{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T16:24:36Z","timestamp":1790267076346,"version":"4.1.0"},"reference-count":40,"publisher":"Impact Journals, LLC","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aging"],"published-print":{"date-parts":[[2020,5,20]]},"DOI":"10.18632\/aging.103270","type":"journal-article","created":{"date-parts":[[2020,5,20]],"date-time":"2020-05-20T17:00:36Z","timestamp":1589994036000},"page":"10457-10472","source":"Crossref","is-referenced-by-count":61,"title":["Ellagic acid protects mice against sleep deprivation-induced memory impairment and anxiety by inhibiting TLR4 and activating Nrf2"],"prefix":"10.18632","volume":"12","author":[{"given":"Wenjun","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, Xi\u2019an 710032, China"},{"name":"College of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang 712046, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liudi","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, Xi'an International University, Xi\u2019an 710077, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianlong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, Xi\u2019an 710032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingwen","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, Xi\u2019an 710032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aidong","family":"Wen","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, Xi\u2019an 710032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, Xi\u2019an 710032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7892","published-online":{"date-parts":[[2020,5,20]]},"reference":[{"key":"1","doi-asserted-by":"publisher","first-page":"e12574","DOI":"10.1111\/jpi.12574","article-title":"Role of melatonin in sleep deprivation-induced intestinal barrier dysfunction in mice.","volume":"6","author":"Chen","year":"2019","journal-title":"J Pineal Res"},{"key":"2","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.smrv.2019.03.008","article-title":"Functional brain alterations in acute sleep deprivation: an activation likelihood estimation meta-analysis.","volume":"4","author":"Tahmasian","year":"2019","journal-title":"Sleep Med Rev"},{"key":"3","doi-asserted-by":"publisher","first-page":"e13021","DOI":"10.1111\/acel.13021","article-title":"Age attenuates the transcriptional changes that occur with sleep in the medial prefrontal cortex.","volume":"1","author":"Pack","year":"2019","journal-title":"Aging Cell"},{"key":"4","doi-asserted-by":"publisher","first-page":"2215","DOI":"10.1017\/S0033291712002875","article-title":"Sleep deprivation amplifies striatal activation to monetary reward.","volume":"4","author":"Franzen","year":"2013","journal-title":"Psychol Med"},{"key":"5","doi-asserted-by":"publisher","first-page":"519","DOI":"10.18632\/aging.100181","article-title":"The sleep-feeding conflict: understanding behavioral integration through genetic analysis in drosophila.","volume":"2","author":"Keene","year":"2010","journal-title":"Aging (Albany NY)"},{"key":"6","doi-asserted-by":"publisher","first-page":"e46807","DOI":"10.15252\/embr.201846807","article-title":"Genetic sleep deprivation: using sleep mutants to study sleep functions.","volume":"2","author":"Bringmann","year":"2019","journal-title":"EMBO Rep"},{"key":"7","doi-asserted-by":"publisher","first-page":"7","DOI":"10.5334\/jcr.183","article-title":"Sleep and microdialysis: an experiment and a systematic review of histamine and several amino acids.","volume":"1","author":"De Vries","year":"2019","journal-title":"J Circadian Rhythms"},{"key":"8","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1186\/s12974-019-1690-2","article-title":"Toll-like receptor 4 agonist and antagonist lipopolysaccharides modify innate immune response in rat brain circumventricular organs.","volume":"1","author":"Leza","year":"2020","journal-title":"J Neuroinflammation"},{"key":"9","doi-asserted-by":"publisher","first-page":"135624","DOI":"10.1016\/j.scitotenv.2019.135624","article-title":"Emerging promise of sulforaphane-mediated Nrf2 signaling cascade against neurological disorders.","volume":"70","author":"Aleya","year":"2020","journal-title":"Sci Total Environ"},{"key":"10","doi-asserted-by":"publisher","first-page":"1971","DOI":"10.18632\/aging.101288","article-title":"Toll-like receptor 4 (TLR4) deficient mice are protected from adipose tissue inflammation in aging.","volume":"9","author":"Yung","year":"2017","journal-title":"Aging (Albany NY)"},{"key":"11","doi-asserted-by":"publisher","first-page":"2091","DOI":"10.1159\/000485947","article-title":"Glaucocalyxin B alleviates lipopolysaccharide-induced parkinson's disease by inhibiting TLR\/NF-\u03baB and activating Nrf2\/HO-1 pathway.","volume":"4","author":"Shang","year":"2017","journal-title":"Cell Physiol Biochem"},{"key":"12","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.neuroscience.2015.05.062","article-title":"Pathological changes in hippocampal neuronal circuits underlie age-associated neurodegeneration and memory loss: positive clue toward SAD.","volume":"30","author":"Anusuyadevi","year":"2015","journal-title":"Neuroscience"},{"key":"13","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.pbb.2018.08.007","article-title":"Ellagic acid: insights into its neuroprotective and cognitive enhancement effects in sporadic alzheimer\u2019s disease.","volume":"17","author":"Shah","year":"2018","journal-title":"Pharmacol Biochem Behav"},{"key":"14","doi-asserted-by":"publisher","first-page":"152921","DOI":"10.1016\/j.phymed.2019.152921","article-title":"Ellagic acid synergistically potentiates inhibitory activities of chemotherapeutic agents to human hepatocellular carcinoma.","volume":"5","author":"Sui","year":"2019","journal-title":"Phytomedicine"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201600587","article-title":"Ellagic acid improves endogenous neural stem cells proliferation and neurorestoration through Wnt\/\u03b2-catenin signaling in vivo and in vitro.","volume":"6","author":"Pang","year":"2017","journal-title":"Mol Nutr Food Res"},{"key":"16","doi-asserted-by":"publisher","first-page":"11179","DOI":"10.1021\/acsomega.8b01716","article-title":"Molecular structure of the photo-oxidation product of ellagic acid in solution.","volume":"3","author":"Akutagawa","year":"2018","journal-title":"ACS Omega"},{"key":"17","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1007\/s00210-018-1524-2","article-title":"Ellagic acid prevents dementia through modulation of PI3-kinase-endothelial nitric oxide synthase signalling in streptozotocin-treated rats.","volume":"39","author":"Bansal","year":"2018","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"18","doi-asserted-by":"publisher","first-page":"423","DOI":"10.23736\/S0390-5616.18.04384-9","article-title":"Improvement in mood, oxidative stress, fatigue, and insomnia following supplementary management with robuvit\u00ae.","volume":"6","author":"Cesarone","year":"2018","journal-title":"J Neurosurg Sci"},{"key":"19","doi-asserted-by":"publisher","first-page":"111724","DOI":"10.1016\/j.ejmech.2019.111724","article-title":"Ellagic acid a multi-target bioactive compound for drug discovery in CNS? a narrative review.","volume":"18","author":"Boggia","year":"2019","journal-title":"Eur J Med Chem"},{"key":"20","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.lfs.2015.01.013","article-title":"Ellagic acid prevents cognitive and hippocampal long-term potentiation deficits and brain inflammation in rat with traumatic brain injury.","volume":"12","author":"Mashhadizadeh","year":"2015","journal-title":"Life Sci"},{"key":"21","doi-asserted-by":"publisher","first-page":"1631","DOI":"10.1016\/j.clnu.2017.07.024","article-title":"The associations between carbohydrate and protein intakes with habitual sleep duration among adults living in urban and rural areas.","volume":"3","author":"Chang","year":"2018","journal-title":"Clin Nutr"},{"key":"22","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1016\/j.nlm.2011.07.004","article-title":"The cognitive cost of sleep lost.","volume":"9","author":"Strecker","year":"2011","journal-title":"Neurobiol Learn Mem"},{"key":"23","doi-asserted-by":"publisher","first-page":"116954","DOI":"10.1016\/j.lfs.2019.116954","article-title":"Ellagic acid improves muscle dysfunction in cuprizone-induced demyelinated mice via mitochondrial Sirt3 regulation.","volume":"23","author":"Khoshnoud","year":"2019","journal-title":"Life Sci"},{"key":"24","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1016\/j.ijcard.2014.06.045","article-title":"Dietary ellagic acid improves oxidant-induced endothelial dysfunction and atherosclerosis: role of Nrf2 activation.","volume":"17","author":"Wen","year":"2014","journal-title":"Int J Cardiol"},{"key":"25","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1016\/j.bbi.2019.03.001","article-title":"Gintonin, a ginseng-derived ingredient, as a novel therapeutic strategy for huntington\u2019s disease: activation of the Nrf2 pathway through lysophosphatidic acid receptors.","volume":"8","author":"Cho","year":"2019","journal-title":"Brain Behav Immun"},{"key":"26","doi-asserted-by":"publisher","first-page":"2889","DOI":"10.3389\/fimmu.2018.02889","article-title":"Neuroprotective effects of ginsenoside-Rg1 against depression-like behaviors via suppressing glial activation, synaptic deficits, and neuronal apoptosis in rats.","volume":"9","author":"Yu","year":"2018","journal-title":"Front Immunol"},{"key":"27","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1038\/nature09973","article-title":"TLR signalling augments macrophage bactericidal activity through mitochondrial ROS.","volume":"47","author":"Ghosh","year":"2011","journal-title":"Nature"},{"key":"28","doi-asserted-by":"publisher","first-page":"569","DOI":"10.4049\/jimmunol.0902315","article-title":"NADPH oxidase-dependent reactive oxygen species mediate amplified TLR4 signaling and sepsis-induced mortality in Nrf2-deficient mice.","volume":"18","author":"Biswal","year":"2010","journal-title":"J Immunol"},{"key":"29","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1007\/s40199-019-00309-9","article-title":"Ellagic acid reduces methotrexate-induced apoptosis and mitochondrial dysfunction via up-regulating Nrf2 expression and inhibiting the I\u0138B\u03b1\/NF\u0138B in rats.","volume":"2","author":"Sabzevari","year":"2019","journal-title":"Daru"},{"key":"30","doi-asserted-by":"publisher","first-page":"2957354","DOI":"10.1155\/2016\/2957354","article-title":"Adiponectin protects against glutamate-induced excitotoxicity via activating SIRT1-dependent PGC-1\u03b1 expression in HT22 hippocampal neurons.","volume":"201","author":"Qu","year":"2016","journal-title":"Oxid Med Cell Longev"},{"key":"31","doi-asserted-by":"publisher","first-page":"e2369","DOI":"10.1038\/cddis.2016.261","article-title":"Adipose-derived mesenchymal stem cells promote the survival of fat grafts via crosstalk between the Nrf2 and TLR4 pathways.","volume":"7","author":"Chen","year":"2016","journal-title":"Cell Death Dis"},{"key":"32","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1007\/s12035-011-8181-5","article-title":"Modulation of Nrf2\/ARE pathway by food polyphenols: a nutritional neuroprotective strategy for cognitive and neurodegenerative disorders.","volume":"4","author":"Fabio","year":"2011","journal-title":"Mol Neurobiol"},{"key":"33","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1042\/BST20150014","article-title":"Dissecting molecular cross-talk between Nrf2 and NF-\u03baB response pathways.","volume":"4","author":"Sanderson","year":"2015","journal-title":"Biochem Soc Trans"},{"key":"34","doi-asserted-by":"publisher","first-page":"104517","DOI":"10.1016\/j.nbd.2019.104517","article-title":"Microglia-mediated synaptic pruning is impaired in sleep-deprived adolescent mice.","volume":"13","author":"Lee","year":"2019","journal-title":"Neurobiol Dis"},{"key":"35","doi-asserted-by":"publisher","first-page":"1282","DOI":"10.1111\/bph.14626","article-title":"Modafinil protects hippocampal neurons by suppressing excessive autophagy and apoptosis in mice with sleep deprivation.","volume":"17","author":"Zhang","year":"2019","journal-title":"Br J Pharmacol"},{"key":"36","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.physbeh.2017.12.030","article-title":"Voluntary exercise impact on cognitive impairments in sleep-deprived intact female rats.","volume":"18","author":"Sheibani","year":"2018","journal-title":"Physiol Behav"},{"key":"37","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/j.phrs.2018.12.024","article-title":"Activation of agrp neurons modulates memory-related cognitive processes in mice.","volume":"14","author":"Dietrich","year":"2019","journal-title":"Pharmacol Res"},{"key":"38","doi-asserted-by":"publisher","first-page":"136942","DOI":"10.1016\/j.scitotenv.2020.136942","article-title":"Aluminum trichloride caused hippocampal neural cells death and subsequent depression-like behavior in rats via the activation of IL-1\u03b2\/JNK signaling pathway.","volume":"71","author":"Fan","year":"2020","journal-title":"Sci Total Environ"},{"key":"39","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1038\/s41386-019-0526-1","article-title":"Accelerated development of cocaine-associated dopamine transients and cocaine use vulnerability following traumatic stress.","volume":"4","author":"Espa\u00f1a","year":"2020","journal-title":"Neuropsychopharmacology"},{"key":"40","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1002\/ana.25028","article-title":"Dysregulation of LIMK-1\/cofilin-1 pathway: a possible basis for alteration of neuronal morphology in experimental cerebral malaria.","volume":"8","author":"Babu","year":"2017","journal-title":"Ann Neurol"}],"container-title":["Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.103270","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,2]],"date-time":"2020-09-02T20:26:02Z","timestamp":1599078362000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.103270"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,20]]},"references-count":40,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2020,6,15]]}},"alternative-id":["103270","32433038"],"URL":"https:\/\/doi.org\/10.18632\/aging.103270","relation":{},"ISSN":["1945-4589"],"issn-type":[{"value":"1945-4589","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,20]]}}}