{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T11:14:26Z","timestamp":1784373266359,"version":"3.55.0"},"reference-count":32,"publisher":"Impact Journals, LLC","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aging"],"published-print":{"date-parts":[[2019,6,5]]},"DOI":"10.18632\/aging.102006","type":"journal-article","created":{"date-parts":[[2019,6,6]],"date-time":"2019-06-06T03:40:09Z","timestamp":1559792409000},"page":"3668-3678","source":"Crossref","is-referenced-by-count":15,"title":["Apigenin inhibits growth and migration of fibroblasts by suppressing FAK signaling"],"prefix":"10.18632","volume":"11","author":[{"given":"Hongyi","family":"Wang","sequence":"first","affiliation":[{"name":"Reconstructive and Plastic Surgery, General Hospital of North Theater, PLA, Shenyang, P.R.China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingyu","family":"Guo","sequence":"additional","affiliation":[{"name":"Reconstructive and Plastic Surgery, General Hospital of North Theater, PLA, Shenyang, P.R.China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shixiu","family":"Lin","sequence":"additional","affiliation":[{"name":"Reconstructive and Plastic Surgery, General Hospital of North Theater, PLA, Shenyang, P.R.China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Chang","sequence":"additional","affiliation":[{"name":"Reconstructive and Plastic Surgery, General Hospital of North Theater, PLA, Shenyang, P.R.China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Tao","sequence":"additional","affiliation":[{"name":"Reconstructive and Plastic Surgery, General Hospital of North Theater, PLA, Shenyang, P.R.China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7892","published-online":{"date-parts":[[2019,6,5]]},"reference":[{"key":"1","doi-asserted-by":"publisher","first-page":"1212","DOI":"10.1038\/jid.2012.499","article-title":"The IL-6 trans-signaling-STAT3 pathway mediates ECM and cellular proliferation in fibroblasts from hypertrophic scar.","volume":"13","author":"Brasier","year":"2013","journal-title":"J Invest Dermatol"},{"key":"2","doi-asserted-by":"publisher","first-page":"e98228","DOI":"10.1371\/journal.pone.0098228","article-title":"Anti-fibrotic actions of interleukin-10 against hypertrophic scarring by activation of PI3K\/AKT and STAT3 signaling pathways in scar-forming fibroblasts.","volume":"9","author":"Zhu","year":"2014","journal-title":"PLoS One"},{"key":"3","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1016\/j.yexcr.2015.01.015","article-title":"Functional characterization of TRAP1-like protein involved in modulating fibrotic processes mediated by TGF-\u03b2\/Smad signaling in hypertrophic scar fibroblasts.","volume":"33","author":"Wang","year":"2015","journal-title":"Exp Cell Res"},{"key":"4","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1007\/s11010-015-2644-3","article-title":"Galangin inhibits hypertrophic scar formation via ALK5\/Smad2\/3 signaling pathway.","volume":"41","author":"Li","year":"2016","journal-title":"Mol Cell Biochem"},{"key":"5","doi-asserted-by":"publisher","first-page":"715","DOI":"10.3892\/or.2017.5752","article-title":"Apigenin overcomes drug resistance by blocking the signal transducer and activator of transcription 3 signaling in breast cancer cells.","volume":"3","author":"Ko","year":"2017","journal-title":"Oncol Rep"},{"key":"6","doi-asserted-by":"publisher","first-page":"BSR20190452","DOI":"10.1042\/BSR20190452","article-title":"Apigenin inhibits epithelial-mesenchymal transition of human colon cancer cells through NF-\u03baB\/Snail signaling pathway.","volume":"3","author":"Han","year":"2019","journal-title":"Biosci Rep"},{"key":"7","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1016\/j.biopha.2017.01.056","article-title":"The natural flavonoid apigenin sensitizes human CD44prostate cancer stem cells to cisplatin therapy.","volume":"8","author":"Erdogan","year":"2017","journal-title":"Biomed Pharmacother"},{"key":"8","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.biopha.2016.11.130","article-title":"Plant-derived flavone Apigenin: The small-molecule with promising activity against therapeutically resistant prostate cancer.","volume":"8","author":"Ganai","year":"2017","journal-title":"Biomed Pharmacother"},{"key":"9","doi-asserted-by":"publisher","first-page":"1452","DOI":"10.1080\/21691401.2016.1247850","article-title":"Development and optimization of apigenin-loaded transfersomal system for skin cancer delivery: in vitro evaluation.","volume":"4","author":"Saraf","year":"2017","journal-title":"Artif Cells Nanomed Biotechnol"},{"key":"10","doi-asserted-by":"publisher","first-page":"5109","DOI":"10.2147\/IJN.S140096","article-title":"Synergistic apoptotic effects of apigenin TPGS liposomes and tyroservatide: implications for effective treatment of lung cancer.","volume":"1","author":"Zhang","year":"2017","journal-title":"Int J Nanomedicine"},{"key":"11","doi-asserted-by":"publisher","first-page":"1512745","DOI":"10.1155\/2017\/1512745","article-title":"Oxidative Stress Triggered by Apigenin Induces Apoptosis in a Comprehensive Panel of Human Cervical Cancer-Derived Cell Lines.","volume":"201","author":"Consolaro","year":"2017","journal-title":"Oxid Med Cell Longev"},{"key":"12","doi-asserted-by":"publisher","first-page":"4438","DOI":"10.3892\/etm.2017.5082","article-title":"Mast cell chymase promotes hypertrophic scar fibroblast proliferation and collagen synthesis by activating TGF-\u03b21\/Smads signaling pathway.","volume":"1","author":"Dong","year":"2017","journal-title":"Exp Ther Med"},{"key":"13","doi-asserted-by":"publisher","first-page":"1468","DOI":"10.1002\/ptr.5150","article-title":"Triggering of p38 MAPK and JNK signaling is important for oleanolic acid-induced apoptosis via the mitochondrial death pathway in hypertrophic scar fibroblasts.","volume":"2","author":"Qin","year":"2014","journal-title":"Phytother Res"},{"key":"14","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.jdermsci.2016.03.003","article-title":"Bone marrow derived mesenchymal stem cells inhibit the proliferative and profibrotic phenotype of hypertrophic scar fibroblasts and keloid fibroblasts through paracrine signaling.","volume":"8","author":"Huo","year":"2016","journal-title":"J Dermatol Sci"},{"key":"15","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1186\/s13287-016-0356-6","article-title":"Adipose tissue-derived stem cells suppress hypertrophic scar fibrosis via the p38\/MAPK signaling pathway.","volume":"7","author":"Han","year":"2016","journal-title":"Stem Cell Res Ther"},{"key":"16","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.actbio.2018.01.002","article-title":"Regulation of fibrotic changes by the synergistic effects of cytokines, dimensionality and matrix: towards the development of an in vitro human dermal hypertrophic scar model.","volume":"6","author":"Ghosh","year":"2018","journal-title":"Acta Biomater"},{"key":"17","doi-asserted-by":"publisher","first-page":"E1915","DOI":"10.3390\/ijms18091915","article-title":"The Role of Focal Adhesion Kinase in Keratinocyte Fibrogenic Gene Expression.","volume":"1","author":"Gurtner","year":"2017","journal-title":"Int J Mol Sci"},{"key":"18","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/j.bbrc.2016.09.159","article-title":"Lumican alleviates hypertrophic scarring by suppressing integrin-FAK signaling.","volume":"48","author":"Lv","year":"2016","journal-title":"Biochem Biophys Res Commun"},{"key":"19","doi-asserted-by":"publisher","first-page":"26023","DOI":"10.1038\/srep26023","article-title":"Simultaneous deactivation of FAK and Src improves the pathology of hypertrophic scar.","volume":"6","author":"Hu","year":"2016","journal-title":"Sci Rep"},{"key":"20","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1002\/cbin.10265","article-title":"Focal adhesion kinase (FAK) siRNA inhibits human hypertrophic scar by suppressing integrin \u03b1, TGF-\u03b2 and \u03b1-SMA.","volume":"3","author":"Fan","year":"2014","journal-title":"Cell Biol Int"},{"key":"21","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1111\/1346-8138.12792","article-title":"MiR-138\/peroxisome proliferator-activated receptor \u03b2 signaling regulates human hypertrophic scar fibroblast proliferation and movement in vitro.","volume":"4","author":"Yang","year":"2015","journal-title":"J Dermatol"},{"key":"22","doi-asserted-by":"publisher","first-page":"1669","DOI":"10.3892\/mmr.2017.6836","article-title":"Homeobox B9 facilitates hypertrophic scar formation via activating the mitogen-activated protein kinase signaling pathway.","volume":"1","author":"Wang","year":"2017","journal-title":"Mol Med Rep"},{"key":"23","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/j.jdermsci.2010.10.018","article-title":"Caveolin 1 inhibits transforming growth factor-\u03b21 activity via inhibition of Smad signaling by hypertrophic scar derived fibroblasts in vitro.","volume":"6","author":"Gao","year":"2011","journal-title":"J Dermatol Sci"},{"key":"24","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1016\/s1734-1140(13)70974-5","article-title":"Apigenin inhibits TGF-beta1 induced fibroblast-to-myofibroblast transition in human lung fibroblast populations.","volume":"6","author":"Michalik","year":"2013","journal-title":"Pharmacol Rep"},{"key":"25","doi-asserted-by":"publisher","first-page":"e0201595","DOI":"10.1371\/journal.pone.0201595","article-title":"Apigenin alleviates TGF-\u03b21-induced nasal mucosa remodeling by inhibiting MAPK \/ NF-kB signaling pathways in chronic rhinosinusitis.","volume":"1","author":"Lee","year":"2018","journal-title":"PLoS One"},{"key":"26","doi-asserted-by":"publisher","first-page":"206","DOI":"10.3389\/fphar.2017.00206","article-title":"Honokiol Alleviates Hypertrophic Scar by Targeting Transforming Growth Factor-\u03b2\/Smad2\/3 Signaling Pathway.","volume":"8","author":"Han","year":"2017","journal-title":"Front Pharmacol"},{"key":"27","doi-asserted-by":"publisher","first-page":"21157","DOI":"10.3390\/molecules201219752","article-title":"Apigenin Attenuates Melanoma Cell Migration by Inducing Anoikis through Integrin and Focal Adhesion Kinase Inhibition.","volume":"2","author":"Lim","year":"2015","journal-title":"Molecules"},{"key":"28","doi-asserted-by":"publisher","first-page":"1306","DOI":"10.1097\/MPA.0b013e31824d64d9","article-title":"Apigenin inhibits NNK-induced focal adhesion kinase activation in pancreatic cancer cells.","volume":"4","author":"Eibl","year":"2012","journal-title":"Pancreas"},{"key":"29","doi-asserted-by":"publisher","first-page":"5529","DOI":"10.1007\/s11033-011-1356-3","article-title":"Apigenin enhances the cytotoxic effects of tumor necrosis factor-related apoptosis-inducing ligand in human rheumatoid arthritis fibroblast-like synoviocytes.","volume":"3","author":"Xu","year":"2012","journal-title":"Mol Biol Rep"},{"key":"30","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.cbi.2009.07.016","article-title":"Apigenin-induced apoptosis is mediated by reactive oxygen species and activation of ERK1\/2 in rheumatoid fibroblast-like synoviocytes.","volume":"18","author":"Lee","year":"2009","journal-title":"Chem Biol Interact"},{"key":"31","doi-asserted-by":"publisher","first-page":"830","DOI":"10.1158\/1940-6207.CAPR-09-0066","article-title":"The chemopreventive bioflavonoid apigenin inhibits prostate cancer cell motility through the focal adhesion kinase\/Src signaling mechanism.","volume":"2","author":"Pelling","year":"2009","journal-title":"Cancer Prev Res (Phila)"},{"key":"32","doi-asserted-by":"publisher","first-page":"2369","DOI":"10.1093\/carcin\/bgn244","article-title":"Apigenin inhibited migration and invasion of human ovarian cancer A2780 cells through focal adhesion kinase.","volume":"2","author":"Fang","year":"2008","journal-title":"Carcinogenesis"}],"container-title":["Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.102006","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,2]],"date-time":"2020-09-02T18:45:49Z","timestamp":1599072349000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.102006"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,5]]},"references-count":32,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2019,6,15]]}},"alternative-id":["102006","31170089"],"URL":"https:\/\/doi.org\/10.18632\/aging.102006","relation":{},"ISSN":["1945-4589"],"issn-type":[{"value":"1945-4589","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,5]]}}}