{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:44:50Z","timestamp":1790775890038,"version":"4.1.0"},"reference-count":69,"publisher":"Impact Journals, LLC","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aging"],"published-print":{"date-parts":[[2017,4,17]]},"DOI":"10.18632\/aging.101225","type":"journal-article","created":{"date-parts":[[2017,4,17]],"date-time":"2017-04-17T15:07:36Z","timestamp":1492441656000},"page":"1248-1268","source":"Crossref","is-referenced-by-count":40,"title":["Ionizing radiation reduces ADAM10 expression in brain microvascular endothelial cells undergoing stress-induced senescence"],"prefix":"10.18632","volume":"9","author":[{"given":"Lucinda S.","family":"McRobb","sequence":"first","affiliation":[{"name":"Department of Clinical Medicine, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, New South Wales, 2109, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew J.","family":"McKay","sequence":"additional","affiliation":[{"name":"Australian Proteome Analysis Facility, Department of Chemistry and Biomolecular Sciences, Macquarie University, Sydney, New South Wales, 2109, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer R.","family":"Gamble","sequence":"additional","affiliation":[{"name":"Vascular Biology Program, Centenary Institute, University of Sydney, Sydney, New South Wales, 2042, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Grace","sequence":"additional","affiliation":[{"name":"Genesis Cancer Care, Macquarie University Hospital, Sydney, New South Wales, 2109, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vaughan","family":"Moutrie","sequence":"additional","affiliation":[{"name":"Genesis Cancer Care, Macquarie University Hospital, Sydney, New South Wales, 2109, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Estevam D.","family":"Santos","sequence":"additional","affiliation":[{"name":"Genesis Cancer Care, Macquarie University Hospital, Sydney, New South Wales, 2109, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivienne S.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, New South Wales, 2109, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenjun","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, New South Wales, 2109, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark P.","family":"Molloy","sequence":"additional","affiliation":[{"name":"Australian Proteome Analysis Facility, Department of Chemistry and Biomolecular Sciences, Macquarie University, Sydney, New South Wales, 2109, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus A.","family":"Stoodley","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, New South Wales, 2109, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7892","published-online":{"date-parts":[[2017,4,17]]},"reference":[{"key":"1","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1016\/S1470-2045(05)70251-5","article-title":"Long-term mortality from heart disease and lung cancer after radiotherapy for early breast cancer: prospective cohort study of about 300,000 women in US SEER cancer registries.","volume":"6","author":"Peto","year":"2005","journal-title":"Lancet Oncol"},{"key":"2","doi-asserted-by":"publisher","first-page":"b5349","DOI":"10.1136\/bmj.b5349","article-title":"Radiation exposure and circulatory disease risk: hiroshima and Nagasaki atomic bomb survivor data, 1950-2003.","volume":"34","author":"Shore","year":"2010","journal-title":"BMJ"},{"key":"3","doi-asserted-by":"publisher","first-page":"1962","DOI":"10.1002\/1097-0142(19890515)63:10<1962::AID-CNCR2820631016>3.0.CO;2-V","article-title":"Subacute brain atrophy after radiation therapy for malignant brain tumor.","volume":"6","author":"Takakura","year":"1989","journal-title":"Cancer"},{"key":"4","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1667\/RR1389.1","article-title":"Early brain response to low-dose radiation exposure involves molecular networks and pathways associated with cognitive functions, advanced aging and Alzheimer\u2019s disease.","volume":"17","author":"Wyrobek","year":"2009","journal-title":"Radiat Res"},{"key":"5","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1007\/BF00294312","article-title":"Cerebral beta amyloid deposition in patients with malignant neoplasms: its prevalence with aging and effects of radiation therapy on vascular amyloid.","volume":"9","author":"Yamaguchi","year":"1995","journal-title":"Acta Neuropathol"},{"key":"6","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1007\/s007020200068","article-title":"Alzheimer disease and cerebrovascular pathology: an update.","volume":"10","author":"Jellinger","year":"2002","journal-title":"J Neural Transm (Vienna)"},{"key":"7","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1093\/jrr\/rrs036","article-title":"Does ionizing radiation influence Alzheimer\u2019s disease risk?","volume":"5","author":"Vares","year":"2012","journal-title":"J Radiat Res (Tokyo)"},{"key":"8","doi-asserted-by":"publisher","first-page":"1539","DOI":"10.1016\/S0169-409X(02)00149-7","article-title":"Amyloidosis and Alzheimer\u2019s disease.","volume":"5","author":"Frangione","year":"2002","journal-title":"Adv Drug Deliv Rev"},{"key":"9","doi-asserted-by":"publisher","first-page":"511","DOI":"10.2307\/3576327","article-title":"Radiosensitivity of vascular tissue. I. Differential radiosensitivity of capillaries: a quantitative in vivo study.","volume":"9","author":"Griem","year":"1984","journal-title":"Radiat Res"},{"key":"10","doi-asserted-by":"publisher","first-page":"1233","DOI":"10.1054\/bjoc.2001.2100","article-title":"Radiation induced CNS toxicity--molecular and cellular mechanisms.","volume":"8","author":"Bamberg","year":"2001","journal-title":"Br J Cancer"},{"key":"11","first-page":"S167","article-title":"Amyloidosis associated with cerebral amyloid angiopathy: cell signaling pathways elicited in cerebral endothelial cells.","volume":"4","author":"Rostagno","year":"2014","journal-title":"J Alzheimers Dis"},{"key":"12","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1111\/j.1750-3639.2008.00133.x","article-title":"Perivascular drainage of amyloid-beta peptides from the brain and its failure in cerebral amyloid angiopathy and Alzheimer\u2019s disease.","volume":"1","author":"Carare","year":"2008","journal-title":"Brain Pathol"},{"key":"13","doi-asserted-by":"publisher","first-page":"1909","DOI":"10.1161\/ATVBAHA.109.188516","article-title":"Alzheimer disease-associated peptide, amyloid beta40, inhibits vascular regeneration with induction of endothelial autophagy.","volume":"2","author":"Morishita","year":"2009","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"14","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.exger.2014.09.018","article-title":"Cellular senescence and the aging brain.","volume":"6","author":"Andersen","year":"2015","journal-title":"Exp Gerontol"},{"key":"15","doi-asserted-by":"publisher","first-page":"R178","DOI":"10.1016\/S0960-9822(98)70105-8","article-title":"Telomeres and senescence: the history, the experiment, the future.","volume":"8","author":"Greider","year":"1998","journal-title":"Curr Biol"},{"key":"16","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1016\/S0531-5565(00)00180-7","article-title":"Cellular and molecular mechanisms of stress-induced premature senescence (SIPS) of human diploid fibroblasts and melanocytes.","volume":"3","author":"von Zglinicki","year":"2000","journal-title":"Exp Gerontol"},{"key":"17","doi-asserted-by":"publisher","first-page":"3628","DOI":"10.4161\/15384101.2014.985507","article-title":"Geroconversion: irreversible step to cellular senescence.","volume":"1","author":"Blagosklonny","year":"2014","journal-title":"Cell Cycle"},{"key":"18","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1016\/j.it.2015.02.009","article-title":"Senescence-associated inflammatory responses: aging and cancer perspectives.","volume":"3","author":"Ben-Neriah","year":"2015","journal-title":"Trends Immunol"},{"key":"19","doi-asserted-by":"publisher","first-page":"331","DOI":"10.4142\/jvs.2012.13.4.331","article-title":"Prolonged expression of senescence markers in mice exposed to gamma-irradiation.","volume":"1","author":"Jo","year":"2012","journal-title":"J Vet Sci"},{"key":"20","doi-asserted-by":"publisher","first-page":"1203","DOI":"10.1021\/pr501141b","article-title":"Integrative proteomics and targeted transcriptomics analyses in cardiac endothelial cells unravel mechanisms of long-term radiation-induced vascular dysfunction.","volume":"1","author":"Tapio","year":"2015","journal-title":"J Proteome Res"},{"key":"21","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1111\/j.1474-9726.2010.00567.x","article-title":"Ionizing radiation-induced long-term expression of senescence markers in mice is independent of p53 and immune status.","volume":"9","author":"Beaus\u00e9jour","year":"2010","journal-title":"Aging Cell"},{"key":"22","doi-asserted-by":"publisher","first-page":"2718","DOI":"10.1002\/pmic.200401163","article-title":"Identification and relative quantification of membrane proteins by surface biotinylation and two-dimensional peptide mapping.","volume":"5","author":"Elia","year":"2005","journal-title":"Proteomics"},{"key":"23","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1038\/nmeth745","article-title":"In vivo protein biotinylation for identification of organ-specific antigens accessible from the vasculature.","volume":"2","author":"Elia","year":"2005","journal-title":"Nat Methods"},{"key":"24","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1038\/nprot.2006.29","article-title":"In vivo protein biotinylation and sample preparation for the proteomic identification of organ- and disease-specific antigens accessible from the vasculature.","volume":"1","author":"Rybak","year":"2006","journal-title":"Nat Protoc"},{"key":"25","doi-asserted-by":"publisher","first-page":"141","DOI":"10.2174\/1570161043476393","article-title":"The role of vascular cell senescence in atherosclerosis: antisenescence as a novel therapeutic strategy for vascular aging.","volume":"2","author":"Komuro","year":"2004","journal-title":"Curr Vasc Pharmacol"},{"key":"26","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1159\/000343572","article-title":"Senescent cells and their secretory phenotype as targets for cancer therapy.","volume":"3","author":"Campisi","year":"2013","journal-title":"Interdiscip Top Gerontol"},{"key":"27","doi-asserted-by":"publisher","first-page":"966","DOI":"10.1172\/JCI64098","article-title":"Cellular senescence and the senescent secretory phenotype: therapeutic opportunities.","volume":"12","author":"Kirkland","year":"2013","journal-title":"J Clin Invest"},{"key":"28","doi-asserted-by":"publisher","first-page":"9363","DOI":"10.1073\/pnas.92.20.9363","article-title":"A biomarker that identifies senescent human cells in culture and in aging skin in vivo.","volume":"9","author":"Pereira-Smith","year":"1995","journal-title":"Proc Natl Acad Sci USA"},{"key":"29","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1038\/labinvest.3700241","article-title":"p53-dependent ICAM-1 overexpression in senescent human cells identified in atherosclerotic lesions.","volume":"8","author":"Kletsas","year":"2005","journal-title":"Lab Invest"},{"key":"30","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1038\/ncb1448","article-title":"Plasminogen activator inhibitor-1 is a critical downstream target of p53 in the induction of replicative senescence.","volume":"8","author":"Bernards","year":"2006","journal-title":"Nat Cell Biol"},{"key":"31","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1093\/geronj\/34.3.328","article-title":"Senescent human diploid cells in culture: survival, DNA synthesis and morphology.","volume":"3","author":"Hayflick","year":"1979","journal-title":"J Gerontol"},{"key":"32","doi-asserted-by":"publisher","first-page":"898","DOI":"10.1080\/15548627.2015.1121361","article-title":"How autophagy both activates and inhibits cellular senescence.","volume":"1","author":"Elledge","year":"2016","journal-title":"Autophagy"},{"key":"33","doi-asserted-by":"crossref","unstructured":"Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016; 12: 1-222.","DOI":"10.1080\/15548627.2015.1100356"},{"key":"34","doi-asserted-by":"publisher","first-page":"244","DOI":"10.18632\/aging.100140","article-title":"Cdk2: a key regulator of the senescence control function of Myc.","volume":"2","author":"Larsson","year":"2010","journal-title":"Aging (Albany NY)"},{"key":"35","doi-asserted-by":"publisher","first-page":"e70024","DOI":"10.1371\/journal.pone.0070024","article-title":"The PI3K\/Akt\/mTOR pathway is implicated in the premature senescence of primary human endothelial cells exposed to chronic radiation.","volume":"8","author":"Tapio","year":"2013","journal-title":"PLoS One"},{"key":"36","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.pneurobio.2015.10.003","article-title":"The alpha secretase ADAM10: A metalloprotease with multiple functions in the brain.","volume":"13","author":"Lichtenthaler","year":"2015","journal-title":"Prog Neurobiol"},{"key":"37","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1007\/s11883-012-0254-z","article-title":"The pathophysiology and clinical presentation of cerebral amyloid angiopathy.","volume":"1","author":"Greenberg","year":"2012","journal-title":"Curr Atheroscler Rep"},{"key":"38","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1128\/MCB.00378-10","article-title":"Rb\/E2F regulates expression of neogenin during neuronal migration.","volume":"3","author":"Slack","year":"2011","journal-title":"Mol Cell Biol"},{"key":"39","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1681\/ASN.2010040430","article-title":"Dangers within: DAMP responses to damage and cell death in kidney disease.","volume":"2","author":"Okusa","year":"2011","journal-title":"J Am Soc Nephrol"},{"key":"40","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1007\/s00401-016-1607-4","article-title":"Down-regulation of neuronal L1 cell adhesion molecule expression alleviates inflammatory neuronal injury.","volume":"13","author":"Sch\u00e4fer","year":"2016","journal-title":"Acta Neuropathol"},{"key":"41","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.nbd.2011.01.021","article-title":"Autophagy failure in Alzheimer\u2019s disease--locating the primary defect.","volume":"4","author":"Yang","year":"2011","journal-title":"Neurobiol Dis"},{"key":"42","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1161\/CIRCRESAHA.116.303805","article-title":"The role of autophagy in vascular biology.","volume":"11","author":"Finkel","year":"2015","journal-title":"Circ Res"},{"key":"43","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1667\/RR1423.1","article-title":"Inhibition of a radiation-induced senescence-like phenotype: a possible mechanism for potentially lethal damage repair in vascular endothelial cells.","volume":"17","author":"Miura","year":"2008","journal-title":"Radiat Res"},{"key":"44","first-page":"232","article-title":"Induction of a senescence-like phenotype in bovine aortic endothelial cells by ionizing radiation.","volume":"15","author":"Mayberg","year":"2001","journal-title":"Radiat Res"},{"key":"45","doi-asserted-by":"publisher","first-page":"71","DOI":"10.3109\/09553002.2014.859763","article-title":"Characterization of DNA damage-induced cellular senescence by ionizing radiation in endothelial cells.","volume":"9","author":"Kim","year":"2014","journal-title":"Int J Radiat Biol"},{"key":"46","doi-asserted-by":"publisher","first-page":"1443","DOI":"10.1093\/gerona\/glt057","article-title":"Ionizing radiation promotes the acquisition of a senescence-associated secretory phenotype and impairs angiogenic capacity in cerebromicrovascular endothelial cells: role of increased DNA damage and decreased DNA repair capacity in microvascular radiosensitivity.","volume":"6","author":"Sonntag","year":"2013","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"47","doi-asserted-by":"publisher","first-page":"e102408","DOI":"10.1371\/journal.pone.0102408","article-title":"Important role of autophagy in endothelial cell response to ionizing radiation.","volume":"9","author":"Koukourakis","year":"2014","journal-title":"PLoS One"},{"key":"48","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/S0014-5793(01)02272-4","article-title":"Pro-atherogenic factors induce telomerase inactivation in endothelial cells through an Akt-dependent mechanism.","volume":"49","author":"Dimmeler","year":"2001","journal-title":"FEBS Lett"},{"key":"49","doi-asserted-by":"publisher","first-page":"1103","DOI":"10.1042\/BST20130134","article-title":"Regulation of autophagy by mTOR-dependent and mTOR-independent pathways: autophagy dysfunction in neurodegenerative diseases and therapeutic application of autophagy enhancers.","volume":"4","author":"Sarkar","year":"2013","journal-title":"Biochem Soc Trans"},{"key":"50","doi-asserted-by":"publisher","first-page":"3535","DOI":"10.18632\/aging.101155","article-title":"Gerosuppression by pan-mTOR inhibitors.","volume":"8","author":"Blagosklonny","year":"2016","journal-title":"Aging (Albany NY)"},{"key":"51","doi-asserted-by":"publisher","first-page":"976","DOI":"10.1227\/NEU.0b013e3181ee36bc","article-title":"Expression of endothelial adhesion molecules after radiosurgery in an animal model of arteriovenous malformation.","volume":"6","author":"Smee","year":"2010","journal-title":"Neurosurgery"},{"key":"52","doi-asserted-by":"publisher","first-page":"113","DOI":"10.3171\/2013.9.JNS122056","article-title":"Durable thrombosis in a rat model of arteriovenous malformation treated with radiosurgery and vascular targeting.","volume":"12","author":"Stoodley","year":"2014","journal-title":"J Neurosurg"},{"key":"53","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1667\/RR14518.1","article-title":"Radiosurgery Alters the Endothelial Surface Proteome: Externalized Intracellular Molecules as Potential Vascular Targets in Irradiated Brain Arteriovenous Malformations.","volume":"18","author":"Stoodley","year":"2017","journal-title":"Radiat Res"},{"key":"54","doi-asserted-by":"publisher","first-page":"1184","DOI":"10.1080\/15548627.2015.1058685","article-title":"Autophagy is a key tolerance mechanism during Staphylococcus aureus infection.","volume":"1","author":"Cadwell","year":"2015","journal-title":"Autophagy"},{"key":"55","doi-asserted-by":"publisher","first-page":"1456","DOI":"10.1172\/JCI20864","article-title":"A disintegrin-metalloproteinase prevents amyloid plaque formation and hippocampal defects in an Alzheimer disease mouse model.","volume":"11","author":"Godaux","year":"2004","journal-title":"J Clin Invest"},{"key":"56","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.radonc.2015.10.019","article-title":"Cranial irradiation significantly reduces beta amyloid plaques in the brain and improves cognition in a murine model of Alzheimer\u2019s Disease (AD).","volume":"11","author":"Martinez","year":"2016","journal-title":"Radiother Oncol"},{"key":"57","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1016\/j.semcdb.2008.09.005","article-title":"The good, the bad and the ugly substrates for ADAM10 and ADAM17 in brain pathology, inflammation and cancer.","volume":"2","author":"Ludwig","year":"2009","journal-title":"Semin Cell Dev Biol"},{"key":"58","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1016\/j.semcdb.2008.11.002","article-title":"The \u201ca disintegrin and metalloprotease\u201d (ADAM) family of sheddases: physiological and cellular functions.","volume":"2","author":"Saftig","year":"2009","journal-title":"Semin Cell Dev Biol"},{"key":"59","doi-asserted-by":"publisher","first-page":"5","DOI":"10.7554\/eLife.12748","article-title":"Systematic substrate identification indicates a central role for the metalloprotease ADAM10 in axon targeting and synapse function.","volume":"5","author":"Saftig","year":"2016","journal-title":"eLife"},{"key":"60","doi-asserted-by":"publisher","first-page":"9040","DOI":"10.1128\/MCB.25.20.9040-9053.2005","article-title":"L1 is sequentially processed by two differently activated metalloproteases and presenilin\/gamma-secretase and regulates neural cell adhesion, cell migration, and neurite outgrowth.","volume":"2","author":"Reiss","year":"2005","journal-title":"Mol Cell Biol"},{"key":"61","doi-asserted-by":"publisher","first-page":"e104624","DOI":"10.1371\/journal.pone.0104624","article-title":"Metalloproteinase-dependent TLR2 ectodomain shedding is involved in soluble toll-like receptor 2 (sTLR2) production.","volume":"9","author":"Hermoso","year":"2014","journal-title":"PLoS One"},{"key":"62","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1038\/ncb2167","article-title":"Klotho suppresses RIG-I-mediated senescence-associated inflammation.","volume":"1","author":"Gu","year":"2011","journal-title":"Nat Cell Biol"},{"key":"63","doi-asserted-by":"publisher","first-page":"3221","DOI":"10.1016\/j.febslet.2009.09.009","article-title":"Klotho is a substrate for alpha-, beta- and gamma-secretase.","volume":"58","author":"Kaether","year":"2009","journal-title":"FEBS Lett"},{"key":"64","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1016\/j.bbrc.2013.03.021","article-title":"Cell surface Nestin is a biomarker for glioma stem cells.","volume":"43","author":"Kim","year":"2013","journal-title":"Biochem Biophys Res Commun"},{"key":"65","doi-asserted-by":"publisher","first-page":"e1377","DOI":"10.1038\/cddis.2014.293","article-title":"Depletion of intermediate filament protein Nestin, a target of microRNA-940, suppresses tumorigenesis by inducing spontaneous DNA damage accumulation in human nasopharyngeal carcinoma.","volume":"5","author":"An","year":"2014","journal-title":"Cell Death Dis"},{"key":"66","doi-asserted-by":"publisher","first-page":"838","DOI":"10.1038\/nn1922","article-title":"RECK modulates Notch signaling during cortical neurogenesis by regulating ADAM10 activity.","volume":"1","author":"Takahashi","year":"2007","journal-title":"Nat Neurosci"},{"key":"67","doi-asserted-by":"publisher","first-page":"1780","DOI":"10.3171\/2015.4.JNS142129","article-title":"Live-cell imaging to detect phosphatidylserine externalization in brain endothelial cells exposed to ionizing radiation: implications for the treatment of brain arteriovenous malformations.","volume":"12","author":"Stoodley","year":"2016","journal-title":"J Neurosurg"},{"key":"68","first-page":"1","article-title":"In vitro and in vivo biotinylation of endothelial cell surface proteins in the pursuit of targets for molecular therapies for brain AVMs.","volume":"S1","author":"Stoodley","year":"2012","journal-title":"Metabolomics"},{"key":"69","doi-asserted-by":"publisher","first-page":"1708","DOI":"10.1074\/mcp.M114.046425","article-title":"Online Peptide fractionation using a multiphasic microfluidic liquid chromatography chip improves reproducibility and detection limits for quantitation in discovery and targeted proteomics.","volume":"1","author":"Molloy","year":"2015","journal-title":"Mol Cell Proteomics"}],"container-title":["Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.101225","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,2]],"date-time":"2020-09-02T12:39:35Z","timestamp":1599050375000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.101225"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4,17]]},"references-count":69,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,4,30]]}},"alternative-id":["101225","28437250"],"URL":"https:\/\/doi.org\/10.18632\/aging.101225","relation":{},"ISSN":["1945-4589"],"issn-type":[{"value":"1945-4589","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4,17]]}}}