{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T19:19:49Z","timestamp":1777835989918,"version":"3.51.4"},"reference-count":55,"publisher":"Impact Journals, LLC","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aging"],"published-print":{"date-parts":[[2019,5,10]]},"DOI":"10.18632\/aging.101954","type":"journal-article","created":{"date-parts":[[2019,5,10]],"date-time":"2019-05-10T21:37:06Z","timestamp":1557524226000},"page":"2822-2835","source":"Crossref","is-referenced-by-count":70,"title":["Phloretin protects against cardiac damage and remodeling via restoring SIRT1 and anti-inflammatory effects in the streptozotocin-induced diabetic mouse model"],"prefix":"10.18632","volume":"11","author":[{"given":"Yin","family":"Ying","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Tongde Hospital of Zhejiang Province, Hangzho, Zhejiang 310012, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Tongde Hospital of Zhejiang Province, Hangzho, Zhejiang 310012, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meiling","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Tongde Hospital of Zhejiang Province, Hangzho, Zhejiang 310012, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiye","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation, Tongde Hospital of Zhejiang Province, Hangzho, Zhejiang 310012, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuyu","family":"Ge","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Tongde Hospital of Zhejiang Province, Hangzho, Zhejiang 310012, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaodong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, Tongde Hospital of Zhejiang Province, Hangzho, Zhejiang 310012, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7892","published-online":{"date-parts":[[2019,5,10]]},"reference":[{"key":"1","doi-asserted-by":"publisher","first-page":"3193","DOI":"10.1007\/s00018-018-2857-1","article-title":"Histones and heart failure in diabetes.","volume":"7","author":"Advani","year":"2018","journal-title":"Cell Mol Life Sci"},{"key":"2","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1038\/nrendo.2015.216","article-title":"Insulin resistance and hyperinsulinaemia in diabetic cardiomyopathy.","volume":"1","author":"Sowers","year":"2016","journal-title":"Nat Rev Endocrinol"},{"key":"3","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1111\/j.1752-8062.2011.00318.x","article-title":"Expression of Neuropeptide Y, Substance P, and their receptors in the right atrium of diabetic patients.","volume":"4","author":"Pradhan","year":"2011","journal-title":"Clin Transl Sci"},{"key":"4","doi-asserted-by":"publisher","first-page":"3417306","DOI":"10.1155\/2017\/3417306","article-title":"Quercetin Improves Glucose and Lipid Metabolism of Diabetic Rats: Involvement of Akt Signaling and SIRT1.","volume":"201","author":"Xie","year":"2017","journal-title":"J Diabetes Res"},{"key":"5","doi-asserted-by":"publisher","first-page":"29","DOI":"10.20517\/2394-5079.2018.18","article-title":"Understanding the inflammation-cancer transformation in the development of primary liver cancer.","volume":"4","author":"Xia","year":"2018","journal-title":"Hepatoma Res"},{"key":"6","doi-asserted-by":"publisher","first-page":"2583","DOI":"10.1093\/eurheartj\/ehq332","article-title":"Flavanols and cardiovascular disease prevention.","volume":"3","author":"Kelm","year":"2010","journal-title":"Eur Heart J"},{"key":"7","doi-asserted-by":"publisher","first-page":"2553","DOI":"10.1111\/jcmm.13176","article-title":"Phloretin attenuates hyperuricemia-induced endothelial dysfunction through co-inhibiting inflammation and GLUT9-mediated uric acid uptake.","volume":"2","author":"Liu","year":"2017","journal-title":"J Cell Mol Med"},{"key":"8","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1016\/j.jbior.2016.09.007","article-title":"Epigenetic regulation of pro-inflammatory cytokine secretion by sphingosine 1-phosphate (S1P) in acute lung injury: role of S1P lyase.","volume":"6","author":"Natarajan","year":"2017","journal-title":"Adv Biol Regul"},{"key":"9","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/j.intimp.2015.01.019","article-title":"Docosahexaenoic acid ester of phloridzin inhibit lipopolysaccharide-induced inflammation in THP-1 differentiated macrophages.","volume":"2","author":"Rupasinghe","year":"2015","journal-title":"Int Immunopharmacol"},{"key":"10","doi-asserted-by":"publisher","first-page":"997","DOI":"10.1039\/c3fo60548e","article-title":"Immunomodulation of phloretin by impairing dendritic cell activation and function.","volume":"5","author":"Huang","year":"2014","journal-title":"Food Funct"},{"key":"11","doi-asserted-by":"publisher","first-page":"972","DOI":"10.1016\/j.foodchem.2012.03.002","article-title":"Evaluation of the anti-inflammatory effects of phloretin and phlorizin in lipopolysaccharide-stimulated mouse macrophages.","volume":"13","author":"Liou","year":"2012","journal-title":"Food Chem"},{"key":"12","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.ceb.2014.09.004","article-title":"AMPK: positive and negative regulation, and its role in whole-body energy homeostasis.","volume":"3","author":"Hardie","year":"2015","journal-title":"Curr Opin Cell Biol"},{"key":"13","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1016\/j.foodchem.2013.02.105","article-title":"The interaction of sesamol with DNA and cytotoxicity, apoptosis, and localization in HepG2 cells.","volume":"14","author":"Liu","year":"2013","journal-title":"Food Chem"},{"key":"14","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.1007\/s00125-014-3197-9","article-title":"miR-195 regulates SIRT1-mediated changes in diabetic retinopathy.","volume":"5","author":"Chakrabarti","year":"2014","journal-title":"Diabetologia"},{"key":"15","doi-asserted-by":"publisher","first-page":"1146","DOI":"10.1080\/15548627.2015.1051295","article-title":"Autophagic adaptations in diabetic cardiomyopathy differ between type 1 and type 2 diabetes.","volume":"1","author":"Minatoguchi","year":"2015","journal-title":"Autophagy"},{"key":"16","doi-asserted-by":"publisher","first-page":"745","DOI":"10.2337\/db17-0996","article-title":"Sirt1: A Guardian of the Development of Diabetic Retinopathy.","volume":"6","author":"Kowluru","year":"2018","journal-title":"Diabetes"},{"key":"17","doi-asserted-by":"publisher","first-page":"4623","DOI":"10.1091\/mbc.e05-01-0033","article-title":"Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins.","volume":"1","author":"Horikawa","year":"2005","journal-title":"Mol Biol Cell"},{"key":"18","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1186\/s13148-016-0224-3","article-title":"Sirtuin functions and modulation: from chemistry to the clinic.","volume":"8","author":"Altucci","year":"2016","journal-title":"Clin Epigenetics"},{"key":"19","doi-asserted-by":"publisher","first-page":"156","DOI":"10.2174\/157489008786263989","article-title":"A review of Sirt1 and Sirt1 modulators in cardiovascular and metabolic diseases.","volume":"3","author":"Pillarisetti","year":"2008","journal-title":"Recent Pat Cardiovasc Drug Discov"},{"key":"20","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1016\/j.tips.2018.02.010","article-title":"Emerging Actors in Diabetic Cardiomyopathy: Heartbreaker Biomarkers or Therapeutic Targets?","volume":"3","author":"V\u00e1zquez-Carrera","year":"2018","journal-title":"Trends Pharmacol Sci"},{"key":"21","doi-asserted-by":"publisher","first-page":"1821359","DOI":"10.1155\/2018\/1821359","article-title":"Recovery of Cardiac Remodeling and Dysmetabolism by Pancreatic Islet Injury Improvement in Diabetic Rats after Yacon Leaf Extract Treatment.","volume":"201","author":"Corr\u00eaa","year":"2018","journal-title":"Oxid Med Cell Longev"},{"key":"22","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1007\/s12020-018-1688-z","article-title":"LncRNAs and miRs as epigenetic signatures in diabetic cardiac fibrosis: new advances and perspectives.","volume":"6","author":"Li","year":"2018","journal-title":"Endocrine"},{"key":"23","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.toxlet.2017.07.212","article-title":"Inhibition of high glucose-induced inflammation and fibrosis by a novel curcumin derivative prevents renal and heart injury in diabetic mice.","volume":"27","author":"Liang","year":"2017","journal-title":"Toxicol Lett"},{"key":"24","doi-asserted-by":"publisher","first-page":"977","DOI":"10.1016\/j.jacc.2010.10.024","article-title":"Diastolic tissue Doppler indexes correlate with the degree of collagen expression and cross-linking in heart failure and normal ejection fraction.","volume":"5","author":"Tsch\u00f6pe","year":"2011","journal-title":"J Am Coll Cardiol"},{"key":"25","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1016\/j.molimm.2018.05.028","article-title":"Erythropoietin alleviates hyperglycaemia-associated inflammation by regulating macrophage polarization via the JAK2\/STAT3 signalling pathway.","volume":"10","author":"Yu","year":"2018","journal-title":"Mol Immunol"},{"key":"26","doi-asserted-by":"publisher","first-page":"3160","DOI":"10.1016\/j.ijcard.2013.07.150","article-title":"An overview of the crosstalk between inflammatory processes and metabolic dysregulation during diabetic cardiomyopathy.","volume":"16","author":"V\u00e1zquez-Carrera","year":"2013","journal-title":"Int J Cardiol"},{"key":"27","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/j.taap.2015.07.009","article-title":"Attenuation of inflammatory response by a novel chalcone protects kidney and heart from hyperglycemia-induced injuries in type 1 diabetic mice.","volume":"28","author":"Zheng","year":"2015","journal-title":"Toxicol Appl Pharmacol"},{"key":"28","doi-asserted-by":"publisher","first-page":"1857","DOI":"10.1111\/jcmm.12557","article-title":"SIRT1 reduction causes renal and retinal injury in diabetes through endothelin 1 and transforming growth factor \u03b21.","volume":"1","author":"Chakrabarti","year":"2015","journal-title":"J Cell Mol Med"},{"key":"29","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1038\/nm.3821","article-title":"Resveratrol activates duodenal Sirt1 to reverse insulin resistance in rats through a neuronal network.","volume":"2","author":"Lam","year":"2015","journal-title":"Nat Med"},{"key":"30","doi-asserted-by":"publisher","first-page":"1316","DOI":"10.1101\/gad.265462.115","article-title":"Structural basis for allosteric, substrate-dependent stimulation of SIRT1 activity by resveratrol.","volume":"2","author":"Xu","year":"2015","journal-title":"Genes Dev"},{"key":"31","doi-asserted-by":"publisher","first-page":"1977","DOI":"10.1007\/s00125-007-0719-8","article-title":"Anti-inflammatory effects of atorvastatin improve left ventricular function in experimental diabetic cardiomyopathy.","volume":"5","author":"Tsch\u00f6pe","year":"2007","journal-title":"Diabetologia"},{"key":"32","doi-asserted-by":"publisher","first-page":"404","DOI":"10.3904\/kjim.2016.208","article-title":"Diabetic cardiomyopathy: where we are and where we are going.","volume":"3","author":"Kim","year":"2017","journal-title":"Korean J Intern Med"},{"key":"33","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1159\/000089840","article-title":"Chloride channel inhibition prevents ROS-dependent apoptosis induced by ischemia-reperfusion in mouse cardiomyocytes.","volume":"1","author":"Okada","year":"2005","journal-title":"Cell Physiol Biochem"},{"key":"34","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.mam.2018.07.001","article-title":"Cardiac fibrosis: cell biological mechanisms, molecular pathways and therapeutic opportunities.","volume":"6","author":"Frangogiannis","year":"2019","journal-title":"Mol Aspects Med"},{"key":"35","doi-asserted-by":"publisher","first-page":"205","DOI":"10.3389\/fncel.2018.00205","article-title":"Growth Differentiation Factor 11 Promotes Neurovascular Recovery After Stroke in Mice.","volume":"1","author":"Zhao","year":"2018","journal-title":"Front Cell Neurosci"},{"key":"36","doi-asserted-by":"publisher","first-page":"868","DOI":"10.3390\/nu10070868","article-title":"Phloretin as a Potent Natural TLR2\/1 Inhibitor Suppresses TLR2-Induced Inflammation.","volume":"1","author":"Kim","year":"2018","journal-title":"Nutrients"},{"key":"37","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.intimp.2017.12.009","article-title":"Phloretin attenuates mucus hypersecretion and airway inflammation induced by cigarette smoke.","volume":"5","author":"Wen","year":"2018","journal-title":"Int Immunopharmacol"},{"key":"38","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1165\/rcmb.2016-0225OC","article-title":"Glucose Transporter 1-Dependent Glycolysis Is Increased during Aging-Related Lung Fibrosis, and Phloretin Inhibits Lung Fibrosis.","volume":"5","author":"Stout-Delgado","year":"2017","journal-title":"Am J Respir Cell Mol Biol"},{"key":"39","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1007\/BF03347084","article-title":"PPAR\u03b1 agonist prevented the apoptosis induced by glucose and fatty acid in neonatal cardiomyocytes.","volume":"3","author":"Ying","year":"2011","journal-title":"J Endocrinol Invest"},{"key":"40","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1186\/1475-2840-8-8","article-title":"The signal transduction pathway of PKC\/NF-kappa B\/c-fos may be involved in the influence of high glucose on the cardiomyocytes of neonatal rats.","volume":"8","author":"Sheng","year":"2009","journal-title":"Cardiovasc Diabetol"},{"key":"41","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1093\/cvr\/cvx012","article-title":"Inflammation and metabolic cardiomyopathy.","volume":"11","author":"Otsu","year":"2017","journal-title":"Cardiovasc Res"},{"key":"42","doi-asserted-by":"publisher","first-page":"72","DOI":"10.3389\/fendo.2017.00072","article-title":"Diabetic Cardiomyopathy: An Immunometabolic Perspective.","volume":"8","author":"Mahata","year":"2017","journal-title":"Front Endocrinol (Lausanne)"},{"key":"43","doi-asserted-by":"publisher","first-page":"2170","DOI":"10.1161\/CIRCULATIONAHA.110.958033","article-title":"Silent information regulator 1 protects the heart from ischemia\/reperfusion.","volume":"12","author":"Sadoshima","year":"2010","journal-title":"Circulation"},{"key":"44","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/j.cca.2014.07.019","article-title":"SIRT1 in cardiovascular aging.","volume":"43","author":"Jiang","year":"2014","journal-title":"Clin Chim Acta"},{"key":"45","doi-asserted-by":"publisher","first-page":"1512","DOI":"10.1161\/01.RES.0000267723.65696.4a","article-title":"Sirt1 regulates aging and resistance to oxidative stress in the heart.","volume":"10","author":"Sadoshima","year":"2007","journal-title":"Circ Res"},{"key":"46","doi-asserted-by":"publisher","first-page":"1599","DOI":"10.1111\/jcmm.12312","article-title":"Resveratrol-enhanced autophagic flux ameliorates myocardial oxidative stress injury in diabetic mice.","volume":"1","author":"Zhao","year":"2014","journal-title":"J Cell Mol Med"},{"key":"47","doi-asserted-by":"publisher","first-page":"2137","DOI":"10.1194\/jlr.R001115","article-title":"Myocardial lipid accumulation and lipotoxicity in heart failure.","volume":"5","author":"Schulze","year":"2009","journal-title":"J Lipid Res"},{"key":"48","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1186\/s12933-016-0430-5","article-title":"Telmisartan improves cardiac fibrosis in diabetes through peroxisome proliferator activated receptor \u03b4 (PPAR\u03b4): from bedside to bench.","volume":"1","author":"Chen","year":"2016","journal-title":"Cardiovasc Diabetol"},{"key":"49","doi-asserted-by":"publisher","first-page":"4602715","DOI":"10.1155\/2017\/4602715","article-title":"SIRT1 Activation by Resveratrol Alleviates Cardiac Dysfunction via Mitochondrial Regulation in Diabetic Cardiomyopathy Mice.","volume":"201","author":"Cao","year":"2017","journal-title":"Oxid Med Cell Longev"},{"key":"50","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1038\/aps.2017.50","article-title":"Resveratrol alleviates diabetic cardiomyopathy in rats by improving mitochondrial function through PGC-1\u03b1 deacetylation.","volume":"3","author":"Liu","year":"2018","journal-title":"Acta Pharmacol Sin"},{"key":"51","doi-asserted-by":"publisher","first-page":"1056","DOI":"10.1038\/nature07813","article-title":"AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity.","volume":"45","author":"Auwerx","year":"2009","journal-title":"Nature"},{"key":"52","doi-asserted-by":"publisher","first-page":"10638","DOI":"10.1073\/pnas.0901501106","article-title":"Controlling transgene expression in subcutaneous implants using a skin lotion containing the apple metabolite phloretin.","volume":"10","author":"Fussenegger","year":"2009","journal-title":"Proc Natl Acad Sci USA"},{"key":"53","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.bios.2018.07.051","article-title":"A novel electrochemical biosensor for antioxidant evaluation of phloretin based on cell-alginate\/\u029f-cysteine\/gold nanoparticle-modified glassy carbon electrode.","volume":"11","author":"Sun","year":"2018","journal-title":"Biosens Bioelectron"},{"key":"54","doi-asserted-by":"publisher","first-page":"2014","DOI":"10.1002\/jcc.21486","article-title":"Multiple ligand simultaneous docking: orchestrated dancing of ligands in binding sites of protein.","volume":"3","author":"Li","year":"2010","journal-title":"J Comput Chem"},{"key":"55","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1002\/pro.3235","article-title":"UCSF ChimeraX: meeting modern challenges in visualization and analysis.","volume":"2","author":"Ferrin","year":"2018","journal-title":"Protein Sci"}],"container-title":["Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.101954","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,2]],"date-time":"2020-09-02T18:42:35Z","timestamp":1599072155000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.101954"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,10]]},"references-count":55,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2019,5,15]]}},"alternative-id":["101954","31076562"],"URL":"https:\/\/doi.org\/10.18632\/aging.101954","relation":{},"ISSN":["1945-4589"],"issn-type":[{"value":"1945-4589","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,10]]}}}