{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T00:28:22Z","timestamp":1772843302611,"version":"3.50.1"},"reference-count":40,"publisher":"Impact Journals, LLC","issue":"14","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aging"],"published-print":{"date-parts":[[2019,7,17]]},"DOI":"10.18632\/aging.102083","type":"journal-article","created":{"date-parts":[[2019,7,17]],"date-time":"2019-07-17T03:03:08Z","timestamp":1563332588000},"page":"4900-4909","source":"Crossref","is-referenced-by-count":15,"title":["Osteoprotegerin as a biomarker of geriatric frailty syndrome"],"prefix":"10.18632","volume":"11","author":[{"given":"Alessia","family":"Valentini","sequence":"first","affiliation":[{"name":"Department of Systems Medicine, University of Rome \u201cTor Vergata\u201d, 00133 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Assunta","family":"Cianfarani","sequence":"additional","affiliation":[{"name":"Department of Systems Medicine, University of Rome \u201cTor Vergata\u201d, 00133 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Umberto","family":"Tarantino","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics and Traumatology, University of Rome \u201cTor Vergata\u201d, 00133 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicola","family":"Di Daniele","sequence":"additional","affiliation":[{"name":"Department of Systems Medicine, University of Rome \u201cTor Vergata\u201d, 00133 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aldo","family":"Bertoli","sequence":"additional","affiliation":[{"name":"Department of Systems Medicine, University of Rome \u201cTor Vergata\u201d, 00133 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7892","published-online":{"date-parts":[[2019,7,17]]},"reference":[{"key":"1","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1093\/ageing\/afu189","article-title":"The challenges of human population ageing.","volume":"4","author":"Rasmussen","year":"2015","journal-title":"Age Ageing"},{"key":"2","doi-asserted-by":"publisher","first-page":"1196","DOI":"10.1016\/S0140-6736(09)61460-4","article-title":"Ageing populations: the challenges ahead.","volume":"37","author":"Vaupel","year":"2009","journal-title":"Lancet"},{"key":"3","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1007\/s10522-010-9287-2","article-title":"Aging, frailty and age-related diseases.","volume":"1","author":"Pawelec","year":"2010","journal-title":"Biogerontology"},{"key":"4","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1159\/000211949","article-title":"Frailty syndrome: a transitional state in a dynamic process.","volume":"5","author":"Zekry","year":"2009","journal-title":"Gerontology"},{"key":"5","doi-asserted-by":"publisher","first-page":"752","DOI":"10.1016\/S0140-6736(12)62167-9","article-title":"Frailty in elderly people.","volume":"38","author":"Rockwood","year":"2013","journal-title":"Lancet"},{"key":"6","doi-asserted-by":"publisher","first-page":"M146","DOI":"10.1093\/gerona\/56.3.M146","article-title":"Frailty in older adults: evidence for a phenotype.","volume":"5","author":"McBurnie","year":"2001","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"7","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1016\/j.arr.2012.03.001","article-title":"Association of frailty with survival: a systematic literature review.","volume":"1","author":"Kane","year":"2013","journal-title":"Ageing Res Rev"},{"key":"8","doi-asserted-by":"publisher","first-page":"433","DOI":"10.2147\/CIA.S45300","article-title":"Frailty syndrome: an overview.","volume":"9","author":"Leng","year":"2014","journal-title":"Clin Interv Aging"},{"key":"9","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1111\/j.1532-5415.2006.00745.x","article-title":"Research agenda for frailty in older adults: toward a better understanding of physiology and etiology: summary from the American Geriatrics Society\/National Institute on Aging Research Conference on Frailty in Older Adults.","volume":"5","author":"Fried","year":"2006","journal-title":"J Am Geriatr Soc"},{"key":"10","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1111\/ggi.12190","article-title":"Frailty as a predictor of all-cause mortality in older men and women.","volume":"1","author":"Hartikainen","year":"2014","journal-title":"Geriatr Gerontol Int"},{"key":"11","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1093\/gerona\/62.7.731","article-title":"Frailty: an emerging research and clinical paradigm--issues and controversies.","volume":"6","author":"Wolfson","year":"2007","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"12","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1016\/j.cger.2010.02.002","article-title":"The assessment of frailty in older adults.","volume":"2","author":"Vellas","year":"2010","journal-title":"Clin Geriatr Med"},{"key":"13","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1111\/j.1447-0594.2011.00797.x","article-title":"Screening tools for frailty in primary health care: a systematic review.","volume":"1","author":"Lesourd","year":"2012","journal-title":"Geriatr Gerontol Int"},{"key":"14","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.ejim.2016.03.007","article-title":"Frailty measurement in research and clinical practice: A review.","volume":"3","author":"Hoogendijk","year":"2016","journal-title":"Eur J Intern Med"},{"key":"15","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1186\/s12916-014-0171-9","article-title":"Standard laboratory tests to identify older adults at increased risk of death.","volume":"1","author":"Rockwood","year":"2014","journal-title":"BMC Med"},{"key":"16","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1186\/1471-2318-10-57","article-title":"A frailty instrument for primary care: findings from the Survey of Health, Ageing and Retirement in Europe (SHARE).","volume":"1","author":"Kenny","year":"2010","journal-title":"BMC Geriatr"},{"key":"17","doi-asserted-by":"publisher","first-page":"963","DOI":"10.1007\/s11357-012-9396-8","article-title":"Immune-endocrine biomarkers as predictors of frailty and mortality: a 10-year longitudinal study in community-dwelling older people.","volume":"3","author":"Sayer","year":"2013","journal-title":"Age (Dordr)"},{"key":"18","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1111\/acel.12068","article-title":"Identification of a metabolic signature for multidimensional impairment and mortality risk in hospitalized older patients.","volume":"1","author":"Pilotto","year":"2013","journal-title":"Aging Cell"},{"key":"19","doi-asserted-by":"publisher","first-page":"335","DOI":"10.2147\/CIA.S125934","article-title":"Low FT3: a possible marker of frailty in the elderly.","volume":"1","author":"Federici","year":"2017","journal-title":"Clin Interv Aging"},{"key":"20","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/S8756-3282(99)00121-0","article-title":"A novel molecular mechanism modulating osteoclast differentiation and function.","volume":"2","author":"Higashio","year":"1999","journal-title":"Bone"},{"key":"21","doi-asserted-by":"publisher","first-page":"638","DOI":"10.1111\/j.1538-7836.2011.04222.x","article-title":"Serum osteoprotegerin is a predictor for incident cardiovascular disease and mortality in a general population: the Troms\u00f8 Study.","volume":"9","author":"Hansen","year":"2011","journal-title":"J Thromb Haemost"},{"key":"22","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1016\/j.jacc.2007.09.058","article-title":"Circulating osteoprotegerin levels and long-term prognosis in patients with acute coronary syndromes.","volume":"5","author":"Caidahl","year":"2008","journal-title":"J Am Coll Cardiol"},{"key":"23","doi-asserted-by":"publisher","first-page":"e0134266","DOI":"10.1371\/journal.pone.0134266","article-title":"Elevated circulating osteoprotegerin and renal dysfunction predict 15-year cardiovascular and all-cause mortality: a prospective study of elderly women.","volume":"1","author":"Prince","year":"2015","journal-title":"PLoS One"},{"key":"24","doi-asserted-by":"publisher","first-page":"2334","DOI":"10.1007\/s00018-007-7104-0","article-title":"RANKL, RANK, osteoprotegerin: key partners of osteoimmunology and vascular diseases.","volume":"6","author":"Heymann","year":"2007","journal-title":"Cell Mol Life Sci"},{"key":"25","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00223-004-0007-2","article-title":"Relationships between the changes of serum levels of OPG and RANKL with age, menopause, bone biochemical markers and bone mineral density in Chinese women aged 20-75.","volume":"7","author":"Chen","year":"2005","journal-title":"Calcif Tissue Int"},{"key":"26","doi-asserted-by":"publisher","first-page":"3162","DOI":"10.1210\/jcem.86.7.7657","article-title":"Osteoprotegerin serum levels in men: correlation with age, estrogen, and testosterone status.","volume":"8","author":"Delmas","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"key":"27","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1007\/s001980200045","article-title":"Correlates of osteoprotegerin levels in women and men.","volume":"1","author":"Riggs","year":"2002","journal-title":"Osteoporos Int"},{"key":"28","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.arr.2016.08.006","article-title":"Inflammation and frailty in the elderly: A systematic review and meta-analysis.","volume":"3","author":"Cosco","year":"2016","journal-title":"Ageing Res Rev"},{"key":"29","doi-asserted-by":"publisher","first-page":"1268","DOI":"10.1046\/j.1532-5415.2002.50315.x","article-title":"Serum interleukin-6 and hemoglobin as physiological correlates in the geriatric syndrome of frailty: a pilot study.","volume":"5","author":"Walston","year":"2002","journal-title":"J Am Geriatr Soc"},{"key":"30","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1016\/j.maturitas.2014.07.014","article-title":"Association between inflammatory markers and frailty in institutionalized older men.","volume":"7","author":"Hwang","year":"2014","journal-title":"Maturitas"},{"key":"31","doi-asserted-by":"publisher","first-page":"864","DOI":"10.1111\/j.1532-5415.2007.01186.x","article-title":"Inflammation and frailty in older women.","volume":"5","author":"Fried","year":"2007","journal-title":"J Am Geriatr Soc"},{"key":"32","doi-asserted-by":"publisher","first-page":"3103","DOI":"10.1111\/j.1582-4934.2009.00733.x","article-title":"Inflammation and frailty measures in older people.","volume":"1","author":"Woodhouse","year":"2009","journal-title":"J Cell Mol Med"},{"key":"33","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1093\/ageing\/afp015","article-title":"The association between dehydroepiandosterone and frailty in older men and women.","volume":"3","author":"Kenny","year":"2009","journal-title":"Age Ageing"},{"key":"34","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1007\/BF03324545","article-title":"Serum levels of insulin-like growth factor-I (IGF-I) and dehydroepiandrosterone sulfate (DHEA-S), and their relationships with serum interleukin-6, in the geriatric syndrome of frailty.","volume":"1","author":"Walston","year":"2004","journal-title":"Aging Clin Exp Res"},{"key":"35","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1007\/s40618-015-0421-5","article-title":"Serum levels of the bone turnover markers dickkopf-1, sclerostin, osteoprotegerin, osteopontin, osteocalcin and 25-hydroxyvitamin D in Swedish geriatric patients aged 75\u00a0years or older with a fresh hip fracture and in healthy controls.","volume":"3","author":"Carlsson","year":"2016","journal-title":"J Endocrinol Invest"},{"key":"36","doi-asserted-by":"publisher","first-page":"1122","DOI":"10.1093\/gerona\/glt012","article-title":"Thyroid hormones as predictors of short- and long-term mortality in very old hospitalized patients.","volume":"6","author":"Di Bari","year":"2013","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"37","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.cger.2010.08.008","article-title":"Frailty defined by deficit accumulation and geriatric medicine defined by frailty.","volume":"2","author":"Mitnitski","year":"2011","journal-title":"Clin Geriatr Med"},{"key":"38","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1210\/jcem.84.1.5364","article-title":"Dangerous dogmas in medicine: the nonthyroidal illness syndrome.","volume":"8","author":"De Groot","year":"1999","journal-title":"J Clin Endocrinol Metab"},{"key":"39","doi-asserted-by":"publisher","first-page":"1867","DOI":"10.1210\/jc.2017-02149","article-title":"Degree of peripheral thyroxin deiodination, frailty, and long-term survival in hospitalized older patients.","volume":"10","author":"Monzani","year":"2018","journal-title":"J Clin Endocrinol Metab"},{"key":"40","doi-asserted-by":"publisher","first-page":"1237","DOI":"10.2147\/CIA.S164174","article-title":"Frailty and nutritional status in older people: the Mini Nutritional Assessment as a screening tool for the identification of frail subjects.","volume":"1","author":"Bertoli","year":"2018","journal-title":"Clin Interv Aging"}],"container-title":["Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.102083","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,2]],"date-time":"2020-09-02T19:09:02Z","timestamp":1599073742000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.102083"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,17]]},"references-count":40,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2019,7,31]]}},"alternative-id":["102083","31311890"],"URL":"https:\/\/doi.org\/10.18632\/aging.102083","relation":{},"ISSN":["1945-4589"],"issn-type":[{"value":"1945-4589","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,17]]}}}