{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T06:11:13Z","timestamp":1792390273240,"version":"4.4.0"},"reference-count":39,"publisher":"Impact Journals, LLC","issue":"15","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aging"],"published-print":{"date-parts":[[2019,8,12]]},"DOI":"10.18632\/aging.102136","type":"journal-article","created":{"date-parts":[[2019,8,12]],"date-time":"2019-08-12T22:47:09Z","timestamp":1565650029000},"page":"5535-5547","source":"Crossref","is-referenced-by-count":163,"title":["HO-1 reduces heat stress-induced apoptosis in bovine granulosa cells by suppressing oxidative stress"],"prefix":"10.18632","volume":"11","author":[{"given":"Yiru","family":"Wang","sequence":"first","affiliation":[{"name":"College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caixia","family":"Yang","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nahla Abdalla Hassan","family":"Elsheikh","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengmin","family":"Li","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangxiao","family":"Yang","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Genlin","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lian","family":"Li","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7892","published-online":{"date-parts":[[2019,8,12]]},"reference":[{"key":"1","doi-asserted-by":"publisher","first-page":"260","DOI":"10.14202\/vetworld.2016.260-268","article-title":"Impact of heat stress on health and performance of dairy animals: A review.","volume":"9","author":"Kumar","year":"2016","journal-title":"Vet World"},{"key":"2","doi-asserted-by":"publisher","first-page":"36","DOI":"10.2527\/1997.77suppl_236x","article-title":"Strategies for managing reproduction in the heat-stressed dairy cow.","volume":"7","author":"Ar\u00e9chiga","year":"1999","journal-title":"J Anim Sci"},{"key":"3","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1007\/s12522-011-0105-6","article-title":"Heat stress on reproductive function and fertility in mammals.","volume":"1","author":"Takahashi","year":"2011","journal-title":"Reprod Med Biol"},{"key":"4","first-page":"322","article-title":"Cellular and molecular basis of therapies to ameliorate effects of heat stress on embryonic development in cattle.","volume":"1","author":"Hansen","year":"2013","journal-title":"Anim Reprod"},{"key":"5","doi-asserted-by":"crossref","first-page":"6","DOI":"10.5455\/OVJ.2015.v5.i1.p6","article-title":"Review on mechanisms of dairy summer infertility and implications for hormonal intervention.","volume":"5","author":"Prabhakar","year":"2015","journal-title":"Open Vet J"},{"key":"6","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.ydbio.2004.08.020","article-title":"Synergistic roles of BMP15 and GDF9 in the development and function of the oocyte-cumulus cell complex in mice: genetic evidence for an oocyte-granulosa cell regulatory loop.","volume":"27","author":"Eppig","year":"2004","journal-title":"Dev Biol"},{"key":"7","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1016\/j.ydbio.2006.12.011","article-title":"Ovarian granulosa cell survival and proliferation requires the gonad-selective TFIID subunit TAF4b.","volume":"30","author":"Freiman","year":"2007","journal-title":"Dev Biol"},{"key":"8","doi-asserted-by":"publisher","first-page":"3890","DOI":"10.1242\/jcs.036400","article-title":"Effect of cell shape and packing density on granulosa cell proliferation and formation of multiple layers during early follicle development in the ovary.","volume":"12","author":"Hardy","year":"2008","journal-title":"J Cell Sci"},{"key":"9","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1530\/rep.0.1220829","article-title":"Oocyte control of ovarian follicular development and function in mammals.","volume":"12","author":"Eppig","year":"2001","journal-title":"Reproduction"},{"key":"10","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1007\/s12192-016-0673-9","article-title":"The effect of heat stress on gene expression, synthesis of steroids, and apoptosis in bovine granulosa cells.","volume":"2","author":"Wang","year":"2016","journal-title":"Cell Stress Chaperones"},{"key":"11","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1016\/j.theriogenology.2017.12.042","article-title":"Oxidative and endoplasmic reticulum stress defense mechanisms of bovine granulosa cells exposed to heat stress.","volume":"11","author":"Tesfaye","year":"2018","journal-title":"Theriogenology"},{"key":"12","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1007\/s11010-015-2610-0","article-title":"Heat stress impairs mice granulosa cell function by diminishing steroids production and inducing apoptosis.","volume":"41","author":"Wang","year":"2016","journal-title":"Mol Cell Biochem"},{"key":"13","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1016\/j.cbi.2014.10.016","article-title":"Free radicals, reactive oxygen species, oxidative stress and its classification.","volume":"22","author":"Lushchak","year":"2014","journal-title":"Chem Biol Interact"},{"key":"14","doi-asserted-by":"publisher","first-page":"11497","DOI":"10.1038\/srep11497","article-title":"Heat stress induced apoptosis is triggered by transcription-independent p53, Ca(2+) dyshomeostasis and the subsequent Bax mitochondrial translocation.","volume":"5","author":"Su","year":"2015","journal-title":"Sci Rep"},{"key":"15","doi-asserted-by":"publisher","first-page":"2653","DOI":"10.1073\/pnas.0511154103","article-title":"Increased production of reactive oxygen species in hyperglycemic conditions requires dynamic change of mitochondrial morphology.","volume":"10","author":"Yoon","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"16","doi-asserted-by":"publisher","first-page":"39387","DOI":"10.1074\/jbc.M111.279893","article-title":"Translocation of heme oxygenase-1 to mitochondria is a novel cytoprotective mechanism against non-steroidal anti-inflammatory drug-induced mitochondrial oxidative stress, apoptosis, and gastric mucosal injury.","volume":"28","author":"Bandyopadhyay","year":"2011","journal-title":"J Biol Chem"},{"key":"17","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.cell.2014.04.043","article-title":"Heme oxygenase-1 drives metaflammation and insulin resistance in mouse and man.","volume":"15","author":"Zapf","year":"2014","journal-title":"Cell"},{"key":"18","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1182\/blood-2006-10-054411","article-title":"Identification of heat shock protein 32 (Hsp32) as a novel survival factor and therapeutic target in neoplastic mast cells.","volume":"11","author":"Valent","year":"2007","journal-title":"Blood"},{"key":"19","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.chemosphere.2018.03.192","article-title":"Autophagy attenuates copper-induced mitochondrial dysfunction by regulating oxidative stress in chicken hepatocytes.","volume":"20","author":"Tang","year":"2018","journal-title":"Chemosphere"},{"key":"20","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1111\/j.1600-0897.2011.01096.x","article-title":"Heme oxygenase-1 expression in the ovary dictates a proper oocyte ovulation, fertilization, and corpora lutea maintenance.","volume":"6","author":"Zenclussen","year":"2012","journal-title":"Am J Reprod Immunol"},{"key":"21","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1007\/s12640-018-9881-7","article-title":"Sulforaphane Attenuated the Pro-Inflammatory State Induced by Hydrogen Peroxide in SH-SY5Y Cells Through the Nrf2\/HO-1 Signaling Pathway.","volume":"3","author":"F\u00fcrstenau","year":"2018","journal-title":"Neurotox Res"},{"key":"22","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/j.fct.2018.02.010","article-title":"T-2 toxin-induced toxicity in neuroblastoma-2a cells involves the generation of reactive oxygen, mitochondrial dysfunction and inhibition of Nrf2\/HO-1 pathway.","volume":"11","author":"Dai","year":"2018","journal-title":"Food Chem Toxicol"},{"key":"23","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1146\/annurev-animal-022516-022849","article-title":"Effect of Heat Stress on Reproduction in Dairy Cows: Insights into the Cellular and Molecular Responses of the Oocyte.","volume":"5","author":"Roth","year":"2017","journal-title":"Annu Rev Anim Biosci"},{"key":"24","doi-asserted-by":"publisher","first-page":"3642","DOI":"10.3168\/jds.2017-13389","article-title":"Symposium review: reduction in oocyte developmental competence by stress is associated with alterations in mitochondrial function.","volume":"10","author":"Roth","year":"2018","journal-title":"J Dairy Sci"},{"key":"25","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1016\/S0378-4320(00)00102-0","article-title":"Impaired reproduction in heat-stressed cattle: basic and applied aspects.","volume":"60","author":"Meidan","year":"2000","journal-title":"Anim Reprod Sci"},{"key":"26","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1530\/rep.1.00456","article-title":"Alterations in follicular dynamics and steroidogenic abilities induced by heat stress during follicular recruitment in goats.","volume":"12","author":"Kanai","year":"2005","journal-title":"Reproduction"},{"key":"27","doi-asserted-by":"publisher","first-page":"390","DOI":"10.3168\/jds.S0022-0302(02)74086-1","article-title":"Effect of season and exposure to heat stress on oocyte competence in Holstein cows.","volume":"8","author":"Hansen","year":"2002","journal-title":"J Dairy Sci"},{"key":"28","doi-asserted-by":"publisher","first-page":"2383","DOI":"10.3168\/jds.2010-3904","article-title":"The low fertility of repeat-breeder cows during summer heat stress is related to a low oocyte competence to develop into blastocysts.","volume":"9","author":"Baruselli","year":"2011","journal-title":"J Dairy Sci"},{"key":"29","doi-asserted-by":"publisher","first-page":"513","DOI":"10.3109\/02656736.2014.971446","article-title":"Reactive oxygen species, heat stress and oxidative-induced mitochondrial damage. A review.","volume":"3","author":"Abdrabbah","year":"2014","journal-title":"Int J Hyperthermia"},{"key":"30","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1007\/s00380-014-0523-6","article-title":"Humid heat exposure induced oxidative stress and apoptosis in cardiomyocytes through the angiotensin II signaling pathway.","volume":"3","author":"Gong","year":"2015","journal-title":"Heart Vessels"},{"key":"31","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1677\/joe.0.1810191","article-title":"Haem oxygenase augments porcine granulosa cell apoptosis in vitro.","volume":"18","author":"Aso","year":"2004","journal-title":"J Endocrinol"},{"key":"32","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1002\/mrd.22316","article-title":"Bovine embryo survival under oxidative-stress conditions is associated with activity of the NRF2-mediated oxidative-stress-response pathway.","volume":"8","author":"Tesfaye","year":"2014","journal-title":"Mol Reprod Dev"},{"key":"33","doi-asserted-by":"publisher","first-page":"26071","DOI":"10.1074\/jbc.274.37.26071","article-title":"Nrf2, a Cap\u2019n\u2019Collar transcription factor, regulates induction of the heme oxygenase-1 gene.","volume":"27","author":"Cook","year":"1999","journal-title":"J Biol Chem"},{"key":"34","doi-asserted-by":"publisher","first-page":"295","DOI":"10.3389\/fphar.2014.00295","article-title":"Heme oxygenase-1 in pregnancy and cancer: similarities in cellular invasion, cytoprotection, angiogenesis, and immunomodulation.","volume":"5","author":"Stevenson","year":"2015","journal-title":"Front Pharmacol"},{"key":"35","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1186\/1748-717X-7-4","article-title":"Amelioration of radiation-induced skin injury by adenovirus-mediated heme oxygenase-1 (HO-1) overexpression in rats.","volume":"7","author":"Wu","year":"2012","journal-title":"Radiat Oncol"},{"key":"36","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/j.redox.2015.07.008","article-title":"Antioxidant responses and cellular adjustments to oxidative stress.","volume":"6","author":"Lamas","year":"2015","journal-title":"Redox Biol"},{"key":"37","doi-asserted-by":"publisher","first-page":"6807","DOI":"10.1002\/jcp.26431","article-title":"miR-181b-induced SMAD7 downregulation controls granulosa cell apoptosis through TGF-\u03b2 signaling by interacting with the TGFBR1 promoter.","volume":"23","author":"Li","year":"2018","journal-title":"J Cell Physiol"},{"key":"38","doi-asserted-by":"publisher","first-page":"4787","DOI":"10.1002\/jcp.27277","article-title":"Heat stress induces distinct responses in porcine cumulus cells and oocytes associated with disrupted gap junction and trans-zonal projection colocalization.","volume":"23","author":"Zhao","year":"2019","journal-title":"J Cell Physiol"},{"key":"39","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1002\/cbin.10177","article-title":"Heat shock protein 32\/heme oxygenase-1 protects mouse Sertoli cells from hyperthermia-induced apoptosis by CO activation of sGC signalling pathways.","volume":"3","author":"Wang","year":"2014","journal-title":"Cell Biol Int"}],"container-title":["Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.102136","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,19]],"date-time":"2023-09-19T01:14:30Z","timestamp":1695086070000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.102136"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,12]]},"references-count":39,"journal-issue":{"issue":"15","published-print":{"date-parts":[[2019,8,15]]}},"alternative-id":["102136","31404912"],"URL":"https:\/\/doi.org\/10.18632\/aging.102136","relation":{},"ISSN":["1945-4589"],"issn-type":[{"value":"1945-4589","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8,12]]}}}