{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T14:25:58Z","timestamp":1790864758568,"version":"4.1.0"},"reference-count":99,"publisher":"Impact Journals, LLC","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aging"],"published-print":{"date-parts":[[2017,5,16]]},"DOI":"10.18632\/aging.101239","type":"journal-article","created":{"date-parts":[[2017,5,16]],"date-time":"2017-05-16T19:24:41Z","timestamp":1494962681000},"page":"1386-1403","source":"Crossref","is-referenced-by-count":22,"title":["Transgenic autoinhibition of p21-activated kinase exacerbates synaptic impairments and fronto-dependent behavioral deficits in an animal model of Alzheimer\u2019s disease"],"prefix":"10.18632","volume":"9","author":[{"given":"Cyril","family":"Bories","sequence":"first","affiliation":[{"name":"Research Center of Institut Universitaire en Sant\u00e9 Mentale de Qu\u00e9bec, Quebec City, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dany","family":"Arsenault","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy Laval University, Quebec City, QC, Canada"},{"name":"Centre Hospitalier de l'Universit\u00e9 Laval (CHUL) Research Center, Quebec City, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myriam","family":"Lemire","sequence":"additional","affiliation":[{"name":"Research Center of Institut Universitaire en Sant\u00e9 Mentale de Qu\u00e9bec, Quebec City, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cyntia","family":"Tremblay","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy Laval University, Quebec City, QC, Canada"},{"name":"Centre Hospitalier de l'Universit\u00e9 Laval (CHUL) Research Center, Quebec City, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yves","family":"De Koninck","sequence":"additional","affiliation":[{"name":"Research Center of Institut Universitaire en Sant\u00e9 Mentale de Qu\u00e9bec, Quebec City, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Calon","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy Laval University, Quebec City, QC, Canada"},{"name":"Centre Hospitalier de l'Universit\u00e9 Laval (CHUL) Research Center, Quebec City, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7892","published-online":{"date-parts":[[2017,5,16]]},"reference":[{"key":"1","doi-asserted-by":"publisher","first-page":"669","DOI":"10.3233\/JAD-131337","article-title":"Neuropsychological correlates of behavioral symptoms in Alzheimer\u2019s disease, frontal variant of frontotemporal, subcortical vascular, and lewy body dementias: a comparative study.","volume":"3","author":"Carlesimo","year":"2014","journal-title":"J Alzheimers Dis"},{"key":"2","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1016\/j.jamda.2014.12.018","article-title":"The course of neuropsychiatric symptoms in dementia: a 3-year longitudinal study.","volume":"1","author":"Ames","year":"2015","journal-title":"J Am Med Dir Assoc"},{"key":"3","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1159\/000107100","article-title":"Neuropsychiatric symptoms are associated with progression from mild cognitive impairment to Alzheimer\u2019s disease.","volume":"2","author":"Cummings","year":"2007","journal-title":"Dement Geriatr Cogn Disord"},{"key":"4","doi-asserted-by":"publisher","first-page":"a006189","DOI":"10.1101\/cshperspect.a006189","article-title":"Neuropathological alterations in Alzheimer disease.","volume":"1","author":"Hyman","year":"2011","journal-title":"Cold Spring Harb Perspect Med"},{"key":"5","doi-asserted-by":"publisher","first-page":"1198","DOI":"10.18632\/aging.100864","article-title":"Epigenetic age of the pre-frontal cortex is associated with neuritic plaques, amyloid load, and Alzheimer\u2019s disease related cognitive functioning.","volume":"7","author":"Horvath","year":"2015","journal-title":"Aging (Albany NY)"},{"key":"6","doi-asserted-by":"publisher","first-page":"547","DOI":"10.2165\/00002512-200724070-00003","article-title":"Epidemiology and management of apathy in patients with Alzheimer\u2019s disease.","volume":"2","author":"Starkstein","year":"2007","journal-title":"Drugs Aging"},{"key":"7","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1097\/00005072-200606000-00007","article-title":"Differential expression of synaptic proteins in the frontal and temporal cortex of elderly subjects with mild cognitive impairment.","volume":"6","author":"Mufson","year":"2006","journal-title":"J Neuropathol Exp Neurol"},{"key":"8","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1007\/s00401-009-0536-x","article-title":"Synaptic degeneration in Alzheimer\u2019s disease.","volume":"11","author":"Arendt","year":"2009","journal-title":"Acta Neuropathol"},{"key":"9","doi-asserted-by":"publisher","first-page":"14132","DOI":"10.1074\/jbc.M708034200","article-title":"P21-activated kinase aberrant activation and translocation in Alzheimer\u2019s disease pathogenesis.","volume":"28","author":"Cole","year":"2008","journal-title":"J Biol Chem"},{"key":"10","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1038\/nn1630","article-title":"Role of p21-activated kinase pathway defects in the cognitive deficits of Alzheimer disease.","volume":"9","author":"Cole","year":"2006","journal-title":"Nat Neurosci"},{"key":"11","doi-asserted-by":"publisher","first-page":"796","DOI":"10.1523\/JNEUROSCI.3501-06.2007","article-title":"Abeta oligomer-induced aberrations in synapse composition, shape, and density provide a molecular basis for loss of connectivity in Alzheimer\u2019s disease.","volume":"2","author":"Klein","year":"2007","journal-title":"J Neurosci"},{"key":"12","doi-asserted-by":"publisher","first-page":"10191","DOI":"10.1523\/JNEUROSCI.3432-04.2004","article-title":"Synaptic targeting by Alzheimer\u2019s-related amyloid beta oligomers.","volume":"2","author":"Klein","year":"2004","journal-title":"J Neurosci"},{"key":"13","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1146\/annurev-pathol-012615-044216","article-title":"Dendritic Spine Pathology in Neurodegenerative Diseases.","volume":"1","author":"Dorostkar","year":"2016","journal-title":"Annu Rev Pathol"},{"key":"14","doi-asserted-by":"publisher","first-page":"16045","DOI":"10.1523\/JNEUROSCI.4006-11.2011","article-title":"From synapse to nucleus and back again--communication over distance within neurons.","volume":"3","author":"Kreutz","year":"2011","journal-title":"J Neurosci"},{"key":"15","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1146\/annurev.cellbio.24.110707.175235","article-title":"Communication between the synapse and the nucleus in neuronal development, plasticity, and disease.","volume":"2","author":"Greenberg","year":"2008","journal-title":"Annu Rev Cell Dev Biol"},{"key":"16","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1152\/physiol.00042.2005","article-title":"Development and regulation of dendritic spine synapses.","volume":"2","author":"Halpain","year":"2006","journal-title":"Physiology (Bethesda)"},{"key":"17","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.mam.2015.05.005","article-title":"Neuropsychiatric symptoms in Alzheimer\u2019s disease: what might be associated brain circuits?","volume":"43","author":"Lyketsos","year":"2015","journal-title":"Mol Aspects Med"},{"key":"18","doi-asserted-by":"publisher","first-page":"1500","DOI":"10.1111\/ene.13076","article-title":"Neuroimaging correlates of neuropsychiatric symptoms in Alzheimer\u2019s disease: a review of 20\u00a0years of research.","volume":"2","author":"Krolak-Salmon","year":"2016","journal-title":"Eur J Neurol"},{"key":"19","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1196\/annals.1401.029","article-title":"Orbitofrontal cortex function and structure in depression.","volume":"112","author":"Drevets","year":"2007","journal-title":"Ann N Y Acad Sci"},{"key":"20","doi-asserted-by":"publisher","first-page":"16082","DOI":"10.1523\/JNEUROSCI.1731-10.2010","article-title":"Antidepressant effect of optogenetic stimulation of the medial prefrontal cortex.","volume":"3","author":"Nestler","year":"2010","journal-title":"J Neurosci"},{"key":"21","doi-asserted-by":"publisher","first-page":"e46111","DOI":"10.1371\/journal.pone.0046111","article-title":"Sex-dependent alterations in social behaviour and cortical synaptic activity coincide at different ages in a model of Alzheimer\u2019s disease.","volume":"7","author":"Calon","year":"2012","journal-title":"PLoS One"},{"key":"22","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1016\/S0896-6273(03)00434-3","article-title":"Triple-transgenic model of Alzheimer\u2019s disease with plaques and tangles: intracellular Abeta and synaptic dysfunction.","volume":"3","author":"LaFerla","year":"2003","journal-title":"Neuron"},{"key":"23","doi-asserted-by":"publisher","first-page":"880","DOI":"10.1016\/j.physbeh.2011.05.023","article-title":"Anomalies in social behaviors and exploratory activities in an APPswe\/PS1 mouse model of Alzheimer\u2019s disease.","volume":"10","author":"Rivest","year":"2011","journal-title":"Physiol Behav"},{"key":"24","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1016\/j.bbr.2008.09.042","article-title":"Aged Tg2576 mice are impaired on social memory and open field habituation tests.","volume":"19","author":"Rawlins","year":"2009","journal-title":"Behav Brain Res"},{"key":"25","doi-asserted-by":"publisher","first-page":"87","DOI":"10.3389\/fncel.2014.00087","article-title":"Sarm1 deficiency impairs synaptic function and leads to behavioral deficits, which can be ameliorated by an mGluR allosteric modulator.","volume":"8","author":"Hsueh","year":"2014","journal-title":"Front Cell Neurosci"},{"key":"26","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.bbr.2013.02.008","article-title":"Novel behavioural characteristics of the APP(Swe)\/PS1\u0394E9 transgenic mouse model of Alzheimer\u2019s disease.","volume":"24","author":"Karl","year":"2013","journal-title":"Behav Brain Res"},{"key":"27","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1176\/jnp.13.1.56","article-title":"Psychiatric symptoms associated with cortical-subcortical dysfunction in Alzheimer\u2019s disease.","volume":"1","author":"DeKosky","year":"2001","journal-title":"J Neuropsychiatry Clin Neurosci"},{"key":"28","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1176\/jnp.7.4.476","article-title":"The relationship between psychiatric symptoms and regional cortical metabolism in Alzheimer\u2019s disease.","volume":"7","author":"Berisford","year":"1995","journal-title":"J Neuropsychiatry Clin Neurosci"},{"key":"29","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1038\/nn.2741","article-title":"Dendritic spine pathology in neuropsychiatric disorders.","volume":"1","author":"Woolfrey","year":"2011","journal-title":"Nat Neurosci"},{"key":"30","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/S0304-3940(02)00210-0","article-title":"Drebrin, a dendritic spine protein, is manifold decreased in brains of patients with Alzheimer\u2019s disease and Down syndrome.","volume":"32","author":"Lubec","year":"2002","journal-title":"Neurosci Lett"},{"key":"31","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1146\/annurev.biochem.72.121801.161742","article-title":"Biology of the p21-activated kinases.","volume":"7","author":"Bokoch","year":"2003","journal-title":"Annu Rev Biochem"},{"key":"32","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1038\/1675","article-title":"PAK3 mutation in nonsyndromic X-linked mental retardation.","volume":"2","author":"Walsh","year":"1998","journal-title":"Nat Genet"},{"key":"33","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1002\/1096-8628(20000814)93:4<294::AID-AJMG8>3.0.CO;2-F","article-title":"Missense mutation in PAK3, R67C, causes X-linked nonspecific mental retardation.","volume":"9","author":"Bou\u00e9","year":"2000","journal-title":"Am J Med Genet"},{"key":"34","doi-asserted-by":"publisher","first-page":"10729","DOI":"10.1523\/JNEUROSCI.1501-13.2013","article-title":"PAK inactivation impairs social recognition in 3xTg-AD Mice without increasing brain deposition of tau and A\u03b2.","volume":"3","author":"Calon","year":"2013","journal-title":"J Neurosci"},{"key":"35","doi-asserted-by":"publisher","first-page":"1516","DOI":"10.1016\/j.neurobiolaging.2008.08.022","article-title":"High-fat diet aggravates amyloid-beta and tau pathologies in the 3xTg-AD mouse model.","volume":"3","author":"Calon","year":"2010","journal-title":"Neurobiol Aging"},{"key":"36","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1016\/j.neuron.2004.05.003","article-title":"Altered cortical synaptic morphology and impaired memory consolidation in forebrain- specific dominant-negative PAK transgenic mice.","volume":"4","author":"Tonegawa","year":"2004","journal-title":"Neuron"},{"key":"37","doi-asserted-by":"publisher","first-page":"11489","DOI":"10.1073\/pnas.0705003104","article-title":"Inhibition of p21-activated kinase rescues symptoms of fragile X syndrome in mice.","volume":"10","author":"Tonegawa","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"key":"38","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.neuropharm.2013.04.048","article-title":"Enhanced excitability in the infralimbic cortex produces anxiety-like behaviors.","volume":"7","author":"Gao","year":"2013","journal-title":"Neuropharmacology"},{"key":"39","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1101\/lm.1041309","article-title":"Extinction circuits for fear and addiction overlap in prefrontal cortex.","volume":"1","author":"Quirk","year":"2009","journal-title":"Learn Mem"},{"key":"40","doi-asserted-by":"publisher","first-page":"12848","DOI":"10.1523\/JNEUROSCI.2669-12.2012","article-title":"Control over stress, but not stress per se increases prefrontal cortical pyramidal neuron excitability.","volume":"3","author":"Cooper","year":"2012","journal-title":"J Neurosci"},{"key":"41","doi-asserted-by":"publisher","first-page":"1781","DOI":"10.1017\/S1461145713000163","article-title":"Involvement of prelimbic medial prefrontal cortex in panic-like elaborated defensive behaviour and innate fear-induced antinociception elicited by GABAA receptor blockade in the dorsomedial and ventromedial hypothalamic nuclei: role of the endocannabinoid CB1 receptor.","volume":"1","author":"Coimbra","year":"2013","journal-title":"Int J Neuropsychopharmacol"},{"key":"42","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1177\/0891988709332939","article-title":"Impaired social cognition in mild Alzheimer disease.","volume":"2","author":"Krolak-Salmon","year":"2009","journal-title":"J Geriatr Psychiatry Neurol"},{"key":"43","doi-asserted-by":"publisher","first-page":"S50","DOI":"10.1097\/WAD.0b013e31815c0f14","article-title":"Divergent social functioning in behavioral variant frontotemporal dementia and Alzheimer disease: reciprocal networks and neuronal evolution.","volume":"2","author":"Miller","year":"2007","journal-title":"Alzheimer Dis Assoc Disord"},{"key":"44","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1017\/S0033291712001870","article-title":"Anxiety is related to Alzheimer cerebrospinal fluid markers in subjects with mild cognitive impairment.","volume":"4","author":"Visser","year":"2013","journal-title":"Psychol Med"},{"key":"45","doi-asserted-by":"publisher","first-page":"812","DOI":"10.1038\/nn.2583","article-title":"Amyloid-beta-induced neuronal dysfunction in Alzheimer\u2019s disease: from synapses toward neural networks.","volume":"1","author":"Mucke","year":"2010","journal-title":"Nat Neurosci"},{"key":"46","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1016\/S0002-9440(10)63360-3","article-title":"Morphological characterization of Thioflavin-S-positive amyloid plaques in transgenic Alzheimer mice and effect of passive Abeta immunotherapy on their clearance.","volume":"16","author":"Buttini","year":"2004","journal-title":"Am J Pathol"},{"key":"47","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1016\/S0197-4580(00)00250-5","article-title":"Life span and synapses: will there be a primary senile dementia?","volume":"2","author":"Katzman","year":"2001","journal-title":"Neurobiol Aging"},{"key":"48","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1002\/ana.410300410","article-title":"Physical basis of cognitive alterations in Alzheimer\u2019s disease: synapse loss is the major correlate of cognitive impairment.","volume":"3","author":"Katzman","year":"1991","journal-title":"Ann Neurol"},{"key":"49","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1016\/j.neuron.2004.08.013","article-title":"Docosahexaenoic acid protects from dendritic pathology in an Alzheimer\u2019s disease mouse model.","volume":"4","author":"Cole","year":"2004","journal-title":"Neuron"},{"key":"50","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1523\/JNEUROSCI.5341-09.2010","article-title":"Many neuronal and behavioral impairments in transgenic mouse models of Alzheimer\u2019s disease are independent of caspase cleavage of the amyloid precursor protein.","volume":"3","author":"Mucke","year":"2010","journal-title":"J Neurosci"},{"key":"51","doi-asserted-by":"publisher","first-page":"768","DOI":"10.1038\/nature05289","article-title":"A network dysfunction perspective on neurodegenerative diseases.","volume":"44","author":"Mucke","year":"2006","journal-title":"Nature"},{"key":"52","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1016\/j.neuron.2007.07.025","article-title":"Aberrant excitatory neuronal activity and compensatory remodeling of inhibitory hippocampal circuits in mouse models of Alzheimer\u2019s disease.","volume":"5","author":"Mucke","year":"2007","journal-title":"Neuron"},{"key":"53","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.bbr.2014.08.030","article-title":"Pathogenic tau species drive a psychosis-like phenotype in a mouse model of Alzheimer\u2019s disease.","volume":"27","author":"Davies","year":"2014","journal-title":"Behav Brain Res"},{"key":"54","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1186\/2051-5960-2-14","article-title":"Neuron-to-neuron wild-type Tau protein transfer through a trans-synaptic mechanism: relevance to sporadic tauopathies.","volume":"2","author":"Bu\u00e9e","year":"2014","journal-title":"Acta Neuropathol Commun"},{"key":"55","doi-asserted-by":"publisher","first-page":"2798","DOI":"10.1016\/j.neurobiolaging.2012.01.015","article-title":"Tau phosphorylation in human brain: relationship to behavioral disturbance in dementia.","volume":"3","author":"Francis","year":"2012","journal-title":"Neurobiol Aging"},{"key":"56","doi-asserted-by":"publisher","first-page":"377","DOI":"10.3233\/JAD-2007-12411","article-title":"Biochemical characterization of Abeta and tau pathologies in mild cognitive impairment and Alzheimer\u2019s disease.","volume":"1","author":"Calon","year":"2007","journal-title":"J Alzheimers Dis"},{"key":"57","doi-asserted-by":"publisher","first-page":"e15477","DOI":"10.1371\/journal.pone.0015477","article-title":"Multiple events lead to dendritic spine loss in triple transgenic Alzheimer\u2019s disease mice.","volume":"5","author":"Herms","year":"2010","journal-title":"PLoS One"},{"key":"58","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1007\/s00429-010-0244-2","article-title":"Dendritic vulnerability in neurodegenerative disease: insights from analyses of cortical pyramidal neurons in transgenic mouse models.","volume":"21","author":"Hof","year":"2010","journal-title":"Brain Struct Funct"},{"key":"59","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1007\/s00401-007-0312-8","article-title":"Alzheimer disease models and human neuropathology: similarities and differences.","volume":"11","author":"Delatour","year":"2008","journal-title":"Acta Neuropathol"},{"key":"60","doi-asserted-by":"publisher","first-page":"1781","DOI":"10.1098\/rstb.1997.0162","article-title":"Changes in the ageing brain in health and disease.","volume":"35","author":"Anderton","year":"1997","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"key":"61","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1016\/S0301-0082(98)00022-7","article-title":"Dendritic changes in Alzheimer\u2019s disease and factors that may underlie these changes.","volume":"5","author":"Weaver","year":"1998","journal-title":"Prog Neurobiol"},{"key":"62","doi-asserted-by":"publisher","first-page":"10810","DOI":"10.1523\/JNEUROSCI.3269-07.2007","article-title":"Paradoxical upregulation of glutamatergic presynaptic boutons during mild cognitive impairment.","volume":"2","author":"Cuello","year":"2007","journal-title":"J Neurosci"},{"key":"63","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/j.neulet.2003.09.027","article-title":"Structural involvement of the glutamatergic presynaptic boutons in a transgenic mouse model expressing early onset amyloid pathology.","volume":"35","author":"Cuello","year":"2003","journal-title":"Neurosci Lett"},{"key":"64","doi-asserted-by":"publisher","first-page":"3699","DOI":"10.1093\/brain\/awq258","article-title":"Concerted changes in transcripts in the prefrontal cortex precede neuropathology in Alzheimer\u2019s disease.","volume":"13","author":"Swaab","year":"2010","journal-title":"Brain"},{"key":"65","doi-asserted-by":"publisher","first-page":"139","DOI":"10.3233\/JAD-2008-15112","article-title":"Differential changes in synaptic proteins in the Alzheimer frontal cortex with marked increase in PSD-95 postsynaptic protein.","volume":"1","author":"Riederer","year":"2008","journal-title":"J Alzheimers Dis"},{"key":"66","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1016\/S0002-9440(10)64573-7","article-title":"Staging of cytoskeletal and beta-amyloid changes in human isocortex reveals biphasic synaptic protein response during progression of Alzheimer\u2019s disease.","volume":"15","author":"Wischik","year":"2000","journal-title":"Am J Pathol"},{"key":"67","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1016\/j.tins.2010.05.004","article-title":"\u2018Too much good news\u2019 - are Alzheimer mouse models trying to tell us how to prevent, not cure, Alzheimer\u2019s disease?","volume":"3","author":"Ashe","year":"2010","journal-title":"Trends Neurosci"},{"key":"68","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1007\/s12035-008-8018-z","article-title":"Dendritic spine loss and synaptic alterations in Alzheimer\u2019s disease.","volume":"3","author":"Mansuy","year":"2008","journal-title":"Mol Neurobiol"},{"key":"69","doi-asserted-by":"publisher","first-page":"7831","DOI":"10.1523\/JNEUROSCI.0839-11.2011","article-title":"Evidence for reduced experience-dependent dendritic spine plasticity in the aging prefrontal cortex.","volume":"3","author":"Morrison","year":"2011","journal-title":"J Neurosci"},{"key":"70","first-page":"453","article-title":"Quantitative study on dendrites and dendritic spines in Alzheimer\u2019s disease and senile dementia.","volume":"1","author":"Tarnowska-Dziduszko","year":"1975","journal-title":"Adv Neurol"},{"key":"71","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1007\/s10571-011-9691-4","article-title":"A\u03b2 oligomer-induced synapse degeneration in Alzheimer\u2019s disease.","volume":"3","author":"Klein","year":"2011","journal-title":"Cell Mol Neurobiol"},{"key":"72","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/0304-3940(90)90420-E","article-title":"Neuronal alterations in patients with dementia: a Golgi study on biopsy samples.","volume":"11","author":"Tu\u00f1\u00f3n","year":"1990","journal-title":"Neurosci Lett"},{"key":"73","doi-asserted-by":"publisher","first-page":"S15","DOI":"10.1002\/gps.934","article-title":"Glutamatergic systems in Alzheimer\u2019s disease.","volume":"1","author":"Francis","year":"2003","journal-title":"Int J Geriatr Psychiatry"},{"key":"74","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1002\/ana.410270502","article-title":"Synapse loss in frontal cortex biopsies in Alzheimer\u2019s disease: correlation with cognitive severity.","volume":"2","author":"Scheff","year":"1990","journal-title":"Ann Neurol"},{"key":"75","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/0197-4580(90)90059-9","article-title":"Quantitative assessment of cortical synaptic density in Alzheimer\u2019s disease.","volume":"1","author":"Price","year":"1990","journal-title":"Neurobiol Aging"},{"key":"76","doi-asserted-by":"publisher","first-page":"1029","DOI":"10.1016\/j.neurobiolaging.2003.08.002","article-title":"Synaptic pathology in Alzheimer\u2019s disease: a review of ultrastructural studies.","volume":"2","author":"Price","year":"2003","journal-title":"Neurobiol Aging"},{"key":"77","doi-asserted-by":"publisher","first-page":"101","DOI":"10.3233\/JAD-2006-9S312","article-title":"Alzheimer\u2019s disease-related alterations in synaptic density: neocortex and hippocampus.","volume":"9","author":"Price","year":"2006","journal-title":"J Alzheimers Dis"},{"key":"78","doi-asserted-by":"publisher","first-page":"1372","DOI":"10.1016\/j.neurobiolaging.2005.09.012","article-title":"Hippocampal synaptic loss in early Alzheimer\u2019s disease and mild cognitive impairment.","volume":"2","author":"Mufson","year":"2006","journal-title":"Neurobiol Aging"},{"key":"79","first-page":"439","article-title":"GABAergic function in Alzheimer\u2019s disease: evidence for dysfunction and potential as a therapeutic target for the treatment of behavioural and psychological symptoms of dementia.","volume":"4","author":"Ingber","year":"2004","journal-title":"Can J Psychiatry"},{"key":"80","doi-asserted-by":"publisher","first-page":"10071","DOI":"10.1073\/pnas.1204606109","article-title":"Loss of functional GABA(A) receptors in the Alzheimer diseased brain.","volume":"10","author":"Miledi","year":"2012","journal-title":"Proc Natl Acad Sci USA"},{"key":"81","doi-asserted-by":"publisher","first-page":"886","DOI":"10.1038\/nm.3639","article-title":"GABA from reactive astrocytes impairs memory in mouse models of Alzheimer\u2019s disease.","volume":"2","author":"Hong","year":"2014","journal-title":"Nat Med"},{"key":"82","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1002\/jnr.490430111","article-title":"Disappearance of actin-binding protein, drebrin, from hippocampal synapses in Alzheimer\u2019s disease.","volume":"4","author":"Hirai","year":"1996","journal-title":"J Neurosci Res"},{"key":"83","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1097\/00019442-200506000-00004","article-title":"A cross-sectional study of neuropsychiatric symptoms in 435 patients with Alzheimer\u2019s disease.","volume":"1","author":"Passmore","year":"2005","journal-title":"Am J Geriatr Psychiatry"},{"key":"84","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1212\/WNL.46.1.130","article-title":"The spectrum of behavioral changes in Alzheimer\u2019s disease.","volume":"4","author":"Gornbein","year":"1996","journal-title":"Neurology"},{"key":"85","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1016\/j.bbr.2012.07.004","article-title":"Cognitive and non-cognitive behaviors in the triple transgenic mouse model of Alzheimer\u2019s disease expressing mutated APP, PS1, and Mapt (3xTg-AD).","volume":"23","author":"Planel","year":"2012","journal-title":"Behav Brain Res"},{"key":"86","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1111\/j.1601-183X.2008.00453.x","article-title":"Cognitive and non-cognitive behaviors in an APPswe\/PS1 bigenic model of Alzheimer\u2019s disease.","volume":"8","author":"Rivest","year":"2009","journal-title":"Genes Brain Behav"},{"key":"87","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2011.09.012","article-title":"Early development of social deficits in APP and APP-PS1 mice.","volume":"3","author":"Cho","year":"2012","journal-title":"Neurobiol Aging"},{"key":"88","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.neubiorev.2006.07.007","article-title":"Modeling behavioral and neuronal symptoms of Alzheimer\u2019s disease in mice: a role for intraneuronal amyloid.","volume":"3","author":"Fern\u00e1ndez-Teruel","year":"2007","journal-title":"Neurosci Biobehav Rev"},{"key":"89","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.brainres.2010.06.011","article-title":"Characterization of the 3xTg-AD mouse model of Alzheimer\u2019s disease: part 2. Behavioral and cognitive changes.","volume":"134","author":"Dyck","year":"2010","journal-title":"Brain Res"},{"key":"90","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1093\/cercor\/11.5.441","article-title":"Fast spiking and regular spiking neural correlates of fear conditioning in the medial prefrontal cortex of the rat.","volume":"1","author":"Jung","year":"2001","journal-title":"Cereb Cortex"},{"key":"91","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1016\/S0304-3940(00)01765-1","article-title":"Haloperidol and clozapine increase neural activity in the rat prefrontal cortex.","volume":"29","author":"Chung","year":"2001","journal-title":"Neurosci Lett"},{"key":"92","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1002\/da.22014","article-title":"Aberrant amygdala-frontal cortex connectivity during perception of fearful faces and at rest in generalized social anxiety disorder.","volume":"3","author":"Phan","year":"2013","journal-title":"Depress Anxiety"},{"key":"93","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/j.bbr.2008.11.047","article-title":"Decreased anxiety-like behavior and locomotor\/exploratory activity, and modulation in hypothalamus, hippocampus, and frontal cortex redox profile in sexually receptive female rats after short-term exposure to male chemical cues.","volume":"19","author":"Moreira","year":"2009","journal-title":"Behav Brain Res"},{"key":"94","doi-asserted-by":"publisher","first-page":"1063","DOI":"10.1016\/j.neurobiolaging.2003.08.012","article-title":"Amyloid deposition precedes tangle formation in a triple transgenic model of Alzheimer\u2019s disease.","volume":"2","author":"LaFerla","year":"2003","journal-title":"Neurobiol Aging"},{"key":"95","doi-asserted-by":"publisher","first-page":"e17397","DOI":"10.1371\/journal.pone.0017397","article-title":"DHA improves cognition and prevents dysfunction of entorhinal cortex neurons in 3xTg-AD mice.","volume":"6","author":"Calon","year":"2011","journal-title":"PLoS One"},{"key":"96","doi-asserted-by":"publisher","first-page":"1344","DOI":"10.1523\/JNEUROSCI.3258-12.2013","article-title":"Differential balance of prefrontal synaptic activity in successful versus unsuccessful cognitive aging.","volume":"3","author":"De Koninck","year":"2013","journal-title":"J Neurosci"},{"key":"97","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1016\/j.biopsych.2004.08.024","article-title":"Anxiety-like state associates with taste to produce conditioned taste aversion.","volume":"5","author":"Dudai","year":"2004","journal-title":"Biol Psychiatry"},{"key":"98","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1186\/1742-2094-11-54","article-title":"IVIg protects the 3xTg-AD mouse model of Alzheimer\u2019s disease from memory deficit and A\u03b2 pathology.","volume":"1","author":"Calon","year":"2014","journal-title":"J Neuroinflammation"},{"key":"99","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.bbr.2003.07.002","article-title":"Decreased social interaction in aged rats may not reflect changes in anxiety-related behaviour.","volume":"15","author":"Singewald","year":"2004","journal-title":"Behav Brain Res"}],"container-title":["Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.101239","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,2]],"date-time":"2020-09-02T16:40:15Z","timestamp":1599064815000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.101239"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5,16]]},"references-count":99,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,5,31]]}},"alternative-id":["101239","28522792"],"URL":"https:\/\/doi.org\/10.18632\/aging.101239","relation":{},"ISSN":["1945-4589"],"issn-type":[{"value":"1945-4589","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,5,16]]}}}