{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T14:07:07Z","timestamp":1781014027608,"version":"3.54.1"},"reference-count":50,"publisher":"Impact Journals, LLC","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aging"],"published-print":{"date-parts":[[2020,4,26]]},"DOI":"10.18632\/aging.103103","type":"journal-article","created":{"date-parts":[[2020,4,26]],"date-time":"2020-04-26T23:28:10Z","timestamp":1587943690000},"page":"7491-7510","source":"Crossref","is-referenced-by-count":14,"title":["RNA-seq analysis of potential lncRNAs for age-related hearing loss in a mouse model"],"prefix":"10.18632","volume":"12","author":[{"given":"Tong","family":"Zhao","sequence":"first","affiliation":[{"name":"Hearing and Speech Rehabilitation Institute, Binzhou Medical University, Yantai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuzhen","family":"Liu","sequence":"additional","affiliation":[{"name":"Clinical Medicine Laboratory, Binzhou Medical University Hospital, Binzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zehua","family":"Sun","sequence":"additional","affiliation":[{"name":"Hearing and Speech Rehabilitation Institute, Binzhou Medical University, Yantai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinjin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Hearing and Speech Rehabilitation Institute, Binzhou Medical University, Yantai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, Binzhou Medical University Hospital, Binzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaoyun","family":"Wang","sequence":"additional","affiliation":[{"name":"Hearing and Speech Rehabilitation Institute, Binzhou Medical University, Yantai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruishuang","family":"Geng","sequence":"additional","affiliation":[{"name":"Hearing and Speech Rehabilitation Institute, Binzhou Medical University, Yantai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tihua","family":"Zheng","sequence":"additional","affiliation":[{"name":"Hearing and Speech Rehabilitation Institute, Binzhou Medical University, Yantai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Li","sequence":"additional","affiliation":[{"name":"Hearing and Speech Rehabilitation Institute, Binzhou Medical University, Yantai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing Yin","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology- Head and Neck Surgery, Case Western Reserve University, Cleveland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7892","published-online":{"date-parts":[[2020,4,26]]},"reference":[{"key":"1","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1002\/path.2102","article-title":"Ageing and hearing loss.","volume":"21","author":"Yan","year":"2007","journal-title":"J Pathol"},{"key":"2","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.heares.2013.01.021","article-title":"Current concepts in age-related hearing loss: epidemiology and mechanistic pathways.","volume":"30","author":"Kondo","year":"2013","journal-title":"Hear Res"},{"key":"3","doi-asserted-by":"publisher","first-page":"788","DOI":"10.1016\/j.jagp.2018.04.003","article-title":"Age-Related Hearing Loss and Its Association with Depression in Later Life.","volume":"2","author":"Rutherford","year":"2018","journal-title":"Am J Geriatr Psychiatry"},{"key":"4","doi-asserted-by":"publisher","first-page":"100963","DOI":"10.1016\/j.arr.2019.100963","article-title":"Age-related hearing loss and tinnitus, dementia risk, and auditory amplification outcomes.","volume":"5","author":"Mohajerani","year":"2019","journal-title":"Ageing Res Rev"},{"key":"5","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1038\/nrg2814","article-title":"Annotating non-coding regions of the genome.","volume":"1","author":"Gerstein","year":"2010","journal-title":"Nat Rev Genet"},{"key":"6","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1038\/nrg3074","article-title":"Non-coding RNAs in human disease.","volume":"1","author":"Esteller","year":"2011","journal-title":"Nat Rev Genet"},{"key":"7","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1016\/j.heares.2012.03.008","article-title":"MicroRNAs in inner ear biology and pathogenesis.","volume":"28","author":"Hu","year":"2012","journal-title":"Hear Res"},{"key":"8","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.neulet.2017.07.044","article-title":"miR-34a\/Bcl-2 signaling pathway contributes to age-related hearing loss by modulating hair cell apoptosis.","volume":"66","author":"Ye","year":"2017","journal-title":"Neurosci Lett"},{"key":"9","doi-asserted-by":"publisher","first-page":"1692","DOI":"10.1016\/j.neurobiolaging.2014.12.034","article-title":"Activation of miR-34a\/SIRT1\/p53 signaling contributes to cochlear hair cell apoptosis: implications for age-related hearing loss.","volume":"3","author":"Zheng","year":"2015","journal-title":"Neurobiol Aging"},{"key":"10","doi-asserted-by":"publisher","first-page":"e3079","DOI":"10.1038\/cddis.2017.462","article-title":"Activation of miR-34a impairs autophagic flux and promotes cochlear cell death via repressing ATG9A: implications for age-related hearing loss.","volume":"8","author":"Zheng","year":"2017","journal-title":"Cell Death Dis"},{"key":"11","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1186\/s12935-018-0503-5","article-title":"Long noncoding RNA LINC01510 promotes the growth of colorectal cancer cells by modulating MET expression.","volume":"1","author":"Li","year":"2018","journal-title":"Cancer Cell Int"},{"key":"12","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1016\/j.biopha.2018.03.011","article-title":"Long noncoding RNA SNHG7 accelerates prostate cancer proliferation and cycle progression through cyclin D1 by sponging miR-503.","volume":"10","author":"Weng","year":"2018","journal-title":"Biomed Pharmacother"},{"key":"13","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1016\/j.neuint.2018.03.011","article-title":"Long noncoding RNA DANCR mediates cisplatin resistance in glioma cells via activating AXL\/PI3K\/Akt\/NF-\u03baB signaling pathway.","volume":"11","author":"Lin","year":"2018","journal-title":"Neurochem Int"},{"key":"14","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1038\/nrd4018","article-title":"Targeting long non-coding RNA to therapeutically upregulate gene expression.","volume":"1","author":"Wahlestedt","year":"2013","journal-title":"Nat Rev Drug Discov"},{"key":"15","doi-asserted-by":"publisher","first-page":"1298","DOI":"10.1016\/j.cell.2013.02.012","article-title":"Long noncoding RNAs: cellular address codes in development and disease.","volume":"15","author":"Chang","year":"2013","journal-title":"Cell"},{"key":"16","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1016\/j.cell.2018.01.011","article-title":"Functional Classification and Experimental Dissection of Long Noncoding RNAs.","volume":"17","author":"Mendell","year":"2018","journal-title":"Cell"},{"key":"17","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.addr.2015.05.012","article-title":"Basic biology and therapeutic implications of lncRNA.","volume":"8","author":"Wahlestedt","year":"2015","journal-title":"Adv Drug Deliv Rev"},{"key":"18","doi-asserted-by":"publisher","first-page":"4","DOI":"10.3390\/ncrna4020012","article-title":"Long Non-Coding RNAs in Neuronal Aging.","volume":"4","author":"Barry","year":"2018","journal-title":"Noncoding RNA"},{"key":"19","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1002\/lio2.134","article-title":"Age-related hearing loss: unraveling the pieces.","volume":"3","author":"Friedman","year":"2018","journal-title":"Laryngoscope Investig Otolaryngol"},{"key":"20","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1159\/000338588","article-title":"Recent advances in the study of age-related hearing loss: a mini-review.","volume":"5","author":"Bao","year":"2012","journal-title":"Gerontology"},{"key":"21","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1016\/j.cellsig.2014.11.024","article-title":"The autophagy pathway maintained signaling crosstalk with the Keap1-Nrf2 system through p62 in auditory cells under oxidative stress.","volume":"2","author":"Ogawa","year":"2015","journal-title":"Cell Signal"},{"key":"22","doi-asserted-by":"publisher","first-page":"3644","DOI":"10.18632\/oncotarget.2874","article-title":"Autophagy through 4EBP1 and AMPK regulates oxidative stress-induced premature senescence in auditory cells.","volume":"6","author":"Ogawa","year":"2015","journal-title":"Oncotarget"},{"key":"23","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1089\/ars.2011.4037","article-title":"Oxidative stress, inflammation, and autophagic stress as the key mechanisms of premature age-related hearing loss in SAMP8 mouse Cochlea.","volume":"1","author":"Wang","year":"2012","journal-title":"Antioxid Redox Signal"},{"key":"24","doi-asserted-by":"publisher","first-page":"1298","DOI":"10.1016\/j.freeradbiomed.2010.07.015","article-title":"Cytotoxic potency of H2O2 in cell cultures: impact of cell concentration and exposure time.","volume":"4","author":"Seibert","year":"2010","journal-title":"Free Radic Biol Med"},{"key":"25","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1016\/j.jdermsci.2019.03.007","article-title":"Berberine protects immortalized line of human melanocytes from HO-induced oxidative stress via activation of Nrf2 and Mitf signaling pathway.","volume":"9","author":"Jian","year":"2019","journal-title":"J Dermatol Sci"},{"key":"26","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1024\/0300-9831\/a000493","article-title":"Epigallocatechin Gallate Protects against TNF\u03b1- or H(2)O(2)- Induced Apoptosis by Modulating Iron Related Proteins in a Cell Culture Model.","volume":"8","author":"Reddy","year":"2018","journal-title":"Int J Vitam Nutr Res"},{"key":"27","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1038\/nature06091","article-title":"Cadherin 23 and protocadherin 15 interact to form tip-link filaments in sensory hair cells.","volume":"44","author":"Kachar","year":"2007","journal-title":"Nature"},{"key":"28","doi-asserted-by":"publisher","first-page":"13898","DOI":"10.1073\/pnas.1304644110","article-title":"Progressive hearing loss and gradual deterioration of sensory hair bundles in the ears of mice lacking the actin-binding protein Eps8L2.","volume":"11","author":"Di Fiore","year":"2013","journal-title":"Proc Natl Acad Sci USA"},{"key":"29","doi-asserted-by":"publisher","first-page":"9208","DOI":"10.1523\/JNEUROSCI.23-27-09208.2003","article-title":"A receptor-like inositol lipid phosphatase is required for the maturation of developing cochlear hair bundles.","volume":"2","author":"Richardson","year":"2003","journal-title":"J Neurosci"},{"key":"30","doi-asserted-by":"publisher","first-page":"6689","DOI":"10.1093\/emboj\/cdf689","article-title":"Myosin VIIa, harmonin and cadherin 23, three Usher I gene products that cooperate to shape the sensory hair cell bundle.","volume":"2","author":"Wolfrum","year":"2002","journal-title":"EMBO J"},{"key":"31","doi-asserted-by":"publisher","first-page":"7957","DOI":"10.1128\/MCB.23.22.7957-7964.2003","article-title":"The DFNA15 deafness mutation affects POU4F3 protein stability, localization, and transcriptional activity.","volume":"2","author":"Avraham","year":"2003","journal-title":"Mol Cell Biol"},{"key":"32","doi-asserted-by":"publisher","first-page":"1950","DOI":"10.1126\/science.279.5358.1950","article-title":"Mutation in transcription factor POU4F3 associated with inherited progressive hearing loss in humans.","volume":"27","author":"Friedman","year":"1998","journal-title":"Science"},{"key":"33","doi-asserted-by":"publisher","first-page":"4333","DOI":"10.1073\/pnas.97.8.4333","article-title":"KCNQ4, a K+ channel mutated in a form of dominant deafness, is expressed in the inner ear and the central auditory pathway.","volume":"9","author":"Jentsch","year":"2000","journal-title":"Proc Natl Acad Sci USA"},{"key":"34","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1016\/S0092-8674(00)80556-5","article-title":"KCNQ4, a novel potassium channel expressed in sensory outer hair cells, is mutated in dominant deafness.","volume":"9","author":"Jentsch","year":"1999","journal-title":"Cell"},{"key":"35","doi-asserted-by":"publisher","first-page":"892","DOI":"10.1111\/cge.12915","article-title":"Extension of the clinical and molecular phenotype of DIAPH1-associated autosomal dominant hearing loss (DFNA1).","volume":"9","author":"Bolz","year":"2017","journal-title":"Clin Genet"},{"key":"36","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1016\/j.ajhg.2009.07.017","article-title":"Mutations in LOXHD1, an evolutionarily conserved stereociliary protein, disrupt hair cell function in mice and cause progressive hearing loss in humans.","volume":"8","author":"Wiltshire","year":"2009","journal-title":"Am J Hum Genet"},{"key":"37","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/j.cub.2010.12.046","article-title":"Regulation of stereocilia length by myosin XVa and whirlin depends on the actin-regulatory protein Eps8.","volume":"2","author":"Kachar","year":"2011","journal-title":"Curr Biol"},{"key":"38","doi-asserted-by":"publisher","first-page":"9864","DOI":"10.1073\/pnas.1401950111","article-title":"FAM65B is a membrane-associated protein of hair cell stereocilia required for hearing.","volume":"11","author":"Blanton","year":"2014","journal-title":"Proc Natl Acad Sci USA"},{"key":"39","doi-asserted-by":"publisher","first-page":"21584","DOI":"10.1074\/jbc.M111.320481","article-title":"Loss of mammal-specific tectorial membrane component carcinoembryonic antigen cell adhesion molecule 16 (CEACAM16) leads to hearing impairment at low and high frequencies.","volume":"28","author":"Schrewe","year":"2012","journal-title":"J Biol Chem"},{"key":"40","doi-asserted-by":"publisher","first-page":"8791","DOI":"10.1074\/jbc.272.13.8791","article-title":"The mouse tectorins. Modular matrix proteins of the inner ear homologous to components of the sperm-egg adhesion system.","volume":"27","author":"Richardson","year":"1997","journal-title":"J Biol Chem"},{"key":"41","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.ajhg.2009.06.003","article-title":"Noncoding mutations of HGF are associated with nonsyndromic hearing loss, DFNB39.","volume":"8","author":"Hassan","year":"2009","journal-title":"Am J Hum Genet"},{"key":"42","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.ajhg.2011.05.027","article-title":"Functional mutation of SMAC\/DIABLO, encoding a mitochondrial proapoptotic protein, causes human progressive hearing loss DFNA64.","volume":"8","author":"Zhang","year":"2011","journal-title":"Am J Hum Genet"},{"key":"43","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.ajhg.2007.09.008","article-title":"Mutations of ESRRB encoding estrogen-related receptor beta cause autosomal-recessive nonsyndromic hearing impairment DFNB35.","volume":"8","author":"Eyupoglu","year":"2008","journal-title":"Am J Hum Genet"},{"key":"44","doi-asserted-by":"publisher","first-page":"6240","DOI":"10.1073\/pnas.082515999","article-title":"Otoancorin, an inner ear protein restricted to the interface between the apical surface of sensory epithelia and their overlying acellular gels, is defective in autosomal recessive deafness DFNB22.","volume":"9","author":"Lathrop","year":"2002","journal-title":"Proc Natl Acad Sci USA"},{"key":"45","doi-asserted-by":"publisher","first-page":"872","DOI":"10.1016\/j.ajhg.2012.09.011","article-title":"Mutations in OTOGL, encoding the inner ear protein otogelin-like, cause moderate sensorineural hearing loss.","volume":"9","author":"Young","year":"2012","journal-title":"Am J Hum Genet"},{"key":"46","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1038\/gim.2016.142","article-title":"A dominant variant in DMXL2 is linked to nonsyndromic hearing loss.","volume":"1","author":"Shi","year":"2017","journal-title":"Genet Med"},{"key":"47","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1038\/s41388-019-0991-3","article-title":"TXNDC9 regulates oxidative stress-induced androgen receptor signaling to promote prostate cancer progression.","volume":"3","author":"Han","year":"2020","journal-title":"Oncogene"},{"key":"48","doi-asserted-by":"publisher","first-page":"1311","DOI":"10.1016\/j.cell.2007.05.022","article-title":"Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs.","volume":"12","author":"Chang","year":"2007","journal-title":"Cell"},{"key":"49","doi-asserted-by":"publisher","first-page":"2573","DOI":"10.1101\/gad.178780.111","article-title":"Long noncoding RNA-mediated anti-apoptotic activity in murine erythroid terminal differentiation.","volume":"2","author":"Lodish","year":"2011","journal-title":"Genes Dev"},{"key":"50","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1093\/annhyg\/mes005","article-title":"Toxicity and genotoxicity of nano-SiO2 on human epithelial intestinal HT-29 cell line.","volume":"5","author":"Chevillard","year":"2012","journal-title":"Ann Occup Hyg"}],"container-title":["Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.103103","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,2]],"date-time":"2020-09-02T20:18:09Z","timestamp":1599077889000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.103103"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,26]]},"references-count":50,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2020,4,30]]}},"alternative-id":["103103","32335544"],"URL":"https:\/\/doi.org\/10.18632\/aging.103103","relation":{},"ISSN":["1945-4589"],"issn-type":[{"value":"1945-4589","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,26]]}}}