{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:27:04Z","timestamp":1787023624912,"version":"build-2736575974"},"reference-count":46,"publisher":"Impact Journals, LLC","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aging"],"published-print":{"date-parts":[[2020,5,19]]},"DOI":"10.18632\/aging.103223","type":"journal-article","created":{"date-parts":[[2020,5,19]],"date-time":"2020-05-19T11:26:17Z","timestamp":1589887577000},"page":"9500-9514","source":"Crossref","is-referenced-by-count":48,"title":["MiR-16-5p regulates postmenopausal osteoporosis by directly targeting VEGFA"],"prefix":"10.18632","volume":"12","author":[{"given":"Tao","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Orthopedic Surgery, Tongji Hospital, Tongji University School of Medicine, Shanghai 200065, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomeng","family":"You","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, MA 02115, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haichao","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Tongji Hospital, Tongji University School of Medicine, Shanghai 200065, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenbao","family":"He","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Tongji Hospital, Tongji University School of Medicine, Shanghai 200065, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihua","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Tongji Hospital, Tongji University School of Medicine, Shanghai 200065, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Tongji Hospital, Tongji University School of Medicine, Shanghai 200065, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiang","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Tongji Hospital, Tongji University School of Medicine, Shanghai 200065, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Tongji Hospital, Tongji University School of Medicine, Shanghai 200065, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youguang","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Tongji Hospital, Tongji University School of Medicine, Shanghai 200065, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangrong","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Tongji Hospital, Tongji University School of Medicine, Shanghai 200065, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Xiong","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunfeng","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Tongji Hospital, Tongji University School of Medicine, Shanghai 200065, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7892","published-online":{"date-parts":[[2020,5,19]]},"reference":[{"key":"1","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1359\/jbmr.061113","article-title":"Incidence and economic burden of osteoporosis-related fractures in the United States, 2005-2025.","volume":"2","author":"Tosteson","year":"2007","journal-title":"J Bone Miner Res"},{"key":"2","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1186\/s12905-019-0808-0","article-title":"Association of breastfeeding and postmenopausal osteoporosis in Chinese women: a community-based retrospective study.","volume":"1","author":"Cao","year":"2019","journal-title":"BMC Womens Health"},{"key":"3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.5339\/jlghs.2016.2","article-title":"Osteoporosis: an under-recognized public health problem.","volume":"2","author":"Rajasree Vijayakumar","year":"2016","journal-title":"Journal of Local and Global Health Science"},{"key":"4","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1016\/S2213-8587(19)30346-8","article-title":"Odanacatib for the treatment of postmenopausal osteoporosis: results of the LOFT multicentre, randomised, double-blind, placebo-controlled trial and LOFT Extension study.","volume":"7","author":"Ling","year":"2019","journal-title":"Lancet Diabetes Endocrinol"},{"key":"5","doi-asserted-by":"publisher","first-page":"1067","DOI":"10.1007\/s40520-015-0509-y","article-title":"Identification of crucial genes related to postmenopausal osteoporosis using gene expression profiling.","volume":"2","author":"Cai","year":"2016","journal-title":"Aging Clin Exp Res"},{"key":"6","doi-asserted-by":"publisher","first-page":"2041","DOI":"10.1007\/s00198-018-4575-9","article-title":"Genetic susceptibility of postmenopausal osteoporosis on sulfide quinone reductase-like gene.","volume":"2","author":"Liu","year":"2018","journal-title":"Osteoporos Int"},{"key":"7","doi-asserted-by":"publisher","first-page":"3202","DOI":"10.3892\/mmr.2019.10570","article-title":"PPWD1 is associated with the occurrence of postmenopausal osteoporosis as determined by weighted gene co-expression network analysis.","volume":"2","author":"Xiao","year":"2019","journal-title":"Mol Med Rep"},{"key":"8","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1038\/nrg3765","article-title":"Identification and consequences of miRNA-target interactions\u2014beyond repression of gene expression.","volume":"1","author":"Zavolan","year":"2014","journal-title":"Nat Rev Genet"},{"key":"9","doi-asserted-by":"publisher","first-page":"1368","DOI":"10.1016\/S1474-4422(16)30246-0","article-title":"MicroRNAs in epilepsy: pathophysiology and clinical utility.","volume":"1","author":"Rosenow","year":"2016","journal-title":"Lancet Neurol"},{"key":"10","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1038\/nmeth.4610","article-title":"Cell-type specific sequencing of microRNAs from complex animal tissues.","volume":"1","author":"Cochella","year":"2018","journal-title":"Nat Methods"},{"key":"11","doi-asserted-by":"publisher","first-page":"553","DOI":"10.3109\/1354750X.2014.935957","article-title":"Plasma miRNA levels correlate with sensitivity to bone mineral density in postmenopausal osteoporosis patients.","volume":"1","author":"Zhang","year":"2014","journal-title":"Biomarkers"},{"key":"12","doi-asserted-by":"publisher","first-page":"4125","DOI":"10.1210\/jc.2016-2365","article-title":"Circulating microRNA Signatures in Patients With Idiopathic and Postmenopausal Osteoporosis and Fragility Fractures.","volume":"10","author":"Hackl","year":"2016","journal-title":"J Clin Endocrinol Metab"},{"key":"13","doi-asserted-by":"publisher","first-page":"e97098","DOI":"10.1371\/journal.pone.0097098","article-title":"MiR-422a as a potential cellular microRNA biomarker for postmenopausal osteoporosis.","volume":"9","author":"Xiao","year":"2014","journal-title":"PLoS One"},{"key":"14","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1093\/abbs\/gmy006","article-title":"MiRNA-133a is involved in the regulation of postmenopausal osteoporosis through promoting osteoclast differentiation.","volume":"5","author":"Huang","year":"2018","journal-title":"Acta Biochim Biophys Sin (Shanghai)"},{"key":"15","doi-asserted-by":"publisher","first-page":"5534","DOI":"10.26355\/eurrev_201712_13989","article-title":"The function of miR-218 and miR-618 in postmenopausal osteoporosis.","volume":"2","author":"Zhang","year":"2017","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"16","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1159\/000445621","article-title":"MiR-27a is Essential for the Shift from Osteogenic Differentiation to Adipogenic Differentiation of Mesenchymal Stem Cells in Postmenopausal Osteoporosis.","volume":"3","author":"Chen","year":"2016","journal-title":"Cell Physiol Biochem"},{"key":"17","doi-asserted-by":"publisher","first-page":"6301","DOI":"10.3892\/mmr.2018.8713","article-title":"MicroRNA-214-5p\/TGF-\u03b2\/Smad2 signaling alters adipogenic differentiation of bone marrow stem cells in postmenopausal osteoporosis.","volume":"1","author":"Chen","year":"2018","journal-title":"Mol Med Rep"},{"key":"18","doi-asserted-by":"publisher","first-page":"5804","DOI":"10.26355\/eurrev_201809_15906","article-title":"MiR-203 is essential for the shift from osteogenic differentiation to adipogenic differentiation of mesenchymal stem cells in postmenopausal osteoporosis.","volume":"2","author":"Wang","year":"2018","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"19","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1038\/s41587-019-0053-y","article-title":"How bioinformatics and open data can boost basic science in countries and universities with limited resources.","volume":"3","author":"Eskin","year":"2019","journal-title":"Nat Biotechnol"},{"key":"20","doi-asserted-by":"publisher","first-page":"925","DOI":"10.1039\/C6NP00018E","article-title":"Bioinformatics for the synthetic biology of natural products: integrating across the Design-Build-Test cycle.","volume":"3","author":"Breitling","year":"2016","journal-title":"Nat Prod Rep"},{"key":"21","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1016\/j.jhep.2014.10.036","article-title":"Bioinformatics and database resources in hepatology.","volume":"6","author":"Teufel","year":"2015","journal-title":"J Hepatol"},{"key":"22","doi-asserted-by":"publisher","first-page":"4","DOI":"10.7554\/eLife.05005","article-title":"Predicting effective microRNA target sites in mammalian mRNAs.","volume":"4","author":"Bartel","year":"2015","journal-title":"eLife"},{"key":"23","doi-asserted-by":"publisher","first-page":"D231","DOI":"10.1093\/nar\/gkv1270","article-title":"DIANA-LncBase v2: indexing microRNA targets on non-coding transcripts.","volume":"4","author":"Hatzigeorgiou","year":"2016","journal-title":"Nucleic Acids Res"},{"key":"24","doi-asserted-by":"publisher","first-page":"3101","DOI":"10.1172\/JCI61209","article-title":"Intracellular VEGF regulates the balance between osteoblast and adipocyte differentiation.","volume":"12","author":"Olsen","year":"2012","journal-title":"J Clin Invest"},{"key":"25","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1002\/stem.581","article-title":"Locally applied vascular endothelial growth factor A increases the osteogenic healing capacity of human adipose-derived stem cells by promoting osteogenic and endothelial differentiation.","volume":"2","author":"Quarto","year":"2011","journal-title":"Stem Cells"},{"key":"26","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1172\/JCI82585","article-title":"Osteoblast-derived VEGF regulates osteoblast differentiation and bone formation during bone repair.","volume":"12","author":"Olsen","year":"2016","journal-title":"J Clin Invest"},{"key":"27","doi-asserted-by":"publisher","first-page":"4599","DOI":"10.26355\/eurrev_201906_18037","article-title":"MiR-20b promotes osteocyte apoptosis in rats with steroid-induced necrosis of the femoral head through BMP signaling pathway.","volume":"2","author":"Wang","year":"2019","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"28","doi-asserted-by":"publisher","first-page":"3173547","DOI":"10.1155\/2017\/3173547","article-title":"MicroRNA-16-5p Inhibits Osteoclastogenesis in Giant Cell Tumor of Bone.","volume":"201","author":"Dong","year":"2017","journal-title":"BioMed Res Int"},{"key":"29","doi-asserted-by":"publisher","first-page":"1584","DOI":"10.1016\/j.spinee.2019.05.003","article-title":"Differential miRNAs profile and bioinformatics analyses in bone marrow mesenchymal stem cells from adolescent idiopathic scoliosis patients.","volume":"1","author":"Zhuang","year":"2019","journal-title":"Spine J"},{"key":"30","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1007\/s10534-018-00162-4","article-title":"MiRNA-target interactions in osteogenic signaling pathways involving zinc via the metal regulatory element.","volume":"3","author":"Grider","year":"2019","journal-title":"Biometals"},{"key":"31","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1089\/gtmb.2015.0282","article-title":"Interactions of Pri-miRNA-34b\/c and TP53 Polymorphisms on the Risk of Osteoporosis.","volume":"2","author":"Fu","year":"2016","journal-title":"Genet Test Mol Biomarkers"},{"key":"32","doi-asserted-by":"publisher","first-page":"1333","DOI":"10.12659\/MSM.894111","article-title":"Identification of transcriptional factors and key genes in primary osteoporosis by DNA microarray.","volume":"2","author":"Gao","year":"2015","journal-title":"Med Sci Monit"},{"key":"33","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.diff.2011.08.008","article-title":"Transcription factors TP53 and SP1 and the osteogenic differentiation of dental stem cells.","volume":"8","author":"Morsczeck","year":"2012","journal-title":"Differentiation"},{"key":"34","doi-asserted-by":"publisher","first-page":"2022","DOI":"10.1038\/cdd.2017.113","article-title":"p53 inhibits SP7\/Osterix activity in the transcriptional program of osteoblast differentiation.","volume":"2","author":"Ventura","year":"2017","journal-title":"Cell Death Differ"},{"key":"35","doi-asserted-by":"publisher","first-page":"912","DOI":"10.1016\/j.archoralbio.2013.02.013","article-title":"Gene clustering analysis in human osteoporosis disease and modifications of the jawbone.","volume":"5","author":"Sbordone","year":"2013","journal-title":"Arch Oral Biol"},{"key":"36","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1186\/s12967-019-2129-3","article-title":"Identifying genetic variants underlying medication-induced osteonecrosis of the jaw in cancer and osteoporosis: a case control study.","volume":"1","author":"Kim","year":"2019","journal-title":"J Transl Med"},{"key":"37","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1089\/ten.tea.2013.0006","article-title":"Cyclic tensile strain enhances osteogenesis and angiogenesis in mesenchymal stem cells from osteoporotic donors.","volume":"2","author":"Loboa","year":"2014","journal-title":"Tissue Eng Part A"},{"key":"38","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1038\/s41419-018-0403-6","article-title":"MiR-16-5p targets SESN1 to regulate the p53 signaling pathway, affecting myoblast proliferation and apoptosis, and is involved in myoblast differentiation.","volume":"9","author":"Zhang","year":"2018","journal-title":"Cell Death Dis"},{"key":"39","doi-asserted-by":"publisher","first-page":"1087","DOI":"10.1159\/000495489","article-title":"miR-16-2* Interferes with WNT5A to Regulate Osteogenesis of Mesenchymal Stem Cells.","volume":"5","author":"Yu","year":"2018","journal-title":"Cell Physiol Biochem"},{"key":"40","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1089\/ten.tea.2017.0460","article-title":"Harnessing an Inhibitory Role of miR-16 in Osteogenesis by Human Mesenchymal Stem Cells for Advanced Scaffold-Based Bone Tissue Engineering.","volume":"2","author":"O\u2019Brien","year":"2019","journal-title":"Tissue Eng Part A"},{"key":"41","doi-asserted-by":"publisher","first-page":"81","DOI":"10.5582\/irdr.2012.v1.2.81","article-title":"Serum microRNA is a promising biomarker for osteogenesis imperfecta.","volume":"1","author":"Han","year":"2012","journal-title":"Intractable Rare Dis Res"},{"key":"42","doi-asserted-by":"publisher","first-page":"D607","DOI":"10.1093\/nar\/gky1131","article-title":"STRING v11: protein-protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets.","volume":"4","author":"Mering","year":"2019","journal-title":"Nucleic Acids Res"},{"key":"43","doi-asserted-by":"publisher","first-page":"2498","DOI":"10.1101\/gr.1239303","article-title":"Cytoscape: a software environment for integrated models of biomolecular interaction networks.","volume":"1","author":"Ideker","year":"2003","journal-title":"Genome Res"},{"key":"44","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-24277-4_9","volume-title":"ggplot2. Elegant Graphics for Data Analysis.","author":"Wickham","year":"2016"},{"key":"45","doi-asserted-by":"publisher","first-page":"2912","DOI":"10.1093\/bioinformatics\/btv300","article-title":"GOplot: an R package for visually combining expression data with functional analysis.","volume":"3","author":"Ricote","year":"2015","journal-title":"Bioinformatics"},{"key":"46","doi-asserted-by":"publisher","first-page":"2811","DOI":"10.1093\/bioinformatics\/btu393","article-title":"circlize Implements and enhances circular visualization in R.","volume":"3","author":"Brors","year":"2014","journal-title":"Bioinformatics"}],"container-title":["Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.103223","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,2]],"date-time":"2020-09-02T16:24:26Z","timestamp":1599063866000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.103223"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,19]]},"references-count":46,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2020,5,31]]}},"alternative-id":["103223","32427128"],"URL":"https:\/\/doi.org\/10.18632\/aging.103223","relation":{},"ISSN":["1945-4589"],"issn-type":[{"value":"1945-4589","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,19]]}}}