{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T05:19:59Z","timestamp":1778822399433,"version":"3.51.4"},"reference-count":98,"publisher":"Impact Journals, LLC","issue":"14","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aging"],"published-print":{"date-parts":[[2019,7,15]]},"DOI":"10.18632\/aging.102089","type":"journal-article","created":{"date-parts":[[2019,7,15]],"date-time":"2019-07-15T21:18:10Z","timestamp":1563225490000},"page":"4943-4969","source":"Crossref","is-referenced-by-count":27,"title":["D-ribose is elevated in T1DM patients and can be involved in the onset of encephalopathy"],"prefix":"10.18632","volume":"11","author":[{"given":"Lexiang","family":"Yu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, University of Chinese Academy of Sciences, Beijing 100101, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yao","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences of Southwest Medical University, Luzhou 646000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Xu","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Southwest Medical University, Luzhou 646000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"He","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences of Southwest Medical University, Luzhou 646000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Wei","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, University of Chinese Academy of Sciences, Beijing 100101, China"},{"name":"CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rongqiao","family":"He","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences of Southwest Medical University, Luzhou 646000, China"},{"name":"State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, University of Chinese Academy of Sciences, Beijing 100101, China"},{"name":"Alzheimer\u2019s Disease Center, Beijing Institute for Brain Disorders, Center for Brain Disorders Research, Capital Medical University, Beijing 100069, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7892","published-online":{"date-parts":[[2019,7,15]]},"reference":[{"key":"1","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1542\/pir.34-5-203","article-title":"Type 1 diabetes mellitus.","volume":"3","author":"Simmons","year":"2013","journal-title":"Pediatr Rev"},{"key":"2","volume-title":"Diabetes and the Brain.","author":"Biessels","year":"2009"},{"key":"3","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1001\/archinte.1922.00110120086003","article-title":"Psychologic tests applied to diabetic patients.","volume":"3","author":"Root","year":"1922","journal-title":"Arch Intern Med (Chic)"},{"key":"4","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1007\/s00592-010-0218-0","article-title":"Encephalopathies: the emerging diabetic complications.","volume":"4","author":"Sima","year":"2010","journal-title":"Acta Diabetol"},{"key":"5","doi-asserted-by":"publisher","first-page":"726","DOI":"10.2337\/diacare.28.3.726","article-title":"The effects of type 1 diabetes on cognitive performance: a meta-analysis.","volume":"2","author":"Kessels","year":"2005","journal-title":"Diabetes Care"},{"key":"6","doi-asserted-by":"publisher","first-page":"988","DOI":"10.1007\/s11427-017-9316-x","article-title":"Amplitude of peroneal compound motor action potential increases in type 2 diabetes with thyroid autoimmunity.","volume":"6","author":"Yang","year":"2018","journal-title":"Sci China Life Sci"},{"key":"7","doi-asserted-by":"publisher","first-page":"1809","DOI":"10.1345\/aph.1M303","article-title":"Lacosamide: an adjunctive agent for partial-onset seizures and potential therapy for neuropathic pain.","volume":"4","author":"Murphy","year":"2009","journal-title":"Ann Pharmacother"},{"key":"8","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1001\/archneur.61.5.661","article-title":"Diabetes mellitus and risk of Alzheimer disease and decline in cognitive function.","volume":"6","author":"Bennett","year":"2004","journal-title":"Arch Neurol"},{"key":"9","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1016\/S0166-2236(00)01656-8","article-title":"Cognition and synaptic plasticity in diabetes mellitus.","volume":"2","author":"Biessels","year":"2000","journal-title":"Trends Neurosci"},{"key":"10","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1038\/nrendo.2010.228","article-title":"Cognitive function, dementia and type 2 diabetes mellitus in the elderly.","volume":"7","author":"Price","year":"2011","journal-title":"Nat Rev Endocrinol"},{"key":"11","doi-asserted-by":"publisher","first-page":"1100","DOI":"10.2337\/diacare.26.4.1100","article-title":"Absence of adverse effects of severe hypoglycemia on cognitive function in school-aged children with diabetes over 18 months.","volume":"2","author":"White","year":"2003","journal-title":"Diabetes Care"},{"key":"12","doi-asserted-by":"publisher","first-page":"2062","DOI":"10.1212\/WNL.0000000000001582","article-title":"White matter hyperintensities in middle-aged adults with childhood-onset type 1 diabetes.","volume":"8","author":"Rosano","year":"2015","journal-title":"Neurology"},{"key":"13","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1111\/1753-0407.12773","article-title":"Accelerated executive functions decline and gray matter structural changes in middle-aged type 1 diabetes mellitus patients with proliferative retinopathy.","volume":"1","author":"Ijzerman","year":"2018","journal-title":"J Diabetes"},{"key":"14","doi-asserted-by":"publisher","first-page":"2694","DOI":"10.1159\/000495960","article-title":"Decreased Spontaneous Brain Activity and Functional Connectivity in Type 1 Diabetic Patients Without Microvascular Complications.","volume":"5","author":"Yin","year":"2018","journal-title":"Cell Physiol Biochem"},{"key":"15","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.jdiacomp.2018.04.003","article-title":"Clinically significant cognitive impairment in older adults with type 1 diabetes.","volume":"3","author":"Weinstock","year":"2019","journal-title":"J Diabetes Complications"},{"key":"16","doi-asserted-by":"publisher","first-page":"816","DOI":"10.3724\/SP.J.1206.2013.00341","article-title":"The Abnormally High Level of Uric D-Ribose for Type-2 Diabetics.","volume":"4","author":"Su","year":"2013","journal-title":"Progress in Biochemistry and Biophysics"},{"key":"17","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/j.ebiom.2017.10.001","article-title":"d-Ribose as a Contributor to Glycated Haemoglobin.","volume":"2","author":"He","year":"2017","journal-title":"EBioMedicine"},{"key":"18","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1021\/bi00892a005","article-title":"Purine Nucleosides. Vi. Further Methylation Studies of Naturally Occurring Purine Nucleosides.","volume":"3","author":"Robins","year":"1964","journal-title":"Biochemistry"},{"key":"19","doi-asserted-by":"publisher","first-page":"1117","DOI":"10.1021\/bi00404a006","article-title":"Biosynthesis of riboflavin: mechanism of formation of the ribitylamino linkage.","volume":"2","author":"Floss","year":"1988","journal-title":"Biochemistry"},{"key":"20","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1161\/01.RES.56.2.220","article-title":"Influence of ribose, adenosine, and \u201cAICAR\u201d on the rate of myocardial adenosine triphosphate synthesis during reperfusion after coronary artery occlusion in the dog.","volume":"5","author":"Schaper","year":"1985","journal-title":"Circ Res"},{"key":"21","doi-asserted-by":"publisher","first-page":"e9052","DOI":"10.1371\/journal.pone.0009052","article-title":"Ribosylation rapidly induces alpha-synuclein to form highly cytotoxic molten globules of advanced glycation end products.","volume":"5","author":"He","year":"2010","journal-title":"PLoS One"},{"key":"22","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1016\/j.bbagen.2012.01.005","article-title":"D-ribose in glycation and protein aggregation.","volume":"182","author":"He","year":"2012","journal-title":"Biochim Biophys Acta"},{"key":"23","doi-asserted-by":"publisher","first-page":"2285","DOI":"10.1016\/j.bbadis.2019.05.005","article-title":"d-Ribose contributes to the glycation of serum protein.","volume":"186","author":"He","year":"2019","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"24","doi-asserted-by":"publisher","first-page":"858","DOI":"10.1007\/s11427-019-9542-2","article-title":"D-ribose increases triglyceride via upregulation of DGAT in the liver.","volume":"6","author":"He","year":"2019","journal-title":"Sci China Life Sci"},{"key":"25","doi-asserted-by":"publisher","first-page":"e05265","DOI":"10.2903\/j.efsa.2018.5363","article-title":"Safety of d-ribose as a novel food pursuant to Regulation (EU) 2015\/2283.","volume":"1","author":"EFSA Panel on Dietetic Products N","year":"2018","journal-title":"EFSA J"},{"key":"26","doi-asserted-by":"publisher","first-page":"2559","DOI":"10.1007\/s00018-009-0058-7","article-title":"D-Ribosylated Tau forms globular aggregates with high cytotoxicity.","volume":"6","author":"He","year":"2009","journal-title":"Cell Mol Life Sci"},{"key":"27","doi-asserted-by":"publisher","first-page":"34128","DOI":"10.18632\/oncotarget.6021","article-title":"Gavage of D-Ribose induces A\u03b2-like deposits, Tau hyperphosphorylation as well as memory loss and anxiety-like behavior in mice.","volume":"6","author":"He","year":"2015","journal-title":"Oncotarget"},{"key":"28","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1007\/s00125-007-0886-7","article-title":"The mechanisms of alloxan- and streptozotocin-induced diabetes.","volume":"5","author":"Lenzen","year":"2008","journal-title":"Diabetologia"},{"key":"29","doi-asserted-by":"publisher","first-page":"2772","DOI":"10.18632\/aging.101586","article-title":"Autophagy of macrophages is regulated by PI3k\/Akt\/mTOR signalling in the development of diabetic encephalopathy.","volume":"1","author":"Huang","year":"2018","journal-title":"Aging (Albany NY)"},{"key":"30","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1007\/s11011-011-9262-x","article-title":"Effects of physical exercise on spatial memory and astroglial alterations in the hippocampus of diabetic rats.","volume":"2","author":"Xavier","year":"2011","journal-title":"Metab Brain Dis"},{"key":"31","doi-asserted-by":"publisher","first-page":"1668","DOI":"10.1159\/000489243","article-title":"Mitochondrial Perturbation Contributing to Cognitive Decline in Streptozotocin-Induced Type 1 Diabetic Rats.","volume":"4","author":"Chen","year":"2018","journal-title":"Cell Physiol Biochem"},{"key":"32","doi-asserted-by":"publisher","first-page":"5782904","DOI":"10.1155\/2016\/5782904","article-title":"A Novel Chemically Modified Curcumin \u201cNormalizes\u201d Wound-Healing in Rats with Experimentally Induced Type I Diabetes: initial Studies.","volume":"201","author":"Golub","year":"2016","journal-title":"J Diabetes Res"},{"key":"33","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1006\/geno.1997.5187","article-title":"The mouse transketolase (TKT) gene: cloning, characterization, and functional promoter analysis.","volume":"4","author":"Sax","year":"1998","journal-title":"Genomics"},{"key":"34","doi-asserted-by":"publisher","first-page":"58","DOI":"10.5653\/cerm.2012.39.2.58","article-title":"Function of the pentose phosphate pathway and its key enzyme, transketolase, in the regulation of the meiotic cell cycle in oocytes.","volume":"3","author":"Lee","year":"2012","journal-title":"Clin Exp Reprod Med"},{"key":"35","doi-asserted-by":"publisher","first-page":"784","DOI":"10.1196\/annals.1333.091","article-title":"Inhibitors of advanced glycation end product formation and neurovascular dysfunction in experimental diabetes.","volume":"104","author":"Cotter","year":"2005","journal-title":"Ann N Y Acad Sci"},{"key":"36","doi-asserted-by":"publisher","first-page":"2291","DOI":"10.1016\/S0140-6736(12)60360-2","article-title":"Diabetes and cognitive dysfunction.","volume":"37","author":"Frier","year":"2012","journal-title":"Lancet"},{"key":"37","doi-asserted-by":"publisher","first-page":"2441","DOI":"10.1093\/brain\/aww187","article-title":"Hyperphosphorylated tau in patients with refractory epilepsy correlates with cognitive decline: a study of temporal lobe resections.","volume":"13","author":"Thom","year":"2016","journal-title":"Brain"},{"key":"38","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1016\/j.jgr.2014.09.002","article-title":"Ginseng improves cognitive deficit via the RAGE\/NF-\u03baB pathway in advanced glycation end product-induced rats.","volume":"3","author":"Jia","year":"2015","journal-title":"J Ginseng Res"},{"key":"39","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1186\/1471-2121-10-10","article-title":"Rapid glycation with D-ribose induces globular amyloid-like aggregations of BSA with high cytotoxicity to SH-SY5Y cells.","volume":"1","author":"He","year":"2009","journal-title":"BMC Cell Biol"},{"key":"40","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1007\/s11011-013-9467-2","article-title":"Enriched environment induces beneficial effects on memory deficits and microglial activation in the hippocampus of type 1 diabetic rats.","volume":"2","author":"Marcuzzo","year":"2014","journal-title":"Metab Brain Dis"},{"key":"41","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.chroma.2004.11.100","article-title":"Determination of several sugars in serum by high-performance anion-exchange chromatography with pulsed amperometric detection.","volume":"108","author":"Mou","year":"2005","journal-title":"J Chromatogr A"},{"key":"42","first-page":"663","article-title":"[A new method for the determination of sugars in cerebrospinal fluid (author\u2019s transl)].","volume":"1","author":"Seuffer","year":"1977","journal-title":"J Clin Chem Clin Biochem"},{"key":"43","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1007\/s001250051591","article-title":"Advanced glycation end-products: a review.","volume":"4","author":"Beilin","year":"2001","journal-title":"Diabetologia"},{"key":"44","doi-asserted-by":"publisher","first-page":"e1117","DOI":"10.1038\/cddis.2014.89","article-title":"D-ribosylation induces cognitive impairment through RAGE-dependent astrocytic inflammation.","volume":"5","author":"He","year":"2014","journal-title":"Cell Death Dis"},{"key":"45","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1016\/j.bbamcr.2018.02.001","article-title":"GRP78 protects CHO cells from ribosylation.","volume":"186","author":"He","year":"2018","journal-title":"Biochim Biophys Acta Mol Cell Res"},{"key":"46","first-page":"1761","article-title":"Elevated formaldehyde in the cecum of APP\/PS1 mouse.","volume":"4","author":"He","year":"2017","journal-title":"Microbiology China"},{"key":"47","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1016\/j.toxrep.2019.02.005","article-title":"Formaldehyde produced from d-ribose under neutral and alkaline conditions.","volume":"6","author":"He","year":"2019","journal-title":"Toxicol Rep"},{"key":"48","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1002\/cbf.290040403","article-title":"Physiological functions of the pentose phosphate pathway.","volume":"4","author":"Wood","year":"1986","journal-title":"Cell Biochem Funct"},{"key":"49","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/S0166-6851(03)00173-7","article-title":"Pentose phosphate metabolism in Leishmania mexicana.","volume":"13","author":"Ogbunude","year":"2003","journal-title":"Mol Biochem Parasitol"},{"key":"50","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1023\/A:1023202805255","article-title":"Pentose phosphate pathway, glutathione-dependent enzymes and antioxidant defense during oxidative stress in diabetic rodent brain and peripheral organs: effects of stobadine and vitamin E.","volume":"2","author":"Karasu","year":"2003","journal-title":"Neurochem Res"},{"key":"51","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.redox.2016.11.003","article-title":"Redox imbalance and mitochondrial abnormalities in the diabetic lung.","volume":"1","author":"Yan","year":"2017","journal-title":"Redox Biol"},{"key":"52","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0922-3371(90)90019-S","article-title":"The initiation of development at fertilization. The initiation of development at fertilization.","volume":"2","author":"Epel","year":"1990","journal-title":"Cell Differ Dev"},{"key":"53","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1007\/s11010-015-2346-x","article-title":"Neonatal hyperglycemia induces oxidative stress in the rat brain: the role of pentose phosphate pathway enzymes and NADPH oxidase.","volume":"40","author":"Dutra-Filho","year":"2015","journal-title":"Mol Cell Biochem"},{"key":"54","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1177\/1470320311422581","article-title":"Spironolactone improves nephropathy by enhancing glucose-6-phosphate dehydrogenase activity and reducing oxidative stress in diabetic hypertensive rat.","volume":"1","author":"Lopes de Faria","year":"2012","journal-title":"J Renin Angiotensin Aldosterone Syst"},{"key":"55","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1038\/ncb1881","article-title":"The bioenergetic and antioxidant status of neurons is controlled by continuous degradation of a key glycolytic enzyme by APC\/C-Cdh1.","volume":"1","author":"Bola\u00f1os","year":"2009","journal-title":"Nat Cell Biol"},{"key":"56","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1038\/nm834","article-title":"Benfotiamine blocks three major pathways of hyperglycemic damage and prevents experimental diabetic retinopathy.","volume":"9","author":"Brownlee","year":"2003","journal-title":"Nat Med"},{"key":"57","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1161\/CIRCHEARTFAILURE.109.903450","article-title":"Vitamin B1 analog benfotiamine prevents diabetes-induced diastolic dysfunction and heart failure through Akt\/Pim-1-mediated survival pathway.","volume":"3","author":"Madeddu","year":"2010","journal-title":"Circ Heart Fail"},{"key":"58","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1016\/j.phrs.2010.02.008","article-title":"The multifaceted therapeutic potential of benfotiamine.","volume":"6","author":"Thangathirupathi","year":"2010","journal-title":"Pharmacol Res"},{"key":"59","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1007\/s12264-009-1113-y","article-title":"A review on research progress of transketolase.","volume":"2","author":"Zhong","year":"2009","journal-title":"Neurosci Bull"},{"key":"60","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1016\/j.biopha.2016.11.078","article-title":"Knockdown of TKTL1 additively complements cisplatin-induced cytotoxicity in nasopharyngeal carcinoma cells by regulating the levels of NADPH and ribose-5-phosphate.","volume":"8","author":"Wang","year":"2017","journal-title":"Biomed Pharmacother"},{"key":"61","doi-asserted-by":"publisher","first-page":"2110","DOI":"10.2337\/diabetes.52.8.2110","article-title":"Prevention of incipient diabetic nephropathy by high-dose thiamine and benfotiamine.","volume":"5","author":"Thornalley","year":"2003","journal-title":"Diabetes"},{"key":"62","doi-asserted-by":"publisher","first-page":"2164","DOI":"10.1007\/s00125-007-0771-4","article-title":"High prevalence of low plasma thiamine concentration in diabetes linked to a marker of vascular disease.","volume":"5","author":"Bodmer","year":"2007","journal-title":"Diabetologia"},{"key":"63","doi-asserted-by":"publisher","first-page":"1423","DOI":"10.1016\/j.freeradbiomed.2010.02.031","article-title":"Protective role of benfotiamine, a fat-soluble vitamin B1 analogue, in lipopolysaccharide-induced cytotoxic signals in murine macrophages.","volume":"4","author":"Ramana","year":"2010","journal-title":"Free Radic Biol Med"},{"key":"64","doi-asserted-by":"publisher","first-page":"914","DOI":"10.1681\/ASN.2010070750","article-title":"Benfotiamine protects against peritoneal and kidney damage in peritoneal dialysis.","volume":"2","author":"Schwenger","year":"2011","journal-title":"J Am Soc Nephrol"},{"key":"65","doi-asserted-by":"publisher","first-page":"2874","DOI":"10.1093\/hmg\/ddy201","article-title":"Benfotiamine treatment activates the Nrf2\/ARE pathway and is neuroprotective in a transgenic mouse model of tauopathy.","volume":"2","author":"Smirnova","year":"2018","journal-title":"Hum Mol Genet"},{"key":"66","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1093\/cvr\/cvs291","article-title":"Boosting the pentose phosphate pathway restores cardiac progenitor cell availability in diabetes.","volume":"9","author":"Madeddu","year":"2013","journal-title":"Cardiovasc Res"},{"key":"67","doi-asserted-by":"publisher","DOI":"10.6002\/ect.2017.0320","article-title":"N-Acetylcysteine and Benfotiamine Protect Autotransplanted Ovarian Tissue From Ischemia-Reperfusion Injury: An Experimental Study.","author":"Ayd\u0131n","year":"2018","journal-title":"Exp Clin Transplant"},{"key":"68","doi-asserted-by":"publisher","first-page":"2231","DOI":"10.2337\/db06-0369","article-title":"Benfotiamine counteracts glucose toxicity effects on endothelial progenitor cell differentiation via Akt\/FoxO signaling.","volume":"5","author":"Federici","year":"2006","journal-title":"Diabetes"},{"key":"69","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1007\/s12264-016-0067-0","article-title":"Long-Term Cognitive Improvement After Benfotiamine Administration in Patients with Alzheimer\u2019s Disease.","volume":"3","author":"Zhong","year":"2016","journal-title":"Neurosci Bull"},{"key":"70","first-page":"018","article-title":"A Brief Study of the Correlation of Urine D-ribose with MMSE Scores of Patients with Alzheimer\u2019s Disease and Cognitively Normal Participants.","volume":"4","author":"Rong-Qiao","year":"2019","journal-title":"Am J Urol Res"},{"key":"71","doi-asserted-by":"publisher","first-page":"1814","DOI":"10.1002\/hbm.23970","article-title":"Regional hippocampal vulnerability in early multiple sclerosis: dynamic pathological spreading from dentate gyrus to CA1.","volume":"3","author":"Tourdias","year":"2018","journal-title":"Hum Brain Mapp"},{"key":"72","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/j.nbd.2018.09.023","article-title":"Ultra-micronized palmitoylethanolamide rescues the cognitive decline-associated loss of neural plasticity in the neuropathic mouse entorhinal cortex-dentate gyrus pathway.","volume":"12","author":"de Novellis","year":"2019","journal-title":"Neurobiol Dis"},{"key":"73","doi-asserted-by":"publisher","first-page":"1753","DOI":"10.4103\/1673-5374.238618","article-title":"Cognitive impairment after traumatic brain injury is associated with reduced long-term depression of excitatory postsynaptic potential in the rat hippocampal dentate gyrus.","volume":"1","author":"Zhang","year":"2018","journal-title":"Neural Regen Res"},{"key":"74","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1038\/nature17172","article-title":"Memory retrieval by activating engram cells in mouse models of early Alzheimer\u2019s disease.","volume":"53","author":"Tonegawa","year":"2016","journal-title":"Nature"},{"key":"75","doi-asserted-by":"publisher","first-page":"4347","DOI":"10.1096\/fj.201700216RR","article-title":"Notch1 deficiency in postnatal neural progenitor cells in the dentate gyrus leads to emotional and cognitive impairment.","volume":"3","author":"Wu","year":"2017","journal-title":"FASEB J"},{"key":"76","doi-asserted-by":"publisher","first-page":"955","DOI":"10.1016\/j.neuron.2012.12.038","article-title":"Differential control of learning and anxiety along the dorsoventral axis of the dentate gyrus.","volume":"7","author":"Hen","year":"2013","journal-title":"Neuron"},{"key":"77","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1016\/j.mcn.2017.05.005","article-title":"Thiamine and benfotiamine prevent stress-induced suppression of hippocampal neurogenesis in mice exposed to predation without affecting brain thiamine diphosphate levels.","volume":"8","author":"Lakaye","year":"2017","journal-title":"Mol Cell Neurosci"},{"key":"78","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.pnpbp.2016.11.001","article-title":"Thiamine and benfotiamine improve cognition and ameliorate GSK-3\u03b2-associated stress-induced behaviours in mice.","volume":"7","author":"Strekalova","year":"2017","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"79","doi-asserted-by":"publisher","first-page":"e24623","DOI":"10.1371\/journal.pone.0024623","article-title":"D-ribose induces cellular protein glycation and impairs mouse spatial cognition.","volume":"6","author":"He","year":"2011","journal-title":"PLoS One"},{"key":"80","doi-asserted-by":"publisher","first-page":"701","DOI":"10.4103\/1673-5374.131569","article-title":"Neuronal cell death and regeneration in diseases associated with advanced glycation end-products accumulation.","volume":"9","author":"Yamamoto","year":"2014","journal-title":"Neural Regen Res"},{"key":"81","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.tcb.2014.07.005","article-title":"Connecting the dots between tau dysfunction and neurodegeneration.","volume":"2","author":"Feany","year":"2015","journal-title":"Trends Cell Biol"},{"key":"82","doi-asserted-by":"publisher","first-page":"760","DOI":"10.1007\/s12272-017-0893-2","article-title":"Phytoceramide ameliorates \u00df-amyloid protein-induced memory impairment and neuronal death in mice.","volume":"4","author":"Seong","year":"2017","journal-title":"Arch Pharm Res"},{"key":"83","doi-asserted-by":"publisher","first-page":"20833","DOI":"10.1038\/srep20833","article-title":"Abnormal tau induces cognitive impairment through two different mechanisms: synaptic dysfunction and neuronal loss.","volume":"6","author":"Alonso","year":"2016","journal-title":"Sci Rep"},{"key":"84","doi-asserted-by":"publisher","first-page":"3598","DOI":"10.1002\/jcp.25828","article-title":"Advanced glycation end products (AGE) potentiates cell death in p53 negative cells via upregulaion of NF-kappa B and impairment of autophagy.","volume":"23","author":"Manna","year":"2017","journal-title":"J Cell Physiol"},{"key":"85","doi-asserted-by":"publisher","first-page":"20873","DOI":"10.1038\/srep20873","article-title":"Hippocampal subfield volumetry in patients with subcortical vascular mild cognitive impairment.","volume":"6","author":"Han","year":"2016","journal-title":"Sci Rep"},{"key":"86","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1016\/j.neuroimage.2012.02.072","article-title":"Hippocampal subfield volumes correlate with memory training benefit in subjective memory impairment.","volume":"6","author":"Walhovd","year":"2012","journal-title":"Neuroimage"},{"key":"87","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1001\/jamaneurol.2013.5847","article-title":"Amyloid-\u03b2 and tau: the trigger and bullet in Alzheimer disease pathogenesis.","volume":"7","author":"Bloom","year":"2014","journal-title":"JAMA Neurol"},{"key":"88","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1016\/j.biopha.2016.09.069","article-title":"Neuroprotective effects of quercetin on memory and anxiogenic-like behavior in diabetic rats: Role of ectonucleotidases and acetylcholinesterase activities.","volume":"8","author":"Morsch","year":"2016","journal-title":"Biomed Pharmacother"},{"key":"89","doi-asserted-by":"publisher","first-page":"224","DOI":"10.2337\/diab.47.2.224","article-title":"Experimental NIDDM: development of a new model in adult rats administered streptozotocin and nicotinamide.","volume":"4","author":"Ribes","year":"1998","journal-title":"Diabetes"},{"key":"90","doi-asserted-by":"publisher","first-page":"1342","DOI":"10.1093\/brain\/awq069","article-title":"Powerful beneficial effects of benfotiamine on cognitive impairment and beta-amyloid deposition in amyloid precursor protein\/presenilin-1 transgenic mice.","volume":"13","author":"Fei","year":"2010","journal-title":"Brain"},{"key":"91","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/j.bbr.2008.09.008","article-title":"Analgesic, learning and memory and anxiolytic effects of insulin in mice.","volume":"19","author":"Ilesanmi","year":"2009","journal-title":"Behav Brain Res"},{"key":"92","doi-asserted-by":"publisher","first-page":"848","DOI":"10.1038\/nprot.2006.116","article-title":"Morris water maze: procedures for assessing spatial and related forms of learning and memory.","volume":"1","author":"Williams","year":"2006","journal-title":"Nat Protoc"},{"key":"93","doi-asserted-by":"publisher","first-page":"e83","DOI":"10.1038\/tp.2012.9","article-title":"Forebrain glutamatergic neurons mediate leptin action on depression-like behaviors and synaptic depression.","volume":"2","author":"Lu","year":"2012","journal-title":"Transl Psychiatry"},{"key":"94","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.tox.2006.12.010","article-title":"The role of ROS in microcystin-LR-induced hepatocyte apoptosis and liver injury in mice.","volume":"23","author":"Shen","year":"2007","journal-title":"Toxicology"},{"key":"95","doi-asserted-by":"publisher","first-page":"1596","DOI":"10.1007\/s11427-018-9441-9","article-title":"A lumbrokinase isozyme targets hepatitis B e-antigen.","volume":"6","author":"He","year":"2018","journal-title":"Sci China Life Sci"},{"key":"96","first-page":"137","article-title":"Screening for neurobehavioral toxicity: the need for and examples of validation of testing procedures.","volume":"1","author":"Cabe","year":"1979","journal-title":"Neurobehav Toxicol"},{"key":"97","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/S0009-8981(02)00277-2","article-title":"A convenient assay of glycoserum by nitroblue tetrazolium with iodoacetamide.","volume":"32","author":"He","year":"2002","journal-title":"Clin Chim Acta"},{"key":"98","doi-asserted-by":"publisher","first-page":"E35","DOI":"10.1038\/s41586-018-0271-3","article-title":"ANKRD16 prevents neuron loss caused by an editing-defective tRNA synthetase (vol 557, pg 510, 2018).","volume":"56","author":"Vo","year":"2018","journal-title":"Nature"}],"container-title":["Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.102089","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,2]],"date-time":"2020-09-02T19:09:08Z","timestamp":1599073748000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.102089"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,15]]},"references-count":98,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2019,7,31]]}},"alternative-id":["102089","31307014"],"URL":"https:\/\/doi.org\/10.18632\/aging.102089","relation":{},"ISSN":["1945-4589"],"issn-type":[{"value":"1945-4589","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,15]]}}}