"11","author":"Camdeviren","year":"2005","journal-title":"Laryngoscope"},{"key":"13","first-page":"392","article-title":"Glutathione S-transferase gene polymorphisms in presbycusis","volume":"2","author":"Camdeviren","year":"2005","journal-title":"Otol Neurotol"},{"key":"14","first-page":"85","article-title":"Separate and combined effects of Sod1 and Cdh23 mutations on age-related hearing loss and cochlear pathology in C57BL\/6J mice","volume":"26","author":"Salvi","year":"2010","journal-title":"Hear Res"},{"key":"15","first-page":"80","article-title":"Genetic background effects on age-related hearing loss associated with Cdh23 variants in mice","volume":"28","author":"Johnson","year":"2012","journal-title":"Hear Res"},{"key":"16","article-title":"Copper\/zinc superoxide dismutase deficiency potentiates age related and noise-hearing loss in SOD-1 mice","author":"Salvi","year":"1999","journal-title":"Assoc. for Res. in Otolaryngology"},{"key":"17","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/s101620010043","article-title":"Targeted mutation of the gene for cellular glutathione peroxidase (Gpx1) increases noise-induced hearing loss in mice","volume":"1","author":"Ho","year":"2000","journal-title":"Journal of the Association for Research in Otolaryngology : JARO"},{"key":"18","first-page":"1424","article-title":"Long-term omega-3 fatty acid supplementation prevents expression changes in cochlear homocysteine metabolism and ameliorates progressive hearing loss in C57BL\/6J mice","volume":"2","author":"Varela-Nieto","year":"2015","journal-title":"J Nutr Biochem"},{"key":"19","first-page":"19432","article-title":"Age-related hearing loss in C57BL\/6J mice is mediated by Bak-dependent mitochondrial apoptosis","volume":"10","author":"Prolla","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"20","first-page":"711","article-title":"Characterization of the dwg mutations: dwg and dwg(Bayer) are new mutant alleles of the Ggt1 gene","volume":"2","author":"Kunieda","year":"2009","journal-title":"Mamm Genome"},{"key":"21","first-page":"151","article-title":"Phenotypic characterization of Ggt1(dwg\/dwg) mice,a mouse model for hereditary gamma-glutamyltransferase deficiency","volume":"6","author":"Kunieda","year":"2013","journal-title":"Exp Anim"},{"key":"22","first-page":"1","article-title":"Thimerosal neurotoxicity is associated with glutathione depletion: protection with glutathione precursors","volume":"2","author":"Jernigan","year":"2005","journal-title":"Neurotoxicology"},{"key":"23","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/S0166-445X(03)00148-6","article-title":"Fish tolerance to organophosphate-induced oxidative stress is dependent on the glutathione metabolism and enhanced by N-acetylcysteine","volume":"6","author":"Pena","year":"2003","journal-title":"Aquat Toxicol"},{"key":"24","first-page":"238","article-title":"Dwarf grey (dwg)","volume":"8","author":"Davisson","year":"1990","journal-title":"Mouse Genome"},{"key":"25","first-page":"7923","article-title":"Growth retardation and cysteine deficiency in gamma-glutamyl transpeptidase-deficient mice","volume":"9","author":"Matzuk","year":"1996","journal-title":"Proc Natl Acad Sci U S A"},{"key":"26","first-page":"305","article-title":"Accumulation of DNA damage in the organs of mice deficient in gamma-glutamyltranspeptidase","volume":"44","author":"Lieberman","year":"2000","journal-title":"Mutat Res"},{"key":"27","first-page":"575","article-title":"Cataract development in gamma-glutamyl transpeptidase-deficient mice","volume":"7","author":"Lieberman","year":"2000","journal-title":"Exp Eye Res"},{"key":"28","first-page":"740","article-title":"gamma-glutamyltranspeptidase-deficient knockout mice as a model to study the relationship between glutathione status, mitochondrial function, and cellular function","volume":"3","author":"Reed","year":"2000","journal-title":"Hepatology"},{"key":"29","first-page":"12560","article-title":"Mice with genetic gamma-glutamyl transpeptidase deficiency exhibit glutathionuria, severe growth failure, reduced life spans, and infertility","volume":"27","author":"Wolff","year":"1997","journal-title":"J Biol Chem"},{"key":"30","first-page":"31","article-title":"gamma-Glutamyl transferase (GGT) deficiency in the GGTenu1 mouse results from a single point mutation that leads to a stop codon in the first coding exon of GGT mRNA","volume":"1","author":"Joyce-Brady","year":"1999","journal-title":"Mutagenesis"},{"key":"31","first-page":"3546","article-title":"Quantitative measures of hair cell loss in CBA and C57BL\/6 mice throughout their life spans","volume":"10","author":"Salvi","year":"1997","journal-title":"J Acoust Soc Am"},{"key":"32","first-page":"101","article-title":"Cu\/Zn SOD deficiency potentiates hearing loss and cochlear pathology in aged 129, CD-1 mice","volume":"41","author":"Salvi","year":"1999","journal-title":"J Comp Neurol"},{"key":"33","first-page":"63","article-title":"A physiological place-frequency map of the cochlea in the CBA\/J mouse","volume":"20","author":"Smolders","year":"2005","journal-title":"Hear Res"},{"key":"34","first-page":"152","article-title":"Selective loss of inner hair cells and type-I ganglion neurons in carboplatin-treated chinchillas. Mechanisms of damage and protection","volume":"88","author":"Mueller","year":"1999","journal-title":"Ann N Y Acad Sci"},{"key":"35","first-page":"65","article-title":"Carboplatin-induced early cochlear lesion in chinchillas","volume":"18","author":"Salvi","year":"2003","journal-title":"Hear Res"},{"key":"36","first-page":"65","article-title":"Early damage of spiral ganglion caused by carboplatin in chinchilla","volume":"6","author":"Salvi","year":"1998","journal-title":"Journal of Audiology and Speech Pathology"},{"key":"37","first-page":"67","article-title":"Effects of selective inner hair cell loss on auditory nerve fiber threshold, tuning and spontaneous and driven discharge rate","volume":"10","author":"Salvi","year":"1997","journal-title":"Hear Res"},{"key":"38","first-page":"71","article-title":"Selective inner hair cell loss does not alter distortion product otoacoustic emissions","volume":"9","author":"Nostrant","year":"1996","journal-title":"Hear Res"},{"key":"39","first-page":"93","article-title":"Cochlear function after selective inner hair cell degeneration induced by carboplatin","volume":"7","author":"Mount","year":"1994","journal-title":"Hear Res"},{"key":"40","first-page":"356","article-title":"Cochlear inner and outer hair cells: functional differences","volume":"17","author":"Raynor","year":"1972","journal-title":"Science"},{"key":"41","first-page":"71","article-title":"N-acetylcysteine attenuates noise-induced permanent hearing loss in diabetic rats","volume":"26","author":"Guo","year":"2010","journal-title":"Hear Res"},{"key":"42","first-page":"28","article-title":"Glutathione limits noise-induced hearing loss","volume":"14","author":"Miller","year":"2000","journal-title":"Hear Res"},{"key":"43","first-page":"1511","article-title":"Genetically altered mice to evaluate glutathione homeostasis in health and disease","volume":"3","author":"Shertzer","year":"2004","journal-title":"Free Radic Biol Med"},{"key":"44","first-page":"75","article-title":"Glutathione-dependent antioxidant systems in the mammalian inner ear: effects of aging, ototoxic drugs and noise","volume":"11","author":"Schacht","year":"1997","journal-title":"Hear Res"},{"key":"45","first-page":"386","article-title":"Mechanism of cisplatin ototoxicity: antioxidant system","volume":"7","author":"Rybak","year":"1995","journal-title":"Pharmacol Toxicol"},{"key":"46","first-page":"559","article-title":"Use of organotypic cultures of Corti's organ to study the protective effects of antioxidant molecules on cisplatin-induced damage of auditory hair cells","volume":"1","author":"Van de Water","year":"1997","journal-title":"Am J Otol"},{"key":"47","first-page":"125","article-title":"Intracochlear infusion of buthionine sulfoximine potentiates carboplatin ototoxicity in the chinchilla","volume":"12","author":"Henderson","year":"1999","journal-title":"Hear Res"},{"key":"48","first-page":"1","article-title":"The role of glutathione in carboplatin ototoxicity in the chinchilla","volume":"3","author":"Ding","year":"2000","journal-title":"Noise Health"},{"key":"49","first-page":"124","article-title":"Glutathione ester but not glutathione protects against cisplatin-induced ototoxicity in a rat model","volume":"1","author":"Hughes","year":"2003","journal-title":"J Am Acad Audiol"},{"key":"50","first-page":"75","article-title":"Sulfhydryl compounds and antioxidants inhibit cytotoxicity to outer hair cells of a gentamicin metabolite in vitro","volume":"7","author":"Schacht","year":"1994","journal-title":"Hear Res"},{"key":"51","first-page":"82","article-title":"Role of glutathione in protection against noise-induced hearing loss","volume":"78","author":"Miller","year":"1998","journal-title":"Brain Res"},{"key":"52","first-page":"21","article-title":"Noise-induced hearing loss in chinchillas pre-treated with glutathione monoethylester and R-PIA","volume":"17","author":"Nicotera","year":"2003","journal-title":"Hear Res"},{"key":"53","first-page":"99","article-title":"The effectiveness of N-acetyl-L-cysteine (L-NAC) in the prevention of severe noise-induced hearing loss","volume":"23","author":"Davis","year":"2008","journal-title":"Hear Res"},{"key":"54","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/1745-6673-5-11","article-title":"N-Acetyl L-Cysteine does not protect mouse ears from the effects of noise*","volume":"5","author":"Alagramam","year":"2010","journal-title":"J Occup Med Toxicol"},{"key":"55","first-page":"49","article-title":"The influence of superoxide dismutase and glutathione peroxidase deficiencies on noise-induced hearing loss in mice","volume":"3","author":"Salvi","year":"2001","journal-title":"Noise Health"},{"key":"56","first-page":"2183","article-title":"Effect of N-acetylcysteine on carboplatin-induced ototoxicity and nitric oxide levels in a rat model","volume":"11","author":"Tolun","year":"2007","journal-title":"Laryngoscope"},{"key":"57","first-page":"E87","article-title":"Cisplatin otoprotection using transtympanic L-N-acetylcysteine: a pilot randomized study in head and neck cancer patients","volume":"12","author":"Winquist","year":"2014","journal-title":"Laryngoscope"},{"key":"58","first-page":"914","article-title":"Noise protection with N-acetyl-l-cysteine (NAC) using a variety of noise exposures, NAC doses, and routes of administration","volume":"12","author":"Henderson","year":"2007","journal-title":"Acta Otolaryngol"},{"key":"59","first-page":"114","article-title":"NAC for noise: from the bench top to the clinic","volume":"22","author":"Balough","year":"2007","journal-title":"Hear Res"},{"key":"60","first-page":"203","article-title":"N-Acetyl L-cysteine does not protect against premature age-related hearing loss in C57BL\/6J mice: a pilot study","volume":"22","author":"Alagramam","year":"2007","journal-title":"Hear Res"},{"key":"61","first-page":"372","article-title":"Antioxidant and free radical scavenging properties of N-acetylcysteine amide (NACA) and comparison with N-acetylcysteine (NAC)","volume":"4","author":"Ercal","year":"2008","journal-title":"Free Radic Res"},{"key":"62","first-page":"132","article-title":"Effects of N-acetylcysteine amide (NACA), a novel thiol antioxidant against glutamate-induced cytotoxicity in neuronal cell line PC12","volume":"105","author":"Ercal","year":"2005","journal-title":"Brain Res"},{"key":"63","first-page":"2032","article-title":"N-Acetylcysteine Amide (NACA) Prevents Retinal Degeneration by Up-Regulating Reduced Glutathione Production and Reversing Lipid Peroxidation","volume":"17","author":"Apte","year":"2011","journal-title":"Am J Pathol"},{"key":"64","first-page":"1078","article-title":"Yeast-like chronological senescence in mammalian cells: phenomenon, mechanism and pharmacological suppression","volume":"3","author":"Blagosklonny","year":"2011","journal-title":"Aging (Albany NY)"},{"key":"65","doi-asserted-by":"publisher","first-page":"19405","DOI":"10.18632\/oncotarget.3740","article-title":"Rejuvenating immunity: \u201canti-aging drug today\u201d eight years later","volume":"6","author":"Blagosklonny","year":"2015","journal-title":"Oncotarget"},{"key":"66","doi-asserted-by":"crossref","first-page":"861","DOI":"10.18632\/aging.100525","article-title":"Answering the ultimate question \u201cwhat is the proximal cause of aging?\u201d","volume":"4","author":"Blagosklonny","year":"2012","journal-title":"Aging (Albany NY)"},{"key":"67","first-page":"715","article-title":"New nanoformulation of rapamycin Rapatar extends lifespan in homozygous p53\u2212\/\u2212 mice by delaying carcinogenesis","volume":"4","author":"Antoch","year":"2012","journal-title":"Aging (Albany NY)"},{"key":"68","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.heares.2005.09.002","article-title":"Characterization of hearing loss in aged type II diabetics","volume":"21","author":"Frisina","year":"2006","journal-title":"Hear Res"},{"key":"69","first-page":"44","article-title":"Interactions of hearing loss and diabetes mellitus in the middle age CBA\/CaJ mouse model of presbycusis","volume":"24","author":"Frisina","year":"2009","journal-title":"Hear Res"},{"key":"70","first-page":"65","article-title":"Metformin protects against gentamicin-induced hair cell death in vitro but not ototoxicity in vivo","volume":"58","author":"Schacht","year":"2014","journal-title":"Neurosci Lett"},{"key":"71","first-page":"1","article-title":"Differential vulnerability of basal and apical hair cells is based on intrinsic susceptibility to free radicals","volume":"15","author":"Schacht","year":"2001","journal-title":"Hear Res"},{"key":"72","first-page":"143","article-title":"Cellular glutathione content in the organ of Corti and its role during ototoxicity","volume":"9","author":"Gale","year":"2015","journal-title":"Front Cell Neurosci"},{"key":"73","first-page":"337","article-title":"Differential cellular distribution of glutathione--an endogenous antioxidant--in the guinea pig inner ear","volume":"74","author":"Ottersen","year":"1996","journal-title":"Brain Res"},{"key":"74","first-page":"1409","article-title":"Cysteine-string protein in inner hair cells of the organ of Corti: synaptic expression and upregulation at the onset of hearing","volume":"1","author":"Safieddine","year":"2002","journal-title":"Eur J Neurosci"},{"key":"75","first-page":"383","article-title":"Enhancement of presynaptic calcium current by cysteine string protein","volume":"53","author":"Stanley","year":"2002","journal-title":"J Physiol"},{"key":"76","doi-asserted-by":"crossref","first-page":"e11045","DOI":"10.1371\/journal.pone.0011045","article-title":"Quercetin targets cysteine string protein (CSPalpha) and impairs synaptic transmission","volume":"5","author":"Braun","year":"2010","journal-title":"PLoS One"},{"key":"77","first-page":"237","article-title":"The synaptic vesicle protein CSP alpha prevents presynaptic degeneration","volume":"4","author":"Sudhof","year":"2004","journal-title":"Neuron"},{"key":"78","first-page":"153","article-title":"Cysteine string protein (CSP) and its role in preventing neurodegeneration","volume":"4","author":"Morgan","year":"2015","journal-title":"Semin Cell Dev Biol"},{"key":"79","first-page":"2761","article-title":"Reversible skeletal abnormalities in gamma-glutamyl transpeptidase-deficient mice","volume":"14","author":"Karsenty","year":"2003","journal-title":"Endocrinology"},{"key":"80","first-page":"2660","article-title":"The location of the cochlear amplifier: spatial representation of a single tone on the guinea pig basilar membrane","volume":"9","author":"Nilsen","year":"1997","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"81","first-page":"2006","article-title":"High-frequency motility of outer hair cells and the cochlear amplifier","volume":"26","author":"Evans","year":"1995","journal-title":"Science"},{"key":"82","first-page":"300","article-title":"Prestin is required for electromotility of the outer hair cell and for the cochlear amplifier","volume":"41","author":"Zuo","year":"2002","journal-title":"Nature"},{"key":"83","first-page":"365","article-title":"Properties of auditory nerve responses in absence of outer hair cells","volume":"4","author":"Harris","year":"1978","journal-title":"J Neurophysiol"},{"key":"84","first-page":"199","article-title":"Quantitative relationship of carboplatin dose to magnitude of inner and outer hair cell loss and the reduction in distortion product otoacoustic emission amplitude in chinchillas","volume":"11","author":"Salvi","year":"1997","journal-title":"Hear Res"},{"key":"85","first-page":"153","article-title":"Inner hair cell loss leads to enhanced response amplitudes in auditory cortex of unanesthetized chinchillas: evidence for increased system gain","volume":"13","author":"Burkard","year":"2000","journal-title":"Hear Res"},{"key":"86","first-page":"374","article-title":"Otoacoustic emission amplification after inner hair cell damage","volume":"11","author":"Harrison","year":"1996","journal-title":"Acta Otolaryngol"},{"key":"87","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1159\/000013800","article-title":"Degeneration of spiral ganglion cells in the chinchilla after inner hair cell loss induced by carboplatin","volume":"3","author":"Harrison","year":"1998","journal-title":"Audiol Neurootol"},{"key":"88","first-page":"146","article-title":"Early carboplatin-induced damage to IHC and type I neurons","volume":"2","author":"Salvi","year":"2002","journal-title":"Abstract Association for Research in Otolaryngology"},{"key":"89","first-page":"23","article-title":"High accumulation of platinum-DNA adducts in strial marginal cells of the cochlea is an early event in cisplatin but not carboplatin ototoxicity","volume":"7","author":"Thomale","year":"2006","journal-title":"Mol Pharmacol"},{"key":"90","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/s10162-006-0035-x","article-title":"Deletion of SLC19A2, the high affinity thiamine transporter, causes selective inner hair cell loss and an auditory neuropathy phenotype","volume":"7","author":"Neufeld","year":"2006","journal-title":"Journal of the Association for Research in Otolaryngology : JARO"},{"key":"91","first-page":"515","article-title":"Cochlear inner hair cells exist transiently in the fetal Bronx Waltzer (bv\/bv) mouse","volume":"36","author":"Zhang","year":"1996","journal-title":"J Comp Neurol"},{"key":"92","doi-asserted-by":"crossref","first-page":"e1002966","DOI":"10.1371\/journal.pgen.1002966","article-title":"A mutation in the Srrm4 gene causes alternative splicing defects and deafness in the Bronx waltzer mouse","volume":"8","author":"Banfi","year":"2012","journal-title":"PLoS Genet"},{"key":"93","first-page":"11296","article-title":"Comparative distribution of glutamate transporters and receptors in relation to afferent innervation density in the mammalian cochlea","volume":"2","author":"Lawton","year":"2003","journal-title":"J Neurosci"},{"key":"94","first-page":"8750","article-title":"Exacerbation of noise-induced hearing loss in mice lacking the glutamate transporter GLAST","volume":"2","author":"Tanaka","year":"2000","journal-title":"J Neurosci"},{"key":"95","first-page":"243","article-title":"Kanamycin ototoxicity in glutamate transporter knockout mice","volume":"38","author":"Gyo","year":"2005","journal-title":"Neurosci Lett"},{"key":"96","first-page":"327","article-title":"Protection by enteral glutamine is mediated by intestinal epithelial cell peroxisome proliferator-activated receptor-gamma during intestinal ischemia\/reperfusion","volume":"4","author":"Kozar","year":"2015","journal-title":"Shock"},{"key":"97","article-title":"Glutamine Administration After Sublethal Lower Limb Ischemia Reduces Inflammatory Reaction and Offers Organ Protection in Ischemia\/Reperfusion Injury","author":"Yeh","year":"2015","journal-title":"JPEN J Parenter Enteral Nutr"},{"issue":"Suppl","key":"98","first-page":"46","article-title":"Neuroprotection by glutamine synthetase","volume":"2","author":"Vardimon","year":"2000","journal-title":"Isr Med Assoc J"},{"key":"99","first-page":"711","article-title":"Glutamate transporters in glial plasma membranes: highly differentiated localizations revealed by quantitative ultrastructural immunocytochemistry","volume":"1","author":"Storm-Mathisen","year":"1995","journal-title":"Neuron"},{"key":"100","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1038\/nm1296-1338","article-title":"N-methyl-D-aspartate antagonists limit aminoglycoside antibiotic-induced hearing loss","volume":"2","author":"Skolnick","year":"1996","journal-title":"Nat Med"},{"key":"101","first-page":"1175","article-title":"The effects of hypoxia on sensory cells of the cochlea in chinchilla","volume":"1","author":"Harrison","year":"1987","journal-title":"Scanning Microsc"},{"key":"102","first-page":"106","article-title":"Differential vulnerability of inner and outer hair cell systems to chronic mild hypoxia and glutamate ototoxicity: insights into the cause of auditory neuropathy","volume":"3","author":"Harrison","year":"2001","journal-title":"J Otolaryngol"},{"key":"103","first-page":"194","article-title":"AMPA\/kainate-type glutamate receptor antagonist reduces progressive inner hair cell loss after transient cochlear ischemia","volume":"97","author":"Gyo","year":"2003","journal-title":"Brain Res"},{"key":"104","first-page":"2","article-title":"Susceptibility of the hair cells of the newborn rat cochlea to hypoxia and ischemia","volume":"18","author":"Gross","year":"2003","journal-title":"Hear Res"},{"key":"105","first-page":"1881","article-title":"Free radical scavenger protects against inner hair cell loss after cochlear ischemia","volume":"1","author":"Gyo","year":"2003","journal-title":"Neuroreport"},{"key":"106","first-page":"273","article-title":"Characterization of a murine high-affinity thiamine transporter, Slc19a2","volume":"7","author":"Neufeld","year":"2001","journal-title":"Mol Genet Metab"},{"key":"107","first-page":"796","article-title":"The impact of oxidative stress in thiamine deficiency: a multifactorial targeting issue","volume":"6","author":"Marques","year":"2013","journal-title":"Neurochem Int"},{"key":"108","first-page":"539","article-title":"Thiamine deficiency induces oxidative stress in brain mitochondria of Mus musculus","volume":"6","author":"Bubber","year":"2013","journal-title":"Journal of Physiology and Biochemistry"},{"key":"109","first-page":"132","article-title":"Induction of spontaneous otoacoustic emissions in chinchillas from carboplatin-induced inner hair cell loss","volume":"15","author":"Salvi","year":"2000","journal-title":"Hearing Research"},{"key":"110","first-page":"113","article-title":"Insensitivity of the audiogram to carboplatin induced inner hair cell loss in chinchillas","volume":"30","author":"Ding","year":"2013","journal-title":"Hear Res"},{"key":"111","first-page":"97","article-title":"Induction of selective inner hair cell damage by carboplatin","volume":"8","author":"Harada","year":"1994","journal-title":"Scanning Microscopy"},{"key":"112","first-page":"21","article-title":"Association of cadherin 23 with polygenic inheritance and genetic modification of sensorineural hearing loss","volume":"3","author":"Johnson","year":"2003","journal-title":"Nat Genet"},{"key":"113","first-page":"405","article-title":"Inner hair cells are not required for survival of spiral ganglion neurons in the adult cochlea","volume":"3","author":"Corfas","year":"2012","journal-title":"J Neurosci"},{"key":"114","first-page":"206","article-title":"Central gain control in tinnitus and hyperacusis","volume":"5","author":"Salvi","year":"2014","journal-title":"Front Neurol"},{"key":"115","first-page":"94","article-title":"Assessment of hearing in 80 inbred strains of mice by ABR threshold analyses","volume":"13","author":"Erway","year":"1999","journal-title":"Hear Res"},{"key":"116","first-page":"1693","article-title":"A locus on distal chromosome 10 (ahl4) affecting age-related hearing loss in A\/J mice","volume":"3","author":"Johnson","year":"2009","journal-title":"Neurobiol Aging"},{"key":"117","first-page":"158","article-title":"Ouabain-induced cochlear degeneration in rat","volume":"2","author":"Salvi","year":"2012","journal-title":"Neurotox Res"},{"key":"118","first-page":"307","article-title":"Co-administration of cisplatin and furosemide causes rapid and massive loss of cochlear hair cells in mice","volume":"2","author":"Salvi","year":"2011","journal-title":"Neurotox Res"},{"key":"119","first-page":"63","article-title":"Too much of a good thing: long-term treatment with salicylate strengthens outer hair cell function but impairs auditory neural activity","volume":"26","author":"Salvi","year":"2010","journal-title":"Hear Res"},{"key":"120","first-page":"39","article-title":"Aging outer hair cells (OHCs) in the Fischer 344 rat cochlea: function and morphology","volume":"24","author":"Henderson","year":"2009","journal-title":"Hear Res"},{"key":"121","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.heares.2006.08.011","article-title":"Prestin gene expression in the rat cochlea following intense noise exposure","volume":"22","author":"Chen","year":"2006","journal-title":"Hear Res"},{"key":"122","first-page":"189","volume-title":"The Auditory Psychobiology of the Mouse","author":"Willott","year":"2001"},{"key":"123","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1007\/s101620020004","article-title":"Calpain immunoreactivity and morphological damage in chinchilla inner ears after carboplatin","volume":"3","author":"Salvi","year":"2002","journal-title":"J Assoc Res Otolaryngol"},{"key":"124","first-page":"63","article-title":"A physiological place-frequency map of the cochlea in the CBA\/J mouse","volume":"20","author":"Smolders","year":"2005","journal-title":"Hear Res"}],"container-title":["Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.100927","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,2]],"date-time":"2020-09-02T12:08:00Z","timestamp":1599048480000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.100927"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3,14]]},"references-count":124,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,4,1]]}},"alternative-id":["100927","26977590"],"URL":"https:\/\/doi.org\/10.18632\/aging.100927","relation":{},"ISSN":["1945-4589"],"issn-type":[{"value":"1945-4589","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,14]]}}}