{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T04:48:06Z","timestamp":1776919686321,"version":"3.51.2"},"reference-count":50,"publisher":"Impact Journals, LLC","issue":"20","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aging"],"published-print":{"date-parts":[[2019,10,26]]},"DOI":"10.18632\/aging.102372","type":"journal-article","created":{"date-parts":[[2019,10,27]],"date-time":"2019-10-27T03:09:11Z","timestamp":1572145751000},"page":"9043-9059","source":"Crossref","is-referenced-by-count":11,"title":["T5224, RSPO2 and AZD5363 are novel drugs against functional pituitary adenoma"],"prefix":"10.18632","volume":"11","author":[{"given":"Sheng","family":"Zhong","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, The First Hospital of Jilin University, Changchun, China"},{"name":"Clinical College, Jilin University, Changchun, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Wu","sequence":"additional","affiliation":[{"name":"Clinical College, Jilin University, Changchun, China"},{"name":"Department of Orthopaedics, The First Hospital of Jilin University, Changchun, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiahui","family":"Li","sequence":"additional","affiliation":[{"name":"Pharmacy College, Jilin University, Chuangchun, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinhui","family":"Wang","sequence":"additional","affiliation":[{"name":"Clinical College, Jilin University, Changchun, China"},{"name":"Department of Oncology, The First Hospital of Jilin University, Changchun, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shanshan","family":"Jiang","sequence":"additional","affiliation":[{"name":"Pharmacy College, Jilin University, Chuangchun, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fangfei","family":"Hu","sequence":"additional","affiliation":[{"name":"Pharmacy College, Jilin University, Chuangchun, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gaojing","family":"Dou","sequence":"additional","affiliation":[{"name":"Clinical College, Jilin University, Changchun, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Clinical College, Jilin University, Changchun, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunjia","family":"Sheng","sequence":"additional","affiliation":[{"name":"Clinical College, Jilin University, Changchun, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gang","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, The First Hospital of Jilin University, Changchun, China"},{"name":"Clinical College, Jilin University, Changchun, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunqian","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, The First Hospital of Jilin University, Changchun, China"},{"name":"Clinical College, Jilin University, Changchun, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, The First Hospital of Jilin University, Changchun, China"},{"name":"Clinical College, Jilin University, Changchun, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7892","published-online":{"date-parts":[[2019,10,26]]},"reference":[{"key":"1","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.wneu.2013.03.015","article-title":"Stereotactic radiosurgery for functioning pituitary adenomas.","volume":"8","author":"Kim","year":"2014","journal-title":"World Neurosurg"},{"key":"2","first-page":"319","article-title":"Pituitary adenomas: an overview.","volume":"8","author":"Cruz","year":"2013","journal-title":"Am Fam Physician"},{"key":"3","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1007\/s11060-013-1354-5","article-title":"Epidemiology and etiopathogenesis of pituitary adenomas.","volume":"11","author":"Korbonits","year":"2014","journal-title":"J Neurooncol"},{"key":"4","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1016\/B978-0-444-59602-4.00024-1","article-title":"Long-term effects of treatment of pituitary adenomas.","volume":"12","author":"Pereira","year":"2014","journal-title":"Handb Clin Neurol"},{"key":"5","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1590\/0004-2730000002961","article-title":"Prolactinoma.","volume":"5","author":"Bronstein","year":"2014","journal-title":"Arq Bras Endocrinol Metabol"},{"key":"6","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1016\/j.wneu.2012.06.024","article-title":"Pituitary tumor surgery: review of 3004 cases.","volume":"7","author":"Manrique-Guzman","year":"2013","journal-title":"World Neurosurg"},{"key":"7","doi-asserted-by":"publisher","first-page":"3857","DOI":"10.1038\/onc.2011.557","article-title":"Downregulation of HMGA-targeting microRNAs has a critical role in human pituitary tumorigenesis.","volume":"3","author":"Fusco","year":"2012","journal-title":"Oncogene"},{"key":"8","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1159\/000355624","article-title":"The EFEMP1 gene: a frequent target for epigenetic silencing in multiple human pituitary adenoma subtypes.","volume":"9","author":"Farrell","year":"2013","journal-title":"Neuroendocrinology"},{"key":"9","doi-asserted-by":"publisher","first-page":"3603","DOI":"10.1210\/en.2012-1231","article-title":"Epigenomic silencing of the BMP-4 gene in pituitary adenomas: a potential target for epidrug-induced re-expression.","volume":"15","author":"Farrell","year":"2012","journal-title":"Endocrinology"},{"key":"10","doi-asserted-by":"publisher","first-page":"6930","DOI":"10.1021\/jm5004733","article-title":"Small molecule inhibitors targeting activator protein 1 (AP-1).","volume":"5","author":"Zhou","year":"2014","journal-title":"J Med Chem"},{"key":"11","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1007\/s00401-013-1132-7","article-title":"Transcriptome analysis of MENX-associated rat pituitary adenomas identifies novel molecular mechanisms involved in the pathogenesis of human pituitary gonadotroph adenomas.","volume":"12","author":"Pellegata","year":"2013","journal-title":"Acta Neuropathol"},{"key":"12","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1007\/s10528-017-9794-9","article-title":"Novel Biomarkers for Non-functioning Invasive Pituitary Adenomas were Identified by Using Analysis of microRNAs Expression Profile.","volume":"5","author":"Zhang","year":"2017","journal-title":"Biochem Genet"},{"key":"13","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1038\/501494a","article-title":"Biodiversity: temperate hotspots.","volume":"50","author":"Tittensor","year":"2013","journal-title":"Nature"},{"key":"14","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1667\/RR14883.1","article-title":"FTIR Microspectroscopy Probes Particle-Radiation Effect on HCT116 cells (p53, p53).","volume":"18","author":"Huang","year":"2018","journal-title":"Radiat Res"},{"key":"15","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1111\/cas.12914","article-title":"Selective activator protein-1 inhibitor T-5224 prevents lymph node metastasis in an oral cancer model.","volume":"10","author":"Shiotani","year":"2016","journal-title":"Cancer Sci"},{"key":"16","doi-asserted-by":"publisher","first-page":"258141","DOI":"10.1155\/2013\/258141","article-title":"The role of morphine in animal models of human cancer: does morphine promote or inhibit the tumor growth?","volume":"201","author":"Arra","year":"2013","journal-title":"Biomed Res Int"},{"key":"17","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1158\/1541-7786.MCR-13-0541","article-title":"Nicotine-mediated cell proliferation and tumor progression in smoking-related cancers.","volume":"1","author":"Chellappan","year":"2014","journal-title":"Mol Cancer Res"},{"key":"18","doi-asserted-by":"publisher","first-page":"2991","DOI":"10.3892\/mmr.2017.6411","article-title":"Expression levels of transcription factors c-Fos and c-Jun and transmembrane protein HAb18G\/CD147 in urothelial carcinoma of the bladder.","volume":"1","author":"Chen","year":"2017","journal-title":"Mol Med Rep"},{"key":"19","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1016\/j.bbamcr.2014.12.013","article-title":"MAPK signaling triggers transcriptional induction of cFOS during amino acid limitation of HepG2 cells.","volume":"185","author":"Kilberg","year":"2015","journal-title":"Biochim Biophys Acta"},{"key":"20","doi-asserted-by":"publisher","first-page":"491740","DOI":"10.1155\/2014\/491740","article-title":"Cytotoxicity of probiotics from Philippine commercial dairy products on cancer cells and the effect on expression of cfos and cjun early apoptotic-promoting genes and Interleukin-1 \u03b2 and Tumor Necrosis Factor-\u03b1 proinflammatory cytokine genes.","volume":"201","author":"Cabrera","year":"2014","journal-title":"Biomed Res Int"},{"key":"21","doi-asserted-by":"publisher","first-page":"2852","DOI":"10.1038\/onc.2015.344","article-title":"Regulation of osteosarcoma cell lung metastasis by the c-Fos\/AP-1 target FGFR1.","volume":"3","author":"Grigoriadis","year":"2016","journal-title":"Oncogene"},{"key":"22","doi-asserted-by":"publisher","first-page":"2036","DOI":"10.1038\/onc.2009.496","article-title":"Wnt5a signaling is involved in the aggressiveness of prostate cancer and expression of metalloproteinase.","volume":"2","author":"Kikuchi","year":"2010","journal-title":"Oncogene"},{"key":"23","doi-asserted-by":"publisher","first-page":"C83","DOI":"10.4103\/0973-1482.145788","article-title":"Wnt5a\/Ca (2+) \/calcineurin\/nuclear factor of activated T signaling pathway as a potential marker of pediatric melanoma.","volume":"1","author":"Qian","year":"2014","journal-title":"J Cancer Res Ther"},{"key":"24","doi-asserted-by":"publisher","first-page":"8042","DOI":"10.1038\/srep08042","article-title":"Wnt5a promotes cancer cell invasion and proliferation by receptor-mediated endocytosis-dependent and -independent mechanisms, respectively.","volume":"5","author":"Kikuchi","year":"2015","journal-title":"Sci Rep"},{"key":"25","doi-asserted-by":"publisher","first-page":"7063","DOI":"10.1038\/srep07063","article-title":"Splicing mutation analysis reveals previously unrecognized pathways in lymph node-invasive breast cancer.","volume":"4","author":"Rogan","year":"2014","journal-title":"Sci Rep"},{"key":"26","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1136\/jclinpath-2011-200416","article-title":"Expression of NCAM and OCIAD1 in well-differentiated thyroid carcinoma: correlation with the risk of distant metastasis.","volume":"6","author":"Chen","year":"2012","journal-title":"J Clin Pathol"},{"key":"27","doi-asserted-by":"publisher","first-page":"e0122882","DOI":"10.1371\/journal.pone.0122882","article-title":"Transcription factors and microRNA-co-regulated genes in gastric cancer invasion in ex vivo.","volume":"1","author":"Li","year":"2015","journal-title":"PLoS One"},{"key":"28","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.stemcr.2014.05.013","article-title":"Wilms\u2019 tumor blastemal stem cells dedifferentiate to propagate the tumor bulk.","volume":"3","author":"Dekel","year":"2014","journal-title":"Stem Cell Reports"},{"key":"29","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1007\/s00467-013-2501-0","article-title":"Targeted therapy aimed at cancer stem cells: Wilms\u2019 tumor as an example.","volume":"2","author":"Dekel","year":"2014","journal-title":"Pediatr Nephrol"},{"key":"30","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1093\/toxsci\/kft110","article-title":"Aryl hydrocarbon receptor negatively regulates expression of the plakoglobin gene (jup).","volume":"13","author":"Vondr\u00e1\u010dek","year":"2013","journal-title":"Toxicol Sci"},{"key":"31","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1007\/s12094-013-1054-9","article-title":"Proteomic analysis of pleural effusion from lung adenocarcinoma patients by shotgun strategy.","volume":"1","author":"Zhu","year":"2014","journal-title":"Clin Transl Oncol"},{"key":"32","doi-asserted-by":"publisher","first-page":"209","DOI":"10.2334\/josnusd.56.209","article-title":"Heterogeneous and abnormal localization of desmosomal proteins in oral intraepithelial neoplasms.","volume":"5","author":"Hasegawa","year":"2014","journal-title":"J Oral Sci"},{"key":"33","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1007\/s12253-016-0116-z","article-title":"Combined Analysis of ChIP Sequencing and Gene Expression Dataset in Breast Cancer.","volume":"2","author":"Zhang","year":"2017","journal-title":"Pathol Oncol Res"},{"key":"34","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1186\/1471-2407-13-410","article-title":"ITGA3 and ITGB4 expression biomarkers estimate the risks of locoregional and hematogenous dissemination of oral squamous cell carcinoma.","volume":"1","author":"Hoshina","year":"2013","journal-title":"BMC Cancer"},{"key":"35","doi-asserted-by":"publisher","first-page":"1007","DOI":"10.3892\/mco.2015.578","article-title":"Diagnostic value of cyclin-dependent kinase\/cyclin-dependent kinase inhibitor expression ratios as biomarkers of locoregional and hematogenous dissemination risks in oral squamous cell carcinoma.","volume":"3","author":"Takagi","year":"2015","journal-title":"Mol Clin Oncol"},{"key":"36","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1097\/CAD.0000000000000496","article-title":"Protein kinase B: emerging mechanisms of isoform-specific regulation of cellular signaling in cancer.","volume":"2","author":"Malik","year":"2017","journal-title":"Anticancer Drugs"},{"key":"37","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1007\/s11060-014-1382-9","article-title":"Role of Akt in human malignant glioma: from oncogenesis to tumor aggressiveness.","volume":"11","author":"Verrelle","year":"2014","journal-title":"J Neurooncol"},{"key":"38","doi-asserted-by":"publisher","first-page":"317186","DOI":"10.1155\/2013\/317186","article-title":"The role of the dysfunctional akt-related pathway in cancer: establishment and maintenance of a malignant cell phenotype, resistance to therapy, and future strategies for drug development.","volume":"201","author":"Romano","year":"2013","journal-title":"Scientifica (Cairo)"},{"key":"39","doi-asserted-by":"publisher","first-page":"1327","DOI":"10.1042\/BST20140177","article-title":"WIPI2b and Atg16L1: setting the stage for autophagosome formation.","volume":"4","author":"Tooze","year":"2014","journal-title":"Biochem Soc Trans"},{"key":"40","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1111\/apm.12633","article-title":"Identification of the potential biomarkers for the metastasis of rectal adenocarcinoma.","volume":"12","author":"Zhang","year":"2017","journal-title":"APMIS"},{"key":"41","doi-asserted-by":"publisher","first-page":"4062","DOI":"10.1073\/pnas.1503696112","article-title":"Neomorphic effects of recurrent somatic mutations in Yin Yang 1 in insulin-producing adenomas.","volume":"11","author":"Westin","year":"2015","journal-title":"Proc Natl Acad Sci USA"},{"key":"42","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1186\/s12885-015-1012-8","article-title":"Androgen-regulation of the protein tyrosine phosphatase PTPRR activates ERK1\/2 signalling in prostate cancer cells.","volume":"1","author":"Elliott","year":"2015","journal-title":"BMC Cancer"},{"key":"43","first-page":"1524","article-title":"RNA-seq reveals determinants of sensitivity to chemotherapy drugs in esophageal carcinoma cells.","volume":"7","author":"Zhao","year":"2014","journal-title":"Int J Clin Exp Pathol"},{"key":"44","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1186\/s12885-017-3646-1","article-title":"The suppressive role of miR-542-5p in NSCLC: the evidence from clinical data and in vivo validation using a chick chorioallantoic membrane model.","volume":"1","author":"Chen","year":"2017","journal-title":"BMC Cancer"},{"key":"45","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1530\/eje.1.01937","article-title":"Differential gene expression in pituitary adenomas by oligonucleotide array analysis.","volume":"15","author":"Grossman","year":"2005","journal-title":"Eur J Endocrinol"},{"key":"46","doi-asserted-by":"publisher","first-page":"3603","DOI":"10.1210\/en.2011-0109","article-title":"Identification of growth arrest and DNA-damage-inducible gene beta (GADD45beta) as a novel tumor suppressor in pituitary gonadotrope tumors.","volume":"15","author":"Wierman","year":"2011","journal-title":"Endocrinology"},{"key":"47","doi-asserted-by":"publisher","first-page":"3679","DOI":"10.1210\/en.2012-1056","article-title":"Genomic characterization of human and rat prolactinomas.","volume":"15","author":"Melmed","year":"2012","journal-title":"Endocrinology"},{"key":"48","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1530\/EJE-12-0760","article-title":"SAGE analysis highlights the putative role of underexpression of ribosomal proteins in GH-secreting pituitary adenomas.","volume":"16","author":"Castro","year":"2012","journal-title":"Eur J Endocrinol"},{"key":"49","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/j.canlet.2017.05.024","article-title":"RSPO2 suppresses colorectal cancer metastasis by counteracting the Wnt5a\/Fzd7-driven noncanonical Wnt pathway.","volume":"40","author":"Wang","year":"2017","journal-title":"Cancer Lett"},{"key":"50","doi-asserted-by":"publisher","first-page":"986","DOI":"10.1016\/j.eururo.2014.08.006","article-title":"Combination AZD5363 with Enzalutamide Significantly Delays Enzalutamide-resistant Prostate Cancer in Preclinical Models.","volume":"6","author":"Zoubeidi","year":"2015","journal-title":"Eur Urol"}],"container-title":["Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.102372","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,2]],"date-time":"2020-09-02T19:34:36Z","timestamp":1599075276000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.102372"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,26]]},"references-count":50,"journal-issue":{"issue":"20","published-print":{"date-parts":[[2019,10,31]]}},"alternative-id":["102372","31655798"],"URL":"https:\/\/doi.org\/10.18632\/aging.102372","relation":{},"ISSN":["1945-4589"],"issn-type":[{"value":"1945-4589","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10,26]]}}}