{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T11:54:02Z","timestamp":1778759642572,"version":"3.51.4"},"reference-count":50,"publisher":"Impact Journals, LLC","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aging"],"published-print":{"date-parts":[[2018,5,22]]},"DOI":"10.18632\/aging.101449","type":"journal-article","created":{"date-parts":[[2018,5,22]],"date-time":"2018-05-22T22:55:05Z","timestamp":1527029705000},"page":"1089-1102","source":"Crossref","is-referenced-by-count":26,"title":["Repeated superovulation increases the risk of osteoporosis and cardiovascular diseases by accelerating ovarian aging in mice"],"prefix":"10.18632","volume":"10","author":[{"given":"Jinjin","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiwen","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People\u2019s Republic of China"},{"name":"Maternal and Child Health Hospital of Zigong, Sichuan, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liangyan","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Hubei Maternity and Child Health Care Hospital, Wuhan, Hubei, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Tian","sequence":"additional","affiliation":[{"name":"The Central Hospital of Enshi Autonomous Prefecture, Enshi Autonomous Prefecture, Hubei, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aiyue","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zheyuan","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangyi","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shixuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7892","published-online":{"date-parts":[[2018,5,22]]},"reference":[{"key":"1","doi-asserted-by":"publisher","first-page":"831","DOI":"10.2217\/WHE.10.67","article-title":"Ovarian stimulation: is there a long-term risk for ovarian, breast and endometrial cancer?","volume":"6","author":"Lunenfeld","year":"2010","journal-title":"Womens Health (Lond)"},{"key":"2","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1055\/s-0032-1307415","article-title":"Consequences of superovulation and ART procedures.","volume":"3","author":"Grifo","year":"2012","journal-title":"Semin Reprod Med"},{"key":"3","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1196\/annals.1338.016","article-title":"Repeated ovarian stimulations induce oxidative damage and mitochondrial DNA mutations in mouse ovaries.","volume":"104","author":"Kao","year":"2005","journal-title":"Ann N Y Acad Sci"},{"key":"4","doi-asserted-by":"publisher","first-page":"1237","DOI":"10.1093\/humrep\/16.6.1237","article-title":"Superovulation of female mice delays embryonic and fetal development.","volume":"1","author":"D\u2019Hooghe","year":"2001","journal-title":"Hum Reprod"},{"key":"5","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1093\/humrep\/16.4.757","article-title":"Differential effects of repeated ovarian stimulation on cytoplasmic and spindle organization in metaphase II mouse oocytes matured in vivo and in vitro.","volume":"1","author":"Davis","year":"2001","journal-title":"Hum Reprod"},{"key":"6","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1007\/BF01555198","article-title":"Response to repetitive cycles of ovulation induction in the same women.","volume":"4","author":"Wentz","year":"1987","journal-title":"J In Vitro Fert Embryo Transf"},{"key":"7","doi-asserted-by":"publisher","first-page":"2320","DOI":"10.1093\/humrep\/16.11.2320","article-title":"The effect of repeated controlled ovarian stimulation in donors.","volume":"1","author":"Remoh\u00ed","year":"2001","journal-title":"Hum Reprod"},{"key":"8","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1016\/j.fertnstert.2004.09.016","article-title":"Ovulation induction and cancer risk.","volume":"8","author":"Lamb","year":"2005","journal-title":"Fertil Steril"},{"key":"9","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/j.maturitas.2011.05.017","article-title":"A woman\u2019s journey through the reproductive, transitional and postmenopausal periods of life: impact on cardiovascular and musculo-skeletal risk and the role of estrogen replacement.","volume":"7","author":"Stevenson","year":"2011","journal-title":"Maturitas"},{"key":"10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/ar.1090980102","article-title":"Development of mouse eggs in the anterior chamber of the eye.","volume":"9","author":"Runner","year":"1947","journal-title":"Anat Rec"},{"key":"11","doi-asserted-by":"publisher","first-page":"S13","DOI":"10.1016\/j.fertnstert.2008.08.031","article-title":"Gonadotropin preparations: past, present, and future perspectives.","volume":"9","author":"Practice Committee of American Society for Reproductive Medicine, Birmingham, Alabama","year":"2008","journal-title":"Fertil Steril"},{"key":"12","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1152\/ajplegacy.1931.97.2.291","article-title":"The gonad-stimulating and the luteinizing hormones of the anterior lobes of the hypophysis.","volume":"9","author":"Leonard","year":"1931","journal-title":"Am J Physiol"},{"key":"13","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1538\/expanim.44.111","article-title":"Efficient induction of superovulation in adult rats by PMSG and hCG.","volume":"4","author":"Ishikawa","year":"1995","journal-title":"Exp Anim"},{"key":"14","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1677\/joe.0.0150374","article-title":"Induction of superovulation and pregnancy in mature mice by gonadotrophins.","volume":"1","author":"Edwards","year":"1957","journal-title":"J Endocrinol"},{"key":"15","doi-asserted-by":"publisher","first-page":"2654","DOI":"10.1001\/jama.2015.17296","article-title":"Live-birth rate associated with repeatfertilization treatment cycles.","volume":"31","author":"Lawlor","year":"2015","journal-title":"JAMA"},{"key":"16","doi-asserted-by":"publisher","first-page":"1329","DOI":"10.1016\/j.fertnstert.2008.03.010","article-title":"Is there a limit for the number of in vitro fertilization cycles for an individual patient?","volume":"9","author":"Orvieto","year":"2009","journal-title":"Fertil Steril"},{"key":"17","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1586\/14779072.2016.1150782","article-title":"Advances in understanding gender difference in cardiometabolic disease risk.","volume":"1","author":"Kaya","year":"2016","journal-title":"Expert Rev Cardiovasc Ther"},{"key":"18","doi-asserted-by":"publisher","first-page":"3885","DOI":"10.2174\/1381612822666160414142426","article-title":"Hypertension and ischemic heart disease in women.","volume":"2","author":"Cenko","year":"2016","journal-title":"Curr Pharm Des"},{"key":"19","doi-asserted-by":"publisher","first-page":"e0121810","DOI":"10.1371\/journal.pone.0121810","article-title":"Sex-specific effects of cardiovascular risk factors on endothelium-dependent dilation and endothelin activity in middle-aged women and men.","volume":"1","author":"Campia","year":"2015","journal-title":"PLoS One"},{"key":"20","doi-asserted-by":"publisher","first-page":"246","DOI":"10.3109\/14647273.2011.608464","article-title":"Anti-Mullerian Hormone (AMH) levels in serum and follicular fluid as predictors of ovarian response in stimulated (IVF and ICSI) cycles.","volume":"1","author":"Loufopoulos","year":"2011","journal-title":"Hum Fertil (Camb)"},{"key":"21","unstructured":"Steiner AZ. (2013). Biomarkers of Ovarian Reserve as Predictors of Reproductive Potential. Seminars in reproductive medicine: Thieme Medical Publishers), pp. 437-442."},{"key":"22","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1093\/humupd\/dml034","article-title":"A systematic review of tests predicting ovarian reserve and IVF outcome.","volume":"1","author":"Lambalk","year":"2006","journal-title":"Hum Reprod Update"},{"key":"23","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1093\/humrep\/deg042","article-title":"Serum anti-M\u00fcllerian hormone is more strongly related to ovarian follicular status than serum inhibin B, estradiol, FSH and LH on day 3.","volume":"1","author":"Taieb","year":"2003","journal-title":"Hum Reprod"},{"key":"24","doi-asserted-by":"publisher","first-page":"3065","DOI":"10.1093\/humrep\/17.12.3065","article-title":"Serum anti-M\u00fcllerian hormone levels: a novel measure of ovarian reserve.","volume":"1","author":"Themmen","year":"2002","journal-title":"Hum Reprod"},{"key":"25","first-page":"226","article-title":"[Anti-M\u00fcllerian hormone - a marker of ovarian function].","volume":"13","author":"Tapanainen","year":"2016","journal-title":"Duodecim"},{"key":"26","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.tem.2007.01.004","article-title":"Female reproductive ageing: current knowledge and future trends.","volume":"1","author":"Fauser","year":"2007","journal-title":"Trends Endocrinol Metab"},{"key":"27","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1002\/path.2108","article-title":"Reproductive ageing in women.","volume":"21","author":"Zosmer","year":"2007","journal-title":"J Pathol"},{"key":"28","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1095\/biolreprod.110.088583","article-title":"Oxidative damage increases and antioxidant gene expression decreases with aging in the mouse ovary.","volume":"8","author":"Luderer","year":"2011","journal-title":"Biol Reprod"},{"key":"29","doi-asserted-by":"publisher","first-page":"E258","DOI":"10.1210\/jc.2012-3037","article-title":"The role of pigment epithelium-derived factor in the pathophysiology and treatment of ovarian hyperstimulation syndrome in mice.","volume":"9","author":"Shalgi","year":"2013","journal-title":"J Clin Endocrinol Metab"},{"key":"30","doi-asserted-by":"publisher","first-page":"1796","DOI":"10.1093\/humrep\/deq136","article-title":"Ovarian follicle loss in humans and mice: lessons from statistical model comparison.","volume":"2","author":"Hawkes","year":"2010","journal-title":"Hum Reprod"},{"key":"31","doi-asserted-by":"publisher","first-page":"1673","DOI":"10.1210\/jc.2011-3032","article-title":"Anti-mullerian hormone as a predictor of time to menopause in late reproductive age women.","volume":"9","author":"Gracia","year":"2012","journal-title":"J Clin Endocrinol Metab"},{"key":"32","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1016\/j.freeradbiomed.2010.05.025","article-title":"Effect of oxidative stress during repeated ovulation on the structure and functions of the ovary, oocytes, and their mitochondria.","volume":"4","author":"Inoue","year":"2010","journal-title":"Free Radic Biol Med"},{"key":"33","doi-asserted-by":"publisher","first-page":"945","DOI":"10.1071\/RD11212","article-title":"Impaired mitochondrial function in murine oocytes is associated with controlled ovarian hyperstimulation and in vitro maturation.","volume":"2","author":"Dong","year":"2012","journal-title":"Reprod Fertil Dev"},{"key":"34","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1089\/152308603770310202","article-title":"The free radical theory of aging.","volume":"5","author":"Harman","year":"2003","journal-title":"Antioxid Redox Signal"},{"key":"35","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1159\/000086899","article-title":"Biological aging and the etiology of aneuploidy.","volume":"11","author":"Warburton","year":"2005","journal-title":"Cytogenet Genome Res"},{"key":"36","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1080\/cmt.4.4.267.272","article-title":"Executive summary: Stages of Reproductive Aging Workshop (STRAW).","volume":"4","author":"Woods","year":"2001","journal-title":"Climacteric"},{"key":"37","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1095\/biolreprod32.3.515","article-title":"Effect of dietary restriction on estrous cyclicity and follicular reserves in aging C57BL\/6J mice.","volume":"3","author":"Felicio","year":"1985","journal-title":"Biol Reprod"},{"key":"38","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1097\/gme.0b013e31815982cf","article-title":"Luteal phase estrogen is decreased in regularly menstruating older women compared with a reference population of younger women.","volume":"1","author":"Cedars","year":"2008","journal-title":"Menopause"},{"key":"39","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1093\/oxfordjournals.humrep.a136796","article-title":"The effect of age on the cyclical patterns of plasma LH, FSH, oestradiol and progesterone in women with regular menstrual cycles.","volume":"3","author":"Cooke","year":"1988","journal-title":"Hum Reprod"},{"key":"40","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1093\/humrep\/15.3.549","article-title":"Serum concentrations of dimeric inhibins, activin A, gonadotrophins and ovarian steroids during the menstrual cycle in older women.","volume":"1","author":"Ledger","year":"2000","journal-title":"Hum Reprod"},{"key":"41","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1530\/jrf.0.1020245","article-title":"Differences in blood flow to uterine segments and placentae in relation to sex, intrauterine location and side in pregnant rats.","volume":"10","author":"vom Saal","year":"1994","journal-title":"J Reprod Fertil"},{"key":"42","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1007\/BF02913324","article-title":"Effect of supplementation of vitamin C and E on oxidative stress in osteoporosis.","volume":"2","author":"Sontakke","year":"2007","journal-title":"Indian J Clin Biochem"},{"key":"43","doi-asserted-by":"publisher","first-page":"706905","DOI":"10.1155\/2012\/706905","article-title":"The anti-inflammatory, phytoestrogenic, and antioxidative role of Labisia pumila in prevention of postmenopausal osteoporosis.","volume":"201","author":"Ima Nirwana","year":"2012","journal-title":"Adv Pharmacol Sci"},{"key":"44","doi-asserted-by":"publisher","first-page":"28","DOI":"10.3390\/molecules16010028","article-title":"Anti-fatigue activity of extracts of stem bark from Acanthopanax senticosus.","volume":"1","author":"Liu","year":"2010","journal-title":"Molecules"},{"key":"45","first-page":"213","article-title":"Effects of L-malate on physical stamina and activities of enzymes related to the malate-aspartate shuttle in liver of mice.","volume":"5","author":"Tan","year":"2007","journal-title":"Physiol Res"},{"key":"46","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1002\/jemt.20303","article-title":"Oocyte-follicle cell interactions during ovarian follicle development, as seen by high resolution scanning and transmission electron microscopy in humans.","volume":"6","author":"Stallone","year":"2006","journal-title":"Microsc Res Tech"},{"key":"47","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1186\/1477-7827-1-11","article-title":"Ovarian follicle counts--not as simple as 1, 2, 3.","volume":"1","author":"Tilly","year":"2003","journal-title":"Reprod Biol Endocrinol"},{"key":"48","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1095\/biolreprod.113.107730","article-title":"Expression patterns and regulatory functions of microRNAs during the initiation of primordial follicle development in the neonatal mouse ovary.","volume":"8","author":"Tian","year":"2013","journal-title":"Biol Reprod"},{"key":"49","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/S0304-4165(02)00192-7","article-title":"Evaluation of progesterone receptor expression in eosinophils using real-time quantitative PCR.","volume":"157","author":"Vandekerckhove","year":"2002","journal-title":"Biochim Biophys Acta"},{"key":"50","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1016\/j.ultrasmedbio.2007.11.001","article-title":"Cardiovascular assessment of fetal mice by in utero echocardiography.","volume":"3","author":"Lo","year":"2008","journal-title":"Ultrasound Med Biol"}],"container-title":["Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.101449","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,2]],"date-time":"2020-09-02T18:05:34Z","timestamp":1599069934000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.101449"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,22]]},"references-count":50,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,5,31]]}},"alternative-id":["101449","29787998"],"URL":"https:\/\/doi.org\/10.18632\/aging.101449","relation":{},"ISSN":["1945-4589"],"issn-type":[{"value":"1945-4589","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5,22]]}}}