{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T16:33:01Z","timestamp":1759336381471},"reference-count":17,"publisher":"Impact Journals, LLC","issue":"21","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aging"],"published-print":{"date-parts":[[2019,11,4]]},"DOI":"10.18632\/aging.102400","type":"journal-article","created":{"date-parts":[[2019,11,5]],"date-time":"2019-11-05T02:48:40Z","timestamp":1572922120000},"page":"9492-9499","source":"Crossref","is-referenced-by-count":4,"title":["Ser-Tyr and Asn-Ala, vasorelaxing dipeptides found by comprehensive screening, reduce blood pressure via different age-dependent mechanisms"],"prefix":"10.18632","volume":"11","author":[{"given":"Daiki","family":"Koyama","sequence":"first","affiliation":[{"name":"Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Gokasho, Uji, Kyoto 611-0011, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinghui","family":"Sun","sequence":"additional","affiliation":[{"name":"Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Gokasho, Uji, Kyoto 611-0011, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaki","family":"Sasai","sequence":"additional","affiliation":[{"name":"Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Gokasho, Uji, Kyoto 611-0011, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigenobu","family":"Matsumura","sequence":"additional","affiliation":[{"name":"Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Gokasho, Uji, Kyoto 611-0011, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuo","family":"Inoue","sequence":"additional","affiliation":[{"name":"Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Gokasho, Uji, Kyoto 611-0011, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kousaku","family":"Ohinata","sequence":"additional","affiliation":[{"name":"Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Gokasho, Uji, Kyoto 611-0011, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7892","published-online":{"date-parts":[[2019,11,4]]},"reference":[{"key":"1","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1161\/HYPERTENSIONAHA.114.03617","article-title":"Aging, arterial stiffness, and hypertension.","volume":"6","author":"Sun","year":"2015","journal-title":"Hypertension"},{"key":"2","doi-asserted-by":"publisher","first-page":"2681","DOI":"10.1002\/1873-3468.12306","article-title":"Soy-ghretropin, a novel ghrelin-releasing peptide derived from soy protein.","volume":"59","author":"Ohinata","year":"2016","journal-title":"FEBS Lett"},{"key":"3","doi-asserted-by":"publisher","first-page":"2121","DOI":"10.1002\/1873-3468.12731","article-title":"Lacto-ghrestatin, a novel bovine milk-derived peptide, suppresses ghrelin secretion.","volume":"59","author":"Ohinata","year":"2017","journal-title":"FEBS Lett"},{"key":"4","doi-asserted-by":"publisher","first-page":"1050","DOI":"10.1016\/j.bbrc.2018.09.195","article-title":"Identification of Rubisco anxiolytic-like peptides (rALPs) by comprehensive analysis of spinach green leaf protein digest.","volume":"50","author":"Ohinata","year":"2018","journal-title":"Biochem Biophys Res Commun"},{"key":"5","doi-asserted-by":"publisher","first-page":"568","DOI":"10.1096\/fj.201700333RR","article-title":"Characterization of soy-deprestatin, a novel orally active decapeptide that exerts antidepressant-like effectsgut-brain communication.","volume":"3","author":"Ohinata","year":"2018","journal-title":"FASEB J"},{"key":"6","doi-asserted-by":"publisher","first-page":"1456","DOI":"10.1002\/mnfr.201200168","article-title":"Novel CCK-dependent vasorelaxing dipeptide, Arg-Phe, decreases blood pressure and food intake in rodents.","volume":"5","author":"Ohinata","year":"2012","journal-title":"Mol Nutr Food Res"},{"key":"7","doi-asserted-by":"publisher","first-page":"1070","DOI":"10.1016\/j.bbrc.2018.06.118","article-title":"Orally active anti-hypertensive peptides found based on enteroendocrine cell responses to a dipeptide library.","volume":"50","author":"Ohinata","year":"2018","journal-title":"Biochem Biophys Res Commun"},{"key":"8","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1093\/oxfordjournals.eurheartj.a059580","article-title":"Endothelium-derived relaxing and contracting factors: potential role in coronary artery disease.","volume":"1","author":"L\u00fcscher","year":"1989","journal-title":"Eur Heart J"},{"key":"9","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1042\/CS20100476","article-title":"Aging and vascular endothelial function in humans.","volume":"12","author":"Donato","year":"2011","journal-title":"Clin Sci (Lond)"},{"key":"10","doi-asserted-by":"publisher","first-page":"H1662","DOI":"10.1152\/ajpheart.00004.2002","article-title":"Aging impairs endothelium-dependent vasodilation in rat skeletal muscle arterioles.","volume":"28","author":"Delp","year":"2002","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"11","doi-asserted-by":"publisher","first-page":"H2249","DOI":"10.1152\/ajpheart.00854.2003","article-title":"Reduced release of nitric oxide to shear stress in mesenteric arteries of aged rats.","volume":"28","author":"Kaley","year":"2004","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"12","doi-asserted-by":"publisher","first-page":"H1829","DOI":"10.1152\/ajpheart.00230.2009","article-title":"eNOS uncoupling and endothelial dysfunction in aged vessels.","volume":"29","author":"Sun","year":"2009","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"13","doi-asserted-by":"publisher","first-page":"H1941","DOI":"10.1152\/ajpheart.1997.273.4.h1941","article-title":"Circulating and cellular markers of endothelial dysfunction with aging in rats.","volume":"27","author":"Michel","year":"1997","journal-title":"Am J Physiol"},{"key":"14","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.mad.2009.12.010","article-title":"Alterations in the activity and expression of endothelial NO synthase in aged human endothelial cells.","volume":"13","author":"Yang","year":"2010","journal-title":"Mech Ageing Dev"},{"key":"15","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1111\/j.1474-9726.2006.00232.x","article-title":"Age-related changes in endothelial nitric oxide synthase phosphorylation and nitric oxide dependent vasodilation: evidence for a novel mechanism involving sphingomyelinase and ceramide-activated phosphatase 2A.","volume":"5","author":"Hagen","year":"2006","journal-title":"Aging Cell"},{"key":"16","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1038\/sj.bjp.0705245","article-title":"Roles for CCKand 5-HTreceptors in the effects of CCK on presympathetic vasomotor neuronal discharge in the rat.","volume":"13","author":"Verberne","year":"2003","journal-title":"Br J Pharmacol"},{"key":"17","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1002\/mnfr.201300334","article-title":"Characterization of Ile-His-Arg-Phe, a novel rice-derived vasorelaxing peptide with hypotensive and anorexigenic activities.","volume":"5","author":"Ohinata","year":"2014","journal-title":"Mol Nutr Food Res"}],"container-title":["Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.102400","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,2]],"date-time":"2020-09-02T19:38:10Z","timestamp":1599075490000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.102400"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,4]]},"references-count":17,"journal-issue":{"issue":"21","published-print":{"date-parts":[[2019,11,15]]}},"alternative-id":["102400","31685714"],"URL":"https:\/\/doi.org\/10.18632\/aging.102400","relation":{},"ISSN":["1945-4589"],"issn-type":[{"value":"1945-4589","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,4]]}}}