{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T07:03:14Z","timestamp":1772262194419,"version":"3.50.1"},"reference-count":24,"publisher":"Impact Journals, LLC","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aging"],"published-print":{"date-parts":[[2020,6,15]]},"DOI":"10.18632\/aging.103316","type":"journal-article","created":{"date-parts":[[2020,6,15]],"date-time":"2020-06-15T15:13:44Z","timestamp":1592234024000},"page":"11568-11578","source":"Crossref","is-referenced-by-count":8,"title":["Integrative analysis of miRNAs-mRNAs reveals that miR-182 up-regulation contributes to proliferation and invasion of nasopharyngeal carcinoma by targeting PTEN"],"prefix":"10.18632","volume":"12","author":[{"given":"Zhaohui","family":"Shi","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology Head and Neck Surgery, Air Force Medical University, XiJing Hospital, Xian, Shanxi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rushi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, The Third Xiangya Hospital of Central South University, Changsha, Hunan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ligui","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Head and Neck Surgery, The 908th Hospital of Chinese People\u2019s Liberation Army Joint Logistic Support Force, Nanchang, Jiangxi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaodong","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Head and Neck Surgery, Air Force Medical University, XiJing Hospital, Xian, Shanxi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Head and Neck Surgery, Air Force Medical University, XiJing Hospital, Xian, Shanxi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dingjun","family":"Zha","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Head and Neck Surgery, Air Force Medical University, XiJing Hospital, Xian, Shanxi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanhong","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, The Third Xiangya Hospital of Central South University, Changsha, Hunan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7892","published-online":{"date-parts":[[2020,6,15]]},"reference":[{"key":"1","doi-asserted-by":"publisher","first-page":"1012","DOI":"10.1016\/S0140-6736(15)00055-0","article-title":"Nasopharyngeal carcinoma.","volume":"38","author":"Chan","year":"2016","journal-title":"Lancet"},{"key":"2","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1016\/j.soc.2015.03.008","article-title":"Nasopharyngeal carcinoma.","volume":"2","author":"Lee","year":"2015","journal-title":"Surg Oncol Clin N Am"},{"key":"3","doi-asserted-by":"publisher","first-page":"4663","DOI":"10.1038\/s41467-018-06889-5","article-title":"Establishment and characterization of new tumor xenografts and cancer cell lines from EBV-positive nasopharyngeal carcinoma.","volume":"9","author":"Zhang","year":"2018","journal-title":"Nat Commun"},{"key":"4","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1038\/nature02871","article-title":"The functions of animal microRNAs.","volume":"43","author":"Ambros","year":"2004","journal-title":"Nature"},{"key":"5","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1038\/nrg2843","article-title":"The widespread regulation of microRNA biogenesis, function and decay.","volume":"1","author":"Filipowicz","year":"2010","journal-title":"Nat Rev Genet"},{"key":"6","doi-asserted-by":"publisher","first-page":"1771","DOI":"10.4155\/fmc.15.107","article-title":"miRNA therapeutics: a new class of drugs with potential therapeutic applications in the heart.","volume":"7","author":"McMullen","year":"2015","journal-title":"Future Med Chem"},{"key":"7","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1038\/nrd.2016.246","article-title":"MicroRNA therapeutics: towards a new era for the management of cancer and other diseases.","volume":"1","author":"Slack","year":"2017","journal-title":"Nat Rev Drug Discov"},{"key":"8","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1038\/nrd4359","article-title":"Therapeutic targeting of microRNAs: current status and future challenges.","volume":"1","author":"Rana","year":"2014","journal-title":"Nat Rev Drug Discov"},{"key":"9","doi-asserted-by":"publisher","first-page":"539","DOI":"10.5732\/cjc.014.10175","article-title":"MicroRNAs in nasopharyngeal carcinoma.","volume":"3","author":"Liu","year":"2014","journal-title":"Chin J Cancer"},{"key":"10","doi-asserted-by":"publisher","first-page":"732","DOI":"10.1101\/gad.257394.114","article-title":"miR-182 integrates apoptosis, growth, and differentiation programs in glioblastoma.","volume":"2","author":"Sznajder","year":"2015","journal-title":"Genes Dev"},{"key":"11","doi-asserted-by":"publisher","first-page":"7173","DOI":"10.1093\/nar\/gkv703","article-title":"The microRNA-183 cluster: the family that plays together stays together.","volume":"4","author":"Nonn","year":"2015","journal-title":"Nucleic Acids Res"},{"key":"12","doi-asserted-by":"publisher","first-page":"446","DOI":"10.3389\/fonc.2018.00446","article-title":"miR-182 and miR-183 promote cell proliferation and invasion by targeting FOXO1 in mesothelioma.","volume":"8","author":"Takeshima","year":"2018","journal-title":"Front Oncol"},{"key":"13","doi-asserted-by":"publisher","first-page":"24","DOI":"10.3389\/fonc.2015.00024","article-title":"PTEN: multiple functions in human Malignant tumors.","volume":"5","author":"Ciuffreda","year":"2015","journal-title":"Front Oncol"},{"key":"14","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1093\/carcin\/bgs346","article-title":"MicroRNA-144 promotes cell proliferation, migration and invasion in nasopharyngeal carcinoma through repression of PTEN.","volume":"3","author":"Fu","year":"2013","journal-title":"Carcinogenesis"},{"key":"15","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1016\/j.ijrobp.2017.09.038","article-title":"Facility volume and survival in nasopharyngeal carcinoma.","volume":"10","author":"Zumsteg","year":"2018","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"16","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1007\/s10555-015-9551-7","article-title":"Metastatic breast cancer: the potential of miRNA for diagnosis and treatment monitoring.","volume":"3","author":"Kerin","year":"2015","journal-title":"Cancer Metastasis Rev"},{"key":"17","doi-asserted-by":"publisher","first-page":"1171","DOI":"10.1016\/j.celrep.2016.12.093","article-title":"miR-182 regulates Slit2-mediated axon guidance by modulating the local translation of a specific mRNA.","volume":"1","author":"Abreu-Goodger","year":"2017","journal-title":"Cell Rep"},{"key":"18","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1002\/mc.22741","article-title":"MiR-182 inhibits the epithelial to mesenchymal transition and metastasis of lung cancer cells by targeting the met gene.","volume":"5","author":"Chen","year":"2018","journal-title":"Mol Carcinog"},{"key":"19","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.ajpath.2016.09.011","article-title":"miR-182-5p inhibition ameliorates ischemic acute kidney injury.","volume":"18","author":"Oberbauer","year":"2017","journal-title":"Am J Pathol"},{"key":"20","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1186\/s12943-016-0563-x","article-title":"MiR-182 promotes cancer invasion by linking RET oncogene activated NF-\u03baB to loss of the HES1\/Notch1 regulatory circuit.","volume":"1","author":"P\u00fctzer","year":"2017","journal-title":"Mol Cancer"},{"key":"21","doi-asserted-by":"publisher","first-page":"2156","DOI":"10.1038\/onc.2014.341","article-title":"EBV-miR-BART7-3p promotes the EMT and metastasis of nasopharyngeal carcinoma cells by suppressing the tumor suppressor PTEN.","volume":"3","author":"Fang","year":"2015","journal-title":"Oncogene"},{"key":"22","doi-asserted-by":"publisher","first-page":"3137","DOI":"10.1093\/bioinformatics\/btx373","article-title":"FQC dashboard: integrates FastQC results into a web-based, interactive, and extensible FASTQ quality control tool.","volume":"3","author":"McCue","year":"2017","journal-title":"Bioinformatics"},{"key":"23","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2.","volume":"1","author":"Anders","year":"2014","journal-title":"Genome Biol"},{"key":"24","doi-asserted-by":"publisher","first-page":"W316","DOI":"10.1093\/nar\/gkr483","article-title":"KOBAS 2.0: a web server for annotation and identification of enriched pathways and diseases.","volume":"3","author":"Wei","year":"2011","journal-title":"Nucleic Acids Res"}],"container-title":["Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.103316","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,2]],"date-time":"2020-09-02T20:28:42Z","timestamp":1599078522000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.103316"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,15]]},"references-count":24,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2020,6,30]]}},"alternative-id":["103316","32541092"],"URL":"https:\/\/doi.org\/10.18632\/aging.103316","relation":{},"ISSN":["1945-4589"],"issn-type":[{"value":"1945-4589","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,15]]}}}