{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T22:08:49Z","timestamp":1787868529243,"version":"build-2784847793"},"reference-count":37,"publisher":"Impact Journals, LLC","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aging"],"published-print":{"date-parts":[[2020,3,8]]},"DOI":"10.18632\/aging.102880","type":"journal-article","created":{"date-parts":[[2020,3,8]],"date-time":"2020-03-08T11:50:25Z","timestamp":1583668225000},"page":"4283-4298","source":"Crossref","is-referenced-by-count":10,"title":["Secondary injury to distal regions after intracerebral hemorrhage influence neurological functional outcome"],"prefix":"10.18632","volume":"12","author":[{"given":"Kangping","family":"Song","sequence":"first","affiliation":[{"name":"Department of Neurology, Institute of Clinical Neuroscience, The First Affiliated Hospital, Jinan University, Guangzhou 510632, Guangdong, China"},{"name":"Department of Neurology, Clinical Medical College, Yangzhou University, Yangzhou 225000, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojie","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Clinical Medical College, Yangzhou University, Yangzhou 225000, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuyue","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Neurology, Clinical Medical College, Yangzhou University, Yangzhou 225000, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingling","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Institute of Clinical Neuroscience, The First Affiliated Hospital, Jinan University, Guangzhou 510632, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongying","family":"Zhang","sequence":"additional","affiliation":[{"name":"Medical Imaging Center, Clinical Medical College, Yangzhou University, Yangzhou 225000, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hailong","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Clinical Medical College, Yangzhou University, Yangzhou 225000, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Clinical Medical College, Yangzhou University, Yangzhou 225000, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-An","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Institute of Clinical Neuroscience, The First Affiliated Hospital, Jinan University, Guangzhou 510632, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingzhu","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurology, Clinical Medical College, Yangzhou University, Yangzhou 225000, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7892","published-online":{"date-parts":[[2020,3,8]]},"reference":[{"key":"1","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1111\/j.1468-1331.2006.01660.x","article-title":"Haemorrhagic pure motor stroke.","volume":"1","author":"Balcells","year":"2007","journal-title":"Eur J Neurol"},{"key":"2","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.jstrokecerebrovasdis.2011.06.013","article-title":"Cognitive impairment and dementia after intracerebral hemorrhage: a cross-sectional study of a hospital-based series.","volume":"2","author":"Godefroy","year":"2013","journal-title":"J Stroke Cerebrovasc Dis"},{"key":"3","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1111\/ane.12185","article-title":"Functioning of long-term survivors of first-ever intracerebral hemorrhage.","volume":"12","author":"Naess","year":"2014","journal-title":"Acta Neurol Scand"},{"key":"4","doi-asserted-by":"publisher","first-page":"857","DOI":"10.3174\/ajnr.A2400","article-title":"Acute damage to the posterior limb of the internal capsule on diffusion tensor tractography as an early imaging predictor of motor outcome after stroke.","volume":"3","author":"Serena","year":"2011","journal-title":"AJNR Am J Neuroradiol"},{"key":"5","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1016\/j.neulet.2007.04.052","article-title":"Motor outcome according to diffusion tensor tractography findings in the early stage of intracerebral hemorrhage.","volume":"42","author":"Jang","year":"2007","journal-title":"Neurosci Lett"},{"key":"6","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1227\/01.NEU.0000311066.03121.B8","article-title":"Diffusion tensor tractography predicts motor functional outcome in patients with spontaneous intracerebral hemorrhage.","volume":"6","author":"Kinouchi","year":"2008","journal-title":"Neurosurgery"},{"key":"7","doi-asserted-by":"publisher","first-page":"1561","DOI":"10.3174\/ajnr.A1639","article-title":"Prediction of functional outcome in acute cerebral hemorrhage using diffusion tensor imaging at 3T: a prospective study.","volume":"3","author":"Hongo","year":"2009","journal-title":"AJNR Am J Neuroradiol"},{"key":"8","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1159\/000338904","article-title":"Prediction of motor function outcome after intracerebral hemorrhage using fractional anisotropy calculated from diffusion tensor imaging.","volume":"3","author":"Ogawa","year":"2012","journal-title":"Cerebrovasc Dis"},{"key":"9","doi-asserted-by":"publisher","first-page":"2019","DOI":"10.1161\/STROKEAHA.113.001321","article-title":"The effect of lacunar infarcts on white matter tract integrity.","volume":"4","author":"Biessels","year":"2013","journal-title":"Stroke"},{"key":"10","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/S0891-0618(01)00160-0","article-title":"Effect of posterior temporal-parietal hematoma on orbital frontal chemistry in relation to a cognitive and anxiety state: a combined 1H-MRS and neuropsychological study of an unusual case as compared with 16 healthy subjects.","volume":"2","author":"Ramachandran","year":"2002","journal-title":"J Chem Neuroanat"},{"key":"11","doi-asserted-by":"publisher","first-page":"1089","DOI":"10.1016\/j.acra.2008.04.008","article-title":"Utility of different MR modalities in mild cognitive impairment and its use as a predictor of conversion to probable dementia.","volume":"1","author":"Medrano","year":"2008","journal-title":"Acad Radiol"},{"key":"12","doi-asserted-by":"publisher","first-page":"e000007","DOI":"10.1136\/bmjopen-2010-000007","article-title":"Magnetic resonance spectroscopy in the prediction of early conversion from amnestic mild cognitive impairment to dementia: a prospective cohort study.","volume":"1","author":"Sarasa","year":"2011","journal-title":"BMJ Open"},{"key":"13","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1080\/02841850802709219","article-title":"Regional metabolic changes in the hippocampus and posterior cingulate area detected with 3-Tesla magnetic resonance spectroscopy in patients with mild cognitive impairment and Alzheimer disease.","volume":"5","author":"Li","year":"2009","journal-title":"Acta Radiol"},{"key":"14","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.clineuro.2014.12.005","article-title":"Brain metabolism assessed via proton magnetic resonance spectroscopy in patients with amnestic or vascular mild cognitive impairment.","volume":"13","author":"Sun","year":"2015","journal-title":"Clin Neurol Neurosurg"},{"key":"15","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.bbrc.2015.12.009","article-title":"In vivo HMRS and lipidomic profiling reveals comprehensive changes of hippocampal metabolism during aging in mice.","volume":"47","author":"Li","year":"2016","journal-title":"Biochem Biophys Res Commun"},{"key":"16","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1016\/0306-4522(91)90001-5","article-title":"Selective vulnerability of the hippocampus in brain ischemia.","volume":"4","author":"Freund","year":"1991","journal-title":"Neuroscience"},{"key":"17","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1002\/ana.21557","article-title":"The brain in the age of old: the hippocampal formation is targeted differentially by diseases of late life.","volume":"6","author":"Small","year":"2008","journal-title":"Ann Neurol"},{"key":"18","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/j.neulet.2007.02.080","article-title":"Nogo-A is involved in secondary axonal degeneration of thalamus in hypertensive rats with focal cortical infarction.","volume":"41","author":"Zeng","year":"2007","journal-title":"Neurosci Lett"},{"key":"19","doi-asserted-by":"publisher","first-page":"790","DOI":"10.1161\/01.STR.21.5.790","article-title":"Neural damage in the rat thalamus after cortical infarcts.","volume":"2","author":"Young","year":"1990","journal-title":"Stroke"},{"key":"20","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.expneurol.2008.05.009","article-title":"Midline brain injury in the immature rat induces sustained cognitive deficits, bihemispheric axonal injury and neurodegeneration.","volume":"21","author":"Raghupathi","year":"2008","journal-title":"Exp Neurol"},{"key":"21","doi-asserted-by":"publisher","first-page":"1767","DOI":"10.1016\/j.neuroimage.2004.03.041","article-title":"Diffusion tensor imaging detects early Wallerian degeneration of the pyramidal tract after ischemic stroke.","volume":"2","author":"R\u00f6ther","year":"2004","journal-title":"Neuroimage"},{"key":"22","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1111\/dmcn.12022","article-title":"Early Wallerian degeneration on magnetic resonance imaging: underappreciated but highly relevant.","volume":"5","author":"Kleinman","year":"2013","journal-title":"Dev Med Child Neurol"},{"key":"23","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1111\/dmcn.12010","article-title":"Association between radiographic Wallerian degeneration and neuropathological changes post childhood stroke.","volume":"5","author":"Askalan","year":"2013","journal-title":"Dev Med Child Neurol"},{"key":"24","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1136\/jnnp.2004.046375","article-title":"Time course of wallerian degeneration after ischaemic stroke revealed by diffusion tensor imaging.","volume":"7","author":"R\u00f6ther","year":"2005","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"25","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1016\/j.neuroimage.2009.04.066","article-title":"A longitudinal diffusion tensor imaging study on Wallerian degeneration of corticospinal tract after motor pathway stroke.","volume":"4","author":"Li","year":"2009","journal-title":"Neuroimage"},{"key":"26","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1111\/j.1440-1819.2006.01562.x","article-title":"Efficacy of milnacipran on cognitive dysfunction with post-stroke depression: preliminary open-label study.","volume":"6","author":"Asada","year":"2006","journal-title":"Psychiatry Clin Neurosci"},{"key":"27","doi-asserted-by":"publisher","first-page":"1310","DOI":"10.1345\/aph.1L703","article-title":"Current concepts in vascular cognitive impairment and pharmacotherapeutic implications.","volume":"4","author":"Moorhouse","year":"2009","journal-title":"Ann Pharmacother"},{"key":"28","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1034\/j.1600-0404.2001.00370.x","article-title":"Abulia and cognitive impairment in two patients with capsular genu infarct.","volume":"10","author":"Inzitari","year":"2001","journal-title":"Acta Neurol Scand"},{"key":"29","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1016\/j.jstrokecerebrovasdis.2014.09.015","article-title":"Basal ganglia cerebral microbleeds and global cognitive function: the Kashima Scan Study.","volume":"2","author":"Hara","year":"2015","journal-title":"J Stroke Cerebrovasc Dis"},{"key":"30","doi-asserted-by":"publisher","first-page":"1978","DOI":"10.1016\/j.jstrokecerebrovasdis.2015.04.047","article-title":"Executive dysfunction in patients with putaminal hemorrhage.","volume":"2","author":"Mori","year":"2015","journal-title":"J Stroke Cerebrovasc Dis"},{"key":"31","doi-asserted-by":"publisher","first-page":"2788","DOI":"10.1016\/j.ejrad.2011.08.010","article-title":"Volumetric MRI and 1H MRS study of hippocampus in unilateral MCAO patients: relationship between hippocampal secondary damage and cognitive disorder following stroke.","volume":"8","author":"Zhu","year":"2012","journal-title":"Eur J Radiol"},{"key":"32","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1002\/ana.22386","article-title":"Glial gap junctional communication involvement in hippocampal damage after middle cerebral artery occlusion.","volume":"7","author":"Zhang","year":"2011","journal-title":"Ann Neurol"},{"key":"33","doi-asserted-by":"publisher","first-page":"9616","DOI":"10.1096\/fj.201900257R","article-title":"Chronic inflammation, cognitive impairment, and distal brain region alteration following intracerebral hemorrhage.","volume":"3","author":"Ducruet","year":"2019","journal-title":"FASEB J"},{"key":"34","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1212\/WNL.0b013e31829a3329","article-title":"MRI and MRS predictors of mild cognitive impairment in a population-based sample.","volume":"8","author":"Boeve","year":"2013","journal-title":"Neurology"},{"key":"35","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1016\/S0967-2109(01)00016-3","article-title":"Metabolic changes in the ischemic penumbra after carotid endarterectomy in stroke patients by localized in vivo proton magnetic resonance spectroscopy (1H-MRS).","volume":"9","author":"Kim","year":"2001","journal-title":"Cardiovasc Surg"},{"key":"36","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1097\/WNR.0000000000000555","article-title":"Proton magnetic resonance spectroscopy as a diagnostic biomarker in mild cognitive impairment following stroke in acute phase.","volume":"2","author":"Su","year":"2016","journal-title":"Neuroreport"},{"key":"37","first-page":"915","article-title":"The morphologic correlate of incidental punctate white matter hyperintensities on MR images.","volume":"1","author":"Lechner","year":"1991","journal-title":"AJNR Am J Neuroradiol"}],"container-title":["Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.102880","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,2]],"date-time":"2020-09-02T20:04:44Z","timestamp":1599077084000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.102880"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,8]]},"references-count":37,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,3,15]]}},"alternative-id":["102880","32146443"],"URL":"https:\/\/doi.org\/10.18632\/aging.102880","relation":{},"ISSN":["1945-4589"],"issn-type":[{"value":"1945-4589","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3,8]]}}}