{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T23:40:18Z","timestamp":1791330018522,"version":"4.3.1"},"reference-count":101,"publisher":"Impact Journals, LLC","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aging"],"published-print":{"date-parts":[[2017,3,9]]},"DOI":"10.18632\/aging.101195","type":"journal-article","created":{"date-parts":[[2017,3,9]],"date-time":"2017-03-09T23:27:12Z","timestamp":1489102032000},"page":"823-851","source":"Crossref","is-referenced-by-count":76,"title":["Amyotrophic lateral sclerosis, gene deregulation in the anterior horn of the spinal cord and frontal cortex area 8: implications in frontotemporal lobar degeneration"],"prefix":"10.18632","volume":"9","author":[{"given":"Pol","family":"Andr\u00e9s-Benito","sequence":"first","affiliation":[{"name":"Institute of Neuropathology, Pathologic Anatomy Service, Bellvitge University Hospital, IDIBELL, Hospitalet de Llobregat, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jes\u00fas","family":"Moreno","sequence":"additional","affiliation":[{"name":"Institute of Neuropathology, Pathologic Anatomy Service, Bellvitge University Hospital, IDIBELL, Hospitalet de Llobregat, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ester","family":"Aso","sequence":"additional","affiliation":[{"name":"Institute of Neuropathology, Pathologic Anatomy Service, Bellvitge University Hospital, IDIBELL, Hospitalet de Llobregat, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00f3nica","family":"Povedano","sequence":"additional","affiliation":[{"name":"Service of Neurology, Bellvitge University Hospital, Hospitalet de Llobregat, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isidro","family":"Ferrer","sequence":"additional","affiliation":[{"name":"Institute of Neuropathology, Pathologic Anatomy Service, Bellvitge University Hospital, IDIBELL, Hospitalet de Llobregat, Spain"},{"name":"Department of Pathology and Experimental Therapeutics, University of Barcelona, Spain"},{"name":"Institute of Neurosciences, University of Barcelona, Barcelona, Spain"},{"name":"Biomedical Network Research Center on Neurodegenerative Diseases (CIBERNED), Institute Carlos III, Hospitalet de Llobregat, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7892","published-online":{"date-parts":[[2017,3,9]]},"reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"Horob\u00e1gyi T, Cairns NJ. Amyotrophic lateral sclerosis and frontotemporal lobar degeneration. In: Kovacs GG (ed) Neuropathology of neurodegenerative diseases: a practical guide. Cambridge Press, Cambridge, 2015; pp 209-248.","DOI":"10.1017\/CBO9781107588660.012"},{"key":"2","doi-asserted-by":"crossref","unstructured":"Strong MJ, Hortob\u00e1gyi T, Okamoto K, Kato S. Amyotrophic lateral sclerosis, primary lateral sclerosis, and spinal muscular atrophy. In: Dickson DW (ed) Neurodegeneration: the molecular pathology of dementia and movement disorders, 2nded. Wiley-Blackwell, Oxford, 2011; pp: 418-433.","DOI":"10.1002\/9781444341256.ch44"},{"key":"3","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.neuron.2006.09.018","article-title":"ALS: a disease of motor neurons and their nonneuronal neighbors.","volume":"5","author":"Cleveland","year":"2006","journal-title":"Neuron"},{"key":"4","doi-asserted-by":"publisher","first-page":"325","DOI":"10.2174\/187152710791292657","article-title":"Involvement of immune response in the pathogenesis of amyotrophic lateral sclerosis: a therapeutic opportunity?","volume":"9","author":"Chi\u00f2","year":"2010","journal-title":"CNS Neurol Disord Drug Targets"},{"key":"5","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1016\/j.freeradbiomed.2013.06.029","article-title":"Clinical perspective on oxidative stress in sporadic amyotrophic lateral sclerosis.","volume":"6","author":"Mitsumoto","year":"2013","journal-title":"Free Radic Biol Med"},{"key":"6","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.mcn.2012.10.008","article-title":"Inflammation and neurovascular changes in amyotrophic lateral sclerosis.","volume":"5","author":"Turner","year":"2013","journal-title":"Mol Cell Neurosci"},{"key":"7","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1007\/s13311-014-0329-3","article-title":"Protective and toxic neuroinflammation in amyotrophic lateral sclerosis.","volume":"1","author":"Appel","year":"2015","journal-title":"Neurotherapeutics"},{"key":"8","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1016\/j.expneurol.2015.09.019","article-title":"Excitotoxicity in ALS: Overstimulation, or overreaction?","volume":"27","author":"Vickers","year":"2016","journal-title":"Exp Neurol"},{"key":"9","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1016\/S0896-6273(00)80997-6","article-title":"Aberrant RNA processing in a neurodegenerative disease: the cause for absent EAAT2, a glutamate transporter, in amyotrophic lateral sclerosis.","volume":"2","author":"Rothstein","year":"1998","journal-title":"Neuron"},{"key":"10","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1001\/archneur.58.3.365","article-title":"Glutamate transporters in neurologic disease.","volume":"5","author":"Rothstein","year":"2001","journal-title":"Arch Neurol"},{"key":"11","doi-asserted-by":"publisher","first-page":"1767","DOI":"10.1172\/JCI71601","article-title":"Emerging mechanisms of molecular pathology in ALS.","volume":"12","author":"Brown","year":"2015","journal-title":"J Clin Invest"},{"key":"12","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1016\/S1474-4422(11)70015-1","article-title":"Neuroinflammation in amyotrophic lateral sclerosis: role of glial activation in motor neuron disease.","volume":"1","author":"Robberecht","year":"2011","journal-title":"Lancet Neurol"},{"key":"13","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.expneurol.2014.05.015","article-title":"Glial cells in amyotrophic lateral sclerosis.","volume":"26","author":"Rothstein","year":"2014","journal-title":"Exp Neurol"},{"key":"14","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1111\/bpa.12355","article-title":"Old versus new mechanisms in the pathogenesis of ALS.","volume":"2","author":"Carr\u00ec","year":"2016","journal-title":"Brain Pathol"},{"key":"15","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/j.bbrc.2004.02.051","article-title":"Intermediate filament steady-state mRNA levels in amyotrophic lateral sclerosis.","volume":"31","author":"Ge","year":"2004","journal-title":"Biochem Biophys Res Commun"},{"key":"16","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1038\/nature20413","article-title":"Decoding ALS: from genes to mechanism.","volume":"53","author":"Cleveland","year":"2016","journal-title":"Nature"},{"key":"17","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1152\/physiolgenomics.00087.2001","article-title":"Molecular signature of late-stage human ALS revealed by expression profiling of postmortem spinal cord gray matter.","volume":"1","author":"Gullans","year":"2004","journal-title":"Physiol Genomics"},{"key":"18","doi-asserted-by":"publisher","first-page":"259","DOI":"10.3389\/fncel.2013.00259","article-title":"Investigating cell death mechanisms in amyotrophic lateral sclerosis using transcriptomics.","volume":"7","author":"Shaw","year":"2013","journal-title":"Front Cell Neurosci"},{"key":"19","doi-asserted-by":"publisher","first-page":"506","DOI":"10.2174\/138920211797904043","article-title":"Can transcriptomics cut the gordian knot of amyotrophic lateral sclerosis?","volume":"1","author":"Gonzalez De Aguilar","year":"2011","journal-title":"Curr Genomics"},{"key":"20","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1016\/S0014-5793(02)03546-9","article-title":"Differentially expressed genes in sporadic amyotrophic lateral sclerosis spinal cords--screening by molecular indexing and subsequent cDNA microarray analysis.","volume":"53","author":"Sobue","year":"2002","journal-title":"FEBS Lett"},{"key":"21","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1046\/j.1471-4159.2001.t01-1-00231.x","article-title":"Differential expression of 14 genes in amyotrophic lateral sclerosis spinal cord detected using gridded cDNA arrays.","volume":"7","author":"de Belleroche","year":"2001","journal-title":"J Neurochem"},{"key":"22","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1186\/1471-2164-8-26","article-title":"Pathways and genes differentially expressed in the motor cortex of patients with sporadic amyotrophic lateral sclerosis.","volume":"8","author":"Cavallaro","year":"2007","journal-title":"BMC Genomics"},{"key":"23","doi-asserted-by":"publisher","first-page":"918","DOI":"10.1016\/j.neuron.2011.01.030","article-title":"Phosphorylation regulates OLIG2 cofactor choice and the motor neuron-oligodendrocyte fate switch.","volume":"6","author":"Richardson","year":"2011","journal-title":"Neuron"},{"key":"24","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1080\/17482960600947689","article-title":"Differential expression of genes in amyotrophic lateral sclerosis revealed by profiling the post mortem cortex.","volume":"7","author":"Connor","year":"2006","journal-title":"Amyotroph Lateral Scler"},{"key":"25","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1007\/s12031-007-9004-z","article-title":"Spinal cord mRNA profile in patients with ALS: comparison with transgenic mice expressing the human SOD-1 mutant.","volume":"3","author":"Ransmayr","year":"2009","journal-title":"J Mol Neurosci"},{"key":"26","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1016\/S0736-5748(00)00083-6","article-title":"Oligodendrocyte development in the spinal cord and telencephalon: common themes and new perspectives.","volume":"1","author":"Richardson","year":"2001","journal-title":"Int J Dev Neurosci"},{"key":"27","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1002\/ana.20379","article-title":"Gene expression profile of spinal motor neurons in sporadic amyotrophic lateral sclerosis.","volume":"5","author":"Doyu","year":"2005","journal-title":"Ann Neurol"},{"key":"28","doi-asserted-by":"publisher","first-page":"e9872","DOI":"10.1371\/journal.pone.0009872","article-title":"Mutations in CHMP2B in lower motor neuron predominant amyotrophic lateral sclerosis (ALS).","volume":"5","author":"Grierson","year":"2010","journal-title":"PLoS One"},{"key":"29","doi-asserted-by":"publisher","first-page":"1686","DOI":"10.1093\/brain\/awh503","article-title":"Mutant SOD1 alters the motor neuronal transcriptome: implications for familial ALS.","volume":"12","author":"Shaw","year":"2005","journal-title":"Brain"},{"key":"30","first-page":"7","article-title":"Excitotoxic mechanisms in the pathogenesis of amyotrophic lateral sclerosis.","volume":"6","author":"Rothstein","year":"1995","journal-title":"Adv Neurol"},{"key":"31","doi-asserted-by":"publisher","first-page":"S3","DOI":"10.1002\/ana.21543","article-title":"Current hypotheses for the underlying biology of amyotrophic lateral sclerosis.","volume":"6","author":"Rothstein","year":"2009","journal-title":"Ann Neurol"},{"key":"32","doi-asserted-by":"publisher","first-page":"1217","DOI":"10.1161\/01.ATV.0000130024.50058.de","article-title":"AIF-1 expression modulates proliferation of human vascular smooth muscle cells by autocrine expression of G-CSF.","volume":"2","author":"Autieri","year":"2004","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"33","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1016\/S0002-9440(10)63003-9","article-title":"Expression of allograft inflammatory factor-1 in T lymphocytes: a role in T-lymphocyte activation and proliferative arteriopathies.","volume":"16","author":"Autieri","year":"2005","journal-title":"Am J Pathol"},{"key":"34","doi-asserted-by":"publisher","first-page":"4627","DOI":"10.1111\/j.1742-4658.2008.06605.x","article-title":"Structural and functional characterization of human Iba proteins.","volume":"27","author":"B\u00fcssow","year":"2008","journal-title":"FEBS J"},{"key":"35","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/S0003-4967(24)43164-6","article-title":"CD68 is not a macrophage-specific antigen.","volume":"6","author":"Beranek","year":"2005","journal-title":"Ann Rheum Dis"},{"key":"36","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1111\/j.1365-3083.2008.02091.x","article-title":"Expression of CD68 in non-myeloid cell types.","volume":"6","author":"Kreutz","year":"2008","journal-title":"Scand J Immunol"},{"key":"37","first-page":"1607","article-title":"Molecular cloning of CD68, a human macrophage marker related to lysosomal glycoproteins.","volume":"8","author":"Simmons","year":"1993","journal-title":"Blood"},{"key":"38","doi-asserted-by":"publisher","first-page":"174","DOI":"10.2174\/187152710791012053","article-title":"Assessing activation states in microglia.","volume":"9","author":"Wilcock","year":"2010","journal-title":"CNS Neurol Disord Drug Targets"},{"key":"39","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1038\/nri3705","article-title":"Innate immune activation in neurodegenerative disease.","volume":"1","author":"Latz","year":"2014","journal-title":"Nat Rev Immunol"},{"key":"40","doi-asserted-by":"publisher","first-page":"1415","DOI":"10.1016\/j.intimp.2011.05.006","article-title":"Toll-like receptors are key players in neurodegeneration.","volume":"1","author":"Iribarren","year":"2011","journal-title":"Int Immunopharmacol"},{"key":"41","doi-asserted-by":"publisher","first-page":"3651","DOI":"10.1074\/jbc.M508125200","article-title":"Activation of Toll-like receptor 2 on microglia promotes cell uptake of Alzheimer disease-associated amyloid \u03b2 peptide.","volume":"28","author":"Wang","year":"2006","journal-title":"J Biol Chem"},{"key":"42","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1385\/IR:31:3:165","article-title":"Role of formyl peptide receptor-like 1 (FPRL1\/FPR2) in mononuclear phagocyte responses in Alzheimer disease.","volume":"3","author":"Wang","year":"2005","journal-title":"Immunol Res"},{"key":"43","doi-asserted-by":"publisher","first-page":"3006","DOI":"10.1093\/brain\/awl249","article-title":"Role of toll-like receptor signalling in Abeta uptake and clearance.","volume":"12","author":"Fukuchi","year":"2006","journal-title":"Brain"},{"key":"44","doi-asserted-by":"publisher","first-page":"6824","DOI":"10.1038\/srep06824","article-title":"Toll-like receptors 2, -3 and -4 prime microglia but not astrocytes across central nervous system regions for ATP-dependent interleukin-1\u03b2 release.","volume":"4","author":"Giusti","year":"2014","journal-title":"Sci Rep"},{"key":"45","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1007\/s11882-011-0207-6","article-title":"The emerging role of interleukin-1\u03b2 in autoinflammatory diseases.","volume":"1","author":"Lachmann","year":"2011","journal-title":"Curr Allergy Asthma Rep"},{"key":"46","doi-asserted-by":"publisher","first-page":"929","DOI":"10.1146\/annurev.immunol.22.012703.104622","article-title":"Interleukin-10 and related cytokines and receptors.","volume":"2","author":"Fisher","year":"2004","journal-title":"Annu Rev Immunol"},{"key":"47","doi-asserted-by":"publisher","first-page":"878","DOI":"10.1016\/j.bbamcr.2011.01.034","article-title":"The pro- and anti-inflammatory properties of the cytokine interleukin-6. Biochim Biophys Acta - Mol.","volume":"181","author":"Rose-Johnb","year":"2011","journal-title":"Cell Res"},{"key":"48","doi-asserted-by":"publisher","first-page":"929","DOI":"10.1002\/pro.5560060501","article-title":"Interleukin-6: structure-function relationships.","volume":"6","author":"Ward","year":"1997","journal-title":"Protein Sci"},{"key":"49","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1038\/icb.2014.16","article-title":"From cytokine to myokine: the emerging role of interleukin-6 in metabolic regulation.","volume":"9","author":"Whitham","year":"2014","journal-title":"Immunol Cell Biol"},{"key":"50","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1016\/S0092-8674(01)00237-9","article-title":"The TNF and TNF receptor superfamilies: integrating mammalian biology.","volume":"10","author":"Lenardo","year":"2001","journal-title":"Cell"},{"key":"51","doi-asserted-by":"publisher","first-page":"5701","DOI":"10.4049\/jimmunol.178.9.5701","article-title":"TNF trafficking to human mast cell granules: mature chain-dependent endocytosis.","volume":"17","author":"Knol","year":"2007","journal-title":"J Immunol"},{"key":"52","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1016\/0003-9861(92)90519-3","article-title":"Purification and characterization of dipeptidyl peptidase I from human spleen.","volume":"29","author":"Thiele","year":"1992","journal-title":"Arch Biochem Biophys"},{"key":"53","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1007\/s12018-011-9095-5","article-title":"The emerging relevance of the cysteine protease cathepsin S in disease.","volume":"9","author":"Scott","year":"2011","journal-title":"Clin Rev Bone Miner Metab"},{"key":"54","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1038\/gene.2015.8","article-title":"Genetic variants of SLC11A1 are associated with both autoimmune and infectious diseases: systematic review and meta-analysis.","volume":"1","author":"O\u2019Brien","year":"2015","journal-title":"Genes Immun"},{"key":"55","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1016\/S0161-5890(01)00069-4","article-title":"Presentation of antigens by MHC class II molecules: getting the most out of them.","volume":"3","author":"Villadangos","year":"2001","journal-title":"Mol Immunol"},{"key":"56","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1038\/ni1187","article-title":"Unconventional topology of self peptide-major histocompatibility complex binding by a human autoimmune T cell receptor.","volume":"6","author":"Wucherpfennig","year":"2005","journal-title":"Nat Immunol"},{"key":"57","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.immuni.2007.01.005","article-title":"Autophagy in MHC class II presentation: sampling from within.","volume":"2","author":"Neefjes","year":"2007","journal-title":"Immunity"},{"key":"58","doi-asserted-by":"publisher","first-page":"3561","DOI":"10.1002\/eji.200526347","article-title":"PD-L2:PD-1 involvement in T cell proliferation, cytokine production, and integrin-mediated adhesion.","volume":"3","author":"Woods","year":"2005","journal-title":"Eur J Immunol"},{"key":"59","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/S0065-2776(07)96002-2","article-title":"Regulation of interferon-gamma during innate and adaptive immune responses.","volume":"9","author":"Wilson","year":"2007","journal-title":"Adv Immunol"},{"key":"60","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1186\/1476-9255-8-22","article-title":"Role of IL-33 in inflammation and disease.","volume":"8","author":"Miller","year":"2011","journal-title":"J Inflamm (Lond)"},{"key":"61","doi-asserted-by":"publisher","first-page":"341","DOI":"10.3389\/fncel.2015.00341","article-title":"Ultrastructural studies of ALS mitochondria connect altered function and permeability with defects of mitophagy and mitochondriogenesis.","volume":"9","author":"Fornai","year":"2015","journal-title":"Front Cell Neurosci"},{"key":"62","article-title":"Pathways to mitochondrial dysfunction in ALS pathogenesis.","author":"Cozzolino","year":"2016","journal-title":"Biochem Biophys Res Commun"},{"key":"63","doi-asserted-by":"publisher","first-page":"1757","DOI":"10.1093\/hmg\/3.10.1757","article-title":"Variants of the heavy neurofilament subunit are associated with the development of amyotrophic lateral sclerosis.","volume":"3","author":"Julien","year":"1994","journal-title":"Hum Mol Genet"},{"key":"64","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1016\/0962-8924(93)90090-N","article-title":"Dynein heavy chain isoforms and axonemal motility.","volume":"3","author":"Brokaw","year":"1993","journal-title":"Trends Cell Biol"},{"key":"65","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1016\/S0014-5793(97)00800-4","article-title":"Isolation of several human axonemal dynein heavy chain genes: genomic structure of the catalytic site, phylogenetic analysis and chromosomal assignment.","volume":"41","author":"Amselem","year":"1997","journal-title":"FEBS Lett"},{"key":"66","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1126\/science.1254198","article-title":"Activation of cytoplasmic dynein motility by dynactin-cargo adapter complexes.","volume":"34","author":"Vale","year":"2014","journal-title":"Science"},{"key":"67","doi-asserted-by":"publisher","first-page":"1469","DOI":"10.1016\/0140-6736(91)92781-V","article-title":"Glutamic acid decarboxylase expression in islets and brain.","volume":"33","author":"Trucco","year":"1991","journal-title":"Lancet"},{"key":"68","doi-asserted-by":"publisher","first-page":"1138","DOI":"10.1126\/science.3518061","article-title":"Brain glutamate decarboxylase cloned in lambda gt-11: fusion protein produces gamma-aminobutyric acid.","volume":"23","author":"Tobin","year":"1986","journal-title":"Science"},{"key":"69","doi-asserted-by":"publisher","first-page":"6958","DOI":"10.1073\/pnas.1400081111","article-title":"Heterodimeric coiled-coil interactions of human GABAB receptor.","volume":"11","author":"Fan","year":"2014","journal-title":"Proc Natl Acad Sci USA"},{"key":"70","doi-asserted-by":"publisher","first-page":"710","DOI":"10.1016\/j.neuron.2010.10.026","article-title":"Bassoon speeds vesicle reloading at a central excitatory synapse.","volume":"6","author":"Eilers","year":"2010","journal-title":"Neuron"},{"key":"71","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/j.neuron.2014.02.012","article-title":"Bassoon specifically controls presynaptic P\/Q-type Ca(2+) channels via RIM-binding protein.","volume":"8","author":"Rusakov","year":"2014","journal-title":"Neuron"},{"key":"72","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/S0736-5748(02)00046-1","article-title":"Gene structure and genetic localization of the PCLO gene encoding the presynaptic active zone protein Piccolo.","volume":"2","author":"Garner","year":"2002","journal-title":"Int J Dev Neurosci"},{"key":"73","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/S0896-6273(00)80883-1","article-title":"Piccolo, a presynaptic zinc finger protein structurally related to bassoon.","volume":"2","author":"Garner","year":"2000","journal-title":"Neuron"},{"key":"74","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1097\/WNR.0000000000000491","article-title":"Possibility of a sex-specific role for a genetic variant in FRMPD4 in schizophrenia, but not cognitive function.","volume":"2","author":"Fernandez-Enright","year":"2016","journal-title":"Neuroreport"},{"key":"75","doi-asserted-by":"publisher","first-page":"1659","DOI":"10.1111\/j.1471-4159.2006.03679.x","article-title":"Postsynaptic recruitment of Dendrin depends on both dendritic mRNA transport and synaptic anchoring.","volume":"9","author":"Barnekow","year":"2006","journal-title":"J Neurochem"},{"key":"76","doi-asserted-by":"publisher","first-page":"2648","DOI":"10.1073\/pnas.94.6.2648","article-title":"Neuritin: a gene induced by neural activity and neurotrophins that promotes neuritogenesis.","volume":"9","author":"Theill","year":"1997","journal-title":"Proc Natl Acad Sci USA"},{"key":"77","doi-asserted-by":"publisher","first-page":"4534","DOI":"10.1523\/JNEUROSCI.1715-15.2016","article-title":"Neuritin mediates activity-dependent axonal branch formation in part via FGF signaling.","volume":"3","author":"Yamagata","year":"2016","journal-title":"J Neurosci"},{"key":"78","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1523\/JNEUROSCI.4178-07.2008","article-title":"A transcriptome database for astrocytes, neurons, and oligodendrocytes: a new resource for understanding brain development and function.","volume":"2","author":"Barres","year":"2008","journal-title":"J Neurosci"},{"key":"79","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1016\/j.cell.2009.04.031","article-title":"Myelin gene regulatory factor is a critical transcriptional regulator required for CNS myelination.","volume":"13","author":"Barres","year":"2009","journal-title":"Cell"},{"key":"80","doi-asserted-by":"publisher","first-page":"e1001624","DOI":"10.1371\/journal.pbio.1001624","article-title":"A Bacteriophage tailspike domain promotes self-cleavage of a human membrane-bound transcription factor, the myelin regulatory factor MYRF.","volume":"1","author":"Marcotte","year":"2013","journal-title":"PLoS Biol"},{"key":"81","doi-asserted-by":"publisher","first-page":"12528","DOI":"10.1523\/JNEUROSCI.1069-12.2012","article-title":"Myelin gene regulatory factor is required for maintenance of myelin and mature oligodendrocyte identity in the adult CNS.","volume":"3","author":"Emery","year":"2012","journal-title":"J Neurosci"},{"key":"82","doi-asserted-by":"publisher","first-page":"906","DOI":"10.1016\/j.neuron.2011.02.005","article-title":"Phosphorylation state of Olig2 regulates proliferation of neural progenitors.","volume":"6","author":"Stiles","year":"2011","journal-title":"Neuron"},{"key":"83","doi-asserted-by":"publisher","first-page":"3521","DOI":"10.1128\/MCB.01689-06","article-title":"Neuropathy-associated Egr2 mutants disrupt cooperative activation of myelin protein zero by Egr2 and Sox10.","volume":"2","author":"Svaren","year":"2007","journal-title":"Mol Cell Biol"},{"key":"84","doi-asserted-by":"publisher","first-page":"14375","DOI":"10.1523\/JNEUROSCI.4456-07.2007","article-title":"Olig1 and Sox10 interact synergistically to drive myelin basic protein transcription in oligodendrocytes.","volume":"2","author":"Richardson","year":"2007","journal-title":"J Neurosci"},{"key":"85","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1242\/dev.095323","article-title":"Genetic evidence that Nkx2.2 and Pdgfra are major determinants of the timing of oligodendrocyte differentiation in the developing CNS.","volume":"14","author":"Qiu","year":"2014","journal-title":"Development"},{"key":"86","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1159\/000112115","article-title":"Iron acquisition and expression of iron regulatory proteins in the developing brain: manipulation by ethanol exposure, iron deprivation and cellular dysfunction.","volume":"1","author":"Connor","year":"1994","journal-title":"Dev Neurosci"},{"key":"87","first-page":"2030","article-title":"Regional brain iron, ferritin and transferrin concentrations during iron deficiency and iron repletion in developing rats.","volume":"12","author":"Beard","year":"1997","journal-title":"J Nutr"},{"key":"88","doi-asserted-by":"publisher","first-page":"9807","DOI":"10.1073\/pnas.83.24.9807","article-title":"Individual exons encode the integral membrane domains of human myelin proteolipid protein.","volume":"8","author":"Stoffel","year":"1986","journal-title":"Proc Natl Acad Sci USA"},{"key":"89","doi-asserted-by":"publisher","first-page":"1610","DOI":"10.1126\/science.280.5369.1610","article-title":"Axonal swellings and degeneration in mice lacking the major proteolipid of myelin.","volume":"28","author":"Nave","year":"1998","journal-title":"Science"},{"key":"90","doi-asserted-by":"publisher","first-page":"8856","DOI":"10.1073\/pnas.122079599","article-title":"The myelin basic protein gene is expressed in differentiated blood cell lineages and in hemopoietic progenitors.","volume":"9","author":"Pessac","year":"2002","journal-title":"Proc Natl Acad Sci USA"},{"key":"91","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1159\/000095110","article-title":"Myelin-associated oligodendrocytic basic protein: a family of abundant CNS myelin proteins in search of a function.","volume":"2","author":"Griffiths","year":"2006","journal-title":"Dev Neurosci"},{"key":"92","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1006\/geno.1995.1137","article-title":"The human myelin oligodendrocyte glycoprotein (MOG) gene: complete nucleotide sequence and structural characterization.","volume":"2","author":"Coppin","year":"1995","journal-title":"Genomics"},{"key":"93","doi-asserted-by":"publisher","first-page":"2521","DOI":"10.1093\/brain\/awv204","article-title":"Myelin-associated glycoprotein gene mutation causes Pelizaeus-Merzbacher disease-like disorder.","volume":"13","author":"Newman","year":"2015","journal-title":"Brain"},{"key":"94","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1002\/jnr.490420316","article-title":"Cloning and characterization of MVP17: a developmentally regulated myelin protein in oligodendrocytes.","volume":"4","author":"Pfeiffer","year":"1995","journal-title":"J Neurosci Res"},{"key":"95","doi-asserted-by":"publisher","first-page":"1335","DOI":"10.1046\/j.1471-4159.1997.69041335.x","article-title":"A comparative study of 2\u2032,3\u2032-cyclic-nucleotide 3\u2032-phosphodiesterase in vertebrates: cDNA cloning and amino acid sequences for chicken and bullfrog enzymes.","volume":"6","author":"Tamai","year":"1997","journal-title":"J Neurochem"},{"key":"96","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1007\/s00726-006-0479-7","article-title":"Structural properties of proteins specific to the myelin sheath.","volume":"3","author":"Kursula","year":"2008","journal-title":"Amino Acids"},{"key":"97","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1038\/ng1095","article-title":"Disruption of Cnp1 uncouples oligodendroglial functions in axonal support and myelination.","volume":"3","author":"Nave","year":"2003","journal-title":"Nat Genet"},{"key":"98","doi-asserted-by":"publisher","first-page":"3305","DOI":"10.1093\/brain\/awt250","article-title":"Transcriptomic indices of fast and slow disease progression in two mouse models of amyotrophic lateral sclerosis.","volume":"13","author":"Bendotti","year":"2013","journal-title":"Brain"},{"key":"99","doi-asserted-by":"publisher","first-page":"R80","DOI":"10.1186\/gb-2004-5-10-r80","article-title":"Bioconductor: open software development for computational biology and bioinformatics.","volume":"5","author":"Huber","year":"2004","journal-title":"Genome Biol"},{"key":"100","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1016\/j.neuint.2006.01.018","article-title":"TaqMan PCR assay in the control of RNA normalization in human post-mortem brain tissue.","volume":"4","author":"Ferrer","year":"2006","journal-title":"Neurochem Int"},{"key":"101","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1007\/s00401-012-1027-z","article-title":"Selection of novel reference genes for use in the human central nervous system: a BrainNet Europe Study.","volume":"12","author":"Palkovits","year":"2012","journal-title":"Acta Neuropathol"}],"container-title":["Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.101195","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T15:21:27Z","timestamp":1750087287000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.101195"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,9]]},"references-count":101,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,3,31]]}},"alternative-id":["101195","28283675"],"URL":"https:\/\/doi.org\/10.18632\/aging.101195","relation":{},"ISSN":["1945-4589"],"issn-type":[{"value":"1945-4589","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,9]]}}}