{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T02:43:14Z","timestamp":1790476994256,"version":"4.1.0"},"reference-count":49,"publisher":"Impact Journals, LLC","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aging"],"published-print":{"date-parts":[[2020,4,20]]},"DOI":"10.18632\/aging.103062","type":"journal-article","created":{"date-parts":[[2020,4,20]],"date-time":"2020-04-20T18:27:06Z","timestamp":1587407226000},"page":"7042-7055","source":"Crossref","is-referenced-by-count":29,"title":["SIRT1 regulates O-GlcNAcylation of tau through OGT"],"prefix":"10.18632","volume":"12","author":[{"given":"Shu","family":"Lu","sequence":"first","affiliation":[{"name":"Department of Intensive Care Unit, The Affiliated Hospital of Nantong University, Nantong, Jiangsu, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomin","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Medical School, Nantong, Jiangsu, P. R. China"},{"name":"Jiangsu Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education of China, Co-innovation Center of Neuroregeneration, Nantong University, Nantong, Jiangsu, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Wang","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education of China, Co-innovation Center of Neuroregeneration, Nantong University, Nantong, Jiangsu, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qun","family":"Gu","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education of China, Co-innovation Center of Neuroregeneration, Nantong University, Nantong, Jiangsu, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Huang","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education of China, Co-innovation Center of Neuroregeneration, Nantong University, Nantong, Jiangsu, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nana","family":"Jin","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education of China, Co-innovation Center of Neuroregeneration, Nantong University, Nantong, Jiangsu, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dandan","family":"Chu","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education of China, Co-innovation Center of Neuroregeneration, Nantong University, Nantong, Jiangsu, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziqi","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Medical School, Nantong, Jiangsu, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Liu","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education of China, Co-innovation Center of Neuroregeneration, Nantong University, Nantong, Jiangsu, P. R. China"},{"name":"Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY 10314, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Qian","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Medical School, Nantong, Jiangsu, P. R. China"},{"name":"Jiangsu Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education of China, Co-innovation Center of Neuroregeneration, Nantong University, Nantong, Jiangsu, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7892","published-online":{"date-parts":[[2020,4,20]]},"reference":[{"key":"1","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/0169-328x(86)90033-1","article-title":"Identification of cDNA clones for the human microtubule-associated protein tau and chromosomal localization of the genes for tau and microtubule-associated protein 2.","volume":"38","author":"Donlon","year":"1986","journal-title":"Brain Res"},{"key":"2","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1016\/S0962-8924(98)01368-3","article-title":"Tau in Alzheimer\u2019s disease.","volume":"8","author":"Mandelkow","year":"1998","journal-title":"Trends Cell Biol"},{"key":"3","doi-asserted-by":"publisher","first-page":"83","DOI":"10.3389\/fneur.2013.00083","article-title":"The importance of tau phosphorylation for neurodegenerative diseases.","volume":"4","author":"Lovestone","year":"2013","journal-title":"Front Neurol"},{"key":"4","first-page":"24374","article-title":"Microtubule-associated protein tau. Abnormal phosphorylation of a non-paired helical filament pool in Alzheimer disease.","volume":"26","author":"Grundke-Iqbal","year":"1993","journal-title":"J Biol Chem"},{"key":"5","doi-asserted-by":"publisher","first-page":"265","DOI":"10.5483\/BMBRep.2018.51.6.077","article-title":"Degradation or aggregation: the ramifications of post-translational modifications on tau.","volume":"5","author":"Lee","year":"2018","journal-title":"BMB Rep"},{"key":"6","first-page":"3308","article-title":"Topography and polypeptide distribution of terminal N-acetylglucosamine residues on the surfaces of intact lymphocytes. Evidence for O-linked GlcNAc.","volume":"25","author":"Hart","year":"1984","journal-title":"J Biol Chem"},{"key":"7","doi-asserted-by":"publisher","first-page":"28741","DOI":"10.1074\/jbc.271.46.28741","article-title":"The microtubule-associated protein tau is extensively modified with O-linked N-acetylglucosamine.","volume":"27","author":"Hart","year":"1996","journal-title":"J Biol Chem"},{"key":"8","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1039\/C8SM02366B","article-title":"Fmoc-FF and hexapeptide-based multicomponent hydrogels as scaffold materials.","volume":"1","author":"Accardo","year":"2019","journal-title":"Soft Matter"},{"key":"9","doi-asserted-by":"publisher","first-page":"1078","DOI":"10.1016\/j.jalz.2016.02.011","article-title":"O-GlcNAcylation: A regulator of tau pathology and neurodegeneration.","volume":"1","author":"Iqbal","year":"2016","journal-title":"Alzheimers Dement"},{"key":"10","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1007\/978-1-4615-1885-3_10","article-title":"O-linked N-acetylglucosamine: the \u201cyin-yang\u201d of Ser\/Thr phosphorylation? Nuclear and cytoplasmic glycosylation.","volume":"37","author":"Hayes","year":"1995","journal-title":"Adv Exp Med Biol"},{"key":"11","doi-asserted-by":"publisher","first-page":"10804","DOI":"10.1073\/pnas.0400348101","article-title":"O-GlcNAcylation regulates phosphorylation of tau: a mechanism involved in Alzheimer\u2019s disease.","volume":"10","author":"Gong","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"key":"12","doi-asserted-by":"publisher","first-page":"1820","DOI":"10.1093\/brain\/awp099","article-title":"Reduced O-GlcNAcylation links lower brain glucose metabolism and tau pathology in Alzheimer\u2019s disease.","volume":"13","author":"Gong","year":"2009","journal-title":"Brain"},{"key":"13","first-page":"2563","article-title":"Enzymatic addition of O-GlcNAc to nuclear and cytoplasmic proteins. Identification of a uridine diphospho-N-acetylglucosamine:peptide beta-N-acetylglucosaminyltransferase.","volume":"26","author":"Hart","year":"1990","journal-title":"J Biol Chem"},{"key":"14","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/0014-5793(74)81206-8","article-title":"Characterisation of human N-acetyl-beta-hexosaminidase C.","volume":"4","author":"Hooghwinkel","year":"1974","journal-title":"FEBS Lett"},{"key":"15","doi-asserted-by":"publisher","first-page":"9838","DOI":"10.1074\/jbc.M010420200","article-title":"Dynamic O-glycosylation of nuclear and cytosolic proteins: cloning and characterization of a neutral, cytosolic beta-N-acetylglucosaminidase from human brain.","volume":"27","author":"Hart","year":"2001","journal-title":"J Biol Chem"},{"key":"16","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/0005-2744(81)90052-8","article-title":"Isolation and further characterization of bovine brain hexosaminidase C.","volume":"65","author":"Lisman","year":"1981","journal-title":"Biochim Biophys Acta"},{"key":"17","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1038\/328175a0","article-title":"Binding of a nuclear protein to the cyclic-AMP response element of the somatostatin gene.","volume":"32","author":"Bilezikjian","year":"1987","journal-title":"Nature"},{"key":"18","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1152\/physrev.00017.2008","article-title":"Transcription factors in long-term memory and synaptic plasticity.","volume":"8","author":"Alberini","year":"2009","journal-title":"Physiol Rev"},{"key":"19","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1007\/s13311-014-0327-5","article-title":"Synaptic therapy in Alzheimer\u2019s disease: a CREB-centric approach.","volume":"1","author":"Arancio","year":"2015","journal-title":"Neurotherapeutics"},{"key":"20","doi-asserted-by":"publisher","first-page":"758","DOI":"10.1016\/j.cmet.2011.10.007","article-title":"Proatherogenic abnormalities of lipid metabolism in SirT1 transgenic mice are mediated through Creb deacetylation.","volume":"1","author":"Accili","year":"2011","journal-title":"Cell Metab"},{"key":"21","doi-asserted-by":"publisher","first-page":"956","DOI":"10.1016\/j.cell.2014.10.045","article-title":"SnapShot: Mammalian Sirtuins.","volume":"15","author":"Hirschey","year":"2014","journal-title":"Cell"},{"key":"22","doi-asserted-by":"publisher","first-page":"4623","DOI":"10.1091\/mbc.e05-01-0033","article-title":"Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins.","volume":"1","author":"Horikawa","year":"2005","journal-title":"Mol Biol Cell"},{"key":"23","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1016\/j.pneurobio.2011.09.001","article-title":"Protective effects and mechanisms of sirtuins in the nervous system.","volume":"9","author":"Chen","year":"2011","journal-title":"Prog Neurobiol"},{"key":"24","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1016\/j.cmet.2012.07.003","article-title":"High-fat diet triggers inflammation-induced cleavage of SIRT1 in adipose tissue to promote metabolic dysfunction.","volume":"1","author":"Guarente","year":"2012","journal-title":"Cell Metab"},{"key":"25","doi-asserted-by":"publisher","first-page":"2011","DOI":"10.1126\/science.1094637","article-title":"Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase.","volume":"30","author":"Jedrychowski","year":"2004","journal-title":"Science"},{"key":"26","doi-asserted-by":"publisher","first-page":"2479","DOI":"10.1242\/jcs.001222","article-title":"Dynamic FoxO transcription factors.","volume":"12","author":"Tindall","year":"2007","journal-title":"J Cell Sci"},{"key":"27","doi-asserted-by":"publisher","first-page":"40364","DOI":"10.1074\/jbc.M509329200","article-title":"SIRT1 protects against microglia-dependent amyloid-beta toxicity through inhibiting NF-kappaB signaling.","volume":"28","author":"Gan","year":"2005","journal-title":"J Biol Chem"},{"key":"28","doi-asserted-by":"publisher","first-page":"2369","DOI":"10.1038\/sj.emboj.7600244","article-title":"Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase.","volume":"2","author":"Mayo","year":"2004","journal-title":"EMBO J"},{"key":"29","doi-asserted-by":"publisher","first-page":"32015","DOI":"10.1074\/jbc.274.45.32015","article-title":"Regulation of a cytosolic and nuclear O-GlcNAc transferase. Role of the tetratricopeptide repeats.","volume":"27","author":"Hart","year":"1999","journal-title":"J Biol Chem"},{"key":"30","doi-asserted-by":"publisher","first-page":"2933","DOI":"10.1093\/bioinformatics\/bti473","article-title":"MatInspector and beyond: promoter analysis based on transcription factor binding sites.","volume":"2","author":"Werner","year":"2005","journal-title":"Bioinformatics"},{"key":"31","doi-asserted-by":"publisher","first-page":"4878","DOI":"10.1093\/nar\/23.23.4878","article-title":"MatInd and MatInspector: new fast and versatile tools for detection of consensus matches in nucleotide sequence data.","volume":"2","author":"Werner","year":"1995","journal-title":"Nucleic Acids Res"},{"key":"32","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1016\/0092-8674(89)90013-5","article-title":"Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133.","volume":"5","author":"Montminy","year":"1989","journal-title":"Cell"},{"key":"33","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3233\/JAD-2006-9101","article-title":"Impaired brain glucose metabolism leads to Alzheimer neurofibrillary degeneration through a decrease in tau O-GlcNAcylation.","volume":"9","author":"Iqbal","year":"2006","journal-title":"J Alzheimers Dis"},{"key":"34","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1016\/j.febslet.2007.12.035","article-title":"Decreased glucose transporters correlate to abnormal hyperphosphorylation of tau in Alzheimer disease.","volume":"58","author":"Gong","year":"2008","journal-title":"FEBS Lett"},{"key":"35","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1038\/nrm3293","article-title":"Sirtuins as regulators of metabolism and healthspan.","volume":"1","author":"Auwerx","year":"2012","journal-title":"Nat Rev Mol Cell Biol"},{"key":"36","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1097\/CCO.0b013e32834d813b","article-title":"SIRT1, metabolism and cancer.","volume":"2","author":"Milner","year":"2012","journal-title":"Curr Opin Oncol"},{"key":"37","doi-asserted-by":"publisher","first-page":"1845","DOI":"10.18632\/oncotarget.12157","article-title":"Sirtuins in glucose and lipid metabolism.","volume":"8","author":"Yang","year":"2017","journal-title":"Oncotarget"},{"key":"38","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.arr.2007.09.002","article-title":"Activation of innate immunity system during aging: NF-kB signaling is the molecular culprit of inflamm-aging.","volume":"7","author":"Suuronen","year":"2008","journal-title":"Ageing Res Rev"},{"key":"39","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1007\/s11357-013-9592-1","article-title":"Activation of sirtuin 1 attenuates cerebral ventricular streptozotocin-induced tau hyperphosphorylation and cognitive injuries in rat hippocampi.","volume":"3","author":"Zhou","year":"2014","journal-title":"Age (Dordr)"},{"key":"40","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/j.cmet.2005.08.004","article-title":"FoxO1 protects against pancreatic beta cell failure through NeuroD and MafA induction.","volume":"2","author":"Accili","year":"2005","journal-title":"Cell Metab"},{"key":"41","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1038\/nature03354","article-title":"Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1.","volume":"43","author":"Puigserver","year":"2005","journal-title":"Nature"},{"key":"42","doi-asserted-by":"publisher","first-page":"415","DOI":"10.18632\/aging.100176","article-title":"miRNAs regulate SIRT1 expression during mouse embryonic stem cell differentiation and in adult mouse tissues.","volume":"2","author":"Verdin","year":"2010","journal-title":"Aging (Albany NY)"},{"key":"43","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1038\/365855a0","article-title":"Phosphorylated CREB binds specifically to the nuclear protein CBP.","volume":"36","author":"Goodman","year":"1993","journal-title":"Nature"},{"key":"44","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1038\/nature02110","article-title":"CREB controls hepatic lipid metabolism through nuclear hormone receptor PPAR-gamma.","volume":"42","author":"Montminy","year":"2003","journal-title":"Nature"},{"key":"45","doi-asserted-by":"publisher","first-page":"356","DOI":"10.3934\/Neuroscience.2016.3.356","article-title":"The Contribution of Spatial and Temporal Molecular Networks in the Induction of Long-term Memory and Its Underlying Synaptic Plasticity.","volume":"3","author":"Kopec","year":"2016","journal-title":"AIMS Neurosci"},{"key":"46","doi-asserted-by":"publisher","first-page":"2089","DOI":"10.2353\/ajpath.2009.090157","article-title":"Dysregulation of insulin signaling, glucose transporters, O-GlcNAcylation, and phosphorylation of tau and neurofilaments in the brain: implication for Alzheimer\u2019s disease.","volume":"17","author":"Gong","year":"2009","journal-title":"Am J Pathol"},{"key":"47","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/S0014-5793(02)03487-7","article-title":"Involvement of aberrant glycosylation in phosphorylation of tau by cdk5 and GSK-3beta.","volume":"53","author":"Gong","year":"2002","journal-title":"FEBS Lett"},{"key":"48","doi-asserted-by":"publisher","first-page":"5535","DOI":"10.1074\/jbc.275.8.5535","article-title":"Phosphorylation of microtubule-associated protein tau is regulated by protein phosphatase 2A in mammalian brain. Implications for neurofibrillary degeneration in Alzheimer\u2019s disease.","volume":"27","author":"Iqbal","year":"2000","journal-title":"J Biol Chem"},{"key":"49","doi-asserted-by":"publisher","first-page":"239","DOI":"10.3233\/JAD-142610","article-title":"PKA-CREB Signaling Suppresses Tau Transcription.","volume":"4","author":"Qian","year":"2015","journal-title":"J Alzheimers Dis"}],"container-title":["Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.103062","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,2]],"date-time":"2020-09-02T20:17:17Z","timestamp":1599077837000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.103062"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,20]]},"references-count":49,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2020,4,30]]}},"alternative-id":["103062","32310828"],"URL":"https:\/\/doi.org\/10.18632\/aging.103062","relation":{},"ISSN":["1945-4589"],"issn-type":[{"value":"1945-4589","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,20]]}}}