{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:26:51Z","timestamp":1787023611511,"version":"build-2736575974"},"reference-count":48,"publisher":"Impact Journals, LLC","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aging"],"published-print":{"date-parts":[[2020,3,22]]},"DOI":"10.18632\/aging.102952","type":"journal-article","created":{"date-parts":[[2020,3,22]],"date-time":"2020-03-22T12:39:17Z","timestamp":1584880757000},"page":"5318-5335","source":"Crossref","is-referenced-by-count":15,"title":["Dexmedetomidine alleviates sleep-restriction-mediated exaggeration of postoperative immunosuppression via splenic TFF2 in aged mice"],"prefix":"10.18632","volume":"12","author":[{"given":"Guangzhi","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Henan Provincial People\u2019s Hospital, Zhengzhou University People\u2019s Hospital, Zhengzhou 450003, Henan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoying","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Henan Provincial People\u2019s Hospital, Zhengzhou University People\u2019s Hospital, Zhengzhou 450003, Henan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guosong","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Henan Provincial People\u2019s Hospital, Zhengzhou University People\u2019s Hospital, Zhengzhou 450003, Henan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuangyin","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Henan Provincial People\u2019s Hospital, Zhengzhou University People\u2019s Hospital, Zhengzhou 450003, Henan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqiang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Henan Provincial People\u2019s Hospital, Zhengzhou University People\u2019s Hospital, Zhengzhou 450003, Henan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7892","published-online":{"date-parts":[[2020,3,22]]},"reference":[{"key":"1","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.surge.2010.07.011","article-title":"Surgery induced immunosuppression.","volume":"9","author":"Hughes","year":"2011","journal-title":"Surgeon"},{"key":"2","doi-asserted-by":"publisher","first-page":"615","DOI":"10.4293\/108680813X13693422519677","article-title":"Postoperative immunosuppression after open and laparoscopic liver resection: assessment of cellular immune function and monocytic HLA-DR expression.","volume":"1","author":"Schmidt","year":"2013","journal-title":"JSLS"},{"key":"3","doi-asserted-by":"publisher","first-page":"972","DOI":"10.1245\/ASO.2003.02.007","article-title":"Potential prophylactic measures against postoperative immunosuppression: could they reduce recurrence rates in oncological patients?","volume":"1","author":"Ben-Eliyahu","year":"2003","journal-title":"Ann Surg Oncol"},{"key":"4","doi-asserted-by":"publisher","first-page":"e2014006","DOI":"10.5620\/eht.2014.29.e2014006","article-title":"Noise in hospital rooms and sleep disturbance in hospitalized medical patients.","volume":"2","author":"Ha","year":"2014","journal-title":"Environ Health Toxicol"},{"key":"5","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1054\/arth.2003.50056","article-title":"An assessment of sleep disturbance in patients before and after total hip arthroplasty.","volume":"1","author":"Devane","year":"2003","journal-title":"J Arthroplasty"},{"key":"6","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1016\/j.jclinane.2003.02.002","article-title":"Sleeping characteristics of adults undergoing outpatient elective surgery: a cohort study.","volume":"1","author":"Caldwell-Andrews","year":"2003","journal-title":"J Clin Anesth"},{"key":"7","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1093\/sleep\/24.1.39","article-title":"Postoperative sleep disturbance: influences of opioids and pain in humans.","volume":"2","author":"Bixler","year":"2001","journal-title":"Sleep"},{"key":"8","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1097\/00000542-199007000-00009","article-title":"Anesthesia with abdominal surgery leads to intense REM sleep during the first postoperative week.","volume":"7","author":"Rose","year":"1990","journal-title":"Anesthesiology"},{"key":"9","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1007\/s00424-011-1044-0","article-title":"Sleep and immune function.","volume":"46","author":"Born","year":"2012","journal-title":"Pflugers Arch"},{"key":"10","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1097\/CCM.0B013E3181643F29","article-title":"Sleep and recovery from critical illness and injury: a review of theory, current practice, and future directions.","volume":"3","author":"Friese","year":"2008","journal-title":"Crit Care Med"},{"key":"11","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1093\/sleep\/20.10.865","article-title":"Sleep loss results in an elevation of cortisol levels the next evening.","volume":"2","author":"Van Cauter","year":"1997","journal-title":"Sleep"},{"key":"12","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1152\/japplphysiol.01604.2011","article-title":"Cardiovascular effects of partial sleep deprivation in healthy volunteers.","volume":"11","author":"Lorenzi-Filho","year":"2012","journal-title":"J Appl Physiol (1985)"},{"key":"13","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.cellimm.2008.05.006","article-title":"Neuroendocrine interactions in the immune system.","volume":"25","author":"Taub","year":"2008","journal-title":"Cell Immunol"},{"key":"14","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.cellimm.2007.09.005","article-title":"Sympathetic modulation of immunity: relevance to disease.","volume":"25","author":"Lorton","year":"2008","journal-title":"Cell Immunol"},{"key":"15","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1016\/j.bbi.2009.02.010","article-title":"Immune perturbations in patients along the perioperative period: alterations in cell surface markers and leukocyte subtypes before and after surgery.","volume":"2","author":"Ben-Eliyahu","year":"2010","journal-title":"Brain Behav Immun"},{"key":"16","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1096\/fasebj.10.5.8621064","article-title":"Partial night sleep deprivation reduces natural killer and cellular immune responses in humans.","volume":"1","author":"Gillin","year":"1996","journal-title":"FASEB J"},{"key":"17","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1111\/j.1365-2249.2008.03822.x","article-title":"Sleep-dependent activity of T cells and regulatory T cells.","volume":"15","author":"Solbach","year":"2009","journal-title":"Clin Exp Immunol"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1111\/jsr.12920","article-title":"A brief period of sleep deprivation leads to subtle changes in mouse gut microbiota.","author":"Havekes","year":"2019","journal-title":"J Sleep Res"},{"key":"19","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/j.lfs.2019.04.006","article-title":"Chronic paradoxical sleep deprivation-induced depression-like behavior, energy metabolism and microbial changes in rats.","volume":"22","author":"Zhou","year":"2019","journal-title":"Life Sci"},{"key":"20","doi-asserted-by":"publisher","first-page":"35405","DOI":"10.1038\/srep35405","article-title":"Chronic Sleep Disruption Alters Gut Microbiota, Induces Systemic and Adipose Tissue Inflammation and Insulin Resistance in Mice.","volume":"6","author":"Gozal","year":"2016","journal-title":"Sci Rep"},{"key":"21","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1038\/nri.2016.42","article-title":"Gut microbiota, metabolites and host immunity.","volume":"1","author":"Garrett","year":"2016","journal-title":"Nat Rev Immunol"},{"key":"22","doi-asserted-by":"publisher","first-page":"507","DOI":"10.3389\/fimmu.2017.00507","article-title":"The Role of Microbiota and Immunobiotics in Granulopoiesis of Immunocompromised Hosts.","volume":"8","author":"Alvarez","year":"2017","journal-title":"Front Immunol"},{"key":"23","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1038\/nature18847","article-title":"The microbiome and innate immunity.","volume":"53","author":"Elinav","year":"2016","journal-title":"Nature"},{"key":"24","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1111\/imm.12896","article-title":"Adaptive immune education by gut microbiota antigens.","volume":"15","author":"Elson","year":"2018","journal-title":"Immunology"},{"key":"25","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1038\/nature18848","article-title":"The microbiota in adaptive immune homeostasis and disease.","volume":"53","author":"Littman","year":"2016","journal-title":"Nature"},{"key":"26","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1002\/eji.201646721","article-title":"Contributions of the intestinal microbiome in lung immunity.","volume":"4","author":"Kolls","year":"2018","journal-title":"Eur J Immunol"},{"key":"27","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1136\/gutjnl-2015-309728","article-title":"The gut microbiota plays a protective role in the host defence against pneumococcal pneumonia.","volume":"6","author":"Wiersinga","year":"2016","journal-title":"Gut"},{"key":"28","doi-asserted-by":"publisher","first-page":"715","DOI":"10.2147\/NDT.S61997","article-title":"Psychobiotics and the gut-brain axis: in the pursuit of happiness.","volume":"1","author":"Foster","year":"2015","journal-title":"Neuropsychiatr Dis Treat"},{"key":"29","doi-asserted-by":"publisher","first-page":"49","DOI":"10.3389\/fnins.2018.00049","article-title":"The Vagus Nerve at the Interface of the Microbiota-Gut-Brain Axis.","volume":"1","author":"Pellissier","year":"2018","journal-title":"Front Neurosci"},{"key":"30","doi-asserted-by":"publisher","first-page":"10517","DOI":"10.1038\/ncomms10517","article-title":"Neural innervation stimulates splenic TFF2 to arrest myeloid cell expansion and cancer.","volume":"7","author":"Asfaha","year":"2016","journal-title":"Nat Commun"},{"key":"31","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.clinph.2017.10.005","article-title":"Dexmedetomidine promotes biomimetic non-rapid eye movement stage 3 sleep in humans: A pilot study.","volume":"12","author":"Brown","year":"2018","journal-title":"Clin Neurophysiol"},{"key":"32","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/j.immuni.2017.06.021","article-title":"Local Modulation of Antigen-Presenting Cell Development after Resolution of Pneumonia Induces Long-Term Susceptibility to Secondary Infections.","volume":"4","author":"Villadangos","year":"2017","journal-title":"Immunity"},{"key":"33","doi-asserted-by":"publisher","first-page":"14919","DOI":"10.1038\/ncomms14919","article-title":"IL-33 contributes to sepsis-induced long-term immunosuppression by expanding the regulatory T cell population.","volume":"8","author":"Liew","year":"2017","journal-title":"Nat Commun"},{"key":"34","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1038\/ni.1937","article-title":"Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm.","volume":"1","author":"Mantovani","year":"2010","journal-title":"Nat Immunol"},{"key":"35","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1093\/bja\/aem340","article-title":"Circadian distribution of sleep phases after major abdominal surgery.","volume":"10","author":"Rosenberg","year":"2008","journal-title":"Br J Anaesth"},{"key":"36","doi-asserted-by":"publisher","first-page":"3278","DOI":"10.1210\/jcem.82.10.4307","article-title":"Rapid eye movement sleep correlates with the overall activities of the hypothalamic-pituitary-adrenal axis and sympathetic system in healthy humans.","volume":"8","author":"Chrousos","year":"1997","journal-title":"J Clin Endocrinol Metab"},{"key":"37","doi-asserted-by":"publisher","first-page":"S23","DOI":"10.1016\/S1389-9457(08)70013-3","article-title":"Metabolic consequences of sleep and sleep loss.","volume":"9","author":"Leproult","year":"2008","journal-title":"Sleep Med"},{"key":"38","doi-asserted-by":"publisher","first-page":"1325","DOI":"10.1152\/physrev.00010.2018","article-title":"The Sleep-Immune Crosstalk in Health and Disease.","volume":"9","author":"Haack","year":"2019","journal-title":"Physiol Rev"},{"key":"39","doi-asserted-by":"publisher","first-page":"R1148","DOI":"10.1152\/ajpregu.1993.265.5.R1148","article-title":"Sustained sleep deprivation impairs host defense.","volume":"26","author":"Everson","year":"1993","journal-title":"Am J Physiol"},{"key":"40","doi-asserted-by":"publisher","first-page":"R905","DOI":"10.1152\/ajpregu.2000.278.4.R905","article-title":"Systemic bacterial invasion induced by sleep deprivation.","volume":"27","author":"Toth","year":"2000","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"41","doi-asserted-by":"publisher","first-page":"1078","DOI":"10.1016\/j.immuni.2016.10.020","article-title":"Autoimmune Renal Disease Is Exacerbated by S1P-Receptor-1-Dependent Intestinal Th17 Cell Migration to the Kidney.","volume":"4","author":"Mittr\u00fccker","year":"2016","journal-title":"Immunity"},{"key":"42","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1038\/nm.4068","article-title":"Commensal microbiota affects ischemic stroke outcome by regulating intestinal \u03b3\u03b4 T cells.","volume":"2","author":"Anrather","year":"2016","journal-title":"Nat Med"},{"key":"43","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/S2468-1253(16)30119-4","article-title":"The role of the gut microbiota in sepsis.","volume":"2","author":"Wiersinga","year":"2017","journal-title":"Lancet Gastroenterol Hepatol"},{"key":"44","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1007\/s40262-017-0507-7","article-title":"Clinical Pharmacokinetics and Pharmacodynamics of Dexmedetomidine.","volume":"5","author":"Colin","year":"2017","journal-title":"Clin Pharmacokinet"},{"key":"45","doi-asserted-by":"publisher","first-page":"979","DOI":"10.1097\/ALN.0000000000001325","article-title":"Low-dose Dexmedetomidine Improves Sleep Quality Pattern in Elderly Patients after Noncardiac Surgery in the Intensive Care Unit: A Pilot Randomized Controlled Trial.","volume":"12","author":"Ma","year":"2016","journal-title":"Anesthesiology"},{"key":"46","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1016\/j.ccc.2009.05.001","article-title":"Sedation and immunomodulation.","volume":"2","author":"Maze","year":"2009","journal-title":"Crit Care Clin"},{"key":"47","doi-asserted-by":"publisher","first-page":"1167","DOI":"10.1038\/nprot.2008.80","article-title":"A reproducible and well-tolerated method for 2\/3 partial hepatectomy in mice.","volume":"3","author":"Willenbring","year":"2008","journal-title":"Nat Protoc"},{"key":"48","doi-asserted-by":"publisher","first-page":"3262","DOI":"10.18632\/aging.101978","article-title":"Abnormal gut microbiota composition contributes to cognitive dysfunction in streptozotocin-induced diabetic mice.","volume":"1","author":"Yang","year":"2019","journal-title":"Aging (Albany NY)"}],"container-title":["Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.102952","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,2]],"date-time":"2020-09-02T16:09:27Z","timestamp":1599062967000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.102952"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,22]]},"references-count":48,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,3,31]]}},"alternative-id":["102952","32200357"],"URL":"https:\/\/doi.org\/10.18632\/aging.102952","relation":{},"ISSN":["1945-4589"],"issn-type":[{"value":"1945-4589","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3,22]]}}}