{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T15:16:21Z","timestamp":1793718981694,"version":"4.6.1"},"reference-count":63,"publisher":"Impact Journals, LLC","issue":"20","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aging"],"published-print":{"date-parts":[[2019,10,22]]},"DOI":"10.18632\/aging.102379","type":"journal-article","created":{"date-parts":[[2019,10,23]],"date-time":"2019-10-23T12:45:55Z","timestamp":1571834755000},"page":"9128-9146","source":"Crossref","is-referenced-by-count":86,"title":["Mesenchymal stem cell senescence alleviates their intrinsic and seno-suppressive paracrine properties contributing to osteoarthritis development"],"prefix":"10.18632","volume":"11","author":[{"given":"Olivier","family":"Malaise","sequence":"first","affiliation":[{"name":"IRMB, University Montpellier, INSERM, Montpellier, France"},{"name":"GIGA Research, CHU of Li\u00e8ge and University of Li\u00e8ge, Li\u00e8ge, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yassin","family":"Tachikart","sequence":"additional","affiliation":[{"name":"IRMB, University Montpellier, INSERM, Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Constantinides","sequence":"additional","affiliation":[{"name":"IRMB, University Montpellier, INSERM, Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus","family":"Mumme","sequence":"additional","affiliation":[{"name":"IRMB, University Montpellier, INSERM, Montpellier, France"},{"name":"Clinic for Orthopedics and Traumatology, University Hospital of Basel, Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosanna","family":"Ferreira-Lopez","sequence":"additional","affiliation":[{"name":"H\u00f4pital Lapeyronie, Clinical immunology and Osteoarticular Diseases Therapeutic Unit, Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Noack","sequence":"additional","affiliation":[{"name":"Trauma Department, Hannover Medical School, Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Krettek","sequence":"additional","affiliation":[{"name":"Trauma Department, Hannover Medical School, Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"No\u00ebl","sequence":"additional","affiliation":[{"name":"IRMB, University Montpellier, INSERM, Montpellier, France"},{"name":"H\u00f4pital Lapeyronie, Clinical immunology and Osteoarticular Diseases Therapeutic Unit, Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[{"name":"INM, University Montpellier, INSERM, Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Jorgensen","sequence":"additional","affiliation":[{"name":"IRMB, University Montpellier, INSERM, Montpellier, France"},{"name":"H\u00f4pital Lapeyronie, Clinical immunology and Osteoarticular Diseases Therapeutic Unit, Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Marc","family":"Brondello","sequence":"additional","affiliation":[{"name":"IRMB, University Montpellier, INSERM, Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7892","published-online":{"date-parts":[[2019,10,22]]},"reference":[{"key":"1","doi-asserted-by":"publisher","first-page":"870","DOI":"10.1038\/nm.3651","article-title":"Stem cell aging: mechanisms, regulators and therapeutic opportunities.","volume":"2","author":"Wagers","year":"2014","journal-title":"Nat Med"},{"key":"2","doi-asserted-by":"publisher","first-page":"1000","DOI":"10.1016\/j.cell.2017.05.015","article-title":"Senescence in Health and Disease.","volume":"16","author":"Sharpless","year":"2017","journal-title":"Cell"},{"key":"3","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1038\/nature13013","article-title":"Geriatric muscle stem cells switch reversible quiescence into senescence.","volume":"50","author":"Mu\u00f1oz-C\u00e1noves","year":"2014","journal-title":"Nature"},{"key":"4","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1186\/ar2592","article-title":"Cartilage homeostasis in health and rheumatic diseases.","volume":"1","author":"Marcu","year":"2009","journal-title":"Arthritis Res Ther"},{"key":"5","doi-asserted-by":"publisher","first-page":"1703","DOI":"10.1136\/ard.2005.037994","article-title":"EULAR report on the use of ultrasonography in painful knee osteoarthritis. Part 1: prevalence of inflammation in osteoarthritis.","volume":"6","author":"Schmidely","year":"2005","journal-title":"Ann Rheum Dis"},{"key":"6","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.cell.2018.07.029","article-title":"Identification of the Human Skeletal Stem Cell.","volume":"17","author":"Marecic","year":"2018","journal-title":"Cell"},{"key":"7","doi-asserted-by":"publisher","first-page":"1294","DOI":"10.1038\/nprot.2018.041","article-title":"Isolation and functional assessment of mouse skeletal stem cell lineage.","volume":"1","author":"Chan","year":"2018","journal-title":"Nat Protoc"},{"key":"8","doi-asserted-by":"publisher","first-page":"834","DOI":"10.1016\/j.scr.2013.05.008","article-title":"Adipose mesenchymal stem cells protect chondrocytes from degeneration associated with osteoarthritis.","volume":"1","author":"No\u00ebl","year":"2013","journal-title":"Stem Cell Res (Amst)"},{"key":"9","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1080\/15384101.2018.1445906","article-title":"Intercellular mitochondria trafficking highlighting the dual role of mesenchymal stem cells as both sensors and rescuers of tissue injury.","volume":"1","author":"Vignais","year":"2018","journal-title":"Cell Cycle"},{"key":"10","doi-asserted-by":"publisher","first-page":"B172","DOI":"10.1093\/gerona\/56.4.B172","article-title":"Telomere erosion and senescence in human articular cartilage chondrocytes.","volume":"5","author":"Buckwalter","year":"2001","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"11","doi-asserted-by":"publisher","first-page":"R58","DOI":"10.1186\/ar4494","article-title":"p16INK4a and its regulator miR-24 link senescence and chondrocyte terminal differentiation-associated matrix remodeling in osteoarthritis.","volume":"1","author":"Brondello","year":"2014","journal-title":"Arthritis Res Ther"},{"key":"12","doi-asserted-by":"publisher","first-page":"e4543","DOI":"10.1371\/journal.pone.0004543","article-title":"C\/EBPbeta Promotes transition from proliferation to hypertrophic differentiation of chondrocytes through transactivation of p57.","volume":"4","author":"Kawaguchi","year":"2009","journal-title":"PLoS One"},{"key":"13","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1038\/nm.4324","article-title":"Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment.","volume":"2","author":"Elisseeff","year":"2017","journal-title":"Nat Med"},{"key":"14","doi-asserted-by":"publisher","first-page":"3604","DOI":"10.1002\/art.34626","article-title":"Antiinflammatory and chondroprotective effects of intraarticular injection of adipose-derived stem cells in experimental osteoarthritis.","volume":"6","author":"van Lent","year":"2012","journal-title":"Arthritis Rheum"},{"key":"15","doi-asserted-by":"publisher","first-page":"1442","DOI":"10.18632\/aging.101481","article-title":"Secreted \u03b1-Klotho maintains cartilage tissue homeostasis by repressingandcatabolic axis.","volume":"1","author":"Brondello","year":"2018","journal-title":"Aging (Albany NY)"},{"key":"16","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1016\/j.cell.2012.12.010","article-title":"Monitoring tumorigenesis and senescence in vivo with a p16(INK4a)-luciferase model.","volume":"15","author":"Sharpless","year":"2013","journal-title":"Cell"},{"key":"17","doi-asserted-by":"publisher","first-page":"e12771","DOI":"10.1111\/acel.12771","article-title":"Expression of p16is a biomarker of chondrocyte aging but does not cause osteoarthritis.","volume":"1","author":"Sharpless","year":"2018","journal-title":"Aging Cell"},{"key":"18","doi-asserted-by":"publisher","first-page":"704","DOI":"10.1038\/nm.3143","article-title":"Inhibition of TGF-\u03b2 signaling in mesenchymal stem cells of subchondral bone attenuates osteoarthritis.","volume":"1","author":"Artemov","year":"2013","journal-title":"Nat Med"},{"key":"19","doi-asserted-by":"publisher","first-page":"1289","DOI":"10.1002\/art.30234","article-title":"Functional mesenchymal stem cell niches in adult mouse knee joint synovium in vivo.","volume":"6","author":"De Bari","year":"2011","journal-title":"Arthritis Rheum"},{"key":"20","doi-asserted-by":"publisher","first-page":"4285215","DOI":"10.1155\/2016\/4285215","article-title":"Mesenchymal Stromal Cells and Tissue-Specific Progenitor Cells: Their Role in Tissue Homeostasis.","volume":"201","author":"Kozlowska","year":"2016","journal-title":"Stem Cells Int"},{"key":"21","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1038\/nrrheum.2017.182","article-title":"Native joint-resident mesenchymal stem cells for cartilage repair in osteoarthritis.","volume":"1","author":"Jones","year":"2017","journal-title":"Nat Rev Rheumatol"},{"key":"22","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1038\/nm1538","article-title":"Dickkopf-1 is a master regulator of joint remodeling.","volume":"1","author":"Lacey","year":"2007","journal-title":"Nat Med"},{"key":"23","doi-asserted-by":"publisher","first-page":"991","DOI":"10.7754\/Clin.Lab.2015.150135","article-title":"Increased Synovial Fluid YKL-40 Levels are Linked with Symptomatic Severity in Knee Osteoarthritis Patients.","volume":"6","author":"Ding","year":"2015","journal-title":"Clin Lab"},{"key":"24","doi-asserted-by":"publisher","first-page":"1861","DOI":"10.1136\/annrheumdis-2013-205020","article-title":"Genome-wide association and functional studies identify a role for IGFBP3 in hip osteoarthritis.","volume":"7","author":"Cummings","year":"2015","journal-title":"Ann Rheum Dis"},{"key":"25","doi-asserted-by":"publisher","first-page":"2956","DOI":"10.4161\/cc.7.19.6780","article-title":"Control of senescence by CXCR2 and its ligands.","volume":"7","author":"Gil","year":"2008","journal-title":"Cell Cycle"},{"key":"26","doi-asserted-by":"publisher","first-page":"978","DOI":"10.1038\/ncb2784","article-title":"A complex secretory program orchestrated by the inflammasome controls paracrine senescence.","volume":"1","author":"Khan","year":"2013","journal-title":"Nat Cell Biol"},{"key":"27","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1089\/jmf.2017.4129","article-title":"Chia Seed Supplementation Reduces Senescence Markers in Epididymal Adipose Tissue of High-Fat Diet-Fed SAMP8 Mice.","volume":"2","author":"Wan","year":"2018","journal-title":"J Med Food"},{"key":"28","first-page":"149","article-title":"Detecting A\u03b2 deposition and RPE cell senescence in the retinas of SAMP8 mice.","volume":"2","author":"Wang","year":"2016","journal-title":"Discov Med"},{"key":"29","doi-asserted-by":"publisher","first-page":"1219","DOI":"10.1007\/s11357-012-9450-6","article-title":"Western-style diet modulates contractile responses to phenylephrine differently in mesenteric arteries from senescence-accelerated prone (SAMP8) and resistant (SAMR1) mice.","volume":"3","author":"Vila","year":"2013","journal-title":"Age (Dordr)"},{"key":"30","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1002\/hep.27339","article-title":"Astrocyte elevated gene-1 and c-Myc cooperate to promote hepatocarcinogenesis in mice.","volume":"6","author":"Chen","year":"2015","journal-title":"Hepatology"},{"key":"31","doi-asserted-by":"publisher","first-page":"5950","DOI":"10.1007\/s12035-019-1493-6","article-title":"ROS-Induced Activation of DNA Damage Responses Drives Senescence-Like State in Postmitotic Cochlear Cells: Implication for Hearing Preservation.","volume":"5","author":"Wang","year":"2019","journal-title":"Mol Neurobiol"},{"key":"32","doi-asserted-by":"publisher","first-page":"2166","DOI":"10.1136\/annrheumdis-2015-208696","article-title":"PPAR\u03b2\/\u03b4 directs the therapeutic potential of mesenchymal stem cells in arthritis.","volume":"7","author":"Djouad","year":"2016","journal-title":"Ann Rheum Dis"},{"key":"33","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/j.joca.2018.09.001","article-title":"CRISPR-Cas9 targeting of MMP13 in human chondrocytes leads to significantly reduced levels of the metalloproteinase and enhanced type II collagen accumulation.","volume":"2","author":"Murphy","year":"2019","journal-title":"Osteoarthritis Cartilage"},{"key":"34","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1093\/gerona\/glp040","article-title":"Use of senescence-accelerated mouse model in bleomycin-induced lung injury suggests that bone marrow-derived cells can alter the outcome of lung injury in aged mice.","volume":"1","author":"Xu","year":"2009","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"35","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1016\/j.bcp.2019.03.017","article-title":"Seno-suppressive molecules as new therapeutic perspectives in rheumatic diseases.","volume":"16","author":"Brondello","year":"2019","journal-title":"Biochem Pharmacol"},{"key":"36","doi-asserted-by":"publisher","first-page":"718","DOI":"10.1038\/nrd.2017.116","article-title":"Senescent cells: an emerging target for diseases of ageing.","volume":"1","author":"van Deursen","year":"2017","journal-title":"Nat Rev Drug Discov"},{"key":"37","doi-asserted-by":"publisher","first-page":"722","DOI":"10.1016\/j.devcel.2014.11.012","article-title":"An essential role for senescent cells in optimal wound healing through secretion of PDGF-AA.","volume":"3","author":"Campisi","year":"2014","journal-title":"Dev Cell"},{"key":"38","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1111\/acel.12455","article-title":"Cellular senescence impact on immune cell fate and function.","volume":"1","author":"Brondello","year":"2016","journal-title":"Aging Cell"},{"key":"39","doi-asserted-by":"publisher","first-page":"2115","DOI":"10.1016\/S0140-6736(11)60243-2","article-title":"Osteoarthritis: an update with relevance for clinical practice.","volume":"37","author":"Lafeber","year":"2011","journal-title":"Lancet"},{"key":"40","doi-asserted-by":"publisher","first-page":"1466","DOI":"10.1002\/art.34315","article-title":"Active involvement of alarmins S100A8 and S100A9 in the regulation of synovial activation and joint destruction during mouse and human osteoarthritis.","volume":"6","author":"van den Berg","year":"2012","journal-title":"Arthritis Rheum"},{"key":"41","doi-asserted-by":"publisher","first-page":"eaar6659","DOI":"10.1126\/scitranslmed.aar6659","article-title":"Stress-activated miR-204 governs senescent phenotypes of chondrocytes to promote osteoarthritis development.","volume":"1","author":"Kim","year":"2019","journal-title":"Sci Transl Med"},{"key":"42","doi-asserted-by":"publisher","first-page":"36396","DOI":"10.1074\/jbc.M111.257071","article-title":"Tumor suppressor and aging biomarker p16(INK4a) induces cellular senescence without the associated inflammatory secretory phenotype.","volume":"28","author":"Campisi","year":"2011","journal-title":"J Biol Chem"},{"key":"43","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1038\/ncomms1473","article-title":"p53 and p16(INK4A) independent induction of senescence by chromatin-dependent alteration of S-phase progression.","volume":"2","author":"Lemaitre","year":"2011","journal-title":"Nat Commun"},{"key":"44","doi-asserted-by":"publisher","first-page":"1865","DOI":"10.1002\/stem.1654","article-title":"Cell senescence abrogates the therapeutic potential of human mesenchymal stem cells in the lethal endotoxemia model.","volume":"3","author":"Gonz\u00e1lez","year":"2014","journal-title":"Stem Cells"},{"key":"45","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/j.lfs.2018.08.019","article-title":"Dickkopf-1: current knowledge and related diseases.","volume":"20","author":"Liu","year":"2018","journal-title":"Life Sci"},{"key":"46","doi-asserted-by":"publisher","first-page":"2961","DOI":"10.1016\/j.yexcr.2010.06.021","article-title":"Stress-induced senescence in human and rodent astrocytes.","volume":"31","author":"Torres","year":"2010","journal-title":"Exp Cell Res"},{"key":"47","doi-asserted-by":"publisher","first-page":"1072","DOI":"10.1038\/nm.4385","article-title":"Targeting cellular senescence prevents age-related bone loss in mice.","volume":"2","author":"Pignolo","year":"2017","journal-title":"Nat Med"},{"key":"48","doi-asserted-by":"publisher","first-page":"2351","DOI":"10.1007\/s10067-017-3690-x","article-title":"Serum levels of the bone turnover markers dickkopf-1, osteoprotegerin, and TNF-\u03b1 in knee osteoarthritis patients.","volume":"3","author":"Jiang","year":"2017","journal-title":"Clin Rheumatol"},{"key":"49","doi-asserted-by":"publisher","first-page":"1865","DOI":"10.1007\/s10067-017-3640-7","article-title":"Association between serum and synovial fluid Dickkopf-1 levels with radiographic severity in primary knee osteoarthritis patients.","volume":"3","author":"Kassi","year":"2017","journal-title":"Clin Rheumatol"},{"key":"50","doi-asserted-by":"publisher","first-page":"3267","DOI":"10.1002\/art.34602","article-title":"Dkk-1 promotes angiogenic responses and cartilage matrix proteinase secretion in synovial fibroblasts from osteoarthritic joints.","volume":"6","author":"Wang","year":"2012","journal-title":"Arthritis Rheum"},{"key":"51","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1016\/j.joca.2008.12.008","article-title":"Inflammation induction of Dickkopf-1 mediates chondrocyte apoptosis in osteoarthritic joint.","volume":"1","author":"Wang","year":"2009","journal-title":"Osteoarthritis Cartilage"},{"key":"52","doi-asserted-by":"publisher","first-page":"e12933","DOI":"10.1111\/acel.12933","article-title":"An early-senescence state in aged mesenchymal stromal cells contributes to hematopoietic stem and progenitor cell clonogenic impairment through the activation of a pro-inflammatory program.","volume":"1","author":"Di Micco","year":"2019","journal-title":"Aging Cell"},{"key":"53","doi-asserted-by":"publisher","first-page":"1356","DOI":"10.1634\/stemcells.2006-0811","article-title":"Induction of senile osteoporosis in normal mice by intra-bone marrow-bone marrow transplantation from osteoporosis-prone mice.","volume":"2","author":"Ikehara","year":"2007","journal-title":"Stem Cells"},{"key":"54","doi-asserted-by":"publisher","first-page":"e3000201","DOI":"10.1371\/journal.pbio.3000201","article-title":"Up-regulation of FOXD1 by YAP alleviates senescence and osteoarthritis.","volume":"1","author":"Liu","year":"2019","journal-title":"PLoS Biol"},{"key":"55","doi-asserted-by":"publisher","first-page":"1246","DOI":"10.1038\/s41591-018-0092-9","article-title":"Senolytics improve physical function and increase lifespan in old age.","volume":"2","author":"Verzosa","year":"2018","journal-title":"Nat Med"},{"key":"56","doi-asserted-by":"publisher","first-page":"754","DOI":"10.1177\/0963689717745890","article-title":"Aging- and Senescence-associated Changes of Mesenchymal Stromal Cells in Myelodysplastic Syndromes.","volume":"2","author":"Poloni","year":"2018","journal-title":"Cell Transplant"},{"key":"57","doi-asserted-by":"publisher","first-page":"6761572","DOI":"10.1155\/2017\/6761572","article-title":"Age-Related Changes in Nucleus Pulposus Mesenchymal Stem Cells: An In Vitro Study in Rats.","volume":"201","author":"Ruan","year":"2017","journal-title":"Stem Cells Int"},{"key":"58","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.stem.2010.12.002","article-title":"A human iPSC model of Hutchinson Gilford Progeria reveals vascular smooth muscle and mesenchymal stem cell defects.","volume":"8","author":"Colman","year":"2011","journal-title":"Cell Stem Cell"},{"key":"59","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.joca.2005.07.014","article-title":"Osteoarthritis cartilage histopathology: grading and staging.","volume":"1","author":"van den Berg","year":"2006","journal-title":"Osteoarthritis Cartilage"},{"key":"60","doi-asserted-by":"publisher","first-page":"1158","DOI":"10.1016\/j.joca.2014.05.022","article-title":"Treatment efficacy of adipose-derived stem cells in experimental osteoarthritis is driven by high synovial activation and reflected by S100A8\/A9 serum levels.","volume":"2","author":"van Lent","year":"2014","journal-title":"Osteoarthritis Cartilage"},{"key":"61","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1016\/j.joca.2005.03.004","article-title":"Osteoarthritis development in novel experimental mouse models induced by knee joint instability.","volume":"1","author":"Kawaguchi","year":"2005","journal-title":"Osteoarthritis Cartilage"},{"key":"62","doi-asserted-by":"publisher","first-page":"914","DOI":"10.1136\/annrheumdis-2016-210426","article-title":"CCL2\/CCR2, but not CCL5\/CCR5, mediates monocyte recruitment, inflammation and cartilage destruction in osteoarthritis.","volume":"7","author":"Robinson","year":"2017","journal-title":"Ann Rheum Dis"},{"key":"63","doi-asserted-by":"publisher","first-page":"R33","DOI":"10.1186\/ar2153","article-title":"Microenvironmental changes during differentiation of mesenchymal stem cells towards chondrocytes.","volume":"9","author":"Jorgensen","year":"2007","journal-title":"Arthritis Res Ther"}],"container-title":["Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.102379","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,2]],"date-time":"2020-09-02T19:34:50Z","timestamp":1599075290000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.102379"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,22]]},"references-count":63,"journal-issue":{"issue":"20","published-print":{"date-parts":[[2019,10,31]]}},"alternative-id":["102379","31644429"],"URL":"https:\/\/doi.org\/10.18632\/aging.102379","relation":{},"ISSN":["1945-4589"],"issn-type":[{"value":"1945-4589","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10,22]]}}}