{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T20:23:16Z","timestamp":1792095796628,"version":"4.4.0"},"reference-count":29,"publisher":"Impact Journals, LLC","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aging"],"published-print":{"date-parts":[[2017,6,28]]},"DOI":"10.18632\/aging.101255","type":"journal-article","created":{"date-parts":[[2017,6,28]],"date-time":"2017-06-28T22:08:17Z","timestamp":1498687697000},"page":"1595-1606","source":"Crossref","is-referenced-by-count":54,"title":["Pressor response to angiotensin II is enhanced in aged mice and associated with inflammation, vasoconstriction and oxidative stress"],"prefix":"10.18632","volume":"9","author":[{"given":"Quynh Nhu","family":"Dinh","sequence":"first","affiliation":[{"name":"Cardiovascular Disease Program, Biomedicine Discovery Institute, Department of Pharmacology, Monash University, Victoria, Australia"},{"name":"Current affiliation: Department of Physiology, Anatomy and Microbiology, School of Life Sciences, La Trobe University, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grant R.","family":"Drummond","sequence":"additional","affiliation":[{"name":"Cardiovascular Disease Program, Biomedicine Discovery Institute, Department of Pharmacology, Monash University, Victoria, Australia"},{"name":"Department of Surgery, Monash Medical Centre, Southern Clinical School, Monash University, Victoria, Australia"},{"name":"Current affiliation: Department of Physiology, Anatomy and Microbiology, School of Life Sciences, La Trobe University, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara K.","family":"Kemp-Harper","sequence":"additional","affiliation":[{"name":"Cardiovascular Disease Program, Biomedicine Discovery Institute, Department of Pharmacology, Monash University, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry","family":"Diep","sequence":"additional","affiliation":[{"name":"Cardiovascular Disease Program, Biomedicine Discovery Institute, Department of Pharmacology, Monash University, Victoria, Australia"},{"name":"Department of Surgery, Monash Medical Centre, Southern Clinical School, Monash University, Victoria, Australia"},{"name":"Current affiliation: Department of Physiology, Anatomy and Microbiology, School of Life Sciences, La Trobe University, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. Michael","family":"De Silva","sequence":"additional","affiliation":[{"name":"Cardiovascular Disease Program, Biomedicine Discovery Institute, Department of Pharmacology, Monash University, Victoria, Australia"},{"name":"Current affiliation: Department of Physiology, Anatomy and Microbiology, School of Life Sciences, La Trobe University, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun Ah","family":"Kim","sequence":"additional","affiliation":[{"name":"Cardiovascular Disease Program, Biomedicine Discovery Institute, Department of Pharmacology, Monash University, Victoria, Australia"},{"name":"Current affiliation: Department of Physiology, Anatomy and Microbiology, School of Life Sciences, La Trobe University, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antony","family":"Vinh","sequence":"additional","affiliation":[{"name":"Cardiovascular Disease Program, Biomedicine Discovery Institute, Department of Pharmacology, Monash University, Victoria, Australia"},{"name":"Department of Surgery, Monash Medical Centre, Southern Clinical School, Monash University, Victoria, Australia"},{"name":"Current affiliation: Department of Physiology, Anatomy and Microbiology, School of Life Sciences, La Trobe University, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avril A.B.","family":"Robertson","sequence":"additional","affiliation":[{"name":"The Institute for Molecular Bioscience, The University of Queensland, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew A.","family":"Cooper","sequence":"additional","affiliation":[{"name":"The Institute for Molecular Bioscience, The University of Queensland, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley","family":"Mansell","sequence":"additional","affiliation":[{"name":"Hudson Institute of Medical Research, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophocles","family":"Chrissobolis","sequence":"additional","affiliation":[{"name":"Cardiovascular Disease Program, Biomedicine Discovery Institute, Department of Pharmacology, Monash University, Victoria, Australia"},{"name":"Current affiliation: Department of Pharmaceutical and Biomedical Sciences, Raabe College of Pharmacy, Ohio Northern University, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher G.","family":"Sobey","sequence":"additional","affiliation":[{"name":"Cardiovascular Disease Program, Biomedicine Discovery Institute, Department of Pharmacology, Monash University, Victoria, Australia"},{"name":"Department of Surgery, Monash Medical Centre, Southern Clinical School, Monash University, Victoria, Australia"},{"name":"Current affiliation: Department of Physiology, Anatomy and Microbiology, School of Life Sciences, La Trobe University, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7892","published-online":{"date-parts":[[2017,6,28]]},"reference":[{"key":"1","doi-asserted-by":"publisher","first-page":"814","DOI":"10.1161\/01.HYP.35.3.814","article-title":"Prevalence, treatment, and control of hypertension by sociodemographic factors among the Dutch elderly.","volume":"3","author":"Grobbee","year":"2000","journal-title":"Hypertension"},{"key":"2","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.phrs.2016.12.032","article-title":"Advanced atherosclerosis is associated with inflammation, vascular dysfunction and oxidative stress, but not hypertension.","volume":"11","author":"Sobey","year":"2017","journal-title":"Pharmacol Res"},{"key":"3","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1186\/s13293-014-0013-7","article-title":"Pressor responsiveness to angiotensin II in female mice is enhanced with age: role of the angiotensin type 2 receptor.","volume":"5","author":"Denton","year":"2014","journal-title":"Biol Sex Differ"},{"key":"4","doi-asserted-by":"publisher","first-page":"406960","DOI":"10.1155\/2014\/406960","article-title":"Roles of inflammation, oxidative stress, and vascular dysfunction in hypertension.","volume":"201","author":"Chrissobolis","year":"2014","journal-title":"BioMed Res Int"},{"key":"5","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1161\/HYPERTENSIONAHA.115.05779","article-title":"Obligatory role for B cells in the development of Angiotensin II-dependent hypertension.","volume":"6","author":"Samuel","year":"2015","journal-title":"Hypertension"},{"key":"6","doi-asserted-by":"publisher","first-page":"5589","DOI":"10.1111\/bph.12876","article-title":"IL-1\u03b2 and IL-18: inflammatory markers or mediators of hypertension?","volume":"17","author":"Drummond","year":"2014","journal-title":"Br J Pharmacol"},{"key":"7","doi-asserted-by":"publisher","first-page":"752","DOI":"10.1111\/bph.13230","article-title":"Inflammasome activity is essential for one kidney\/deoxycorticosterone acetate\/salt-induced hypertension in mice.","volume":"17","author":"Kemp-Harper","year":"2016","journal-title":"Br J Pharmacol"},{"key":"8","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1093\/gerona\/glv078","article-title":"The expression changes of inflammasomes in the aging rat kidneys.","volume":"7","author":"Chen","year":"2016","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"9","doi-asserted-by":"publisher","first-page":"2860","DOI":"10.1097\/01.ASN.0000035087.11758.ED","article-title":"A mouse model of angiotensin II slow pressor response: role of oxidative stress.","volume":"1","author":"Wilcox","year":"2002","journal-title":"J Am Soc Nephrol"},{"key":"10","doi-asserted-by":"publisher","first-page":"1089","DOI":"10.1161\/01.RES.0000101912.01071.FF","article-title":"AT1b receptor predominantly mediates contractions in major mouse blood vessels.","volume":"9","author":"Periasamy","year":"2003","journal-title":"Circ Res"},{"key":"11","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.tcm.2006.11.002","article-title":"AT(1) receptors and control of blood pressure: the kidney and more.....","volume":"1","author":"Coffman","year":"2007","journal-title":"Trends Cardiovasc Med"},{"key":"12","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/S0008-6363(99)00183-2","article-title":"Angiotensin II-induced superoxide anion generation in human vascular endothelial cells: role of membrane-bound NADH-\/NADPH-oxidases.","volume":"4","author":"Daniel","year":"1999","journal-title":"Cardiovasc Res"},{"key":"13","doi-asserted-by":"publisher","first-page":"809","DOI":"10.1038\/sj.bjp.0705448","article-title":"Angiotensin AT2 receptors: cardiovascular hope or hype?","volume":"14","author":"Gaspari","year":"2003","journal-title":"Br J Pharmacol"},{"key":"14","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1161\/01.HYP.34.4.659","article-title":"Activation of AT(2) receptors by endogenous angiotensin II is involved in flow-induced dilation in rat resistance arteries.","volume":"3","author":"Henrion","year":"1999","journal-title":"Hypertension"},{"key":"15","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.1097\/01.hjh.0000166845.49850.39","article-title":"Negative regulation of RhoA\/Rho kinase by angiotensin II type 2 receptor in vascular smooth muscle cells: role in angiotensin II-induced vasodilation in stroke-prone spontaneously hypertensive rats.","volume":"2","author":"Touyz","year":"2005","journal-title":"J Hypertens"},{"key":"16","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1007\/s10522-011-9345-4","article-title":"Mechanism of attenuation of pro-inflammatory Ang II-induced NF-\u03baB activation by genistein in the kidneys of male rats during aging.","volume":"1","author":"Chung","year":"2011","journal-title":"Biogerontology"},{"key":"17","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1016\/j.yjmcc.2004.12.015","article-title":"IL-1beta and TNF-alpha upregulate angiotensin II type 1 (AT1) receptors on cardiac fibroblasts and are associated with increased AT1 density in the post-MI heart.","volume":"3","author":"Greenberg","year":"2005","journal-title":"J Mol Cell Cardiol"},{"key":"18","doi-asserted-by":"publisher","first-page":"748","DOI":"10.1038\/377748a0","article-title":"Effects on blood pressure and exploratory behaviour of mice lacking angiotensin II type-2 receptor.","volume":"37","author":"Inagami","year":"1995","journal-title":"Nature"},{"key":"19","doi-asserted-by":"publisher","first-page":"6731093","DOI":"10.1155\/2016\/6731093","article-title":"Age-associated changes in the vascular renin-angiotensin system in mice.","volume":"201","author":"Choi","year":"2016","journal-title":"Oxid Med Cell Longev"},{"key":"20","doi-asserted-by":"publisher","first-page":"R18","DOI":"10.1152\/ajpregu.00327.2006","article-title":"An integrated view of oxidative stress in aging: basic mechanisms, functional effects, and pathological considerations.","volume":"29","author":"Zhang","year":"2007","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"21","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1111\/j.1474-9726.2011.00783.x","article-title":"Superoxide-lowering therapy with TEMPOL reverses arterial dysfunction with aging in mice.","volume":"1","author":"Sindler","year":"2012","journal-title":"Aging Cell"},{"key":"22","doi-asserted-by":"publisher","first-page":"925","DOI":"10.1172\/JCI7886","article-title":"Angiotensin II type 2 receptor overexpression activates the vascular kinin system and causes vasodilation.","volume":"10","author":"Mori","year":"1999","journal-title":"J Clin Invest"},{"key":"23","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/j.lfs.2014.02.027","article-title":"Endothelin-1 but not angiotensin II contributes to functional aging in murine carotid arteries.","volume":"11","author":"Prossnitz","year":"2014","journal-title":"Life Sci"},{"key":"24","doi-asserted-by":"publisher","first-page":"3521","DOI":"10.1073\/pnas.92.8.3521","article-title":"Regulation of blood pressure by the type 1A angiotensin II receptor gene.","volume":"9","author":"Coffman","year":"1995","journal-title":"Proc Natl Acad Sci USA"},{"key":"25","doi-asserted-by":"publisher","first-page":"S4","DOI":"10.1093\/gerona\/glu057","article-title":"Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases.","volume":"6","author":"Campisi","year":"2014","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"26","doi-asserted-by":"publisher","first-page":"609","DOI":"10.2174\/138161210790883840","article-title":"Age-related inflammation: the contribution of different organs, tissues and systems. How to face it for therapeutic approaches.","volume":"1","author":"Pini","year":"2010","journal-title":"Curr Pharm Des"},{"key":"27","first-page":"248","article-title":"A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases.","volume":"2","author":"Haneklaus","year":"2015","journal-title":"Nat Med"},{"key":"28","doi-asserted-by":"crossref","first-page":"27","DOI":"10.2147\/PROM.S8384","article-title":"Angiotensin II type 1 receptor antagonists in the treatment of hypertension in elderly patients: focus on patient outcomes.","volume":"2","author":"Karamyan","year":"2011","journal-title":"Patient Relat Outcome Meas"},{"key":"29","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1038\/nprot.2008.73","article-title":"Analyzing real-time PCR data by the comparative C(T) method.","volume":"3","author":"Livak","year":"2008","journal-title":"Nat Protoc"}],"container-title":["Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.101255","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,2]],"date-time":"2020-09-02T16:42:02Z","timestamp":1599064922000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.101255"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,28]]},"references-count":29,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,6,30]]}},"alternative-id":["101255","28659507"],"URL":"https:\/\/doi.org\/10.18632\/aging.101255","relation":{},"ISSN":["1945-4589"],"issn-type":[{"value":"1945-4589","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,28]]}}}