{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:07:33Z","timestamp":1777374453275,"version":"3.51.4"},"reference-count":33,"publisher":"Impact Journals, LLC","issue":"24","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aging"],"published-print":{"date-parts":[[2019,12,18]]},"DOI":"10.18632\/aging.102574","type":"journal-article","created":{"date-parts":[[2019,12,18]],"date-time":"2019-12-18T15:36:35Z","timestamp":1576683395000},"page":"12315-12327","source":"Crossref","is-referenced-by-count":14,"title":["\u03b2-arrestin2 alleviates L-dopa\u2013induced dyskinesia via lower D1R activity in Parkinson\u2019s rats"],"prefix":"10.18632","volume":"11","author":[{"given":"Xing-Ru","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zeng-Rui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Huzhou Central Hospital, Zhejiang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Si-Yan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen-Wen","family":"Wang","sequence":"additional","affiliation":[{"name":"The center of Traditional Chinese Medicine, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin-Shi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin-Cai","family":"He","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng-Long","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7892","published-online":{"date-parts":[[2019,12,18]]},"reference":[{"key":"1","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1136\/jnnp.51.6.745","article-title":"The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson\u2019s disease.","volume":"5","author":"Lees","year":"1988","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"2","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1016\/S1474-4422(06)70521-X","article-title":"Continuous dopamine-receptor treatment of Parkinson\u2019s disease: scientific rationale and clinical implications.","volume":"5","author":"Stocchi","year":"2006","journal-title":"Lancet Neurol"},{"key":"3","doi-asserted-by":"publisher","first-page":"1451","DOI":"10.1002\/mds.26362","article-title":"New treatments for levodopa-induced motor complications.","volume":"3","author":"Ferreira","year":"2015","journal-title":"Mov Disord"},{"key":"4","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1002\/mds.1090","article-title":"Frequency of levodopa-related dyskinesias and motor fluctuations as estimated from the cumulative literature.","volume":"1","author":"Muenter","year":"2001","journal-title":"Mov Disord"},{"key":"5","doi-asserted-by":"publisher","first-page":"1106","DOI":"10.1016\/S1474-4422(10)70218-0","article-title":"Levodopa-induced dyskinesias in patients with Parkinson\u2019s disease: filling the bench-to-bedside gap.","volume":"9","author":"Picconi","year":"2010","journal-title":"Lancet Neurol"},{"key":"6","doi-asserted-by":"publisher","first-page":"71","DOI":"10.3389\/fnbeh.2011.00071","article-title":"L-DOPA-Induced Dyskinesia and Abnormal Signaling in Striatal Medium Spiny Neurons: Focus on Dopamine D1 Receptor-Mediated Transmission.","volume":"5","author":"Fisone","year":"2011","journal-title":"Front Behav Neurosci"},{"key":"7","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1002\/syn.20481","article-title":"Receptor-activity modifying protein 1 expression is increased in the striatum following repeated L-DOPA administration in a 6-hydroxydopamine lesioned rat model of Parkinson\u2019s disease.","volume":"6","author":"Brotchie","year":"2008","journal-title":"Synapse"},{"key":"8","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1124\/jpet.108.150425","article-title":"Pharmacological modulation of glutamate transmission in a rat model of L-DOPA-induced dyskinesia: effects on motor behavior and striatal nuclear signaling.","volume":"33","author":"Cenci","year":"2009","journal-title":"J Pharmacol Exp Ther"},{"key":"9","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1016\/j.biopsych.2009.04.025","article-title":"Genetic inactivation of dopamine D1 but not D2 receptors inhibits L-DOPA-induced dyskinesia and histone activation.","volume":"6","author":"Moratalla","year":"2009","journal-title":"Biol Psychiatry"},{"key":"10","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1042\/bj20031076","article-title":"Multifaceted roles of beta-arrestins in the regulation of seven-membrane-spanning receptor trafficking and signalling.","volume":"37","author":"Lefkowitz","year":"2003","journal-title":"Biochem J"},{"key":"11","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1038\/nature17154","article-title":"The conformational signature of \u03b2-arrestin2 predicts its trafficking and signalling functions.","volume":"53","author":"Luttrell","year":"2016","journal-title":"Nature"},{"key":"12","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1016\/j.jmb.2010.12.034","article-title":"Crystal structure of arrestin-3 reveals the basis of the difference in receptor binding between two non-visual subtypes.","volume":"40","author":"Spiller","year":"2011","journal-title":"J Mol Biol"},{"key":"13","doi-asserted-by":"publisher","first-page":"3773","DOI":"10.1523\/JNEUROSCI.19-10-03773.1999","article-title":"Distinct domains of the CB1 cannabinoid receptor mediate desensitization and internalization.","volume":"1","author":"Mackie","year":"1999","journal-title":"J Neurosci"},{"key":"14","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1124\/mol.61.3.477","article-title":"Desensitization of cannabinoid-mediated presynaptic inhibition of neurotransmission between rat hippocampal neurons in culture.","volume":"6","author":"Thayer","year":"2002","journal-title":"Mol Pharmacol"},{"key":"15","doi-asserted-by":"publisher","first-page":"1200","DOI":"10.1038\/1801200a0","article-title":"3,4-Dihydroxyphenylalanine and 5-hydroxytryptophan as reserpine antagonists.","volume":"18","author":"Magnusson","year":"1957","journal-title":"Nature"},{"key":"16","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1111\/j.1471-4159.2007.04586.x","article-title":"Dopamine depletion and subsequent treatment with L-DOPA, but not the long-lived dopamine agonist pergolide, enhances activity of the Akt pathway in the rat striatum.","volume":"10","author":"Gurevich","year":"2007","journal-title":"J Neurochem"},{"key":"17","doi-asserted-by":"publisher","first-page":"16","DOI":"10.3389\/fncel.2016.00016","article-title":"Striatal Plasticity in L-DOPA- and Graft-Induced Dyskinesia; The Common Link?","volume":"1","author":"Lane","year":"2016","journal-title":"Front Cell Neurosci"},{"key":"18","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.phrs.2016.05.010","article-title":"G protein-coupled receptor kinases as regulators of dopamine receptor functions.","volume":"11","author":"Gurevich","year":"2016","journal-title":"Pharmacol Res"},{"key":"19","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.biopsych.2005.05.044","article-title":"ERK phosphorylation and FosB expression are associated with L-DOPA-induced dyskinesia in hemiparkinsonian mice.","volume":"5","author":"Moratalla","year":"2006","journal-title":"Biol Psychiatry"},{"key":"20","doi-asserted-by":"publisher","first-page":"12011","DOI":"10.1073\/pnas.0704849104","article-title":"Functional specialization of beta-arrestin interactions revealed by proteomic analysis.","volume":"10","author":"Lefkowitz","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"key":"21","doi-asserted-by":"publisher","first-page":"E2517","DOI":"10.1073\/pnas.1502740112","article-title":"Targeting \u03b2-arrestin2 in the treatment of L-DOPA-induced dyskinesia in Parkinson\u2019s disease.","volume":"11","author":"Caron","year":"2015","journal-title":"Proc Natl Acad Sci USA"},{"key":"22","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1038\/321075a0","article-title":"Cloning of the gene and cDNA for mammalian beta-adrenergic receptor and homology with rhodopsin.","volume":"32","author":"Sigal","year":"1986","journal-title":"Nature"},{"key":"23","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.tips.2003.12.008","article-title":"The molecular acrobatics of arrestin activation.","volume":"2","author":"Gurevich","year":"2004","journal-title":"Trends Pharmacol Sci"},{"key":"24","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1016\/j.pharmthera.2005.09.008","article-title":"The structural basis of arrestin-mediated regulation of G-protein-coupled receptors.","volume":"11","author":"Gurevich","year":"2006","journal-title":"Pharmacol Ther"},{"key":"25","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1186\/gb-2006-7-9-236","article-title":"Arrestins: ubiquitous regulators of cellular signaling pathways.","volume":"7","author":"Gurevich","year":"2006","journal-title":"Genome Biol"},{"key":"26","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1002\/ana.20296","article-title":"Increased D1 dopamine receptor signaling in levodopa-induced dyskinesia.","volume":"5","author":"Bezard","year":"2005","journal-title":"Ann Neurol"},{"key":"27","volume-title":"The rat brain in stereotaxic coordinates.","author":"Watson","year":"1986","edition":"2nd"},{"key":"28","doi-asserted-by":"publisher","first-page":"2477","DOI":"10.1038\/npp.2009.74","article-title":"Differential involvement of D1 and D2 dopamine receptors in L-DOPA-induced angiogenic activity in a rat model of Parkinson\u2019s disease.","volume":"3","author":"Cenci","year":"2009","journal-title":"Neuropsychopharmacology"},{"key":"29","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1016\/j.nbd.2013.01.005","article-title":"Persistent activation of the D1R\/Shp-2\/Erk1\/2 pathway in l-DOPA-induced dyskinesia in the 6-hydroxy-dopamine rat model of Parkinson\u2019s disease.","volume":"5","author":"Missale","year":"2013","journal-title":"Neurobiol Dis"},{"key":"30","doi-asserted-by":"publisher","first-page":"23527","DOI":"10.1038\/srep23527","article-title":"Inhibition of Glycogen Synthase Kinase-3\u03b2 (GSK-3\u03b2) as potent therapeutic strategy to ameliorates L-dopa-induced dyskinesia in 6-OHDA parkinsonian rats.","volume":"6","author":"Liu","year":"2016","journal-title":"Sci Rep"},{"key":"31","doi-asserted-by":"publisher","first-page":"2694","DOI":"10.1046\/j.1460-9568.1998.00285.x","article-title":"L-DOPA-induced dyskinesia in the rat is associated with striatal overexpression of prodynorphin- and glutamic acid decarboxylase mRNA.","volume":"1","author":"Bj\u00f6rklund","year":"1998","journal-title":"Eur J Neurosci"},{"key":"32","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1016\/j.biopha.2018.08.062","article-title":"Modulation of CaMKIIa-GluN2B interaction in levodopa-induced dyskinesia in 6-OHDA-lesioned Parkinson\u2019s rats.","volume":"10","author":"Xie","year":"2018","journal-title":"Biomed Pharmacother"},{"key":"33","doi-asserted-by":"publisher","first-page":"7506","DOI":"10.1038\/srep07506","article-title":"Levodopa\/benserazide microsphere (LBM) prevents L-dopa induced dyskinesia by inactivation of the DR1\/PKA\/P-tau pathway in 6-OHDA-lesioned Parkinson\u2019s rats.","volume":"4","author":"Liu","year":"2014","journal-title":"Sci Rep"}],"container-title":["Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.102574","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,2]],"date-time":"2020-09-02T19:44:05Z","timestamp":1599075845000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.102574"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,18]]},"references-count":33,"journal-issue":{"issue":"24","published-print":{"date-parts":[[2019,12,31]]}},"alternative-id":["102574","31891566"],"URL":"https:\/\/doi.org\/10.18632\/aging.102574","relation":{},"ISSN":["1945-4589"],"issn-type":[{"value":"1945-4589","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12,18]]}}}