{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T16:38:07Z","timestamp":1770827887174,"version":"3.50.1"},"reference-count":29,"publisher":"Impact Journals, LLC","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aging"],"published-print":{"date-parts":[[2020,2,12]]},"DOI":"10.18632\/aging.102798","type":"journal-article","created":{"date-parts":[[2020,2,12]],"date-time":"2020-02-12T17:19:00Z","timestamp":1581527940000},"page":"3042-3052","source":"Crossref","is-referenced-by-count":19,"title":["Entorhinal cortex-based metabolic profiling of chronic restraint stress mice model of depression"],"prefix":"10.18632","volume":"12","author":[{"given":"Xi","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Neurology, Yongchuan Hospital of Chongqing Medical University, Chongqing 402460, China"},{"name":"Chongqing Key Laboratory of Neurobiology, Chongqing 400016, China"},{"name":"Institute of Neuroscience and the Collaborative Innovation Center for Brain Science, Chongqing Medical University, Chongqing 400016, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tianlan","family":"Lan","sequence":"additional","affiliation":[{"name":"Chongqing Key Laboratory of Neurobiology, Chongqing 400016, China"},{"name":"Institute of Neuroscience and the Collaborative Innovation Center for Brain Science, Chongqing Medical University, Chongqing 400016, China"},{"name":"College of Biomedical Engineering, Chongqing Medical University, Chongqing 400016, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Wang","sequence":"additional","affiliation":[{"name":"Chongqing Key Laboratory of Neurobiology, Chongqing 400016, China"},{"name":"Institute of Neuroscience and the Collaborative Innovation Center for Brain Science, Chongqing Medical University, Chongqing 400016, China"},{"name":"Institute of Neuroscience, Basic Medical College, Chongqing Medical University, Chongqing 400016, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"He","sequence":"additional","affiliation":[{"name":"Chongqing Key Laboratory of Neurobiology, Chongqing 400016, China"},{"name":"Institute of Neuroscience and the Collaborative Innovation Center for Brain Science, Chongqing Medical University, Chongqing 400016, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhonghao","family":"Wu","sequence":"additional","affiliation":[{"name":"Chongqing Key Laboratory of Neurobiology, Chongqing 400016, China"},{"name":"Institute of Neuroscience and the Collaborative Innovation Center for Brain Science, Chongqing Medical University, Chongqing 400016, China"},{"name":"College of Biomedical Engineering, Chongqing Medical University, Chongqing 400016, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China"},{"name":"Chongqing Key Laboratory of Neurobiology, Chongqing 400016, China"},{"name":"Institute of Neuroscience and the Collaborative Innovation Center for Brain Science, Chongqing Medical University, Chongqing 400016, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China"},{"name":"Chongqing Key Laboratory of Neurobiology, Chongqing 400016, China"},{"name":"Institute of Neuroscience and the Collaborative Innovation Center for Brain Science, Chongqing Medical University, Chongqing 400016, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengge","family":"Bai","sequence":"additional","affiliation":[{"name":"Chongqing Key Laboratory of Neurobiology, Chongqing 400016, China"},{"name":"Institute of Neuroscience and the Collaborative Innovation Center for Brain Science, Chongqing Medical University, Chongqing 400016, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Zhou","sequence":"additional","affiliation":[{"name":"Chongqing Key Laboratory of Neurobiology, Chongqing 400016, China"},{"name":"Institute of Neuroscience and the Collaborative Innovation Center for Brain Science, Chongqing Medical University, Chongqing 400016, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanping","family":"Zhang","sequence":"additional","affiliation":[{"name":"Chongqing Key Laboratory of Neurobiology, Chongqing 400016, China"},{"name":"Institute of Neuroscience and the Collaborative Innovation Center for Brain Science, Chongqing Medical University, Chongqing 400016, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ke","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China"},{"name":"Chongqing Key Laboratory of Neurobiology, Chongqing 400016, China"},{"name":"Institute of Neuroscience, Basic Medical College, Chongqing Medical University, Chongqing 400016, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Neurology, Yongchuan Hospital of Chongqing Medical University, Chongqing 402460, China"},{"name":"Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China"},{"name":"Chongqing Key Laboratory of Neurobiology, Chongqing 400016, China"},{"name":"Institute of Neuroscience and the Collaborative Innovation Center for Brain Science, Chongqing Medical University, Chongqing 400016, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7892","published-online":{"date-parts":[[2020,2,12]]},"reference":[{"key":"1","doi-asserted-by":"publisher","first-page":"692","DOI":"10.1038\/mp.2012.144","article-title":"Evidence for a differential role of HPA-axis function, inflammation and metabolic syndrome in melancholic versus atypical depression.","volume":"1","author":"Penninx","year":"2013","journal-title":"Mol Psychiatry"},{"key":"2","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.biopsych.2009.02.007","article-title":"Gender-specific impact of brain-derived neurotrophic factor signaling on stress-induced depression-like behavior.","volume":"6","author":"Monteggia","year":"2009","journal-title":"Biol Psychiatry"},{"key":"3","doi-asserted-by":"publisher","first-page":"16065","DOI":"10.1038\/nrdp.2016.65","article-title":"Major depressive disorder.","volume":"2","author":"Schatzberg","year":"2016","journal-title":"Nat Rev Dis Primers"},{"key":"4","doi-asserted-by":"publisher","first-page":"894","DOI":"10.1038\/nature07455","article-title":"The molecular neurobiology of depression.","volume":"45","author":"Nestler","year":"2008","journal-title":"Nature"},{"key":"5","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1038\/nrn1846","article-title":"New approaches to antidepressant drug discovery: beyond monoamines.","volume":"7","author":"Nestler","year":"2006","journal-title":"Nat Rev Neurosci"},{"key":"6","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1111\/jnc.14641","article-title":"Validation of the targeted metabolomic pathway in the hippocampus and comparative analysis with the prefrontal cortex of social defeat model mice.","volume":"14","author":"Dong","year":"2019","journal-title":"J Neurochem"},{"key":"7","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.bbr.2016.11.035","article-title":"Potential antidepressant and resilience mechanism revealed by metabolomic study on peripheral blood mononuclear cells of stress resilient rats.","volume":"32","author":"Xie","year":"2017","journal-title":"Behav Brain Res"},{"key":"8","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.2147\/NDT.S186071","article-title":"Metabonomics reveals peripheral and central short-chain fatty acid and amino acid dysfunction in a naturally occurring depressive model of macaques.","volume":"1","author":"Xie","year":"2019","journal-title":"Neuropsychiatr Dis Treat"},{"key":"9","doi-asserted-by":"publisher","first-page":"886","DOI":"10.1016\/j.biopsych.2016.05.005","article-title":"Glutamate and Gamma-Aminobutyric Acid Systems in the Pathophysiology of Major Depression and Antidepressant Response to Ketamine.","volume":"8","author":"Jr","year":"2017","journal-title":"Biol Psychiatry"},{"key":"10","doi-asserted-by":"publisher","first-page":"3784","DOI":"10.1021\/acs.jproteome.6b00577","article-title":"Targeted Metabolomic Pathway Analysis and Validation Revealed Glutamatergic Disorder in the Prefrontal Cortex among the Chronic Social Defeat Stress Mice Model of Depression.","volume":"1","author":"Xie","year":"2016","journal-title":"J Proteome Res"},{"key":"11","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1038\/s41398-017-0018-1","article-title":"Hippocampal metabolic differences implicate distinctions between physical and psychological stress in four rat models of depression.","volume":"8","author":"Xie","year":"2018","journal-title":"Transl Psychiatry"},{"key":"12","doi-asserted-by":"publisher","first-page":"1328","DOI":"10.1038\/nm.2219","article-title":"A negative regulator of MAP kinase causes depressive behavior.","volume":"1","author":"Duman","year":"2010","journal-title":"Nat Med"},{"key":"13","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1016\/j.neuron.2016.01.011","article-title":"Direct Ventral Hippocampal-Prefrontal Input Is Required for Anxiety-Related Neural Activity and Behavior.","volume":"8","author":"Gordon","year":"2016","journal-title":"Neuron"},{"key":"14","doi-asserted-by":"publisher","first-page":"1878","DOI":"10.1038\/mp.2017.219","article-title":"Protein kinase M\u03b6 in medial prefrontal cortex mediates depressive-like behavior and antidepressant response.","volume":"2","author":"Wang","year":"2018","journal-title":"Mol Psychiatry"},{"key":"15","doi-asserted-by":"publisher","first-page":"658","DOI":"10.1016\/j.neuron.2013.06.016","article-title":"BLA to vHPC inputs modulate anxiety-related behaviors.","volume":"7","author":"Tye","year":"2013","journal-title":"Neuron"},{"key":"16","doi-asserted-by":"publisher","first-page":"658","DOI":"10.1038\/s41591-018-0002-1","article-title":"Stimulation of entorhinal cortex-dentate gyrus circuitry is antidepressive.","volume":"2","author":"Kang","year":"2018","journal-title":"Nat Med"},{"key":"17","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1016\/j.biopsych.2011.01.029","article-title":"Depression, hypothalamic pituitary adrenal axis, and hippocampal and entorhinal cortex volumes\u2014the SMART Medea study.","volume":"7","author":"Geerlings","year":"2011","journal-title":"Biol Psychiatry"},{"key":"18","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1038\/nn.3606","article-title":"Molecular drivers and cortical spread of lateral entorhinal cortex dysfunction in preclinical Alzheimer\u2019s disease.","volume":"1","author":"Small","year":"2014","journal-title":"Nat Neurosci"},{"key":"19","first-page":"201","article-title":"Serotonergic modulation of Neural activities in the entorhinal cortex.","volume":"4","author":"Lei","year":"2012","journal-title":"Int J Physiol Pathophysiol Pharmacol"},{"key":"20","doi-asserted-by":"publisher","first-page":"1506","DOI":"10.1126\/science.1217139","article-title":"Long-range-projecting GABAergic neurons modulate inhibition in hippocampus and entorhinal cortex.","volume":"33","author":"Monyer","year":"2012","journal-title":"Science"},{"key":"21","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1038\/nrd2462","article-title":"Targeting the glutamatergic system to develop novel, improved therapeutics for mood disorders.","volume":"7","author":"Manji","year":"2008","journal-title":"Nat Rev Drug Discov"},{"key":"22","doi-asserted-by":"publisher","first-page":"1310","DOI":"10.1016\/j.biopsych.2007.03.017","article-title":"Increased levels of glutamate in brains from patients with mood disorders.","volume":"6","author":"Iyo","year":"2007","journal-title":"Biol Psychiatry"},{"key":"23","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1016\/j.cell.2016.03.014","article-title":"On the Dependency of Cellular Protein Levels on mRNA Abundance.","volume":"16","author":"Aebersold","year":"2016","journal-title":"Cell"},{"key":"24","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1007\/s00406-012-0315-x","article-title":"Differences between unipolar and bipolar I depression in the quantitative analysis of glutamic acid decarboxylase-immunoreactive neuropil.","volume":"26","author":"Bogerts","year":"2012","journal-title":"Eur Arch Psychiatry Clin Neurosci"},{"key":"25","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1503\/jpn.100048","article-title":"Decreased BDNF, trkB-TK+ and GAD67 mRNA expression in the hippocampus of individuals with schizophrenia and mood disorders.","volume":"3","author":"Webster","year":"2011","journal-title":"J Psychiatry Neurosci"},{"key":"26","doi-asserted-by":"publisher","first-page":"24137","DOI":"10.1074\/jbc.M009003200","article-title":"Characterization of an N-system amino acid transporter expressed in retina and its involvement in glutamine transport.","volume":"27","author":"Jiang","year":"2001","journal-title":"J Biol Chem"},{"key":"27","doi-asserted-by":"publisher","first-page":"1537","DOI":"10.1126\/science.1193692","article-title":"miR-16 targets the serotonin transporter: a new facet for adaptive responses to antidepressants.","volume":"32","author":"Kellermann","year":"2010","journal-title":"Science"},{"key":"28","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/j.lfs.2018.09.016","article-title":"iTRAQ-based proteomics suggests LRP6, NPY and NPY2R perturbation in the hippocampus involved in CSDS may induce resilience and susceptibility.","volume":"21","author":"Xie","year":"2018","journal-title":"Life Sci"},{"key":"29","doi-asserted-by":"publisher","first-page":"e45","DOI":"10.1093\/nar\/29.9.e45","article-title":"A new mathematical model for relative quantification in real-time RT-PCR.","volume":"2","author":"Pfaffl","year":"2001","journal-title":"Nucleic Acids Res"}],"container-title":["Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.102798","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,2]],"date-time":"2020-09-02T20:03:03Z","timestamp":1599076983000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.102798"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,12]]},"references-count":29,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,2,15]]}},"alternative-id":["102798","32074509"],"URL":"https:\/\/doi.org\/10.18632\/aging.102798","relation":{},"ISSN":["1945-4589"],"issn-type":[{"value":"1945-4589","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2,12]]}}}