{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T15:23:54Z","timestamp":1790177034820,"version":"4.1.0"},"reference-count":32,"publisher":"Impact Journals, LLC","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aging"],"published-print":{"date-parts":[[2019,4,19]]},"DOI":"10.18632\/aging.101905","type":"journal-article","created":{"date-parts":[[2019,4,19]],"date-time":"2019-04-19T18:05:41Z","timestamp":1555697141000},"page":"2202-2216","source":"Crossref","is-referenced-by-count":73,"title":["Doxycycline, Azithromycin and Vitamin C (DAV): A potent combination therapy for targeting mitochondria and eradicating cancer stem cells (CSCs)"],"prefix":"10.18632","volume":"11","author":[{"given":"Marco","family":"Fiorillo","sequence":"first","affiliation":[{"name":"Translational Medicine, School of Environment and Life Sciences, Biomedical Research Centre (BRC), University of Salford, Greater Manchester, M5 4WT, United Kingdom"},{"name":"The Department of Pharmacy, Health and Nutritional Sciences, The University of Calabria, Cosenza, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanni","family":"T\u00f3th","sequence":"additional","affiliation":[{"name":"Translational Medicine, School of Environment and Life Sciences, Biomedical Research Centre (BRC), University of Salford, Greater Manchester, M5 4WT, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Sotgia","sequence":"additional","affiliation":[{"name":"Translational Medicine, School of Environment and Life Sciences, Biomedical Research Centre (BRC), University of Salford, Greater Manchester, M5 4WT, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael P.","family":"Lisanti","sequence":"additional","affiliation":[{"name":"Translational Medicine, School of Environment and Life Sciences, Biomedical Research Centre (BRC), University of Salford, Greater Manchester, M5 4WT, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7892","published-online":{"date-parts":[[2019,4,19]]},"reference":[{"key":"1","doi-asserted-by":"publisher","first-page":"4569","DOI":"10.18632\/oncotarget.3174","article-title":"Antibiotics that target mitochondria effectively eradicate cancer stem cells, across multiple tumor types: treating cancer like an infectious disease.","volume":"6","author":"Lisanti","year":"2015","journal-title":"Oncotarget"},{"key":"2","doi-asserted-by":"publisher","first-page":"14005","DOI":"10.18632\/oncotarget.4159","article-title":"Doxycycline down-regulates DNA-PK and radiosensitizes tumor initiating cells: implications for more effective radiation therapy.","volume":"6","author":"Lisanti","year":"2015","journal-title":"Oncotarget"},{"key":"3","doi-asserted-by":"publisher","first-page":"56126","DOI":"10.18632\/oncotarget.18445","article-title":"Targeting hypoxic cancer stem cells (CSCs) with Doxycycline: implications for optimizing anti-angiogenic therapy.","volume":"8","author":"Lisanti","year":"2017","journal-title":"Oncotarget"},{"key":"4","doi-asserted-by":"publisher","first-page":"2091","DOI":"10.1080\/15384101.2018.1515551","article-title":"A mitochondrial based oncology platform for targeting cancer stem cells (CSCs): MITO-ONC-RX.","volume":"1","author":"Lisanti","year":"2018","journal-title":"Cell Cycle"},{"key":"5","doi-asserted-by":"publisher","first-page":"452","DOI":"10.3389\/fonc.2018.00452","article-title":"Doxycycline, an Inhibitor of Mitochondrial Biogenesis, Effectively Reduces Cancer Stem Cells (CSCs) in Early Breast Cancer Patients: A Clinical Pilot Study.","volume":"8","author":"Naccarato","year":"2018","journal-title":"Front Oncol"},{"key":"6","doi-asserted-by":"publisher","first-page":"20667","DOI":"10.18632\/oncotarget.15400","article-title":"NADH autofluorescence, a new metabolic biomarker for cancer stem cells: identification of Vitamin C and CAPE as natural products targeting \u201cstemness\u201d.","volume":"8","author":"Lisanti","year":"2017","journal-title":"Oncotarget"},{"key":"7","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1002\/iub.1124","article-title":"Sodium-dependent transport of ascorbic acid in U937 cell mitochondria.","volume":"6","author":"Cantoni","year":"2013","journal-title":"IUBMB Life"},{"key":"8","doi-asserted-by":"publisher","first-page":"1686","DOI":"10.3390\/ijms18081686","article-title":"Intramitochondrial Ascorbic Acid Enhances the Formation of Mitochondrial Superoxide Induced by Peroxynitrite via a Ca-Independent Mechanism.","volume":"1","author":"Cantoni","year":"2017","journal-title":"Int J Mol Sci"},{"key":"9","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1016\/j.freeradbiomed.2014.02.021","article-title":"Mitochondrial ascorbic acid transport is mediated by a low-affinity form of the sodium-coupled ascorbic acid transporter-2.","volume":"7","author":"Rivas","year":"2014","journal-title":"Free Radic Biol Med"},{"key":"10","doi-asserted-by":"publisher","first-page":"1502","DOI":"10.1089\/ars.2017.7253","article-title":"Mitochondrial Uptake and Accumulation of Vitamin C: What Can We Learn from Cell Culture Studies?","volume":"2","author":"Fiorani","year":"2018","journal-title":"Antioxid Redox Signal"},{"key":"11","doi-asserted-by":"publisher","first-page":"58","DOI":"10.3389\/fmolb.2018.00058","article-title":"Characterization of a Novel Mitochondrial Ascorbate Transporter From Rat Liver and Potato Mitochondria.","volume":"5","author":"Tonazzi","year":"2018","journal-title":"Front Mol Biosci"},{"key":"12","doi-asserted-by":"publisher","first-page":"11029","DOI":"10.18632\/oncotarget.2789","article-title":"Mitochondria as new therapeutic targets for eradicating cancer stem cells: quantitative proteomics and functional validation via MCT1\/2 inhibition.","volume":"5","author":"Sotgia","year":"2014","journal-title":"Oncotarget"},{"key":"13","doi-asserted-by":"publisher","first-page":"30472","DOI":"10.18632\/oncotarget.5401","article-title":"High mitochondrial mass identifies a sub-population of stem-like cancer cells that are chemo-resistant.","volume":"6","author":"Lisanti","year":"2015","journal-title":"Oncotarget"},{"key":"14","doi-asserted-by":"publisher","first-page":"14777","DOI":"10.18632\/oncotarget.4401","article-title":"Mitochondrial biogenesis is required for the anchorage-independent survival and propagation of stem-like cancer cells.","volume":"6","author":"Sotgia","year":"2015","journal-title":"Oncotarget"},{"key":"15","doi-asserted-by":"publisher","first-page":"677","DOI":"10.3389\/fonc.2018.00677","article-title":"\u201cEnergetic\u201d Cancer Stem Cells (e-CSCs): A New Hyper-Metabolic and Proliferative Tumor Cell Phenotype, Driven by Mitochondrial Energy.","volume":"8","author":"Lisanti","year":"2019","journal-title":"Front Oncol"},{"key":"16","first-page":"351","article-title":"Effects of vitamin C on myocardial mitochondrial function and ATP content in hypoxic rats.","volume":"1","author":"Zhang","year":"1998","journal-title":"Zhongguo Yao Li Xue Bao"},{"key":"17","doi-asserted-by":"publisher","first-page":"1147S","DOI":"10.1093\/ajcn\/54.6.1147s","article-title":"Ascorbic acid and carnitine biosynthesis.","volume":"5","author":"Rebouche","year":"1991","journal-title":"Am J Clin Nutr"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2018.08.032","article-title":"Feeding mitochondria: potential role of nutritional components to improve critical illness convalescence.","author":"van Zanten","year":"2018","journal-title":"Clin Nutr"},{"key":"19","doi-asserted-by":"publisher","first-page":"2059","DOI":"10.4161\/cc.10.13.16233","article-title":"Accelerated aging in the tumor microenvironment: connecting aging, inflammation and cancer metabolism with personalized medicine.","volume":"1","author":"Sotgia","year":"2011","journal-title":"Cell Cycle"},{"key":"20","doi-asserted-by":"publisher","first-page":"253","DOI":"10.4161\/cc.11.2.19006","article-title":"Is cancer a metabolic rebellion against host aging? In the quest for immortality, tumor cells try to save themselves by boosting mitochondrial metabolism.","volume":"1","author":"Lisanti","year":"2012","journal-title":"Cell Cycle"},{"key":"21","doi-asserted-by":"publisher","first-page":"3294","DOI":"10.18632\/aging.101633","article-title":"Azithromycin and Roxithromycin define a new family of \u201csenolytic\u201d drugs that target senescent human fibroblasts.","volume":"1","author":"Lisanti","year":"2018","journal-title":"Aging (Albany NY)"},{"key":"22","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1038\/nrclinonc.2016.60","article-title":"Cancer metabolism: a therapeutic perspective.","volume":"1","author":"Lisanti","year":"2017","journal-title":"Nat Rev Clin Oncol"},{"key":"23","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1038\/nrc3915","article-title":"Caveolae and signalling in cancer.","volume":"1","author":"Lisanti","year":"2015","journal-title":"Nat Rev Cancer"},{"key":"24","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1053\/j.seminoncol.2014.03.002","article-title":"Tumor microenvironment and metabolic synergy in breast cancers: critical importance of mitochondrial fuels and function.","volume":"4","author":"Lisanti","year":"2014","journal-title":"Semin Oncol"},{"key":"25","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.semcancer.2014.01.005","article-title":"Catabolic cancer-associated fibroblasts transfer energy and biomass to anabolic cancer cells, fueling tumor growth.","volume":"2","author":"Sotgia","year":"2014","journal-title":"Semin Cancer Biol"},{"key":"26","doi-asserted-by":"publisher","first-page":"1445","DOI":"10.4161\/cc.19841","article-title":"Mitochondrial metabolism in cancer metastasis: visualizing tumor cell mitochondria and the \u201creverse Warburg effect\u201d in positive lymph node tissue.","volume":"1","author":"Lisanti","year":"2012","journal-title":"Cell Cycle"},{"key":"27","doi-asserted-by":"publisher","first-page":"2412","DOI":"10.4161\/cc.9.12.11989","article-title":"Glycolytic cancer associated fibroblasts promote breast cancer tumor growth, without a measurable increase in angiogenesis: evidence for stromal-epithelial metabolic coupling.","volume":"9","author":"Lisanti","year":"2010","journal-title":"Cell Cycle"},{"key":"28","doi-asserted-by":"publisher","first-page":"3984","DOI":"10.4161\/cc.8.23.10238","article-title":"The reverse Warburg effect: aerobic glycolysis in cancer associated fibroblasts and the tumor stroma.","volume":"8","author":"Lisanti","year":"2009","journal-title":"Cell Cycle"},{"key":"29","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1182\/blood-2015-12-688051","article-title":"Metabolic reprogramming of bone marrow stromal cells by leukemic extracellular vesicles in acute lymphoblastic leukemia.","volume":"12","author":"Saha","year":"2016","journal-title":"Blood"},{"key":"30","doi-asserted-by":"publisher","first-page":"34084","DOI":"10.18632\/oncotarget.9122","article-title":"Repurposing atovaquone: targeting mitochondrial complex III and OXPHOS to eradicate cancer stem cells.","volume":"7","author":"Lisanti","year":"2016","journal-title":"Oncotarget"},{"key":"31","doi-asserted-by":"publisher","first-page":"1593","DOI":"10.18632\/aging.100983","article-title":"Bedaquiline, an FDA-approved antibiotic, inhibits mitochondrial function and potently blocks the proliferative expansion of stem-like cancer cells (CSCs).","volume":"8","author":"Lisanti","year":"2016","journal-title":"Aging (Albany NY)"},{"key":"32","doi-asserted-by":"publisher","first-page":"3553","DOI":"10.18632\/oncotarget.3348","article-title":"Graphene oxide selectively targets cancer stem cells, across multiple tumor types: implications for non-toxic cancer treatment, via \u201cdifferentiation-based nano-therapy\u201d.","volume":"6","author":"Lisanti","year":"2015","journal-title":"Oncotarget"}],"container-title":["Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.101905","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,2]],"date-time":"2020-09-02T18:40:23Z","timestamp":1599072023000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.101905"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,19]]},"references-count":32,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2019,4,30]]}},"alternative-id":["101905","31002656"],"URL":"https:\/\/doi.org\/10.18632\/aging.101905","relation":{},"ISSN":["1945-4589"],"issn-type":[{"value":"1945-4589","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4,19]]}}}