{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T19:52:55Z","timestamp":1780602775292,"version":"3.54.1"},"reference-count":43,"publisher":"Impact Journals, LLC","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aging"],"published-print":{"date-parts":[[2020,3,22]]},"DOI":"10.18632\/aging.102954","type":"journal-article","created":{"date-parts":[[2020,3,22]],"date-time":"2020-03-22T22:06:20Z","timestamp":1584914780000},"page":"5336-5351","source":"Crossref","is-referenced-by-count":41,"title":["Overexpressed ITGA2 contributes to paclitaxel resistance by ovarian cancer cells through the activation of the AKT\/FoxO1 pathway"],"prefix":"10.18632","volume":"12","author":[{"given":"Linlin","family":"Ma","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing 100730, R.P. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Pancreatic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China"},{"name":"Sino-German Laboratory of Personalized Medicine for Pancreatic Cancer, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Li","sequence":"additional","affiliation":[{"name":"Cardiovascular Medicine Department, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hansong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing 100730, R.P. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Jin","sequence":"additional","affiliation":[{"name":"Sino-German Laboratory of Personalized Medicine for Pancreatic Cancer, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China"},{"name":"Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dianyun","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Pancreatic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China"},{"name":"Sino-German Laboratory of Personalized Medicine for Pancreatic Cancer, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7892","published-online":{"date-parts":[[2020,3,22]]},"reference":[{"key":"1","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3322\/caac.21442","article-title":"Cancer statistics, 2018.","volume":"6","author":"Jemal","year":"2018","journal-title":"CA Cancer J Clin"},{"key":"2","doi-asserted-by":"publisher","first-page":"v23","DOI":"10.1093\/annonc\/mdq244","article-title":"Newly diagnosed and relapsed epithelial ovarian carcinoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up.","volume":"2","author":"Castiglione","year":"2010","journal-title":"Ann Oncol"},{"key":"3","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1007\/s00428-012-1203-5","article-title":"Ovarian carcinomas: five distinct diseases with different origins, genetic alterations, and clinicopathological features.","volume":"46","author":"Prat","year":"2012","journal-title":"Virchows Arch"},{"key":"4","doi-asserted-by":"publisher","first-page":"280","DOI":"10.3322\/caac.21559","article-title":"Epithelial ovarian cancer: evolution of management in the era of precision medicine.","volume":"6","author":"Oza","year":"2019","journal-title":"CA Cancer J Clin"},{"key":"5","doi-asserted-by":"publisher","first-page":"2527","DOI":"10.2353\/ajpath.2010.100017","article-title":"Collagen XIII induced in vascular endothelium mediates alpha1beta1 integrin-dependent transmigration of monocytes in renal fibrosis.","volume":"17","author":"Cosgrove","year":"2010","journal-title":"Am J Pathol"},{"key":"6","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1242\/jcs.1987.Supplement_8.13","article-title":"Integrin, a transmembrane glycoprotein complex mediating cell-substratum adhesion.","volume":"8","author":"Horwitz","year":"1987","journal-title":"J Cell Sci Suppl"},{"key":"7","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1006\/scbi.2000.0337","article-title":"New aspects of integrin signaling in cancer.","volume":"1","author":"Juliano","year":"2000","journal-title":"Semin Cancer Biol"},{"key":"8","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1038\/nrc727","article-title":"Role of integrins in cell invasion and migration.","volume":"2","author":"Cheresh","year":"2002","journal-title":"Nat Rev Cancer"},{"key":"9","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1186\/1477-3163-6-11","article-title":"Alpha2beta1 integrin affects metastatic potential of ovarian carcinoma spheroids by supporting disaggregation and proteolysis.","volume":"6","author":"Ahmed","year":"2007","journal-title":"J Carcinog"},{"key":"10","doi-asserted-by":"publisher","first-page":"1717","DOI":"10.3892\/ijo_00000302","article-title":"Reorganization of the integrin alpha2 subunit controls cell adhesion and cancer cell invasion in prostate cancer.","volume":"3","author":"Steelant","year":"2009","journal-title":"Int J Oncol"},{"key":"11","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1097\/mpa.0b013e31811f4526","article-title":"The integrin-extracellular matrix axis in pancreatic cancer.","volume":"3","author":"Bouvet","year":"2007","journal-title":"Pancreas"},{"key":"12","doi-asserted-by":"publisher","first-page":"E3966","DOI":"10.3390\/ijms20163966","article-title":"New Molecular Markers Involved in Regulation of Ovarian Granulosa Cell Morphogenesis, Development and Differentiation during Short-Term Primary In Vitro Culture-Transcriptomic and Histochemical Study Based on Ovaries and Individual Separated Follicles.","volume":"2","author":"Kempisty","year":"2019","journal-title":"Int J Mol Sci"},{"key":"13","doi-asserted-by":"publisher","first-page":"9584","DOI":"10.1002\/jcp.26866","article-title":"Methylation-independent ITGA2 overexpression is associated with poor prognosis in de novo acute myeloid leukemia.","volume":"23","author":"Qian","year":"2018","journal-title":"J Cell Physiol"},{"key":"14","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1186\/s12575-018-0073-x","article-title":"Blockade of ITGA2 Induces Apoptosis and Inhibits Cell Migration in Gastric Cancer.","volume":"2","author":"Liao","year":"2018","journal-title":"Biol Proced Online"},{"key":"15","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/j.ygyno.2015.02.003","article-title":"The PI3K\/AKT\/mTOR pathway as a therapeutic target in ovarian cancer.","volume":"13","author":"Sasano","year":"2015","journal-title":"Gynecol Oncol"},{"key":"16","doi-asserted-by":"publisher","first-page":"995","DOI":"10.15252\/embj.201695534","article-title":"AKT-phosphorylated FOXO1 suppresses ERK activation and chemoresistance by disrupting IQGAP1-MAPK interaction.","volume":"3","author":"Huang","year":"2017","journal-title":"EMBO J"},{"key":"17","doi-asserted-by":"publisher","first-page":"1068","DOI":"10.1038\/sj.bjc.6604279","article-title":"The involvement of FOXO1 in cytotoxic stress and drug-resistance induced by paclitaxel in ovarian cancers.","volume":"9","author":"Tsuda","year":"2008","journal-title":"Br J Cancer"},{"key":"18","doi-asserted-by":"publisher","first-page":"871","DOI":"10.3892\/ol.2013.1759","article-title":"TLR4 induces tumor growth and inhibits paclitaxel activity in MyD88-positive human ovarian carcinoma","volume":"7","author":"Sheng","year":"2014","journal-title":"Oncol Lett"},{"key":"19","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1186\/s12885-018-4155-6","article-title":"Compound A attenuates toll-like receptor 4-mediated paclitaxel resistance in breast cancer and melanoma through suppression of IL-8.","volume":"1","author":"Thuwajit","year":"2018","journal-title":"BMC Cancer"},{"key":"20","doi-asserted-by":"publisher","first-page":"4353","DOI":"10.1038\/onc.2009.289","article-title":"TLR4 signaling induced by lipopolysaccharide or paclitaxel regulates tumor survival and chemoresistance in ovarian cancer.","volume":"2","author":"Whiteside","year":"2009","journal-title":"Oncogene"},{"key":"21","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1089\/jmf.2012.0222","article-title":"Genes related to suppression of malignant phenotype induced by Maitake D-Fraction in breast cancer cells.","volume":"1","author":"Balogh","year":"2013","journal-title":"J Med Food"},{"key":"22","doi-asserted-by":"publisher","first-page":"81423","DOI":"10.18632\/oncotarget.13234","article-title":"Dapper homolog 1 alpha suppresses metastasis ability of gastric cancer through inhibiting planar cell polarity pathway.","volume":"7","author":"Zhao","year":"2016","journal-title":"Oncotarget"},{"key":"23","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1002\/jcp.25441","article-title":"Gene and MicroRNA Expression Are Predictive of Tumor Response in Rectal Adenocarcinoma Patients Treated With Preoperative Chemoradiotherapy.","volume":"23","author":"Esposito","year":"2017","journal-title":"J Cell Physiol"},{"key":"24","doi-asserted-by":"publisher","first-page":"1338","DOI":"10.2353\/ajpath.2009.090234","article-title":"A key role for the integrin alpha2beta1 in experimental and developmental angiogenesis.","volume":"17","author":"Iozzo","year":"2009","journal-title":"Am J Pathol"},{"key":"25","doi-asserted-by":"publisher","first-page":"1980","DOI":"10.1182\/blood-2007-06-094680","article-title":"alpha2beta1 integrin expression in the tumor microenvironment enhances tumor angiogenesis in a tumor cell-specific manner.","volume":"11","author":"Zutter","year":"2008","journal-title":"Blood"},{"key":"26","doi-asserted-by":"publisher","first-page":"1110","DOI":"10.1002\/ijc.28765","article-title":"Genome-wide DNA methylation patterns in pancreatic ductal adenocarcinoma reveal epigenetic deregulation of SLIT-ROBO, ITGA2 and MET signaling.","volume":"13","author":"Christ","year":"2014","journal-title":"Int J Cancer"},{"key":"27","doi-asserted-by":"publisher","first-page":"e0135128","DOI":"10.1371\/journal.pone.0135128","article-title":"Epigenetic silencing of ITGA2 by MiR-373 promotes cell migration in breast cancer.","volume":"1","author":"Yan","year":"2015","journal-title":"PLoS One"},{"key":"28","doi-asserted-by":"publisher","first-page":"e115276","DOI":"10.1371\/journal.pone.0115276","article-title":"EZH2 regulates cofilin activity and colon cancer cell migration by targeting ITGA2 gene.","volume":"9","author":"Pintzas","year":"2014","journal-title":"PLoS One"},{"key":"29","doi-asserted-by":"publisher","first-page":"12884","DOI":"10.1002\/jcp.27953","article-title":"Coexpression of UCA1 and ITGA2 in pancreatic cancer cells target the expression of miR-107 through focal adhesion pathway.","volume":"23","author":"Yu","year":"2019","journal-title":"J Cell Physiol"},{"key":"30","doi-asserted-by":"publisher","first-page":"77683","DOI":"10.18632\/oncotarget.12760","article-title":"Integrin \u03b12\u03b21 inhibits MST1 kinase phosphorylation and activates Yes-associated protein oncogenic signaling in hepatocellular carcinoma.","volume":"7","author":"Luk","year":"2016","journal-title":"Oncotarget"},{"key":"31","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1111\/bjh.12980","article-title":"Epstein-Barr virus infection induces an increase of T regulatory type 1 cells in Hodgkin lymphoma patients.","volume":"16","author":"Delhem","year":"2014","journal-title":"Br J Haematol"},{"key":"32","doi-asserted-by":"publisher","first-page":"7951","DOI":"10.1007\/s13277-015-4696-0","article-title":"MicroRNA-128 inhibits EMT of human osteosarcoma cells by directly targeting integrin \u03b12.","volume":"3","author":"Fang","year":"2016","journal-title":"Tumour Biol"},{"key":"33","doi-asserted-by":"publisher","first-page":"1382","DOI":"10.3892\/ol.2015.4051","article-title":"Identification of genes and signaling pathways associated with squamous cell carcinoma by bioinformatics analysis.","volume":"1","author":"Jiang","year":"2016","journal-title":"Oncol Lett"},{"key":"34","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1038\/s41568-019-0216-7","article-title":"The PI3K-AKT network at the interface of oncogenic signalling and cancer metabolism.","volume":"2","author":"Manning","year":"2020","journal-title":"Nat Rev Cancer"},{"key":"35","doi-asserted-by":"publisher","first-page":"1669","DOI":"10.1002\/jbmr.1604","article-title":"miR-182 is a negative regulator of osteoblast proliferation, differentiation, and skeletogenesis through targeting FoxO1.","volume":"2","author":"Lim","year":"2012","journal-title":"J Bone Miner Res"},{"key":"36","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1007\/s00774-019-00997-y","article-title":"miR-142-5p promotes the osteoclast differentiation of bone marrow-derived macrophages via PTEN\/PI3K\/AKT\/FoxO1 pathway.","volume":"3","author":"Zhang","year":"2019","journal-title":"J Bone Miner Metab"},{"key":"37","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1177\/1535370217746611","article-title":"MiR-145 regulates osteogenic differentiation of human adipose-derived mesenchymal stem cells through targeting FoxO1.","volume":"24","author":"Wang","year":"2018","journal-title":"Exp Biol Med (Maywood)"},{"key":"38","doi-asserted-by":"publisher","first-page":"4085","DOI":"10.3892\/ol.2017.5986","article-title":"Resistance to nanoparticle albumin-bound paclitaxel is mediated by ABCB1 in urothelial cancer cells.","volume":"1","author":"Cinatl","year":"2017","journal-title":"Oncol Lett"},{"key":"39","first-page":"817","article-title":"[Retrospective Analysis of Weekly Paclitaxel Chemotherapy for Gemcitabine- and S-1-Resistant Pancreatic Cancer].","volume":"4","author":"Saito","year":"2018","journal-title":"Gan To Kagaku Ryoho"},{"key":"40","doi-asserted-by":"publisher","first-page":"940591","DOI":"10.1155\/2014\/940591","article-title":"Combination therapy of albumin-bound Paclitaxel and Carboplatin as first line therapy in a patient with ovarian cancer.","volume":"201","author":"Gopal","year":"2014","journal-title":"Case Rep Oncol Med"},{"key":"41","doi-asserted-by":"publisher","first-page":"21380","DOI":"10.1002\/jcp.28747","article-title":"microRNA-16-5p-containing exosomes derived from bone marrow-derived mesenchymal stem cells inhibit proliferation, migration, and invasion, while promoting apoptosis of colorectal cancer cells by downregulating ITGA2.","volume":"23","author":"Ouyang","year":"2019","journal-title":"J Cell Physiol"},{"key":"42","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1186\/s13046-019-1496-1","article-title":"Overexpressed ITGA2 promotes malignant tumor aggression by up-regulating PD-L1 expression through the activation of the STAT3 signaling pathway.","volume":"3","author":"Wu","year":"2019","journal-title":"J Exp Clin Cancer Res"},{"key":"43","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1177\/1087057104271865","article-title":"Homogeneous, bioluminescent protease assays: caspase-3 as a model.","volume":"1","author":"Wood","year":"2005","journal-title":"J Biomol Screen"}],"container-title":["Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.102954","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,2]],"date-time":"2020-09-02T20:09:29Z","timestamp":1599077369000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.102954"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,22]]},"references-count":43,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,3,31]]}},"alternative-id":["102954","32202508"],"URL":"https:\/\/doi.org\/10.18632\/aging.102954","relation":{},"ISSN":["1945-4589"],"issn-type":[{"value":"1945-4589","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3,22]]}}}