{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T13:50:45Z","timestamp":1768917045609,"version":"3.49.0"},"reference-count":43,"publisher":"Impact Journals, LLC","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aging"],"published-print":{"date-parts":[[2019,2,6]]},"DOI":"10.18632\/aging.101790","type":"journal-article","created":{"date-parts":[[2019,2,7]],"date-time":"2019-02-07T05:16:29Z","timestamp":1549516589000},"page":"908-920","source":"Crossref","is-referenced-by-count":16,"title":["Genetical modification on adipose-derived stem cells facilitates facial nerve regeneration"],"prefix":"10.18632","volume":"11","author":[{"given":"Jian","family":"Tan","sequence":"first","affiliation":[{"name":"Department of Plastic Surgery, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yipin","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinhai","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, China"},{"name":"Department of Facial Plastic and Reconstructive Surgery, Eye and ENT Hospital of Fudan University, Shanghai 200031, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7892","published-online":{"date-parts":[[2019,2,6]]},"reference":[{"key":"1","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1016\/j.otc.2013.07.001","article-title":"Traumatic facial nerve injury.","volume":"4","author":"Boahene","year":"2013","journal-title":"Otolaryngol Clin North Am"},{"key":"2","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1097\/MOO.0000000000000292","article-title":"Current state of stem cell-mediated therapies for facial nerve injury.","volume":"2","author":"Pepper","year":"2016","journal-title":"Curr Opin Otolaryngol Head Neck Surg"},{"key":"3","first-page":"996","article-title":"Stem cells and related factors involved in facial nerve function regeneration.","volume":"6","author":"Gerber","year":"2015","journal-title":"Postepy Hig Med Dosw (Online)"},{"key":"4","doi-asserted-by":"publisher","first-page":"1552","DOI":"10.1002\/glia.20761","article-title":"Negative regulation of myelination: relevance for development, injury, and demyelinating disease.","volume":"5","author":"Mirsky","year":"2008","journal-title":"Glia"},{"key":"5","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1159\/000369336","article-title":"Adipose-derived stem cells for nerve repair: hype or reality?","volume":"20","author":"Wiberg","year":"2014","journal-title":"Cells Tissues Organs"},{"key":"6","doi-asserted-by":"publisher","first-page":"23803","DOI":"10.18632\/oncotarget.15866","article-title":"Adipose-derived mesenchymal stem cells promote osteosarcoma proliferation and metastasis by activating the STAT3 pathway.","volume":"8","author":"Chen","year":"2017","journal-title":"Oncotarget"},{"key":"7","doi-asserted-by":"publisher","first-page":"74537","DOI":"10.18632\/oncotarget.12902","article-title":"Intravenous administration of xenogenic adipose-derived mesenchymal stem cells (ADMSC) and ADMSC-derived exosomes markedly reduced brain infarct volume and preserved neurological function in rat after acute ischemic stroke.","volume":"7","author":"Yip","year":"2016","journal-title":"Oncotarget"},{"key":"8","doi-asserted-by":"publisher","first-page":"36829","DOI":"10.18632\/oncotarget.9208","article-title":"GDNF secreted from adipose-derived stem cells stimulates VEGF-independent angiogenesis.","volume":"7","author":"Du","year":"2016","journal-title":"Oncotarget"},{"key":"9","doi-asserted-by":"publisher","first-page":"389","DOI":"10.14573\/altex.2012.4.389","article-title":"Development, validation and testing of a human tissue engineered hypertrophic scar model.","volume":"2","author":"Gibbs","year":"2012","journal-title":"ALTEX"},{"key":"10","doi-asserted-by":"publisher","first-page":"1143","DOI":"10.1002\/lary.25667","article-title":"Comparison of ASCs and BMSCs combined with atelocollagen for vocal fold scar regeneration.","volume":"12","author":"Ito","year":"2016","journal-title":"Laryngoscope"},{"key":"11","doi-asserted-by":"publisher","first-page":"9010279","DOI":"10.1155\/2016\/9010279","article-title":"Adipose-Derived Mesenchymal Stem Cells in the Regeneration of Vocal Folds: A Study on a Chronic Vocal Fold Scar.","volume":"201","author":"Apostolos","year":"2016","journal-title":"Stem Cells Int"},{"key":"12","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1111\/j.1524-475X.2009.00501.x","article-title":"Collagen cross-linking by adipose-derived mesenchymal stromal cells and scar-derived mesenchymal cells: are mesenchymal stromal cells involved in scar formation?","volume":"1","author":"Ulrich","year":"2009","journal-title":"Wound Repair Regen"},{"key":"13","doi-asserted-by":"publisher","first-page":"e109856","DOI":"10.1371\/journal.pone.0109856","article-title":"Non-genetic direct reprogramming and biomimetic platforms in a preliminary study for adipose-derived stem cells into corneal endothelia-like cells.","volume":"9","author":"Chen","year":"2014","journal-title":"PLoS One"},{"key":"14","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1007\/s00266-014-0354-y","article-title":"Inhibition of oxygen-glucose deprivation-induced apoptosis of human adipose-derived stem cells by genetic modification with antiapoptotic protein bcl-2.","volume":"3","author":"Tan","year":"2014","journal-title":"Aesthetic Plast Surg"},{"key":"15","doi-asserted-by":"publisher","first-page":"6015","DOI":"10.1016\/j.biomaterials.2014.04.055","article-title":"The epigenetic promotion of osteogenic differentiation of human adipose-derived stem cells by the genetic and chemical blockade of histone demethylase LSD1.","volume":"3","author":"Zhou","year":"2014","journal-title":"Biomaterials"},{"key":"16","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.jdermsci.2012.02.010","article-title":"Genetic modification of human adipose-derived stem cells for promoting wound healing.","volume":"6","author":"Cha","year":"2012","journal-title":"J Dermatol Sci"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.27922","article-title":"Adipose-derived stem cells for wound healing.","author":"Xian","year":"2018","journal-title":"J Cell Physiol"},{"key":"18","doi-asserted-by":"publisher","first-page":"1406","DOI":"10.1089\/scd.2017.0304","article-title":"Adipose-derived mesenchymal stem cells: a new tool for the treatment of renal fibrosis.","volume":"2","author":"Sun","year":"2018","journal-title":"Stem Cells Dev"},{"key":"19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1017\/S1462399403005817","article-title":"Skin repair and scar formation: the central role of TGF-beta.","volume":"5","author":"Ting","year":"2003","journal-title":"Expert Rev Mol Med"},{"key":"20","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/j.tibtech.2007.12.007","article-title":"Novel therapies for scar reduction and regenerative healing of skin wounds.","volume":"2","author":"Gourdie","year":"2008","journal-title":"Trends Biotechnol"},{"key":"21","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/j.placenta.2008.12.007","article-title":"Connective tissue and related disorders and preterm birth: clues to genes contributing to prematurity.","volume":"3","author":"Strauss","year":"2009","journal-title":"Placenta"},{"key":"22","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1159\/000430385","article-title":"Loureirin B inhibits hypertrophic scar formation via inhibition of the TGF-beta1-ERK\/JNK pathway.","volume":"3","author":"Hu","year":"2015","journal-title":"Cell Physiol Biochem"},{"key":"23","doi-asserted-by":"publisher","first-page":"4","DOI":"10.7554\/eLife.05005","article-title":"Predicting effective microRNA target sites in mammalian mRNAs.","volume":"4","author":"Bartel","year":"2015","journal-title":"eLife"},{"key":"24","doi-asserted-by":"publisher","first-page":"288","DOI":"10.4252\/wjsc.v6.i3.288","article-title":"Osteogenic potential: comparison between bone marrow and adipose-derived mesenchymal stem cells.","volume":"6","author":"Chen","year":"2014","journal-title":"World J Stem Cells"},{"key":"25","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1111\/dgd.12049","article-title":"Adipose-derived mesenchymal stem cells and regenerative medicine.","volume":"5","author":"Kawamoto","year":"2013","journal-title":"Dev Growth Differ"},{"key":"26","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1016\/j.tibtech.2006.01.010","article-title":"Fat tissue: an underappreciated source of stem cells for biotechnology.","volume":"2","author":"Hedrick","year":"2006","journal-title":"Trends Biotechnol"},{"key":"27","doi-asserted-by":"publisher","first-page":"1294","DOI":"10.1634\/stemcells.2005-0342","article-title":"Comparative analysis of mesenchymal stem cells from bone marrow, umbilical cord blood, or adipose tissue.","volume":"2","author":"Bieback","year":"2006","journal-title":"Stem Cells"},{"key":"28","doi-asserted-by":"publisher","first-page":"375","DOI":"10.14348\/molcells.2016.0013","article-title":"MicroRNA target recognition: insights from transcriptome-wide non-canonical interactions.","volume":"3","author":"Chi","year":"2016","journal-title":"Mol Cells"},{"key":"29","doi-asserted-by":"publisher","first-page":"12472","DOI":"10.18632\/oncotarget.13957","article-title":"The crosstalk between lncRNA and microRNA in cancer metastasis: orchestrating the epithelial-mesenchymal plasticity.","volume":"8","author":"Liang","year":"2017","journal-title":"Oncotarget"},{"key":"30","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1016\/j.stem.2009.04.007","article-title":"MicroRNA-124: micromanager of neurogenesis.","volume":"4","author":"Kosik","year":"2009","journal-title":"Cell Stem Cell"},{"key":"31","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/j.stem.2008.01.016","article-title":"MicroRNA regulation of cell lineages in mouse and human embryonic stem cells.","volume":"2","author":"Srivastava","year":"2008","journal-title":"Cell Stem Cell"},{"key":"32","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/j.stem.2008.02.008","article-title":"MicroRNA regulation of stem cell fate.","volume":"2","author":"Gregory","year":"2008","journal-title":"Cell Stem Cell"},{"key":"33","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1038\/ncb2241","article-title":"Control of vertebrate multiciliogenesis by miR-449 through direct repression of the Delta\/Notch pathway.","volume":"1","author":"Birembaut","year":"2011","journal-title":"Nat Cell Biol"},{"key":"34","doi-asserted-by":"publisher","first-page":"213","DOI":"10.4161\/cc.9.2.10502","article-title":"miR-449 regulates CDK-Rb-E2F1 through an auto-regulatory feedback circuit.","volume":"9","author":"Yu","year":"2010","journal-title":"Cell Cycle"},{"key":"35","doi-asserted-by":"publisher","first-page":"1629","DOI":"10.3892\/ijo.2016.3659","article-title":"miR-449 overexpression inhibits papillary thyroid carcinoma cell growth by targeting RET kinase-\u03b2-catenin signaling pathway.","volume":"4","author":"Ma","year":"2016","journal-title":"Int J Oncol"},{"key":"36","doi-asserted-by":"publisher","first-page":"54","DOI":"10.5966\/sctm.2013-0081","article-title":"Sox2 suppression by miR-21 governs human mesenchymal stem cell properties.","volume":"3","author":"Roubelakis","year":"2014","journal-title":"Stem Cells Transl Med"},{"key":"37","doi-asserted-by":"publisher","first-page":"42840","DOI":"10.1038\/srep42840","article-title":"Effects of miR-146a on the osteogenesis of adipose-derived mesenchymal stem cells and bone regeneration.","volume":"7","author":"Fan","year":"2017","journal-title":"Sci Rep"},{"key":"38","doi-asserted-by":"publisher","first-page":"1160","DOI":"10.1038\/s41598-017-01294-2","article-title":"miR-301b~miR-130b-PPAR\u03b3 axis underlies the adipogenic capacity of mesenchymal stem cells with different tissue origins.","volume":"7","author":"Zhang","year":"2017","journal-title":"Sci Rep"},{"key":"39","doi-asserted-by":"publisher","first-page":"16567","DOI":"10.18632\/oncotarget.7767","article-title":"miR-155-5p inhibition promotes the transition of bone marrow mesenchymal stem cells to gastric cancer tissue derived MSC-like cells via NF-\u03baB p65 activation.","volume":"7","author":"Xu","year":"2016","journal-title":"Oncotarget"},{"key":"40","doi-asserted-by":"publisher","first-page":"29161","DOI":"10.18632\/oncotarget.16254","article-title":"Bone marrow-derived mesenchymal stem cells overexpressing MiR-21 efficiently repair myocardial damage in rats.","volume":"8","author":"Chen","year":"2017","journal-title":"Oncotarget"},{"key":"41","doi-asserted-by":"publisher","first-page":"7","DOI":"10.18632\/oncotarget.6589","article-title":"miR-195 in human primary mesenchymal stromal\/stem cells regulates proliferation, osteogenesis and paracrine effect on angiogenesis.","volume":"7","author":"Barbosa","year":"2016","journal-title":"Oncotarget"},{"key":"42","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1159\/000457013","article-title":"MiR-125b regulates the osteogenic differentiation of human mesenchymal stem cells by targeting BMPR1b.","volume":"4","author":"Dong","year":"2017","journal-title":"Cell Physiol Biochem"},{"key":"43","doi-asserted-by":"publisher","first-page":"780","DOI":"10.1159\/000478069","article-title":"MiR-495 promotes senescence of mesenchymal stem cells by targeting Bmi-1.","volume":"4","author":"Zhao","year":"2017","journal-title":"Cell Physiol Biochem"}],"container-title":["Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.101790","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,2]],"date-time":"2020-09-02T18:26:00Z","timestamp":1599071160000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.101790"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2,6]]},"references-count":43,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,2,15]]}},"alternative-id":["101790","30728320"],"URL":"https:\/\/doi.org\/10.18632\/aging.101790","relation":{},"ISSN":["1945-4589"],"issn-type":[{"value":"1945-4589","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,2,6]]}}}