{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T14:14:13Z","timestamp":1791814453921,"version":"4.3.4"},"reference-count":69,"publisher":"Impact Journals, LLC","issue":"16","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aging"],"published-print":{"date-parts":[[2019,8,18]]},"DOI":"10.18632\/aging.102173","type":"journal-article","created":{"date-parts":[[2019,8,18]],"date-time":"2019-08-18T12:51:27Z","timestamp":1566132687000},"page":"5895-5923","source":"Crossref","is-referenced-by-count":400,"title":["DNA methylation-based estimator of telomere length"],"prefix":"10.18632","volume":"11","author":[{"given":"Ake T.","family":"Lu","sequence":"first","affiliation":[{"name":"Department of Human Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Seeboth","sequence":"additional","affiliation":[{"name":"Centre for Genomic and Experimental Medicine, Institute of Genetics & Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei-Chien","family":"Tsai","sequence":"additional","affiliation":[{"name":"Department of Twin Research and Genetic Epidemiology, Kings College London, London SE1 7EH, UK"},{"name":"Department of Biomedical Sciences, Chang Gung University, Taoyuan, Taiwan"},{"name":"Genomic Medicine Research Core Laboratory, Chang Gung Memorial Hospital, Linkou, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dianjianyi","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing, China"},{"name":"Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA 70112, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Austin","family":"Quach","sequence":"additional","affiliation":[{"name":"Department of Human Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex P.","family":"Reiner","sequence":"additional","affiliation":[{"name":"Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Kooperberg","sequence":"additional","affiliation":[{"name":"Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Ferrucci","sequence":"additional","affiliation":[{"name":"Longitudinal Studies Section, Translational Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lifang","family":"Hou","sequence":"additional","affiliation":[{"name":"Center for Population Epigenetics, Robert H. Lurie Comprehensive Cancer Center and Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea A.","family":"Baccarelli","sequence":"additional","affiliation":[{"name":"Laboratory of Environmental Epigenetics, Departments of Environmental Health Sciences Epidemiology, Columbia University Mailman School of Public Health, New York, NY 10032, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Li","sequence":"additional","affiliation":[{"name":"Departments of Genetics, Biostatistics, Computer Science, University of North Carolina, Chapel Hill, NC 27599, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah E.","family":"Harris","sequence":"additional","affiliation":[{"name":"Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, University of Edinburgh, Edinburgh EH8 9JZ, UK"},{"name":"Department of Psychology, University of Edinburgh, Edinburgh EH8 9JZ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janie","family":"Corley","sequence":"additional","affiliation":[{"name":"Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, University of Edinburgh, Edinburgh EH8 9JZ, UK"},{"name":"Department of Psychology, University of Edinburgh, Edinburgh EH8 9JZ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adele","family":"Taylor","sequence":"additional","affiliation":[{"name":"Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, University of Edinburgh, Edinburgh EH8 9JZ, UK"},{"name":"Department of Psychology, University of Edinburgh, Edinburgh EH8 9JZ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian J.","family":"Deary","sequence":"additional","affiliation":[{"name":"Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, University of Edinburgh, Edinburgh EH8 9JZ, UK"},{"name":"Department of Psychology, University of Edinburgh, Edinburgh EH8 9JZ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James D.","family":"Stewart","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC 27599, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric A.","family":"Whitsel","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC 27599, USA"},{"name":"Department of Medicine, School of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Themistocles L.","family":"Assimes","sequence":"additional","affiliation":[{"name":"VA Palo Alto Health Care System, Palo Alto, CA 94304, USA"},{"name":"Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA 70112, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengxu","family":"Li","sequence":"additional","affiliation":[{"name":"Children\u2019s Minnesota Research Institute, Children\u2019s Hospitals and Clinics of Minnesota, Minneapolis, MN 55404, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Mangino","sequence":"additional","affiliation":[{"name":"Department of Twin Research and Genetic Epidemiology, Kings College London, London SE1 7EH, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordana T.","family":"Bell","sequence":"additional","affiliation":[{"name":"Department of Twin Research and Genetic Epidemiology, Kings College London, London SE1 7EH, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James G.","family":"Wilson","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS 39216, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abraham","family":"Aviv","sequence":"additional","affiliation":[{"name":"Center of Development and Aging, New Jersey Medical School, Rutgers State University of New Jersey, Newark, NJ 07103, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo E.","family":"Marioni","sequence":"additional","affiliation":[{"name":"Centre for Genomic and Experimental Medicine, Institute of Genetics & Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK"},{"name":"Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, University of Edinburgh, Edinburgh EH8 9JZ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth","family":"Raj","sequence":"additional","affiliation":[{"name":"Radiation Effects Department, Centre for Radiation, Chemical and Environmental Hazards, Public Health England, Chilton, Didcot, Oxfordshire OX11 0RQ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve","family":"Horvath","sequence":"additional","affiliation":[{"name":"Department of Human Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA"},{"name":"Department of Biostatistics, Fielding School of Public Health, University of California Los Angeles, Los Angeles, CA 90095, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7892","published-online":{"date-parts":[[2019,8,18]]},"reference":[{"key":"1","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1038\/ejhg.2009.178","article-title":"Large-scale parent-child comparison confirms a strong paternal influence on telomere length.","volume":"1","author":"Roos","year":"2010","journal-title":"Eur J Hum Genet"},{"key":"2","doi-asserted-by":"publisher","first-page":"1597","DOI":"10.1038\/ncomms2602","article-title":"Telomeres shorten at equivalent rates in somatic tissues of adults.","volume":"4","author":"Aviv","year":"2013","journal-title":"Nat Commun"},{"key":"3","doi-asserted-by":"publisher","first-page":"17312","DOI":"10.1073\/pnas.0407162101","article-title":"Accelerated telomere shortening in response to life stress.","volume":"10","author":"Cawthon","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"key":"4","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1093\/aje\/kwj346","article-title":"Leukocyte telomere length and cardiovascular disease in the cardiovascular health study.","volume":"16","author":"Aviv","year":"2007","journal-title":"Am J Epidemiol"},{"key":"5","doi-asserted-by":"publisher","first-page":"1649","DOI":"10.1161\/ATVBAHA.110.205492","article-title":"Cellular aging reflected by leukocyte telomere length predicts advanced atherosclerosis and cardiovascular disease risk.","volume":"3","author":"Kiechl","year":"2010","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"6","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1093\/gerona\/glq180","article-title":"Is telomere length a biomarker of aging? A review.","volume":"6","author":"Christensen","year":"2011","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"7","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1097\/EDE.0000000000000299","article-title":"Leukocyte telomere length and mortality in the National Health and Nutrition Examination Survey, 1999-2002.","volume":"2","author":"Epel","year":"2015","journal-title":"Epidemiology"},{"key":"8","doi-asserted-by":"publisher","first-page":"1983","DOI":"10.18632\/aging.101293","article-title":"Leukocyte telomere length, T cell composition and DNA methylation age.","volume":"9","author":"Aviv","year":"2017","journal-title":"Aging (Albany NY)"},{"key":"9","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.ebiom.2017.03.046","article-title":"Biological Age Predictors.","volume":"2","author":"H\u00e4gg","year":"2017","journal-title":"EBioMedicine"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2016.0436","article-title":"Reflections on telomere dynamics and ageing-related diseases in humans.","volume":"37","author":"Shay","year":"2018","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"key":"11","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1016\/j.molcel.2012.10.016","article-title":"Genome-wide methylation profiles reveal quantitative views of human aging rates.","volume":"4","author":"Rajapakse","year":"2013","journal-title":"Mol Cell"},{"key":"12","doi-asserted-by":"publisher","first-page":"R115","DOI":"10.1186\/gb-2013-14-10-r115","article-title":"DNA methylation age of human tissues and cell types.","volume":"1","author":"Horvath","year":"2013","journal-title":"Genome Biol"},{"key":"13","doi-asserted-by":"publisher","first-page":"394","DOI":"10.18632\/aging.100908","article-title":"DNA methylation levels at individual age-associated CpG sites can be indicative for life expectancy.","volume":"8","author":"Wagner","year":"2016","journal-title":"Aging (Albany NY)"},{"key":"14","doi-asserted-by":"publisher","first-page":"1758","DOI":"10.18632\/aging.101508","article-title":"Epigenetic clock for skin and blood cells applied to Hutchinson Gilford Progeria Syndrome andstudies.","volume":"1","author":"Maierhofer","year":"2018","journal-title":"Aging (Albany NY)"},{"key":"15","doi-asserted-by":"publisher","first-page":"573","DOI":"10.18632\/aging.101414","article-title":"An epigenetic biomarker of aging for lifespan and healthspan.","volume":"1","author":"Reiner","year":"2018","journal-title":"Aging (Albany NY)"},{"key":"16","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1038\/s41576-018-0004-3","article-title":"DNA methylation-based biomarkers and the epigenetic clock theory of ageing.","volume":"1","author":"Raj","year":"2018","journal-title":"Nat Rev Genet"},{"key":"17","doi-asserted-by":"publisher","first-page":"303","DOI":"10.18632\/aging.101684","article-title":"DNA methylation GrimAge strongly predicts lifespan and healthspan.","volume":"1","author":"Horvath","year":"2019","journal-title":"Aging (Albany NY)"},{"key":"18","doi-asserted-by":"crossref","unstructured":"Breitling LP, Saum K-U, Perna L, Sch\u00f6ttker B, Holleczek B, Brenner H. Frailty is associated with the epigenetic clock but not with telomere length in a German cohort. Clin Epigenetics. 2016; 8:21. https:\/\/doi.org\/10.1186\/s13148-016-0186-5.","DOI":"10.1186\/s13148-016-0186-5"},{"key":"19","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1038\/s41467-017-02697-5","article-title":"GWAS of epigenetic aging rates in blood reveals a critical role for TERT.","volume":"9","author":"Mangino","year":"2018","journal-title":"Nat Commun"},{"key":"20","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1093\/ije\/dyw041","article-title":"The epigenetic clock and telomere length are independently associated with chronological age and mortality.","volume":"4","author":"Deary","year":"2016","journal-title":"Int J Epidemiol"},{"key":"21","doi-asserted-by":"publisher","first-page":"726","DOI":"10.1038\/nbt.3605","article-title":"Quantitative comparison of DNA methylation assays for biomarker development and clinical applications.","volume":"3","author":"BLUEPRINT consortium","year":"2016","journal-title":"Nat Biotechnol"},{"key":"22","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1186\/1756-0500-7-877","article-title":"Leukocyte telomere length variation due to DNA extraction method.","volume":"7","author":"Charchar","year":"2014","journal-title":"BMC Res Notes"},{"key":"23","doi-asserted-by":"publisher","first-page":"1683","DOI":"10.1093\/ije\/dyv166","article-title":"Commentary: the reliability of telomere length measurements.","volume":"4","author":"Aviv","year":"2015","journal-title":"Int J Epidemiol"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0143889","article-title":"Preanalytical Conditions and DNA Isolation Methods Affect Telomere Length Quantification in Whole Blood.","volume":"1","author":"Holdt","year":"2015","journal-title":"PLoS One"},{"key":"25","doi-asserted-by":"publisher","first-page":"1596","DOI":"10.1038\/nprot.2010.124","article-title":"Measurement of telomere length by the Southern blot analysis of terminal restriction fragment lengths.","volume":"5","author":"Aviv","year":"2010","journal-title":"Nat Protoc"},{"key":"26","doi-asserted-by":"publisher","first-page":"697","DOI":"10.3389\/fgene.2018.00697","article-title":"The Alteration of Subtelomeric DNA Methylation in Aging-Related Diseases.","volume":"9","author":"Duan","year":"2019","journal-title":"Front Genet"},{"key":"27","doi-asserted-by":"publisher","first-page":"876","DOI":"10.1016\/j.ajhg.2013.10.004","article-title":"Global analysis of DNA methylation variation in adipose tissue from twins reveals links to disease-associated variants in distal regulatory elements.","volume":"9","author":"Small","year":"2013","journal-title":"Am J Hum Genet"},{"key":"28","doi-asserted-by":"publisher","first-page":"15538","DOI":"10.1073\/pnas.1412759111","article-title":"Obesity accelerates epigenetic aging of human liver.","volume":"11","author":"Sipos","year":"2014","journal-title":"Proc Natl Acad Sci USA"},{"key":"29","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1016\/j.cmet.2013.07.004","article-title":"DNA methylation analysis in nonalcoholic fatty liver disease suggests distinct disease-specific and remodeling signatures after bariatric surgery.","volume":"1","author":"Sipos","year":"2013","journal-title":"Cell Metab"},{"key":"30","doi-asserted-by":"publisher","first-page":"5366","DOI":"10.1038\/ncomms6366","article-title":"Age-related variations in the methylome associated with gene expression in human monocytes and T cells.","volume":"5","author":"Hoeschele","year":"2014","journal-title":"Nat Commun"},{"key":"31","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1111\/j.1467-9868.2005.00503.x","article-title":"Regularization and variable selection via the elastic net.","volume":"6","author":"Hastie","year":"2005","journal-title":"J R Stat Soc Series B Stat Methodol"},{"key":"32","doi-asserted-by":"publisher","first-page":"1688","DOI":"10.1093\/ije\/dyv165","article-title":"Leukocyte telomere length dynamics in women and men: menopause vs age effects.","volume":"4","author":"Aviv","year":"2015","journal-title":"Int J Epidemiol"},{"key":"33","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1111\/j.1474-9726.2008.00397.x","article-title":"Leukocyte telomeres are longer in African Americans than in whites: the National Heart, Lung, and Blood Institute Family Heart Study and the Bogalusa Heart Study.","volume":"7","author":"Aviv","year":"2008","journal-title":"Aging Cell"},{"key":"34","doi-asserted-by":"publisher","first-page":"9327","DOI":"10.1073\/pnas.1604558113","article-title":"Menopause accelerates biological aging.","volume":"11","author":"Wong","year":"2016","journal-title":"Proc Natl Acad Sci USA"},{"key":"35","doi-asserted-by":"publisher","first-page":"17605","DOI":"10.1038\/s41598-018-35871-w","article-title":"Identification of 55,000 Replicated DNA Methylation QTL.","volume":"8","author":"Starr","year":"2018","journal-title":"Sci Rep"},{"key":"36","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1038\/ng.2566","article-title":"Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer.","volume":"4","author":"Lawrenson","year":"2013","journal-title":"Nat Genet"},{"key":"37","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1038\/ng.2528","article-title":"Identification of seven loci affecting mean telomere length and their association with disease.","volume":"4","author":"Mateo Leach","year":"2013","journal-title":"Nat Genet"},{"key":"38","doi-asserted-by":"publisher","first-page":"5056","DOI":"10.1093\/hmg\/ddt355","article-title":"A genome-wide association scan (GWAS) for mean telomere length within the COGS project: identified loci show little association with hormone-related cancer risk.","volume":"2","author":"Khaw","year":"2013","journal-title":"Hum Mol Genet"},{"key":"39","doi-asserted-by":"crossref","unstructured":"Steenstrup T, Hjelmborg JVB, Mortensen LH, Kimura M, Christensen K, Aviv A. Leukocyte telomere length dynamics in women and men: menopause vs age effects. Int J Epidemiol. 2013; 28:181-87. https:\/\/doi.org\/10.1007\/s10654-013-9780-4.","DOI":"10.1007\/s10654-013-9780-4"},{"key":"40","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1093\/gerona\/glq223","article-title":"Longitudinal versus cross-sectional evaluations of leukocyte telomere length dynamics: age-dependent telomere shortening is the rule.","volume":"6","author":"Aviv","year":"2011","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkt370","article-title":"The telomere lengthening conundrum--artifact or biology?","volume":"4","author":"Aviv","year":"2013","journal-title":"Nucleic Acids Res"},{"key":"42","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1016\/j.exphem.2008.11.009","article-title":"Leukocyte telomere dynamics and human hematopoietic stem cell kinetics during somatic growth.","volume":"3","author":"Aviv","year":"2009","journal-title":"Exp Hematol"},{"key":"43","doi-asserted-by":"publisher","first-page":"1040","DOI":"10.1016\/j.exphem.2004.07.023","article-title":"Estimating human hematopoietic stem cell kinetics using granulocyte telomere lengths.","volume":"3","author":"Abkowitz","year":"2004","journal-title":"Exp Hematol"},{"key":"44","doi-asserted-by":"publisher","first-page":"854","DOI":"10.1016\/j.exphem.2010.06.010","article-title":"Synchrony of telomere length among hematopoietic cells.","volume":"3","author":"Aviv","year":"2010","journal-title":"Exp Hematol"},{"key":"45","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2015-3927","article-title":"Leukocyte Telomere Length in Newborns: Implications for the Role of Telomeres in Human Disease.","volume":"13","author":"Aviv","year":"2016","journal-title":"Pediatrics"},{"key":"46","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1196\/annals.1349.027","article-title":"Role of telomerase in hematopoietic stem cells.","volume":"104","author":"Lansdorp","year":"2005","journal-title":"Ann N Y Acad Sci"},{"key":"47","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.psychres.2018.09.035","article-title":"Leukocyte telomere length in patients with bipolar disorder: an updated meta-analysis and subgroup analysis by mood status.","volume":"27","author":"Lin","year":"2018","journal-title":"Psychiatry Res"},{"key":"48","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1038\/npp.2017.125","article-title":"Telomere Length and Bipolar Disorder.","volume":"4","author":"Breen","year":"2018","journal-title":"Neuropsychopharmacology"},{"key":"49","doi-asserted-by":"publisher","first-page":"2800","DOI":"10.18632\/aging.101588","article-title":"Epigenetic ageing is distinct from senescence-mediated ageing and is not prevented by telomerase expression.","volume":"1","author":"Raj","year":"2018","journal-title":"Aging (Albany NY)"},{"key":"50","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1093\/gerona\/gly184","article-title":"Epigenetic Clock and Relative Telomere Length Represent Largely Different Aspects of Aging in the Berlin Aging Study II (BASE-II).","volume":"7","author":"Demuth","year":"2019","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"51","doi-asserted-by":"publisher","first-page":"1024","DOI":"10.1001\/2012.jama.11374","article-title":"Association between omega-3 fatty acid supplementation and risk of major cardiovascular disease events: a systematic review and meta-analysis.","volume":"30","author":"Elisaf","year":"2012","journal-title":"JAMA"},{"key":"52","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1001\/jamacardio.2017.5205","article-title":"Associations of Omega-3 Fatty Acid Supplement Use With Cardiovascular Disease Risks: Meta-analysis of 10 Trials Involving 77\u202f917 Individuals.","volume":"3","author":"Collins","year":"2018","journal-title":"JAMA Cardiol"},{"key":"53","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1007\/s11886-017-0856-8","article-title":"Does Supplementation with Omega-3 PUFAs Add to the Prevention of Cardiovascular Disease?","volume":"1","author":"Elisaf","year":"2017","journal-title":"Curr Cardiol Rep"},{"key":"54","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/S0197-2456(97)00078-0","article-title":"Design of the Women\u2019s Health Initiative clinical trial and observational study.","volume":"1","author":"Anonymous","year":"1998","journal-title":"Control Clin Trials"},{"key":"55","doi-asserted-by":"publisher","first-page":"S5","DOI":"10.1016\/S1047-2797(03)00043-7","article-title":"Implementation of the women\u2019s health initiative study design.","volume":"1","author":"Prentice","year":"2003","journal-title":"Ann Epidemiol"},{"key":"56","first-page":"S6","article-title":"Toward resolution of cardiovascular health disparities in African Americans: design and methods of the Jackson Heart Study.","volume":"1","author":"Wyatt","year":"2005","journal-title":"Ethn Dis"},{"key":"57","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1093\/bioinformatics\/bts680","article-title":"A beta-mixture quantile normalization method for correcting probe design bias in Illumina Infinium 450 k DNA methylation data.","volume":"2","author":"Beck","year":"2013","journal-title":"Bioinformatics"},{"key":"58","doi-asserted-by":"publisher","first-page":"e90","DOI":"10.1093\/nar\/gkt090","article-title":"Low-level processing of Illumina Infinium DNA Methylation BeadArrays.","volume":"4","author":"Siegmund","year":"2013","journal-title":"Nucleic Acids Res"},{"key":"59","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1093\/bioinformatics\/btw691","article-title":"Preprocessing, normalization and integration of the Illumina HumanMethylationEPIC array with minfi.","volume":"3","author":"Hansen","year":"2017","journal-title":"Bioinformatics"},{"key":"60","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1186\/s13059-016-1030-0","article-title":"An epigenetic clock analysis of race\/ethnicity, sex, and coronary heart disease.","volume":"1","author":"Li","year":"2016","journal-title":"Genome Biol"},{"key":"61","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1186\/1471-2105-13-86","article-title":"DNA methylation arrays as surrogate measures of cell mixture distribution.","volume":"1","author":"Kelsey","year":"2012","journal-title":"BMC Bioinformatics"},{"key":"62","doi-asserted-by":"publisher","first-page":"15353","DOI":"10.1038\/ncomms15353","article-title":"Genetic architecture of epigenetic and neuronal ageing rates in human brain regions.","volume":"8","author":"Horvath","year":"2017","journal-title":"Nat Commun"},{"key":"63","doi-asserted-by":"publisher","first-page":"10561","DOI":"10.1038\/ncomms10561","article-title":"Genetic variants near MLST8 and DHX57 affect the epigenetic age of the cerebellum.","volume":"7","author":"Horvath","year":"2016","journal-title":"Nat Commun"},{"key":"64","doi-asserted-by":"publisher","first-page":"1901","DOI":"10.1093\/bioinformatics\/btw080","article-title":"solarius: an R interface to SOLAR for variance component analysis in pedigrees.","volume":"3","author":"Soria","year":"2016","journal-title":"Bioinformatics"},{"key":"65","doi-asserted-by":"publisher","first-page":"1563","DOI":"10.1093\/infdis\/jiv277","article-title":"HIV-1 infection accelerates age according to the epigenetic clock.","volume":"21","author":"Levine","year":"2015","journal-title":"J Infect Dis"},{"key":"66","doi-asserted-by":"publisher","first-page":"419","DOI":"10.18632\/aging.101168","article-title":"Epigenetic clock analysis of diet, exercise, education, and lifestyle factors.","volume":"9","author":"Tsao","year":"2017","journal-title":"Aging (Albany NY)"},{"key":"67","doi-asserted-by":"publisher","first-page":"D930","DOI":"10.1093\/nar\/gkr917","article-title":"HaploReg: a resource for exploring chromatin states, conservation, and regulatory motif alterations within sets of genetically linked variants.","volume":"4","author":"Kellis","year":"2012","journal-title":"Nucleic Acids Res"},{"key":"68","doi-asserted-by":"publisher","first-page":"1363","DOI":"10.1093\/bioinformatics\/btu049","article-title":"Minfi: a flexible and comprehensive Bioconductor package for the analysis of Infinium DNA methylation microarrays.","volume":"3","author":"Irizarry","year":"2014","journal-title":"Bioinformatics"},{"key":"69","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1186\/1471-2164-14-293","article-title":"A data-driven approach to preprocessing Illumina 450K methylation array data.","volume":"1","author":"Schalkwyk","year":"2013","journal-title":"BMC Genomics"}],"container-title":["Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.102173","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,2]],"date-time":"2020-09-02T15:12:42Z","timestamp":1599059562000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.102173"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,18]]},"references-count":69,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2019,8,31]]}},"alternative-id":["102173","31422385"],"URL":"https:\/\/doi.org\/10.18632\/aging.102173","relation":{},"ISSN":["1945-4589"],"issn-type":[{"value":"1945-4589","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8,18]]}}}