{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T16:22:50Z","timestamp":1776270170490,"version":"3.50.1"},"reference-count":47,"publisher":"Impact Journals, LLC","issue":"18","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aging"],"published-print":{"date-parts":[[2019,9,25]]},"DOI":"10.18632\/aging.102299","type":"journal-article","created":{"date-parts":[[2019,9,25]],"date-time":"2019-09-25T15:23:51Z","timestamp":1569425031000},"page":"7938-7947","source":"Crossref","is-referenced-by-count":23,"title":["The effects of dietary fatty acids on bone, hematopoietic marrow and marrow adipose tissue in a murine model of senile osteoporosis"],"prefix":"10.18632","volume":"11","author":[{"given":"Ebrahim","family":"Bani Hassan","sequence":"first","affiliation":[{"name":"Australian Institute for Musculoskeletal Science (AIMSS), The University of Melbourne and Western Health, St. Albans, VIC, Australia"},{"name":"Department of Medicine-Western Health, The University of Melbourne, St. Albans, VIC, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mostafa","family":"Alderghaffar","sequence":"additional","affiliation":[{"name":"Ageing Bone Research Program, Sydney Medical School Nepean, The University of Sydney, Penrith, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabien","family":"Wauquier","sequence":"additional","affiliation":[{"name":"Human Nutrition Unit, UMR1019, INRA\/Universit\u00e9 Clermont Auvergne, Clermont-Ferrand, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veronique","family":"Coxam","sequence":"additional","affiliation":[{"name":"Human Nutrition Unit, UMR1019, INRA\/Universit\u00e9 Clermont Auvergne, Clermont-Ferrand, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oddom","family":"Demontiero","sequence":"additional","affiliation":[{"name":"Ageing Bone Research Program, Sydney Medical School Nepean, The University of Sydney, Penrith, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Vogrin","sequence":"additional","affiliation":[{"name":"Australian Institute for Musculoskeletal Science (AIMSS), The University of Melbourne and Western Health, St. Albans, VIC, Australia"},{"name":"Department of Medicine-Western Health, The University of Melbourne, St. Albans, VIC, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yohann","family":"Wittrant","sequence":"additional","affiliation":[{"name":"Human Nutrition Unit, UMR1019, INRA\/Universit\u00e9 Clermont Auvergne, Clermont-Ferrand, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gustavo","family":"Duque","sequence":"additional","affiliation":[{"name":"Australian Institute for Musculoskeletal Science (AIMSS), The University of Melbourne and Western Health, St. Albans, VIC, Australia"},{"name":"Department of Medicine-Western Health, The University of Melbourne, St. Albans, VIC, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7892","published-online":{"date-parts":[[2019,9,25]]},"reference":[{"key":"1","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1007\/s00223-018-0412-6","article-title":"Marrow Adipose Tissue in Older Men: Association with Visceral and Subcutaneous Fat, Bone Volume, Metabolism, and Inflammation.","volume":"10","author":"Duque","year":"2018","journal-title":"Calcif Tissue Int"},{"key":"2","doi-asserted-by":"publisher","first-page":"982","DOI":"10.1111\/j.1582-4934.2009.00751.x","article-title":"Inhibition of fatty acid biosynthesis prevents adipocyte lipotoxicity on human osteoblasts in vitro.","volume":"1","author":"Duque","year":"2010","journal-title":"J Cell Mol Med"},{"key":"3","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1016\/j.exger.2009.05.009","article-title":"Differential expression of cytokines in subcutaneous and marrow fat of aging C57BL\/6J mice.","volume":"4","author":"Duque","year":"2009","journal-title":"Exp Gerontol"},{"key":"4","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1210\/en.2013-1712","article-title":"Mechanisms of palmitate-induced lipotoxicity in human osteoblasts.","volume":"15","author":"Duque","year":"2014","journal-title":"Endocrinology"},{"key":"5","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1007\/s11914-018-0427-y","article-title":"Good, Bad, or Ugly: the Biological Roles of Bone Marrow Fat.","volume":"1","author":"Duque","year":"2018","journal-title":"Curr Osteoporos Rep"},{"key":"6","doi-asserted-by":"publisher","first-page":"E1041","DOI":"10.1152\/ajpendo.00557.2006","article-title":"Aging results in paradoxical susceptibility of fat cell progenitors to lipotoxicity.","volume":"29","author":"Kirkland","year":"2007","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"7","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1016\/S0531-5565(02)00014-1","article-title":"Adipogenesis and aging: does aging make fat go MAD?","volume":"3","author":"Karagiannides","year":"2002","journal-title":"Exp Gerontol"},{"key":"8","doi-asserted-by":"publisher","first-page":"2294","DOI":"10.1210\/jc.2012-3949","article-title":"Vertebral bone marrow fat associated with lower trabecular BMD and prevalent vertebral fracture in older adults.","volume":"9","author":"Li","year":"2013","journal-title":"J Clin Endocrinol Metab"},{"key":"9","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1007\/BF02555043","article-title":"Bone marrow fat content in relation to bone remodeling and serum chemistry in intact and ovariectomized dogs.","volume":"4","author":"Lucas","year":"1990","journal-title":"Calcif Tissue Int"},{"key":"10","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1016\/j.bone.2011.05.030","article-title":"Borage and fish oils lifelong supplementation decreases inflammation and improves bone health in a murine model of senile osteoporosis.","volume":"5","author":"Coxam","year":"2012","journal-title":"Bone"},{"key":"11","doi-asserted-by":"publisher","first-page":"M181","DOI":"10.1093\/geronj\/45.6.M181","article-title":"Body fat distribution in healthy young and older men.","volume":"4","author":"Abrass","year":"1990","journal-title":"J Gerontol"},{"key":"12","doi-asserted-by":"publisher","first-page":"1011","DOI":"10.1038\/sj.ijo.0803005","article-title":"Health consequences of obesity in the elderly: a review of four unresolved questions.","volume":"2","author":"Bosello","year":"2005","journal-title":"Int J Obes"},{"key":"13","doi-asserted-by":"publisher","first-page":"2055","DOI":"10.1194\/jlr.D800010-JLR200","article-title":"Composition of adipose tissue and marrow fat in humans by 1H NMR at 7 Tesla.","volume":"4","author":"Malloy","year":"2008","journal-title":"J Lipid Res"},{"key":"14","doi-asserted-by":"publisher","first-page":"4081","DOI":"10.1210\/en.2015-1303","article-title":"Oleate Abrogates Palmitate-Induced Lipotoxicity and Proinflammatory Response in Human Bone Marrow-Derived Mesenchymal Stem Cells and Osteoblastic Cells.","volume":"15","author":"Rasschaert","year":"2015","journal-title":"Endocrinology"},{"key":"15","doi-asserted-by":"publisher","first-page":"4196","DOI":"10.1210\/jcem.82.12.4450","article-title":"Subcutaneous adipose tissue releases interleukin-6, but not tumor necrosis factor-alpha, in vivo.","volume":"8","author":"Coppack","year":"1997","journal-title":"J Clin Endocrinol Metab"},{"key":"16","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1186\/1742-4933-2-14","article-title":"Osteoporosis, inflammation and ageing.","volume":"2","author":"De Martinis","year":"2005","journal-title":"Immun Ageing"},{"key":"17","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1016\/j.hoc.2014.04.005","article-title":"Anemia of inflammation.","volume":"2","author":"Ganz","year":"2014","journal-title":"Hematol Oncol Clin North Am"},{"key":"18","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/S0378-5122(02)00022-1","article-title":"Polyunsaturated fatty acids.","volume":"4","author":"Coupland","year":"2002","journal-title":"Is there a role in postmenopausal osteoporosis prevention? Maturitas"},{"key":"19","doi-asserted-by":"publisher","first-page":"1206","DOI":"10.1359\/jbmr.2003.18.7.1206","article-title":"Dietary n-3 fatty acids decrease osteoclastogenesis and loss of bone mass in ovariectomized mice.","volume":"1","author":"Fernandes","year":"2003","journal-title":"J Bone Miner Res"},{"key":"20","doi-asserted-by":"publisher","first-page":"304","DOI":"10.3945\/an.111.000505","article-title":"(n-3) Fatty acids alleviate adipose tissue inflammation and insulin resistance: mechanistic insights.","volume":"2","author":"Moustaid-Moussa","year":"2011","journal-title":"Adv Nutr"},{"key":"21","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1056\/NEJM198902023200501","article-title":"The effect of dietary supplementation with n-3 polyunsaturated fatty acids on the synthesis of interleukin-1 and tumor necrosis factor by mononuclear cells.","volume":"32","author":"Dinarello","year":"1989","journal-title":"N Engl J Med"},{"key":"22","doi-asserted-by":"publisher","first-page":"2747","DOI":"10.1002\/art.24781","article-title":"Inhibition of interleukin-6 receptor directly blocks osteoclast formation in vitro and in vivo.","volume":"6","author":"Schett","year":"2009","journal-title":"Arthritis Rheum"},{"key":"23","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1016\/j.cyto.2004.02.001","article-title":"Human interleukin-1-induced murine osteoclastogenesis is dependent on RANKL, but independent of TNF-\u03b1.","volume":"2","author":"Goodman","year":"2004","journal-title":"Cytokine"},{"key":"24","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.exger.2010.09.014","article-title":"Obesity-mediated inflammatory microenvironment stimulates osteoclastogenesis and bone loss in mice.","volume":"4","author":"Fernandes","year":"2011","journal-title":"Exp Gerontol"},{"key":"25","doi-asserted-by":"publisher","first-page":"780","DOI":"10.1016\/j.bbrc.2009.03.111","article-title":"Bone marrow adipocytes support dexamethasone-induced osteoclast differentiation.","volume":"38","author":"Shindo","year":"2009","journal-title":"Biochem Biophys Res Commun"},{"key":"26","doi-asserted-by":"publisher","first-page":"1896","DOI":"10.3892\/mmr.2013.1446","article-title":"Fish oil suppresses bone resorption by inhibiting osteoclastogenesis through decreased expression of M-CSF, PU.1, MITF and RANK in ovariectomized rats.","volume":"7","author":"Tsukamoto","year":"2013","journal-title":"Mol Med Rep"},{"key":"27","doi-asserted-by":"publisher","first-page":"e0215926","DOI":"10.1371\/journal.pone.0215926","article-title":"Fatty acids from fish or vegetable oils promote the adipogenic fate of mesenchymal stem cells derived from gilthead sea bream bone potentially through different pathways.","volume":"1","author":"Capilla","year":"2019","journal-title":"PLoS One"},{"key":"28","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1097\/BLO.0b013e31802cfa9e","article-title":"Statins and dietary fish oils improve lipid composition in bone marrow and joints.","volume":"45","author":"Pritchett","year":"2007","journal-title":"Clin Orthop Relat Res"},{"key":"29","doi-asserted-by":"publisher","first-page":"2821","DOI":"10.1210\/en.2015-1258","article-title":"Fish Oil-Rich Diet Promotes Hematopoiesis and Alters Hematopoietic Niche.","volume":"15","author":"Qi","year":"2015","journal-title":"Endocrinology"},{"key":"30","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.bone.2018.01.020","article-title":"Characterization of the bone marrow adipocyte niche with three-dimensional electron microscopy.","volume":"11","author":"Scheller","year":"2019","journal-title":"Bone"},{"key":"31","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1471-2318-8-1","article-title":"Prevalence of anaemia in older persons: systematic review.","volume":"8","author":"McQuay","year":"2008","journal-title":"BMC Geriatr"},{"key":"32","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1007\/s001980170031","article-title":"Identifying bone-mass-related risk factors for fracture to guide bone densitometry measurements: a systematic review of the literature.","volume":"1","author":"Granados","year":"2001","journal-title":"Osteoporos Int"},{"key":"33","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1002\/jbmr.5650070514","article-title":"Risk of fractures in patients with pernicious anemia.","volume":"7","author":"Melton","year":"1992","journal-title":"J Bone Miner Res"},{"key":"34","doi-asserted-by":"publisher","first-page":"325","DOI":"10.2165\/00002512-200825040-00005","article-title":"Anaemia and the risk of injurious falls in a community-dwelling elderly population.","volume":"2","author":"Piech","year":"2008","journal-title":"Drugs Aging"},{"key":"35","doi-asserted-by":"publisher","first-page":"2199","DOI":"10.1210\/jc.2017-00266","article-title":"Older Men With Anemia Have Increased Fracture Risk Independent of Bone Mineral Density.","volume":"10","author":"Wu","year":"2017","journal-title":"J Clin Endocrinol Metab"},{"key":"36","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.mad.2016.10.001","article-title":"Mouse models of ageing and their relevance to disease.","volume":"16","author":"Vandenbroucke","year":"2016","journal-title":"Mech Ageing Dev"},{"key":"37","doi-asserted-by":"publisher","first-page":"934","DOI":"10.1093\/ajcn\/81.4.934","article-title":"Ratio of n-6 to n-3 fatty acids and bone mineral density in older adults: the Rancho Bernardo Study.","volume":"8","author":"von M\u00fchlen","year":"2005","journal-title":"Am J Clin Nutr"},{"key":"38","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.plipres.2015.03.001","article-title":"Pros and cons of fatty acids in bone biology.","volume":"5","author":"Wittrant","year":"2015","journal-title":"Prog Lipid Res"},{"key":"39","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1007\/BF01626534","article-title":"Accuracy and the influence of marrow fat on quantitative CT and dual-energy X-ray absorptiometry measurements of the femoral neck in vitro.","volume":"6","author":"Sch\u00fctte","year":"1996","journal-title":"Osteoporos Int"},{"key":"40","doi-asserted-by":"publisher","first-page":"765","DOI":"10.2967\/jnumed.108.057372","article-title":"Transplantation of embryonic fibroblasts treated with platelet-rich plasma induces osteogenesis in SAMP8 mice monitored by molecular imaging.","volume":"5","author":"Deng","year":"2009","journal-title":"J Nucl Med"},{"key":"41","first-page":"219","article-title":"A multicompartment body composition technique based on computerized tomography.","volume":"1","author":"L\u00f6fgren","year":"1994","journal-title":"Int J Obes Relat Metab Disord"},{"key":"42","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1038\/sj.ijo.0803409","article-title":"Validity of a new automated software program for visceral adipose tissue estimation.","volume":"3","author":"Towne","year":"2007","journal-title":"Int J Obes"},{"key":"43","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1016\/j.exger.2011.01.001","article-title":"Validation of noninvasive quantification of bone marrow fat volume with microCT in aging rats.","volume":"4","author":"Duque","year":"2011","journal-title":"Exp Gerontol"},{"key":"44","first-page":"452","article-title":"Abdominal obesity as important component of insulin-resistance syndrome.","volume":"9","author":"Despr\u00e9s","year":"1993","journal-title":"Nutrition"},{"key":"45","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1126\/science.6997993","article-title":"Computed medical imaging.","volume":"21","author":"Hounsfield","year":"1980","journal-title":"Science"},{"key":"46","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1259\/0007-1285-60-717-907","article-title":"Average soft-tissue and bone models for use in radiation dosimetry.","volume":"6","author":"Hammond","year":"1987","journal-title":"Br J Radiol"},{"key":"47","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1088\/0031-9155\/45\/2\/314","article-title":"Correlation between CT numbers and tissue parameters needed for Monte Carlo simulations of clinical dose distributions.","volume":"4","author":"Schlegel","year":"2000","journal-title":"Phys Med Biol"}],"container-title":["Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.102299","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,2]],"date-time":"2020-09-02T19:21:10Z","timestamp":1599074470000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.102299"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,25]]},"references-count":47,"journal-issue":{"issue":"18","published-print":{"date-parts":[[2019,9,30]]}},"alternative-id":["102299","31553309"],"URL":"https:\/\/doi.org\/10.18632\/aging.102299","relation":{},"ISSN":["1945-4589"],"issn-type":[{"value":"1945-4589","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,25]]}}}