{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T05:11:04Z","timestamp":1782623464683,"version":"3.54.5"},"reference-count":53,"publisher":"Impact Journals, LLC","issue":"17","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aging"],"published-print":{"date-parts":[[2019,9,6]]},"DOI":"10.18632\/aging.102238","type":"journal-article","created":{"date-parts":[[2019,9,7]],"date-time":"2019-09-07T02:44:28Z","timestamp":1567824268000},"page":"7083-7097","source":"Crossref","is-referenced-by-count":29,"title":["Telomere length, vitamin B12 and mortality in persons undergoing coronary angiography: the Ludwigshafen risk and cardiovascular health study"],"prefix":"10.18632","volume":"11","author":[{"given":"Irene","family":"Pusceddu","sequence":"first","affiliation":[{"name":"Department of Clinical Pathology, Hospital of Bolzano, Bolzano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Herrmann","sequence":"additional","affiliation":[{"name":"Department of Clinical Chemistry, University of Saarland, Homburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus E.","family":"Kleber","sequence":"additional","affiliation":[{"name":"Medical Clinic V - Nephrology, Hypertensiology, Rheumatology, Endocrinology, Diabetology, Medical Faculty of Mannheim, University of Heidelberg, Mannheim, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hubert","family":"Scharnagl","sequence":"additional","affiliation":[{"name":"Medical University of Graz, Clinical Institute of Medical and Chemical Laboratory Diagnostics, Graz, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Winfried","family":"M\u00e4rz","sequence":"additional","affiliation":[{"name":"Medical Clinic V - Nephrology, Hypertensiology, Rheumatology, Endocrinology, Diabetology, Medical Faculty of Mannheim, University of Heidelberg, Mannheim, Germany"},{"name":"Medical University of Graz, Clinical Institute of Medical and Chemical Laboratory Diagnostics, Graz, Austria"},{"name":"Synlab Academy, Synlab Holding Deutschland GmbH, Mannheim, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Herrmann","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology, Hospital of Bolzano, Bolzano, Italy"},{"name":"Medical University of Graz, Clinical Institute of Medical and Chemical Laboratory Diagnostics, Graz, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7892","published-online":{"date-parts":[[2019,9,6]]},"reference":[{"key":"1","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1093\/gerona\/glq224","article-title":"Leukocyte telomere length and mortality in the Cardiovascular Health Study.","volume":"6","author":"Aviv","year":"2011","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"2","doi-asserted-by":"publisher","first-page":"djv074","DOI":"10.1093\/jnci\/djv074","article-title":"Peripheral blood leukocyte telomere length and mortality among 64,637 individuals from the general population.","volume":"10","author":"Bojesen","year":"2015","journal-title":"J Natl Cancer Inst"},{"key":"3","doi-asserted-by":"publisher","first-page":"e0198373","DOI":"10.1371\/journal.pone.0198373","article-title":"Telomere length and mortality in the Ludwigshafen Risk and Cardiovascular Health study.","volume":"1","author":"Herrmann","year":"2018","journal-title":"PLoS One"},{"key":"4","doi-asserted-by":"publisher","first-page":"4769","DOI":"10.1038\/s41598-017-05205-3","article-title":"Association between homocysteine levels and all-cause mortality: a dose-response meta-analysis of prospective studies.","volume":"7","author":"Zhong","year":"2017","journal-title":"Sci Rep"},{"key":"5","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1093\/ajcn\/74.1.130","article-title":"Plasma total homocysteine and cardiovascular and noncardiovascular mortality: the Hordaland Homocysteine Study.","volume":"7","author":"Ueland","year":"2001","journal-title":"Am J Clin Nutr"},{"key":"6","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1056\/NEJMcp1113996","article-title":"Clinical practice. Vitamin B12 deficiency.","volume":"36","author":"Stabler","year":"2013","journal-title":"N Engl J Med"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1515\/9783110214499","article-title":"Vitamins in the prevention of human diseases.","author":"Obeid","year":"2011","journal-title":"De Gruyter"},{"key":"8","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1111\/eci.12034","article-title":"Utility and limitations of biochemical markers of vitamin B12 deficiency.","volume":"4","author":"Obeid","year":"2013","journal-title":"Eur J Clin Invest"},{"key":"9","doi-asserted-by":"publisher","first-page":"1241","DOI":"10.1093\/ajcn\/77.5.1241","article-title":"Screening for vitamin B-12 and folate deficiency in older persons.","volume":"7","author":"Scott","year":"2003","journal-title":"Am J Clin Nutr"},{"key":"10","doi-asserted-by":"publisher","first-page":"27","DOI":"10.3389\/fmolb.2016.00027","article-title":"Biomarkers and Algorithms for the Diagnosis of Vitamin B12 Deficiency.","volume":"3","author":"Blom","year":"2016","journal-title":"Front Mol Biosci"},{"key":"11","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.mam.2016.11.007","article-title":"One-carbon metabolism and epigenetics.","volume":"5","author":"Choi","year":"2017","journal-title":"Mol Aspects Med"},{"key":"12","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1073\/pnas.0909737107","article-title":"Homocystamides promote free-radical and oxidative damage to proteins.","volume":"10","author":"Strongin","year":"2010","journal-title":"Proc Natl Acad Sci USA"},{"key":"13","doi-asserted-by":"publisher","first-page":"1194","DOI":"10.1016\/j.cell.2013.05.039","article-title":"The hallmarks of aging.","volume":"15","author":"Kroemer","year":"2013","journal-title":"Cell"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1007\/s00394-019-01993-8","article-title":"Subclinical inflammation, telomere shortening, homocysteine, vitamin B6, and mortality: the Ludwigshafen Risk and Cardiovascular Health Study.","author":"Herrmann","year":"2019","journal-title":"Eur J Nutr"},{"key":"15","doi-asserted-by":"publisher","first-page":"3259","DOI":"10.3390\/nu6083259","article-title":"Vegan diet, subnormal vitamin B-12 status and cardiovascular health.","volume":"6","author":"Celermajer","year":"2014","journal-title":"Nutrients"},{"key":"16","doi-asserted-by":"publisher","first-page":"1506","DOI":"10.1161\/01.CIR.101.13.1506","article-title":"Hyperhomocysteinemia increases risk of death, especially in type 2 diabetes : 5-year follow-up of the Hoorn Study.","volume":"10","author":"Stehouwer","year":"2000","journal-title":"Circulation"},{"key":"17","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.clnu.2011.08.010","article-title":"Increased Vitamin B12 levels are associated with mortality in critically ill medical patients.","volume":"3","author":"van Heerden","year":"2012","journal-title":"Clin Nutr"},{"key":"18","doi-asserted-by":"publisher","first-page":"1258","DOI":"10.1093\/gerona\/gly035","article-title":"Elevated total homocysteine in all participants and plasma vitamin B12 concentrations in woman are associated with all-cause and cardiovascular mortality in the very old: the Newcastle 85+ study.","volume":"7","author":"Hill","year":"2018","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"19","doi-asserted-by":"publisher","first-page":"1067","DOI":"10.2147\/TCRM.S164200","article-title":"Elevated levels of vitamin B12 in chronic stable heart failure: a marker for subclinical liver damage and impaired prognosis.","volume":"1","author":"Agacdiken Agir","year":"2018","journal-title":"Ther Clin Risk Manag"},{"key":"20","doi-asserted-by":"publisher","first-page":"e76","DOI":"10.1016\/j.clnme.2014.01.003","article-title":"High vitamin B12 levels are not associated with increased mortality risk for ICU patients after adjusting for liver function: a cohort study.","volume":"9","author":"McDonald","year":"2014","journal-title":"ESPEN J"},{"key":"21","doi-asserted-by":"publisher","first-page":"794","DOI":"10.3945\/ajcn.112.051557","article-title":"One-carbon metabolism factors and leukocyte telomere length.","volume":"9","author":"De Vivo","year":"2013","journal-title":"Am J Clin Nutr"},{"key":"22","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1016\/j.nut.2014.08.005","article-title":"Plasma micronutrient levels and telomere length in children.","volume":"3","author":"Fenech","year":"2015","journal-title":"Nutrition"},{"key":"23","doi-asserted-by":"publisher","first-page":"538","DOI":"10.3945\/jn.116.243162","article-title":"Serum folate, vitamin B12, vitamin A, y-tocopherol, \u03b1-tocopherol, and carotenoids do not modify associations between cadmium exposure and leukocyte telomere length in the general US adults population.","volume":"14","author":"Zota","year":"2017","journal-title":"J Nutr"},{"key":"24","doi-asserted-by":"publisher","first-page":"7","DOI":"10.7762\/cnr.2016.5.1.7","article-title":"Leukocyte telomere length is associated with serum vitamin B12 and homocysteine levels in older adults with the presence of systemic inflammation.","volume":"5","author":"Baik","year":"2016","journal-title":"Clin Nutr Res"},{"key":"25","doi-asserted-by":"publisher","first-page":"S1","DOI":"10.1517\/14622416.2.1.S1","article-title":"Rationale and design of the LURIC study\u2014a resource for functional genomics, pharmacogenomics and long-term prognosis of cardiovascular disease.","volume":"2","author":"Senges","year":"2001","journal-title":"Pharmacogenomics"},{"key":"26","doi-asserted-by":"publisher","first-page":"1863","DOI":"10.1007\/s00394-015-1003-1","article-title":"Prospective study of telomere length and LINE-1 methylation in peripheral blood cells: the role of B vitamins supplementation.","volume":"5","author":"Herrmann","year":"2016","journal-title":"Eur J Nutr"},{"key":"27","doi-asserted-by":"publisher","first-page":"1887","DOI":"10.1007\/s00394-016-1231-z","article-title":"One-carbon metabolites and telomere length in a prospective and randomized study of B- and\/or D-vitamin supplementation.","volume":"5","author":"Herrmann","year":"2017","journal-title":"Eur J Nutr"},{"key":"28","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1093\/qjmed\/hcn138","article-title":"An update on cobalamin deficiency in adults.","volume":"10","author":"Andr\u00e8s","year":"2009","journal-title":"QJM"},{"key":"29","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1177\/0310057X0903700510","article-title":"Inflammation, vitamin deficiencies and organ failure in critically ill patients.","volume":"3","author":"Ho","year":"2009","journal-title":"Anaesth Intensive Care"},{"key":"30","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1002\/jcsm.12260","article-title":"Vitamin B12 deficiency and impaired expression of amnionless during aging.","volume":"9","author":"Feige","year":"2018","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"31","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1177\/0004563212473279","article-title":"Vitamin B12 and ageing: current issues and interaction with folate.","volume":"5","author":"McNulty","year":"2013","journal-title":"Ann Clin Biochem"},{"key":"32","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/j.ijcard.2016.01.066","article-title":"Telomere shortening and telomerase activity in ischaemic cardiomyopathy patients - Potential markers of ventricular arrhythmia.","volume":"20","author":"Sporton","year":"2016","journal-title":"Int J Cardiol"},{"key":"33","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.ijcard.2017.02.125","article-title":"Telomere length: A newly marker for predicting atrial fibrillation?","volume":"23","author":"Liu","year":"2017","journal-title":"Int J Cardiol"},{"key":"34","doi-asserted-by":"publisher","first-page":"157","DOI":"10.5853\/jos.2015.01599","article-title":"Ischemic Stroke after heart transplantation.","volume":"1","author":"Martini","year":"2016","journal-title":"J Stroke"},{"key":"35","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1177\/2396987317732648","article-title":"Postoperative atrial fibrillation and ischemic stroke: the role of homocysteine.","volume":"3","author":"Martini","year":"2018","journal-title":"Eur Stroke J"},{"key":"36","doi-asserted-by":"publisher","first-page":"e98","DOI":"10.1136\/annrheumdis-2018-213789","article-title":"Inflammatory cytokines, life-threatening arrhythmias and premature mortality in chronic inflammatory arthritis: time to focus on.","volume":"7","author":"Capecchi","year":"2019","journal-title":"Ann Rheum Dis"},{"key":"37","doi-asserted-by":"publisher","first-page":"e011006","DOI":"10.1161\/JAHA.118.011006","article-title":"Systemic inflammation rapidly induces reversible atrial electrical remodeling: the role of interleukin-6-mediated changes in connexin expression.","volume":"8","author":"Migliacci","year":"2019","journal-title":"J Am Heart Assoc"},{"key":"38","doi-asserted-by":"publisher","first-page":"1420","DOI":"10.1177\/1741826711424568","article-title":"Serum homocysteine and folate but not vitamin B12 are predictors of CHD mortality in older adults.","volume":"1","author":"Mitchell","year":"2012","journal-title":"Eur J Prev Cardiol"},{"key":"39","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1136\/heartjnl-2014-306022","article-title":"Vitamin B12 and folate deficiency in chronic heart failure.","volume":"10","author":"van der Meer","year":"2015","journal-title":"Heart"},{"key":"40","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1007\/s11845-010-0639-3","article-title":"Vitamin B12 status, homocysteine and mortality amongst community-dwelling Irish elders.","volume":"18","author":"Cunningham","year":"2011","journal-title":"Ir J Med Sci"},{"key":"41","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1016\/j.freeradbiomed.2009.04.023","article-title":"A novel role for vitamin B(12): cobalamins are intracellular antioxidants in vitro.","volume":"4","author":"Williams","year":"2009","journal-title":"Free Radic Biol Med"},{"key":"42","doi-asserted-by":"publisher","first-page":"e23","DOI":"10.1016\/j.nut.2012.01.005","article-title":"Folate and vitamin B12 deficiency and hyperhomocysteinemia promote oxidative stress in adult type 2 diabetes.","volume":"2","author":"Ouhtit","year":"2012","journal-title":"Nutrition"},{"key":"43","doi-asserted-by":"publisher","first-page":"118","DOI":"10.3390\/nu8030118","article-title":"Associations between vitamin B-12 status and oxidative stress and inflammation in diabetic vegetarians and omnivores.","volume":"8","author":"Lin","year":"2016","journal-title":"Nutrients"},{"key":"44","doi-asserted-by":"publisher","first-page":"e008517","DOI":"10.1161\/JAHA.117.008517","article-title":"Effect of combined treatment with folic acid, vitamin B6, and vitamin B12 on plasma biomarkers of inflammation and endothelial dysfunction in women.","volume":"7","author":"Manson","year":"2018","journal-title":"J Am Heart Assoc"},{"key":"45","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1177\/1358863X15622281","article-title":"Effect of vitamin B12 and folic acid supplementation on biomarkers of endothelial function and inflammation among elderly individuals with hyperhomocysteinemia.","volume":"2","author":"Lips","year":"2016","journal-title":"Vasc Med"},{"key":"46","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1046\/j.1365-2362.2003.01135.x","article-title":"Homocysteine-lowering treatment with folic acid plus vitamin B6 lowers urinary albumin excretion but not plasma markers of endothelial function or C-reactive protein: further analysis of secondary end-points of a randomized clinical trial.","volume":"3","author":"Stehouwer","year":"2003","journal-title":"Eur J Clin Invest"},{"key":"47","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1373\/clinchem.2007.091959","article-title":"C-reactive protein and all-cause mortality in a large hospital-based cohort.","volume":"5","author":"Endler","year":"2008","journal-title":"Clin Chem"},{"key":"48","doi-asserted-by":"publisher","first-page":"e0116206","DOI":"10.1371\/journal.pone.0116206","article-title":"Systemic inflammation predicts all-cause mortality: a glasgow inflammation outcome study.","volume":"1","author":"Morrison","year":"2015","journal-title":"PLoS One"},{"key":"49","doi-asserted-by":"publisher","first-page":"e11794","DOI":"10.1097\/MD.0000000000011794","article-title":"The prognostic significance of hTERT overexpression in cancers: A systematic review and meta-analysis.","volume":"9","author":"Hao","year":"2018","journal-title":"Medicine (Baltimore)"},{"key":"50","first-page":"78","article-title":"Prognostic significance of coronary arteriography.","volume":"8","author":"Ross","year":"1970","journal-title":"Trans Assoc Am Physicians"},{"key":"51","unstructured":"Gensini. The coronary artery disease scoring and retrieval system of Gensini. In: Gensini GG, editor. Coronary arteriography. New York (NY): Futura Pub. Co.; 1975. pp. 271-4."},{"key":"52","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1111\/j.1365-3083.2009.02261.x","article-title":"Association between asymmetric dimethylarginine and neopterin in patients with and without angiographic coronary artery disease.","volume":"7","author":"Fuchs","year":"2009","journal-title":"Scand J Immunol"},{"key":"53","doi-asserted-by":"publisher","first-page":"926","DOI":"10.1160\/TH09-07-0422","article-title":"Total homocysteine in patients with angiographic coronary artery disease correlates with inflammation markers.","volume":"10","author":"Fuchs","year":"2010","journal-title":"Thromb Haemost"}],"container-title":["Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.102238","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,2]],"date-time":"2020-09-02T19:15:41Z","timestamp":1599074141000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.102238"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,6]]},"references-count":53,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2019,9,15]]}},"alternative-id":["102238","31492825"],"URL":"https:\/\/doi.org\/10.18632\/aging.102238","relation":{},"ISSN":["1945-4589"],"issn-type":[{"value":"1945-4589","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,6]]}}}