{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T23:37:20Z","timestamp":1791329840060,"version":"4.3.1"},"reference-count":49,"publisher":"Impact Journals, LLC","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aging"],"published-print":{"date-parts":[[2016,12,27]]},"DOI":"10.18632\/aging.101150","type":"journal-article","created":{"date-parts":[[2016,12,27]],"date-time":"2016-12-27T17:49:49Z","timestamp":1482860989000},"page":"3552-3567","source":"Crossref","is-referenced-by-count":51,"title":["Sodium fluoride (NaF) induces the splenic apoptosis via endoplasmic reticulum (ER) stress pathway in vivo and in vitro"],"prefix":"10.18632","volume":"8","author":[{"given":"Huidan","family":"Deng","sequence":"first","affiliation":[{"name":"College of Veterinary Medicine, Sichuan Agricultural University, Ya\u2019an 625014, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Kuang","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Sichuan Agricultural University, Ya\u2019an 625014, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hengmin","family":"Cui","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Sichuan Agricultural University, Ya\u2019an 625014, China"},{"name":"Key Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, Ya\u2019an 625014, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lian","family":"Chen","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Sichuan Agricultural University, Ya\u2019an 625014, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Luo","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Sichuan Agricultural University, Ya\u2019an 625014, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Fang","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Sichuan Agricultural University, Ya\u2019an 625014, China"},{"name":"Key Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, Ya\u2019an 625014, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhicai","family":"Zuo","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Sichuan Agricultural University, Ya\u2019an 625014, China"},{"name":"Key Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, Ya\u2019an 625014, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junliang","family":"Deng","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Sichuan Agricultural University, Ya\u2019an 625014, China"},{"name":"Key Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, Ya\u2019an 625014, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xun","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Sichuan Agricultural University, Ya\u2019an 625014, China"},{"name":"Key Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, Ya\u2019an 625014, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Zhao","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Sichuan Agricultural University, Ya\u2019an 625014, China"},{"name":"Key Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, Ya\u2019an 625014, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7892","published-online":{"date-parts":[[2016,12,27]]},"reference":[{"key":"1","first-page":"115","article-title":"Trace elements in human nutrition: a review.","volume":"2","author":"Marjan","year":"2013","journal-title":"Int J Med Invest."},{"key":"2","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1111\/j.1600-0528.1999.tb01990.x","article-title":"Biological mechanisms of dental fluorosis relevant to the use of fluoride supplements.","volume":"2","author":"DenBesten","year":"1999","journal-title":"Community Dent Oral Epidemiol"},{"key":"3","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/8756-3282(89)90004-5","article-title":"Skeletal fluorosis: histomorphometric analysis of bone changes and bone fluoride content in 29 patients.","volume":"1","author":"Meunier","year":"1989","journal-title":"Bone"},{"key":"4","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/j.tox.2004.06.058","article-title":"Effect of fluoride intoxication on lipidperoxidation and antioxidant status in experimental rats.","volume":"20","author":"Subramanian","year":"2004","journal-title":"Toxicology"},{"key":"5","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1007\/s12011-011-9194-7","article-title":"Protective effects of curcumin against sodium fluoride-induced toxicity in rat kidneys.","volume":"14","author":"Nabavi","year":"2012","journal-title":"Biol Trace Elem Res"},{"key":"6","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1007\/s12011-009-8599-z","article-title":"Effect of high fluorine on the cell cycle and apoptosis of renal cells in chickens.","volume":"13","author":"Cui","year":"2010","journal-title":"Biol Trace Elem Res"},{"key":"7","doi-asserted-by":"publisher","first-page":"1282","DOI":"10.1177\/0960327110388538","article-title":"Decreased antioxidase activities and oxidative stress in the spleen of chickens fed on high-fluorine diets.","volume":"3","author":"Gong","year":"2011","journal-title":"Hum Exp Toxicol"},{"key":"8","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1177\/0960327110379022","article-title":"Cell-cycle blockage associated with increased apoptotic cells in the thymus of chickens fed on diets high in fluorine.","volume":"3","author":"Peng","year":"2011","journal-title":"Hum Exp Toxicol"},{"key":"9","first-page":"735","article-title":"Inorganic fluoride. Divergent effects on human proximal tubular cell viability.","volume":"15","author":"Iwata","year":"1997","journal-title":"Am J Pathol"},{"key":"10","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/S0300-483X(01)00448-6","article-title":"Mechanisms in fluoride-induced interleukin-8 synthesis in human lung epithelial cells.","volume":"16","author":"Schwarze","year":"2001","journal-title":"Toxicology"},{"key":"11","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1007\/s12011-009-8373-2","article-title":"Decreased percentages of the peripheral blood T-cell subsets and the serum IL-2 contents in chickens fed on diets excess in fluorine.","volume":"13","author":"Cui","year":"2009","journal-title":"Biol Trace Elem Res"},{"key":"12","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1007\/s12011-010-8733-y","article-title":"Effect of pineal proteins at different dose level on fluoride-induced changes in plasma biochemicals and blood antioxidants enzymes in rats.","volume":"14","author":"Srivastava","year":"2011","journal-title":"Biol Trace Elem Res"},{"key":"13","doi-asserted-by":"publisher","first-page":"1287","DOI":"10.1177\/002215540405201005","article-title":"Immunoarchitecture of distinct reticular fibroblastic domains in the white pulp of mouse spleen.","volume":"5","author":"Szakal","year":"2004","journal-title":"J Histochem Cytochem"},{"key":"14","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1046\/j.1365-2567.2002.01443.x","article-title":"The strict regulation of lymphocyte migration to splenic white pulp does not involve common homing receptors.","volume":"10","author":"Mebius","year":"2002","journal-title":"Immunology"},{"key":"15","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1080\/01926230600867743","article-title":"Normal structure, function, and histology of the spleen.","volume":"3","author":"Cesta","year":"2006","journal-title":"Toxicol Pathol"},{"key":"16","first-page":"231","article-title":"Morphological effects of sodium fluoride on hematopoietic organs in mice.","volume":"3","author":"Tarasiuk","year":"2002","journal-title":"Fluoride"},{"key":"17","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1080\/15476910600631587","article-title":"Fluoride-induced immunotoxicity in adult male albino rat: a correlative approach to oxidative stress.","volume":"3","author":"Ghosh","year":"2006","journal-title":"J Immunotoxicol"},{"key":"18","first-page":"237","article-title":"Histopathology and cell cycle alteration in the spleen of mice from low and high doses of sodium fluoride.","volume":"4","author":"Ranjan","year":"2010","journal-title":"Fluoride"},{"key":"19","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1038\/35037710","article-title":"The biochemistry of apoptosis.","volume":"40","author":"Hengartner","year":"2000","journal-title":"Nature"},{"key":"20","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1016\/j.toxlet.2013.11.001","article-title":"The role of the IRE1 pathway in excessive iodide- and\/or fluoride-induced apoptosis in Nthy-ori 3-1 cells in vitro.","volume":"22","author":"Wang","year":"2014","journal-title":"Toxicol Lett"},{"key":"21","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.exer.2014.04.015","article-title":"Endoplasmic reticulum stress and the unfolded protein responses in retinal degeneration.","volume":"12","author":"Wang","year":"2014","journal-title":"Exp Eye Res"},{"key":"22","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1038\/nri2359","article-title":"The endoplasmic reticulum stress response in immunity and autoimmunity.","volume":"8","author":"Glimcher","year":"2008","journal-title":"Nat Rev Immunol"},{"key":"23","doi-asserted-by":"publisher","first-page":"488","DOI":"10.2478\/s11658-006-0040-4","article-title":"Endoplasmic reticulum stress and apoptosis.","volume":"1","author":"Vojtesek","year":"2006","journal-title":"Cell Mol Biol Lett"},{"key":"24","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.mrfmmm.2004.06.056","article-title":"ER stress and the unfolded protein response.","volume":"56","author":"Kaufman","year":"2005","journal-title":"Mutat Res"},{"key":"25","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1146\/annurev.biochem.73.011303.074134","article-title":"The mammalian unfolded protein response.","volume":"7","author":"Kaufman","year":"2005","journal-title":"Annu Rev Biochem"},{"key":"26","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1042\/bj3550019","article-title":"Identification of the G13 (cAMP-response-element-binding protein-related protein) gene product related to activating transcription factor 6 as a transcriptional activator of the mammalian unfolded protein response.","volume":"35","author":"Mori","year":"2001","journal-title":"Biochem J"},{"key":"27","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1016\/j.toxlet.2012.04.009","article-title":"The role of the IRE1 pathway in PBDE-47-induced toxicity in human neuroblastoma SH-SY5Y cells in vitro.","volume":"21","author":"Wang","year":"2012","journal-title":"Toxicol Lett"},{"key":"28","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1016\/j.toxlet.2013.11.001","article-title":"The role of the IRE1 pathway in excessive iodide- and\/or fluoride-induced apoptosis in Nthy-ori 3-1 cells in vitro.","volume":"22","author":"Wang","year":"2014","journal-title":"Toxicol Lett"},{"key":"29","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1007\/s12011-014-0192-4","article-title":"Fluorosis induces endoplasmic reticulum stress and apoptosis in osteoblasts in vivo.","volume":"16","author":"Ma","year":"2015","journal-title":"Biol Trace Elem Res"},{"key":"30","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.beem.2009.08.010","article-title":"Iodine excess.","volume":"2","author":"B\u00fcrgi","year":"2010","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"key":"31","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1089\/thy.2008.0295","article-title":"Influence of iodide excess and interferon-gamma on human primary thyroid cell proliferation, thyroglobulin secretion, and intracellular adhesion molecule-1 and human leukocyte antigen-DR expression.","volume":"1","author":"Curcio","year":"2009","journal-title":"Thyroid"},{"key":"32","article-title":"Sodium fluoride induces apoptosis in cultured splenic lymphocytes from mice.","author":"Zhao","year":"2016","journal-title":"Oncotarget"},{"key":"33","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1023\/A:1016175429877","article-title":"Endoplasmic reticulum stress-mediated apoptosis in pancreatic beta-cells.","volume":"7","author":"Mori","year":"2002","journal-title":"Apoptosis"},{"key":"34","doi-asserted-by":"publisher","first-page":"488","DOI":"10.2478\/s11658-006-0040-4","article-title":"Endoplasmic reticulum stress and apoptosis.","volume":"1","author":"Vojtesek","year":"2006","journal-title":"Cell Mol Biol Lett"},{"key":"35","doi-asserted-by":"publisher","first-page":"1406","DOI":"10.1016\/j.bbrc.2006.09.009","article-title":"ER stress contributes to ischemia-induced cardiomyocyte apoptosis.","volume":"34","author":"Samali","year":"2006","journal-title":"Biochem Biophys Res Commun"},{"key":"36","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1038\/415092a","article-title":"IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA.","volume":"41","author":"Ron","year":"2002","journal-title":"Nature"},{"key":"37","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1038\/nrm2199","article-title":"Signal integration in the endoplasmic reticulum unfolded protein response.","volume":"8","author":"Walter","year":"2007","journal-title":"Nat Rev Mol Cell Biol"},{"key":"38","doi-asserted-by":"publisher","first-page":"897","DOI":"10.1016\/S1097-2765(00)80330-5","article-title":"Perk is essential for translational regulation and cell survival during the unfolded protein response.","volume":"5","author":"Ron","year":"2000","journal-title":"Mol Cell"},{"key":"39","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.tox.2014.07.006","article-title":"A role for PERK in the mechanism underlying fluoride-induced bone turnover.","volume":"32","author":"Xu","year":"2014","journal-title":"Toxicology"},{"key":"40","doi-asserted-by":"publisher","first-page":"589589","DOI":"10.1155\/2012\/589589","article-title":"ER stress and apoptosis: a new mechanism for retinal cell death.","volume":"201","author":"Zhang","year":"2012","journal-title":"Exp Diabetes Res"},{"key":"41","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/0014-5793(96)01016-2","article-title":"Ectopic expression of CHOP (GADD153) induces apoptosis in M1 myeloblastic leukemia cells.","volume":"39","author":"Akira","year":"1996","journal-title":"FEBS Lett"},{"key":"42","doi-asserted-by":"publisher","first-page":"664","DOI":"10.1126\/science.287.5453.664","article-title":"Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1.","volume":"28","author":"Ron","year":"2000","journal-title":"Science"},{"key":"43","doi-asserted-by":"publisher","first-page":"664","DOI":"10.1126\/science.287.5453.664","article-title":"Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1.","volume":"28","author":"Ron","year":"2000","journal-title":"Science"},{"key":"44","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1093\/embo-reports\/kve046","article-title":"ASK1 is required for sustained activations of JNK\/p38 MAP kinases and apoptosis.","volume":"2","author":"Ichijo","year":"2001","journal-title":"EMBO Rep"},{"key":"45","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1038\/47513","article-title":"Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta.","volume":"40","author":"Yuan","year":"2000","journal-title":"Nature"},{"key":"46","first-page":"13935","article-title":"Activation of caspase-12, an endoplastic reticulum (ER) resident caspase, through tumor necrosis factor receptor-associated factor 2-dependent mechanism in response to the ER stress.","volume":"27","author":"Tohyama","year":"2001","journal-title":"J Biol Chem"},{"key":"47","doi-asserted-by":"publisher","first-page":"34287","DOI":"10.1074\/jbc.M204973200","article-title":"An endoplasmic reticulum stress-specific caspase cascade in apoptosis. Cytochrome c-independent activation of caspase-9 by caspase-12.","volume":"27","author":"Yasuhiko","year":"2002","journal-title":"J Biol Chem"},{"key":"48","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1039\/a809656b","article-title":"A water-soluble tetrazolium salt useful for colorimetric cell viability assay.","volume":"3","author":"Watanabe","year":"1999","journal-title":"Anal Commun"},{"key":"49","first-page":"10","article-title":"Lymphocyte proliferation response during Eimeria tenella infection assessed by a new, reliable, nonradioactive colorimetric assay.","volume":"4","author":"Lillehoj","year":"2002","journal-title":"Avian Dis"}],"container-title":["Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.101150","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,2]],"date-time":"2020-09-02T16:35:27Z","timestamp":1599064527000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.101150"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12,27]]},"references-count":49,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2016,12,31]]}},"alternative-id":["101150","28039491"],"URL":"https:\/\/doi.org\/10.18632\/aging.101150","relation":{},"ISSN":["1945-4589"],"issn-type":[{"value":"1945-4589","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12,27]]}}}